Helicobacter pylori infection is associated with high incidence of gastric diseases. The extensive therapy of H. pylori infection with antibiotics has increased its resistance rates worldwide. ...Ovatodiolide, a pure constituent isolated from Anisomeles indica, has been demonstrated to possess bactericidal activity against H. pylori. In this study, ovatodiolide inhibited the growth of both H. pylori reference strain and clinical multidrug-resistant isolates. Docking analysis revealed that ovatodiolide fits into the hydrophobic pocket of a ribosomal protein, RpsB. Furthermore, ovatodiolide inhibited bacterial growth by reducing levels of RpsB, which plays a crucial role in protein translation. Our results demonstrate that ovatodiolide binds to a ribosomal protein and interferes with protein synthesis. This study provides evidence that ovatodiolide has the potential to be developed into a potent therapeutic agent for treating H. pylori infection.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The dietary intake of aleurone is beneficial to health, but higher aleurone supplementation is not conducive to wheat flour processing. Transglutaminase has been widely recognized for the positive ...role in improving the quality of wheat flour products. In the study, protein aggregation behavior and quality of aleurone-riched fine dried noodles were evaluated to explain the effect of transglutaminase on quality and protein characteristics of aleurone-riched fine dried noodles, so as to expand the utilization of wheat by-products and the production of nutrient-riched noodles. The results showed that the aleurone-riched fine dried noodles containing 1.0% TGase had the best texture properties, less cooking loss, and better sensory performance, and noodles had a tighter binding structure. Moreover, transglutaminase could inhibit the extraction of SDS soluble protein in aleurin-riched dried noodles, promoting the transformation of free sulfhydryl group to disulfide bond. Meanwhile, the protein of the aleurin-riched fine dried noodles had a higher proportion of β-sheets, the thermal stability is improved. However, a large amount of TGase can still lead to the poor quality of noodles. Therefore, the addition of 1.0% transglutaminase has a positive effect on the quality of aleurone-riched fine dried noodles through covalent interaction.
•The quality of aleurone-riched dried noodles were improved by Transglutaminase (TGase).•TGase induced a better compact structure of aleurone-riched dried noodles.•TGase promoted structural changes of samples by covalent interaction.•The thermal stability of the aleurone-riched dried noodles improved under the action of TGase.•With the TGase action, the protein of samples underwent β-turns and random coils to β-sheets.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Spontaneously Hypertensive Rats (SHR) have chronically elevated blood pressures at 30 weeks of age (systolic: 191.0 ± 1.0, diastolic: 128.8 ± 0.9). However, despite this chronic malignant ...hypertension, SHR kidneys remain relatively free of pathology due to having an augmented myogenic constriction (MC). We hypothesized that the enhanced MC in the SHR preglomerular vessels was due to increased prostaglandin and decreased nitric oxide (NO) synthesis, providing renal protection.
SHR and Wistar Kyoto (WKY) arcuate and mesenteric arteries were treated with indomethacin (prostaglandin synthesis inhibitor), N omega-nitro-L-arginine (L-NNA, NO synthase inhibitor), and nifedipine (L-type calcium channel blocker); and MC was measured in these vessels. The role of endothelium in MC was examined by removing endothelium from WKY and SHR preglomerular and mesenteric arteries using human hair, and measuring MC. We also studied the source of prostaglandin in the SHR by treating endothelium-removed arcuate arteries with indomethacin and furegrelate (thromboxane synthase inhibitor).
MC was enhanced in the SHR preglomerular vessels but not the mesenteric arteries. Indomethacin and LNNA removed the enhanced MC in the SHR. Nifedipine also inhibited MC in both WKY and SHR arcuate and mesenteric arteries. Removing endothelium did not change MC in either arcuate or mesenteric arteries of WKY and SHR rats; and did not remove the augmented MC in the SHR arcuate arteries. Indomethacin and furegrelate decreased MC in endothelium-removed SHR arcuate arteries and obliterated the enhanced MC in the SHR.
The enhanced MC in the SHR arcuate arteries was due to thromboxane A2 synthesis from the tunica media and/or adventitia layers. MC was not dependent on endothelium, but was dependent on L-type calcium channels. Nevertheless, SHR arcuate arteries displayed differential intracellular calcium signaling compared to the WKYs.
The Junggar Basin is a typical superimposed system characterized by multilateral steep thrusts and extrusions and one of the primary petroliferous basins in Western China. To date, geologists have ...been most interested in the basin's tectonic evolution and petroleum geology characteristics. Based on field outcrops, lithologic combinations, logging curves, and seismic reflection characteristics, we present a systematic study of the sequence stratigraphy pattern for the Jurassic central Junggar Basin. Herein, we identify the central Junggar area as having a “dual” characteristic sequence framework composed of a lowstand system tract (LST) and a transgressive system tract (TST), which is distinguishable from the traditional three system tract (LST, TST, and highstand system tract HST). In each third‐order sequence, the LST consists of conglomerate or pebbly sandstone deposits, displaying the characteristics of braided channel and fan delta. The TST consists of siltstone, argillaceous siltstone, and mudstone, displaying fine‐grained, shore‐shallow lacustrine deposits. It is considered that the combination of multiphasic thrust extrusion and subsequent, steady deposition is likely responsible for the dual‐system tract. The forming process of the dual‐system tract pattern could divide into four stages: the quiet stage of tectonic activity, the early stage of compression, the continuous stage of compression, and the rapid rebound stage. Additionally, two reservoir predictive models are proposed: the progradational predicting model on the edge of the depression and truncated and pinchout predicting model on the palaeo‐uplift. We conclude that the coarse clastic unit of the LST has bright prospects for oil and gas exploration within the superimposed system in Western China.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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Classifying many-body quantum states with distinct properties and phases of matter is one of the most fundamental tasks in quantum many-body physics. However, due to the exponential ...complexity that emerges from the enormous numbers of interacting particles, classifying large-scale quantum states has been extremely challenging for classical approaches. Here, we propose a new approach called quantum neuronal sensing. Utilizing a 61-qubit superconducting quantum processor, we show that our scheme can efficiently classify two different types of many-body phenomena: namely the ergodic and localized phases of matter. Our quantum neuronal sensing process allows us to extract the necessary information coming from the statistical characteristics of the eigenspectrum to distinguish these phases of matter by measuring only one qubit and offers better phase resolution than conventional methods, such as measuring the imbalance. Our work demonstrates the feasibility and scalability of quantum neuronal sensing for near-term quantum processors and opens new avenues for exploring quantum many-body phenomena in larger-scale systems.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Purpose This study aims to investigate the impacts of three slope restoration techniques, namely, soil spray sowing, vegetation fiber, and vegetation concrete, on soil fertility, pH, and organic ...matter content during the summer drought period. The study also aims to explore the advantages of these three different restoration techniques, providing a basis for slope restoration in the Northeast Jiangxi region. Methods The study used experimental slopes established with three different restoration techniques: soil spray sowing, vegetation fiber, and vegetation concrete. Soil samples were collected during the rainy season in July 2022 and the drought season in September 2022. The changes in hydrolyzable nitrogen, available potassium, available phosphorus content, pH, and organic matter in the soil after restoration were comprehensively investigated. The study relies on the Qi-Wu expressway, and all the experiments are set on the slopes on both sides of the expressway. Results①For the soil restored using soil spray sowing during the drought season, the content of hydrolyzable nitrogen and available potassium was higher than that of the original soil, while the content of available phosphorus significantly decreased. The pH changed from acidic to weakly alkaline. ②For the soil restored using vegetation fiber during the drought season, although the content of available phosphorus increased, it was still relatively low. The content of available potassium decreased, but the total amount remained high. The content of hydrolyzable nitrogen was high and showed an increasing trend. The pH slightly decreased from weakly acidic to acidic. ③For the soil restored using vegetation concrete during the drought season, the content of hydrolyzable nitrogen, available potassium, and available phosphorus was high and showed an increasing trend. The pH slightly decreased, but it remained weakly alkaline before and after the drought. Conclusion Soil spray sowing, vegetation fiber, and vegetation concrete, all three restoration techniques, could demonstrate good performance during the drought period in the Northeastern Jiangxi region. In terms of their overall performance, the ranking from strong to weak is as follows: vegetation concrete > vegetation fiber > soil spray sowing. Soil spray sowing, as the most convenient and cost-effective slope restoration technique, could in the future incorporate additives that can improve local soil properties according to different regional characteristics. Vegetation fiber not only needs to improve soil acidity-alkalinity but should also appropriately incorporate phosphorus-containing additives. Vegetation concrete needs to address the issue of reducing soil acidity-alkalinity after restoration in the future.
A novel Eu-based MOF Eu(IMS1)
2
Cl·4H
2
O (
1
) was successfully constructed based on a semi-rigid zwitterionic 1,3-bis(4-carboxylbenzyl)-imidazolium (IMS1) ligand, featuring a 3-fold ...interpenetrating dia net structure with a point symbol of 6
6
and charged permanent micropores. Considering its excellent luminescent property as well as thermal and chemical stability, complex
1
was explored as a potential sensor for detecting Fe
3+
ions. The results show that complex
1
has a high sensitivity and selectivity for Fe
3+
based on a 'turn-off' effect, for which the electrostatic interaction between Fe
3+
ions and the inner surface of the micropores may play a critical role. The fluorescence quenching mechanism reveals that dynamic quenching and competitive adsorption between Fe
3+
and
1
lead to the quenching effect of
1
.
A channel-structured Eu-based metal-organic framework with a zwitterionic ligand may serve as a sensor for selectively detecting Fe
3+
ions.
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IJS, KILJ, NUK, UL, UM, UPUK
This Letter reports all-optically tunable and highly indistinguishable single Raman photons from a driven single quantum dot spin. The frequency, linewidth, and lifetime of the Raman photons are ...tunable by varying the driving field power and detuning. Under continuous-wave excitation, subnatural linewidth single photons from off-resonant Raman scattering show an indistinguishability of 0.98(3). Under π pulse excitation, spin- and time-tagged Raman fluorescence photons show an almost vanishing multiphoton emission probability of 0.01(2) and a two-photon quantum interference visibility of 0.95(3). Lastly, Hong-Ou-Mandel interference is demonstrated between two single photons emitted from remote, independent quantum dots with an unprecedented visibility of 0.87(4).
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
Thin-film lithium niobate (TFLN) based traveling-wave modulators maintain simultaneously excellent performances, including large modulation bandwidth, high extinction ratio, low optical loss, and ...high modulation efficiency. Nevertheless, there still exists a balance between the driving voltage and modulation bandwidth. Here, we demonstrate an ultra-large bandwidth electro-optic modulator without compromising the driving voltage based on the TFLN platform on a silicon substrate, using a periodic capacitively loaded traveling-wave electrode. In order to compensate the slow-wave effect, an undercut etching technique for the silicon substrate is introduced to decrease the microwave refractive index. Our demonstrated devices represent both low optical and low microwave losses, which leads to a negligible optical insertion loss of 0.2 dB and a large electro-optic bandwidth with a roll-off of 1.4 dB at 67 GHz for a 10 mm-long device. A low half-wave voltage of 2.2 V is also achieved. Data rates up to 112 Gb s−1 with PAM-4 modulation are demonstrated. The compatibility of the proposed modulator to silicon photonics facilitates its integration with matured silicon photonic components using, e.g., hybrid integration technologies.
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