A
bstract
With data samples collected with the BESIII detector at seven energy points at
$$ \sqrt{s} $$
s
= 3
.
68
−
3
.
71 GeV, corresponding to an integrated luminosity of 333 pb
−
1
, we present a ...study of the Λ transverse polarization in the
e
+
e
−
→
$$ \Lambda \overline{\Lambda} $$
Λ
Λ
¯
reaction. The significance of polarization by combining the seven energy points is found to be 2.6
σ
including the systematic uncertainty, which implies a non-zero phase between the transition amplitudes of the
$$ \Lambda \overline{\Lambda} $$
Λ
Λ
¯
helicity states. The modulus ratio and the relative phase of EM-
psionic
form factors combined with all energy points are measured to be
R
Ψ
=
$$ {0.71}_{-0.10}^{+0.10} $$
0.71
−
0.10
+
0.10
±
0.03 and ∆Φ
Ψ
=
$$ {23}_{-8.0}^{+8.8} $$
23
−
8.0
+
8.8
±
1.6
°
, where the first uncertainties are statistical and the second systematic.
To investigate the association between gout and myocardial infarction (MI) in a representative cohort in Taiwan.
Data were collected from the Taiwan National Health Insurance database. Adults >20 ...years of age without history of MI were included. Patients were considered to have gout if they received a diagnosis of gout requiring medical treatment. Multivariate Cox proportional hazards models were used to evaluate the risk of MI in gout patients.
Of the 704 503 patients included, 26 556 (3.8%) had gout. In total, 3718 (with gout, n = 463; without gout, n = 3255) patients had an MI, 299 (with gout, n = 35; without gout, n = 264) of whom died. The incidence of MI was 2.20 and 0.60 per 1000 patient-years in individuals with and without gout, respectively (log-rank test, P < 0.001). After adjustment for age, sex and history of diabetes mellitus, hypertension, coronary heart disease (CHD), stroke and end-stage renal disease, gout was associated with MIs hazard ratio (HR), 1.23 and non-fatal MIs (HR, 1.26). In individuals without cardiovascular risk factors, gout was associated with MIs (HR 1.84; 95% CI 1.51, 2.24) and non-fatal MIs (HR 1.80; 95% CI 1.49, 3.95), after adjustment for age and sex. Moreover, in our study population, the HRs for MI decreased as age increased.
Gout is an independent risk factor for MI, and the increased risk of MI is present even in young people and those without cardiovascular risk factors.
Heme is the most bioavailable form of dietary iron and a component of many cellular proteins. Controversy exists as to whether heme uptake occurs via specific transport mechanisms or passive ...diffusion. The aims of this study were to quantify cellular heme uptake with a fluorescent heme analog and to determine whether heme uptake is mediated by a heme transporter in intestinal and hepatic cell lines. A zinc-substituted porphyrin, zinc mesoporphyrin (ZnMP), was validated as a heme homolog in uptake studies of intestinal (Caco-2, I-407) and hepatic (HepG2) cell lines. Uptake experiments to determine time dependence, heme inhibition, concentration dependence, temperature dependence, and response to the heme synthesis inhibitor succinylacetone were performed. Fluorescence microscope images were used to quantify uptake and determine the cellular localization of ZnMP; ZnMP uptake was seen in intestinal and hepatic cell lines, with cytoplasmic uptake and nuclear sparing. Uptake was dose- and temperature dependent, inhibited by heme competition, and saturated over time. Preincubation with succinylacetone augmented uptake, with an increased initial uptake rate. These findings establish a new method for quantifying heme uptake in individual cells and provide strong evidence that this uptake is a regulated, carrier-mediated process.
The cross section of the process e+e−→η′J/ψ is measured at center-of-mass (c.m.) energies from s=4.178 to 4.600 GeV using data samples corresponding to a total integrated luminosity of 11 fb−1 ...collected with the BESIII detector operating at the BEPCII storage ring. The dependence of the cross section on s shows an enhancement around 4.2 GeV. While the shape of the cross section cannot be fully explained with a single ψ(4160) or ψ(4260) state, a coherent sum of the two states does provide a reasonable description of the data.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
We conduct an inverse modeling analysis of measurements of atmospheric CO from the TES and MOPITT satellite instruments using the GEOS-Chem global chemical transport model to quantify emissions of CO ...in the tropics in November 2004. We also assess the consistency of the information provided by TES and MOPITT on surface emissions of CO. We focus on the tropics in November 2004, during the biomass burning season, because TES observations of CO and O3 and MOPITT observations of CO reveal significantly greater abundances of these gases than simulated by the GEOS-Chem model during that period. We find that both datasets suggest substantially greater emissions of CO from sub-equatorial Africa and the Indonesian/Australian region than in the climatological emissions in the model. The a posteriori emissions from sub-equatorial Africa based on TES and MOPITT data were 173 Tg CO/yr and 184 Tg CO/yr, respectively, compared to the a priori of 95 Tg CO/yr. In the Indonesian/Australian region, the a posteriori emissions inferred from TES and MOPITT data were 155 Tg CO/yr and 185 Tg CO/yr, respectively, whereas the a priori was 69 Tg CO/yr. The differences between the a posteriori emission estimates obtained from the two datasets are generally less than 20%. The a posteriori emissions significantly improve the simulated distribution of CO, however, large regional residuals remain, and are likely due to systematic errors in the analysis. Reducing these residuals and improving the accuracy of top-down emission estimates will require better characterization of systematic errors in the observations and the model (chemistry and transport).
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