Despite multiple treatment options being available, many critical challenges are still ongoing in the treatment of oral squamous cell carcinoma (OSCC). Particularly, the major hurdle is to avoid ...facial disfigurement and oral function disability during treatment. Herein, nanoengineered mesenchymal stem cells (MSCs) are developed as a supersonosensitizer, named M/LPV/O2, for improving nondestructive sonodynamic therapy (SDT) against OSCC along with good therapeutic compliance. M/LPV/O2 is composed of an MSCs membrane functionalized liposomal formulation of oxygen‐loading perfluorocarbon and sonosensitizer verteporfin (M/LPV/O2), which can not only increase circulation and targeting efficacy but also supply oxygen to overcome tumor‐hypoxia‐associated resistance in SDT, resulting in enhanced therapeutic outcomes in vitro and in vivo. It is identified that M/LPV/O2 effectively stimulates the generation of reactive oxygen species even in hypoxic conditions, and consequently tremendously induces cancer cell death. In addition, M/LPV/O2 displays good tumor accumulation and penetration under ultrasound stimulation, and efficiently induces tumor inhibition and even abrogation, leading to prolonged survival of tumor‐bearing mice. Importantly, M/LPV/O2‐based SDT exhibits minimal systemic adverse effects and successfully maintains oral functions with no facial tissue damage. Therefore, these studies provide a promising therapeutic strategy for OSCC, which has a potential to enhance life quality and compliance after treatment.
Nondestructive sonodynamic therapy (SDT) is developed for the treatment of oral cancer with good compliance. An ultrasound‐responsive mesenchymal stem cells membrane functionalized liposome is designed for co‐delivery of sonosensitizer and oxygen, which not only increases tumor targeting and penetration but also supplies oxygen to enhance SDT effects to eliminate tumors, resulting in prolonged survival and maintenance of oral functions.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
The innovative application of microwave transduction technology in the field of gas sensors make it possible to develop wireless passive room-temperature gas sensor integrated on wearable device. ...Herein, the ultra-narrowband microwave filter was designed as microwave transducer device, and the microwave sensing measurements were extended to reflected coefficient. Meanwhile, the SnO2/bionic porous (BP) carbon composites based thick film were deposited on the coupled line spacing blank surface via blade coating method. According to the SnO2 nanoparticles were well distributed on BP carbon with abundant micro pores, the gas adsorption and desorption can be enhanced, and the sensor response signal base on microwave transduction was finally improved. Without the influence of temperature and humility, the proposed SnO2/BP carbon microwave gas sensor exhibited excellent NH3 sensing behavior at room temperature including wide concentration range (10–200 ppm), relatively fast response and recovery rate, superior selectivity, as well as good reversibility and stability. More importantly, the dielectric constant of microwave sensor has been proved strongly correlation with injected ammonia concentration. This work further proves the feasibility and frontier of microwave transduction technology in gas sensor application.
•The ultra-narrowband microwave filter was used as microwave gas sensor which can be operating at room temperature.•The SnO2/BP carbon composites was synthesized as sensitive material for microwave gas sensor.•The proposed SnO2/BP carbon microwave gas sensor exhibited excellent NH3 sensing behavior at room temperature.•The sensitive materials’ dielectric constant has strongly correlation with NH3 concentration.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Effective elimination of heavy metal ions from water is an arduous task for their toxic effects to aquatic ecosystem and human health. Herein, a novel alkynyl functionalized molybdenum disulfide ...(C-MoS2) is fabricated via mechanochemical method with well interlayered spacing, meso porosity, and high surface area (~211 m2g−1). Mineral MoS2 was first peeled mechanically and oxidized in situ to MoS2−xOx, and then reduced by ball milling with CaC2 to form the C-MoS2 composite. The as-obtained C-MoS2 shows extraordinary adsorptivity for heavy metal ions, viz. 1194 mg-Hg g−1 (Hg(NO3)2 solution, pH= 5, 303.15 K, equilibrium Hg(II) concentration Ce= 36.9 μg·g−1, ionic strength I= 17.2 mmolL−1), and 442.3 mg-Pbg−1 (Pb(NO3)2 solution, pH= 5, 303.15 K, equilibrium Pb(II) concentration Ce= 46.9μgg−1, I= 5.8 mmolL−1), respectively, along with excellent recyclability, representing one of the best sorbents till now. The adsorption isotherms of Hg(II) followed the Langmuir model and the adsorption kinetics followed the pseudo-second-order model. The adsorption is an endothermic and entropy driven spontaneous process. The excellent adsorption performance of C-MoS2 is attributed to its very high S-content, availability, and soft acid-base interaction with mercury and lead anions. The C-MoS2 is an advanced sorbent for Hg(II) and Pb(II) with excellent adsorption performance and recyclability.
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•A functionalized C-MoS2 composite is fabricated via mechanochemical redox method.•C-MoS2 shows extraordinary high adsorption capacity for Hg(II) and Pb(II).•Superb adsorptivity of C-MoS2 is due to its high sulfur availability and porosity.•The method is viable for preparation of porous materials from layered substrates.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The partial discharge (PD) classification for electric power equipment based on machine learning algorithms often leads to insufficient generalization ability and low recognition accuracy. To solve ...the problem, this article develops an improved Wasserstein generative adversarial network with gradient penalty (WGAN-GP) based data augmentation model. The improved WGAN-GP model can generate data samples to supplement the low-data input set in PD source classification. First, an improved WGAN-GP model with conditional generation is trained and various new data samples are generated. Then, the new data samples are utilized to expand the raw dataset. Finally, the expanded dataset is trained to get a new PD classifier. Experimental results demonstrate that the proposed model can generate new high-quality data samples more stably. Moreover, the proposed method can suppress the overfitting risk caused by low data or imbalanced data distributions and the classification accuracy is effectively improved.
In this paper, we successfully prepared Ru-doped Co3O4 flower-like hollow microspheres by a simple hydrothermal method. The microstructure characterization results indicated the formation of ...well-organized microflowers with a size of 0.5–1 µm, which were composed of nanosheets. The gas sensing performances of sensors by using the synthesized Ru-doped Co3O4 hollow microflowers as sensing material were investigated. The 1 at% Ru-doped Co3O4 sensor showed the best acetone sensing performance and had a response 18.8–10 ppm acetone, which was almost 5.4 times that of pure Co3O4. Significantly, the sensor had an ultra-low detection limit, with a response value of 1.5–50 ppb acetone at 137.5 °C (30%RH). We propose a plausible mechanism for sensing performance improvement. Namely, the substitution of Ru4+ regulated the carrier concentration and induced the change of Co3O4 defect oxygen and chemisorbed oxygen.
•Ru-doped Co3O4 flower-like hollow microspheres were synthesized via a facile one-step hydrothermal method.•1 at% Ru-doped Co3O4 flower-like hollow microspheres exhibited better acetone gas sensing performance.•1 at% Ru-doped Co3O4 sensor had a response 18.8–10 ppm acetone at 137.5 ℃.•1 at% Ru-doped Co3O4 sensor had a low detection limit (50 ppb-1.5).
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•Material status, as-forged, is significant different from others’ work.•The microstructure of 42CrMo was observed through metallographic experiments, and the accuracy of the hot processing map was ...verified.•The best process parameters of 42CrMo alloy are the deformation temperature of 1000°C-1125°C and the strain rate of 3.16 s-1-10s-1.•DRX volume fraction model and the grain size model of the material were established.
42CrMo steel belongs to low-alloy medium carbon steel and also belongs to ultra-high-strength steel. In this study, thermal compression tests (800°C - 1200°C, 0.01s-1 - 10s-1) and subsequent calculations proved that many material constants of 42CrMo alloy steel have a similar functional relationship with Z parameter: Material constants=a*Zb. The thermal processing maps under strains of 0.2, 0.4, 0.6 and 0.8 were established, and the practical application of the processing maps was verified in combination with metallographic diagram analysis. The optimum thermal processing parameters range of the material was obtained: the temperature range of 1000°C - 1125°C and the strain rate range of 3.16 s-1 - 10s-1.The dynamic recrystallization volume fraction model and grain size model of the material were established, and the typical sigmodal curve was obtained. The hot workability and recrystallization behavior of 42CrMo were further analyzed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
In our previous study, we have found that persimmon, guava, and sweetsop owned considerably high antioxidant activity and contained high total phenolic contents as well. In order to further supply ...information on the antibacterial and antioxidant activity of these three tropic fruits, they were extracted by 80% methanol. We then examined the extractions about their phenolic compounds and also studied the extractions and phenolic contents about their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against twelve targeted pathogens including 8 standard strains (Staphylococcus aureus, Bacillus cereus, Staphylococcus epidermidis, Monilia albican, Escherichia coli, Salmonella typhimurium, Shigella flexneri, and Pseudomonas aeruginosa) and 4 multidrug-resistant strains (methicillin-resistant Staphylococcus aureus, ESBLs-producing Escherichia coli, carbapenems-resistant Pseudomonas aeruginosa, and multidrug-resistant Acinetobacter baumannii), which are common and comprehensive in clinic. We also employed two ways, that is, FRAP and TEAC, to evaluate their antioxidant activities, using ultraviolet and visible spectrophotometer. Our study indicated that the three tropical fruits possessed obvious antioxidant and antibacterial activity, which supported the possibility of developing the fruits into new natural resource food and functional food as well as new natural antimicrobial agent and food preservatives. Moreover, phenolic compounds detected in the fruits could be used as a potential natural antibacterial agent and antioxidant.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
Mucus production is a process involved in the pathogenesis of Community-acquired pneumonia (CAP). The study is to determine Mucin 5B (MUC5B) protein concentration and its proportion in the ...bronchoalveolar lavage fluid (BALF) of CAP patients and evaluate its value to help assess disease severity.
A total of 118 patients were enrolled in this cross-sectional study, including 45 with severe CAP (SCAP) and 73 with non-severe CAP (NSCAP). MUC5B concentration in BALF were determined by immunoblotting analysis. Total protein concentration of BALF was detected by Pierce BCA kit. Cytokines IL6, IL10, IFNγ, IL13, and IL17 in BALF were measured using commercial enzyme-linked immunosorbent assay (ELISA). Spearman's correlation analysis was applied to evaluate the relationships between MUC5B concentration or MUC5B/total protein ratio and the CURB-65 score, as well as cytokines. Logistic regression analysis was used to identify the independent factors associated with severe CAP. Receiver operating characteristic (ROC) curve was used to evaluate the assessment value of MUC5B/total protein ratio and other indexes for CAP severity.
MUC5B concentration in the BALF of NSCAP group was higher than that in SCAP group NSCAP 13.56 µg/ml (IQR 5.92-25.79) vs. SCAP 8.20 µg/ml (IQR 4.97-14.03), p = 0.011. The total protein concentration in the BALF of NSCAP group was lower than that in SCAP group NSCAP 0.38 mg/ml (IQR 0.15-1.10) vs. SCAP 0.68 mg/ml (IQR 0.46-1.69), p = 0.002. The MUC5B/total protein ratio was remarkably higher in NSCAP group than that in SCAP groups NSCAP 3.66% (IQR 1.50-5.56%) vs. SCAP 1.38% (IQR 0.73-1.76%), p < 0.001. MUC5B/total protein ratio was negatively correlated with total protein concentration (r
= - 0.576, p < 0.001), IL6 (r
= - 0.312, p = 0.001), IL10 (r
= - 0.228, p = 0.013), IL13 (r
= - 0.183, p = 0.048), IL17 (r
= - 0.282, p = 0.002) and CURB-65 score (r
= - 0.239, p = 0.009). Logistic regression identified that MUC5B/total protein ratio, IL6 level and CURB-65 score as independent variables related to CAP severity. ROC curve demonstrated best assessment value of MUC5B/total protein ratio for SCAP (AUC 0.803, p < 0.001), with a sensitivity of 88.9% and a specificity of 64.4%.
Respiratory MUC5B disproportion is related to CAP severity. MUC5B/total protein ratio may serve as an assessment marker and a potential therapeutic target for severe CAP.
We report a simple and effective nickel-based catalytic system, NiCl2·6H2O/ t BuOK, for the electrophilically activated hydrosilylation of terminal alkenes with primary silanes. This protocol ...provides excellent performance under mild reaction conditions: exclusive anti-Markovnikov selectivity, broad functional group tolerance (36 examples), and good scalability (TON = 5500). However, the secondary and tertiary silanes are not suitable. Mechanistic studies revealed that this homogeneous catalytic hydrosilylation includes an electrophilically activated Si–H bond process without the generation of nickel hydrides.
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IJS, KILJ, NUK, PNG, UL, UM
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