MOF-based luminescent sensors have garnered considerable attention due to their potential in recognition and discrimination with high sensitivity, selectivity, and fast response in the last decades. ...Herein, this work describes the bulk preparation of a novel luminescent homochiral MOF, namely, Cd(
-
)(NO
)
(MOF-
), from an enantiopure pyridyl-functionalized ligand with rigid binaphthol skeleton under mild synthetic condition. Except for the features of porosity and crystallinity, the MOF-
has also been characterized with water-stability, luminescence, and homochirality. Most important, the MOF-
exhibits highly sensitive molecular recognition toward the4-nitrobenzoic acid (NBC) and moderate enantioselective detection of proline, arginine, and 1-phenylethanol.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Phthalates are well-known obesogens, but a few studies have explored their impacts on the childhood fat mass index (FMI), body shape index (ABSI) and body roundness index (BRI). Information from 2950 ...participants recruited in the Ma'anshan Birth Cohort was analyzed. The relationships between six maternal phthalate metabolites and their mixture and childhood FMI, ABSI and BRI were investigated. FMI, ABSI and BRI in children aged 3.5 y, 4.0 y, 4.5 y, 5.0 y, 5.5 y and 6.0 y were calculated. The latent class trajectory modeling categorized the FMI trajectories into “rapidly increasing FMI” (4.71%) and “stable FMI” (95.29%) groups; ABSI trajectories were categorized as “decreasing ABSI” (32.74%), “stable ABSI” (46.55%), “slowly increasing ABSI” (13.26%), “moderately increasing ABSI” (5.27%) and “rapidly increasing ABSI” (2.18%) groups; BRI trajectories were categorized as “increasing BRI” (2.82%), “stable BRI” (19.85%), and “decreasing BRI” (77.34%) groups. Prenatal MEP exposure was associated with repeated measurements of FMI (β = 0.111, 95% CI = 0.002–0.221), ABSI (β = 0.145, 95% CI = 0.023–0.268) and BRI (β = 0.046, 95% CI = −0.005–0.097). Compared with each stable trajectory group, prenatal MEP (OR = 0.650, 95% CI = 0.502–0.844) and MBP (OR = 0.717, 95% CI = 0.984–1.015) were linked to a decreased risk of “decreasing BRI” in children; there was a negative relationship between MBP and the “decreasing ABSI” group (OR = 0.667, 95% CI = 0.487–0.914), and MEP increased the risks of “slowly increasing ABSI” (OR = 1.668, 95% CI = 1.210–2.299) and “rapidly increasing ABSI” (OR = 2.522, 95% CI = 1.266–5.024) in children. Phthalate mixture during pregnancy showed significant relationships with all anthropometric indicator trajectories, with MEP and MBP always being of the largest importance. In conclusion, this study suggested that prenatal phthalate coexposure increased the childhood probability of being in higher ABSI and BRI trajectory groups. That is, children were more likely to be obese when they were exposed to higher levels of some phthalate metabolites and their mixture. The low-molecular weight phthalates, including MEP and MBP, contributed the greatest weights.
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•The 1st study shows relations of prenatal PAEs with child ABSI and BRI trajectories.•Prenatal MEP exposure is associated with repeated measurements of FMI, ABSI and BRI.•PAE mixture increases the probability of being in higher ABSI and BRI trajectories.•MEP and MBP show largest weights for PAE mixture related to the adiposity trajectory.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The green and efficient remediation of soil cadmium (Cd) is an urgent task, and plant-microbial joint remediation has become a research hotspot due to its advantages. High-throughput sequencing and ...metabolomics have technical advantages in analyzing the microbiological mechanism of plant growth-promoting bacteria in improving phytoremediation of soil heavy metal pollution. In this experiment, a pot trial was conducted to investigate the effects of inoculating the plant growth-promoting bacterium
sp. VY on the growth and Cd remediation efficiency of the energy plant
. The test strain VY-1 was analyzed using high-throughput sequencing and metabolomics to assess its effects on microbial community composition and metabolic function. The results demonstrated that
sp. VY-1 effectively mitigated Cd stress on
, resulting in increased plant biomass, Cd accumulation, and translocation factor, thereby enhancing phytoremediation efficiency. Analysis of soil physical-chemical properties revealed that strain VY-1 could increase soil total nitrogen, total phosphorus, available phosphorus, and available potassium content. Principal coordinate analysis (PCoA) indicated that strain VY-1 significantly influenced bacterial community composition, with Proteobacteria, Firmicutes, Chloroflexi, among others, being the main differential taxa. Redundancy analysis (RDA) revealed that available phosphorus, available potassium, and pH were the primary factors affecting bacterial communities. Partial Least Squares Discriminant Analysis (PLS-DA) demonstrated that strain VY-1 modulated the metabolite profile of
rhizosphere soil, with 27 differential metabolites showing significant differences, including 19 up-regulated and eight down-regulated expressions. These differentially expressed metabolites were primarily involved in metabolism and environmental information processing, encompassing pathways such as glutamine and glutamate metabolism, α-linolenic acid metabolism, pyrimidine metabolism, and purine metabolism. This study utilized 16S rRNA high-throughput sequencing and metabolomics technology to investigate the impact of the plant growth-promoting bacterium
sp. VY-1 on the growth and Cd enrichment of
, providing insights into the regulatory role of plant growth-promoting bacteria in microbial community structure and metabolic function, thereby improving the microbiological mechanisms of phytoremediation.
Blood-brain barrier (BBB) dysfunction has been suggested to play an important role in epilepsy. However, the mechanism mediating the transition from cerebrovascular damage to epilepsy remains ...unknown. Here, we report that endothelial cyclin-dependent kinase 5 (CDK5) is a central regulator of neuronal excitability. Endothelial-specific Cdk5 knockout led to spontaneous seizures in mice. Knockout mice showed increased endothelial chemokine (C-X-C motif) ligand 1 (Cxcl1) expression, decreased astrocytic glutamate reuptake through the glutamate transporter 1 (GLT1), and increased glutamate synaptic function. Ceftriaxone restored astrocytic GLT1 function and inhibited seizures in endothelial Cdk5-deficient mice, and these effects were also reversed after silencing Cxcl1 in endothelial cells and its receptor chemokine (C-X-C motif) receptor 2 (Cxcr2) in astrocytes, respectively, in the CA1 by AAV transfection. These results reveal a previously unknown link between cerebrovascular factors and epileptogenesis and provide a rationale for targeting endothelial signaling as a potential treatment for epilepsy.
The prostate is a vital accessory gonad in the mammalian male reproductive system. With the ever-increasing proportion of the population over 60 years of age worldwide, the incidence of prostate ...diseases, such as benign prostatic hyperplasia (BPH) and prostate cancer (PCa), is on the rise and is gradually becoming a significant medical problem globally. The notch signaling pathway is essential in regulating prostate early development. However, the potential regulatory mechanism of Notch signaling in prostatic enlargement and hyperplasia remains unclear. In this study, we proved that overactivation of Notch1 signaling in mouse prostatic epithelial cells (
OEx
) led to prostatic enlargement via enhancing proliferation and inhibiting apoptosis of prostatic epithelial cells. Further study showed that N1ICD/RBPJ directly up-regulated the androgen receptor (AR) and enhanced prostatic sensitivity to androgens. Hyper-proliferation was not found in orchidectomized
OEx
mice without androgen supply but was observed after Dihydrotestosterone (DHT) supplementation. Our data showed that the number of mitochondrion in prostatic epithelial cells of
OEx
mice was increased, but the mitochondrial function was impaired, and the essential activity of the mitochondrial respiratory electron transport chain was significantly weakened. Disordered mitochondrial number and metabolic function further resulted in excessive accumulation of reactive oxygen species (ROS). Importantly, anti-oxidant N-Acetyl-L-Cysteine (NAC) therapy could alleviate prostatic hyperplasia caused by the over-activation of Notch1 signaling. Furthermore, we observed the incremental Notch signaling activity in progenitor-like club cells in the scRNA-seq data set of human BPH patients. Moreover, the increased number of TROP2
+
progenitors and Club cells was also confirmed in our
OEx
mice. In conclusion, our study revealed that over-activated Notch1 signaling induces prostatic enlargement by increasing androgen receptor sensitivity, disrupting cellular mitochondrial metabolism, increasing ROS, and a higher number of progenitor cells, all of which can be effectively rescued by NAC treatment.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
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•An ultra-small hydrazone-linked covalent organic polymer (UHCOP) was synthesized.•UHCOP presented good stability and strong fluorescence in aqueous solution.•UHCOP is promising as ...fluorescent sensor for Fe3+detection in aqueous solution.
A novel ultra-small hydrazone-linked covalent organic polymer (UHCOP) was synthesized based on the Schiff-base reaction between 2,4,6-trihydroxy-1,3,5-benzenetricarbaldehyde and 1,4-benzenedicarbohydrazide at room temperature and utilized as a sensitive fluorescent sensor for rapid (<2 min) and selective detection of Fe3+ in aqueous solution. The prepared UHCOP displayed ultra-small size with the diameter of 7.98 ± 0.97 nm and gave a stable fluorescent emission at 510 nm. UHCOP exhibited good sensitivity and highly selectivity towards Fe3+. The coordination interaction between UHCOP and Fe3+ resulted in the obviously aggregation-caused quenching response of UHCOP. The linear range was from 5.0 μM to 1.4 mM (R2 = 0.999) with the detection limit of 2.5 μM. Finally, UHCOP has been successfully applied in the detection of Fe3+ in real water samples, proving the fabricated UHCOP is promising as a sensitive fluorescent sensor for selective detection of Fe3+ in aqueous solution.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The recently emerged multicomponent (or medium/high entropy) alloys have generated considerable excitement globally in the last 10 years because of their excellent mechanical and functional ...properties, particularly in terms of strength-ductility combinations that can surpass most other metallic materials. However, the achieved high strength level (above 1 GPa in many cases) fuels strong concerns about hydrogen embrittlement (HE). Detailed investigation in this field is still scarce, especially pertaining to the face-centered cubic medium entropy alloys (MEA) that are typically strengthened by ordered precipitates. Here, we unravel the effect of γ' (L12) ordered precipitates on H-induced damage behavior and the associated HE resistance in CoCrNi-based MEAs. Compared with the equi-molar CoCrNi MEA, the precipitation-hardened (CoCrNi)94Al3Ti3 MEA shows an enhanced HE resistance even at a higher strength level. Both alloys are fractured due to H-assisted intergranular cracking at the initial failure stage when loaded in the presence of H. The formation of intergranular cracks is primarily attributed to the H-induced decohesion at grain boundaries, where a high stress/strain concentration accompanied by a more intensive dislocation planar slip (or stacking fault formation) caused by H was observed. The presence of γ' precipitates serves to slow down the internal diffusion/migration of H due to the trapping effects. The precipitates with a relatively larger size (∼50 nm) also hinder dislocation planar slip thus decreasing the number of pile-up dislocations at grain boundaries. Both effects collectively reduce the tendency of H-induced intergranular cracking, leading to the improved HE resistance. The work reveals the positive role of ordered precipitates in H tolerance and thus provides some insights in further microstructure design of medium/high entropy alloys for applications in H-abundant environment.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Coherent twin boundaries (CTBs) are internal interfaces that can play a key role in markedly enhancing the strength of metallic materials while preserving their ductility. They are known to ...accommodate plastic deformation primarily through their migration, while experimental evidence documenting large-scale sliding of CTBs to facilitate deformation has thus far not been reported. We show here that CTB sliding is possible whenever the loading orientation enables the Schmid factors of leading and trailing partial dislocations to be comparable to each other. This theoretical prediction is confirmed by real-time transmission electron microscope experimental observations during uniaxial deformation of copper pillars with different orientations and is further validated at the atomic scale by recourse to molecular dynamics simulations. Our findings provide mechanistic insights into the evolution of plasticity in heavily twinned face-centered cubic metals, with the potential for optimizing mechanical properties with nanoscale CTBs in material design.
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