Highlights • EGCG favors the survival of newborn neurons in the hippocampus. • EGCG is proneurogenic upon adult hippocampal precursor cells in culture. • EGCG might act through phospho-Akt.
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Context.
Repeating fast radio bursts (FRBs) present excellent opportunities to identify FRB progenitors and host environments as well as to decipher the underlying emission mechanism. Detailed ...studies of repeating FRBs might also hold clues as to the origin of FRBs as a population.
Aims.
We aim to detect bursts from the first two repeating FRBs, FRB 121102 (R1) and FRB 180814.J0422+73 (R2), and to characterise their repeat statistics. We also want to significantly improve the sky localisation of R2 and identify its host galaxy.
Methods.
We used the Westerbork Synthesis Radio Telescope to conduct extensive follow-up of these two repeating FRBs. The new phased-array feed system, Apertif, allows one to cover the entire sky position uncertainty of R2 with fine spatial resolution in a single pointing. The data were searched for bursts around the known dispersion measures of the two sources. We characterise the energy distribution and the clustering of detected R1 bursts.
Results.
We detected 30 bursts from R1. The non-Poissonian nature is clearly evident from the burst arrival times, which is consistent with earlier claims. Our measurements indicate a dispersion measure (DM) of 563.5(2) pc cm
−3
, suggesting a significant increase in DM over the past few years. Assuming a constant position angle across the burst, we place an upper limit of 8% on the linear polarisation fraction for the brightest burst in our sample. We did not detect any bursts from R2.
Conclusions.
A single power-law might not fit the R1 burst energy distribution across the full energy range or widely separated detections. Our observations provide improved constraints on the clustering of R1 bursts. Our stringent upper limits on the linear polarisation fraction imply a significant depolarisation, either intrinsic to the emission mechanism or caused by the intervening medium at 1400 MHz, which is not observed at higher frequencies. The non-detection of any bursts from R2, despite nearly 300 h of observations, implies either a highly clustered nature of the bursts, a steep spectral index, or a combination of the two assuming that the source is still active. Another possibility is that R2 has turned off completely, either permanently or for an extended period of time.
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Aims.
We present the results of three commissioning H
I
observations obtained with the MeerKAT radio telescope. These observations make up part of the preparation for the forthcoming MHONGOOSE ...nearby galaxy survey, which is a MeerKAT large survey project that will study the accretion of gas in galaxies and the link between gas and star formation.
Methods.
We used the available H
I
data sets, along with ancillary data at other wavelengths, to study the morphology of the MHONGOOSE sample galaxy, ESO 302-G014, which is a nearby gas-rich dwarf galaxy.
Results.
We find that ESO 302-G014 has a lopsided, asymmetric outer disc with a low column density. In addition, we find a tail or filament of H
I
clouds extending away from the galaxy, as well as an isolated H
I
cloud some 20 kpc to the south of the galaxy. We suggest that these features indicate a minor interaction with a low-mass galaxy. Optical imaging shows a possible dwarf galaxy near the tail, but based on the current data, we cannot confirm any association with ESO 302-G014. Nonetheless, an interaction scenario with some kind of low-mass companion is still supported by the presence of a significant amount of molecular gas, which is almost equal to the stellar mass, and a number of prominent stellar clusters, which suggest recently triggered star formation.
Conclusions.
These data show that MeerKAT produces exquisite imaging data. The forthcoming full-depth survey observations of ESO 302-G014 and other sample galaxies will, therefore, offer insights into the fate of neutral gas as it moves from the intergalactic medium onto galaxies.
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Summary Background The annual number of hospital admissions and in-hospital deaths due to severe acute lower respiratory infections (ALRI) in young children worldwide is unknown. We aimed to estimate ...the incidence of admissions and deaths for such infections in children younger than 5 years in 2010. Methods We estimated the incidence of admissions for severe and very severe ALRI in children younger than 5 years, stratified by age and region, with data from a systematic review of studies published between Jan 1, 1990, and March 31, 2012, and from 28 unpublished population-based studies. We applied these incidence estimates to population estimates for 2010, to calculate the global and regional burden in children admitted with severe ALRI in that year. We estimated in-hospital mortality due to severe and very severe ALRI by combining incidence estimates with case fatality ratios from hospital-based studies. Findings We identified 89 eligible studies and estimated that in 2010, 11·9 million (95% CI 10·3–13·9 million) episodes of severe and 3·0 million (2·1–4·2 million) episodes of very severe ALRI resulted in hospital admissions in young children worldwide. Incidence was higher in boys than in girls, the sex disparity being greatest in South Asian studies. On the basis of data from 37 hospital studies reporting case fatality ratios for severe ALRI, we estimated that roughly 265 000 (95% CI 160 000–450 000) in-hospital deaths took place in young children, with 99% of these deaths in developing countries. Therefore, the data suggest that although 62% of children with severe ALRI are treated in hospitals, 81% of deaths happen outside hospitals. Interpretation Severe ALRI is a substantial burden on health services worldwide and a major cause of hospital referral and admission in young children. Improved hospital access and reduced inequities, such as those related to sex and rural status, could substantially decrease mortality related to such infection. Community-based management of severe disease could be an important complementary strategy to reduce pneumonia mortality and health inequities. Funding WHO.
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Context.
Detection of the electromagnetic emission from coalescing binary neutron stars (BNS) is important for understanding the merger and afterglow.
Aims.
We present a search for a radio ...counterpart to the gravitational-wave (GW) source GW190425, a BNS merger, using Apertif on the Westerbork Synthesis Radio Telescope (WSRT).
Methods.
We observed a field of high probability in the associated localisation region for three epochs at Δ
T
= 68, 90, 109 d post merger. We identified all sources that exhibit flux variations consistent with the expected afterglow emission of GW190425. We also looked for possible transients. These are sources that are only present in one epoch. In addition, we quantified our ability to search for radio afterglows in the fourth and future observing runs of the GW detector network using Monte Carlo simulations.
Results.
We found 25 afterglow candidates based on their variability. None of these could be associated with a possible host galaxy at the luminosity distance of GW190425. We also found 55 transient afterglow candidates that were only detected in one epoch. All of these candidates turned out to be image artefacts. In the fourth observing run, we predict that up to three afterglows will be detectable by Apertif.
Conclusions.
While we did not find a source related to the afterglow emission of GW190425, the search validates our methods for future searches of radio afterglows.
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ABSTRACT
We present the first targeted measurement of the power spectrum of anisotropies of the radio synchrotron background, at 140 MHz, where it is the overwhelmingly dominant photon background. ...This measurement is important for understanding the background level of radio sky brightness, which is dominated by steep-spectrum synchrotron radiation at frequencies below ν ∼ 0.5 GHz and has been measured to be significantly higher than that produced by known classes of extragalactic sources and most models of Galactic halo emission. We determine the anisotropy power spectrum on scales ranging from 2° to 0.2 arcmin with Low-Frequency Array observations of two 18-deg2 fields – one centred on the Northern hemisphere’s coldest patch of radio sky where the Galactic contribution is smallest and the other offset from that location by 15°. We find that the anisotropy power is higher than that attributable to the distribution of point sources above 100 $\mu$Jy in flux. This level of radio anisotropy power indicates that if it results from point sources, those sources are likely at low fluxes and incredibly numerous, and likely clustered in a specific manner.
Super massive black holes at the centres of galaxies can cycle through periods of activity and quiescence. Characterising the duty cycle of active galactic nuclei (AGN) is crucial for understanding ...the impact of the energy they release on the host galaxy. For radio AGN, this can be done by identifying dying (remnant) and restarted radio galaxies from their radio spectral properties. Using the combination of the images at 1400 MHz produced by Apertif, the new phased-array feed receiver installed on the Westerbork Synthesis Radio Telescope, and images at 150 MHz provided by LOFAR, we have derived resolved spectral index images (at a resolution of ~15 arcsec) for all the sources within an approximately 6 deg
2
area of the Lockman Hole region. In this way, we were able to select 15 extended radio sources with emission (partly or entirely) characterised by extremely steep spectral indices (steeper than 1.2). These objects represent cases of radio sources in the remnant or the restarted phases of their life cycle. Our findings confirm that these objects are not as rare as previously thought, suggesting a relatively fast cycle. They also show a variety of properties that can be relevant for modelling the evolution of radio galaxies. For example, the restarted activity can occur while the remnant structure from a previous phase of activity is still visible. This provides constraints on the duration of the “off” (dying) phase. In extended remnants with ultra-steep spectra at low frequencies, the activity likely stopped a few hundred megayears ago, and they correspond to the older tail of the age distribution of radio galaxies, in agreement with the results of simulations of radio source evolution. We find remnant radio sources with a variety of structures (from double-lobed to amorphous), possibly suggesting different types of progenitors. The present work sets the stage for exploiting the powerful tool of low-frequency spectral index studies of extended sources by taking advantage of the large areas common to the LOFAR and the Apertif surveys.
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ABSTRACT
We report the detection of a bright fast radio burst, FRB 191108, with Apertif on the Westerbork Synthesis Radio Telescope. The interferometer allows us to localize the FRB to a narrow 5 ...arcsec × 7 arcmin ellipse by employing both multibeam information within the Apertif phased-array feed beam pattern, and across different tied-array beams. The resulting sightline passes close to Local Group galaxy M33, with an impact parameter of only 18 kpc with respect to the core. It also traverses the much larger circumgalactic medium (CGM) of M31, the Andromeda Galaxy. We find that the shared plasma of the Local Group galaxies could contribute ∼10 per cent of its dispersion measure of 588 pc cm−3. FRB 191108 has a Faraday rotation measure (RM) of +474 $\pm \, 3$ rad m−2, which is too large to be explained by either the Milky Way or the intergalactic medium. Based on the more moderate RMs of other extragalactic sources that traverse the halo of M33, we conclude that the dense magnetized plasma resides in the host galaxy. The FRB exhibits frequency structure on two scales, one that is consistent with quenched Galactic scintillation and broader spectral structure with Δν ≈ 40 MHz. If the latter is due to scattering in the shared M33/M31 CGM, our results constrain the Local Group plasma environment. We found no accompanying persistent radio sources in the Apertif imaging survey data.
Summary Background The global burden of disease attributable to seasonal influenza virus in children is unknown. We aimed to estimate the global incidence of and mortality from lower respiratory ...infections associated with influenza in children younger than 5 years. Methods We estimated the incidence of influenza episodes, influenza-associated acute lower respiratory infections (ALRI), and influenza-associated severe ALRI in children younger than 5 years, stratified by age, with data from a systematic review of studies published between Jan 1, 1995, and Oct 31, 2010, and 16 unpublished population-based studies. We applied these incidence estimates to global population estimates for 2008 to calculate estimates for that year. We estimated possible bounds for influenza-associated ALRI mortality by combining incidence estimates with case fatality ratios from hospital-based reports and identifying studies with population-based data for influenza seasonality and monthly ALRI mortality. Findings We identified 43 suitable studies, with data for around 8 million children. We estimated that, in 2008, 90 million (95% CI 49–162 million) new cases of influenza (data from nine studies), 20 million (13–32 million) cases of influenza-associated ALRI (13% of all cases of paediatric ALRI; data from six studies), and 1 million (1–2 million) cases of influenza-associated severe ALRI (7% of cases of all severe paediatric ALRI; data from 39 studies) occurred worldwide in children younger than 5 years. We estimated there were 28 000–111 500 deaths in children younger than 5 years attributable to influenza-associated ALRI in 2008, with 99% of these deaths occurring in developing countries. Incidence and mortality varied substantially from year to year in any one setting. Interpretation Influenza is a common pathogen identified in children with ALRI and results in a substantial burden on health services worldwide. Sufficient data to precisely estimate the role of influenza in childhood mortality from ALRI are not available. Funding WHO; Bill & Melinda Gates Foundation.
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Herein we present details of the design, simulation, and performance of a 100-GW linear transformer driver (LTD) cavity at Sandia National Laboratories. The cavity consists of 20 “bricks.” Each brick ...is comprised of two 80 nF, 100 kV capacitors connected electrically in series with a custom, 200 kV, three-electrode, field-distortion gas switch. The brick capacitors are bipolar charged to±100kVfor a total switch voltage of 200 kV. Typical brick circuit parameters are 40 nF capacitance (two 80 nF capacitors in series) and 160 nH inductance. The switch electrodes are fabricated from aWCualloy and are operated with breathable air. Over the course of 6,556 shots the cavity generated a peak electrical current and power of 1.03 MA (±1.8%) and 106 GW (±3.1%). Experimental results are consistent (to within uncertainties) with circuit simulations for normal operation, and expected failure modes including prefire and late-fire events. New features of this development that are reported here in detail include: (1) 100 ns, 1 MA, 100-GW output from a 2.2 m diameter LTD into a0.1Ωload, (2) high-impedance solid charging resistors that are optimized for this application, and (3) evaluation of maintenance-free trigger circuits using capacitive coupling and inductive isolation.
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