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  • Deep learning in cancer pat... Deep learning in cancer pathology: a new generation of clinical biomarkers
    Echle, Amelie; Rindtorff, Niklas Timon; Brinker, Titus Josef ... British journal of cancer, 02/2021, Volume: 124, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    Clinical workflows in oncology rely on predictive and prognostic molecular biomarkers. However, the growing number of these complex biomarkers tends to increase the cost and time for decision-making ...
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2.
  • Apoptosis and necroptosis i... Apoptosis and necroptosis in the liver: a matter of life and death
    Schwabe, Robert F; Luedde, Tom Nature reviews. Gastroenterology & hepatology, 12/2018, Volume: 15, Issue: 12
    Journal Article
    Peer reviewed
    Open access

    Cell death represents a basic biological paradigm that governs outcomes and long-term sequelae in almost every hepatic disease condition. Acute liver failure is characterized by massive loss of ...
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  • Deep learning can predict m... Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer
    Kather, Jakob Nikolas; Pearson, Alexander T; Halama, Niels ... Nature medicine, 07/2019, Volume: 25, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Microsatellite instability determines whether patients with gastrointestinal cancer respond exceptionally well to immunotherapy. However, in clinical practice, not every patient is tested for MSI, ...
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4.
  • Cell Death and Cell Death R... Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance
    Luedde, Tom; Kaplowitz, Neil; Schwabe, Robert F Gastroenterology, 10/2014, Volume: 147, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    Hepatocellular death is present in almost all types of human liver disease and is used as a sensitive parameter for the detection of acute and chronic liver disease of viral, toxic, metabolic, or ...
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  • Artificial intelligence for... Artificial intelligence for the prevention and clinical management of hepatocellular carcinoma
    Calderaro, Julien; Seraphin, Tobias Paul; Luedde, Tom ... Journal of hepatology, June 2022, 2022-06-00, 20220601, Volume: 76, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Hepatocellular carcinoma (HCC) currently represents the fifth most common malignancy and the third-leading cause of cancer-related death worldwide, with incidence and mortality rates that are ...
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  • Circulating MicroRNAs as Bi... Circulating MicroRNAs as Biomarkers for Sepsis
    Benz, Fabian; Roy, Sanchari; Trautwein, Christian ... International Journal of Molecular Sciences, 01/2016, Volume: 17, Issue: 1
    Journal Article, Book Review
    Peer reviewed
    Open access

    Sepsis represents a major cause of lethality during intensive care unit (ICU) treatment. Pharmacological treatment strategies for sepsis are still limited and mainly based on the early initiation of ...
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  • Predicting survival from co... Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study
    Kather, Jakob Nikolas; Krisam, Johannes; Charoentong, Pornpimol ... PLoS medicine, 01/2019, Volume: 16, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    For virtually every patient with colorectal cancer (CRC), hematoxylin-eosin (HE)-stained tissue slides are available. These images contain quantitative information, which is not routinely used to ...
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  • Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis
    Krenkel, Oliver; Hundertmark, Jana; Abdallah, Ali T ... Gut, 03/2020, Volume: 69, Issue: 3
    Journal Article
    Peer reviewed

    Bone marrow-derived myeloid cells accumulate in the liver as monocytes and macrophages during the progression of obesity-related non-alcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH). ...
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  • Therapeutic inhibition of i... Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis
    Krenkel, Oliver; Puengel, Tobias; Govaere, Olivier ... Hepatology, April 2018, Volume: 67, Issue: 4
    Journal Article
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    Open access

    Macrophages are key regulators of liver fibrosis progression and regression in nonalcoholic steatohepatitis (NASH). Liver macrophages comprise resident phagocytes, Kupffer cells, and monocyte‐derived ...
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10.
  • The Role of miRNAs in the P... The Role of miRNAs in the Pathophysiology of Liver Diseases and Toxicity
    Schueller, Florian; Roy, Sanchari; Vucur, Mihael ... International journal of molecular sciences, 01/2018, Volume: 19, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Both acute and chronic liver toxicity represents a major global health burden and an important cause of morbidity and lethality worldwide. Despite epochal progress in the treatment of hepatitis C ...
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