The cross section of the e+e−→Λc+Λ¯c− process is measured with unprecedented precision using data collected with the BESIII detector at /¯s=4574.5, 4580.0, 4590.0 and 4599.5 MeV. The nonzero cross ...section near the Λc+Λ¯c− production threshold is cleared. At center-of-mass energies /¯s=4574.5 and 4599.5 MeV, the higher statistics data enable us to measure the Λc polar angle distributions. From these, the Λc electric over magnetic form-factor ratios (|GE/GM|) are measured for the first time. They are found to be 1.14±0.14±0.07 and 1.23±0.05±0.03, respectively, where the first uncertainties are statistical and the second are systematic.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM
Olefin metathesis reactions with 3E-1,3-dienes using Z-selective cyclometalated ruthenium benzylidene catalysts are described. In particular, a procedure for employing 3E-1,3-dienes in Z-selective ...homodimerization and cross-metathesis with terminal alkenes is detailed. The reaction takes advantage of the pronounced chemoselectivity of a recently reported ruthenium-based catalyst containing a cyclometalated NHC ligand for terminal alkenes in the presence of internal E-alkenes. A wide array of commonly encountered functional groups can be tolerated, and only a small excess (1.5 equiv) of the diene coupling partner is required to achieve high yields of the desired internal E,Z-diene cross-metathesis product. Computational studies have been performed to elucidate the reaction mechanism. The computations are consistent with a diene-first pathway. The reaction can be used to quickly assemble structurally complex targets. The power of this cross-metathesis reaction is demonstrated by the concise syntheses of two insect pheromones.
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IJS, KILJ, NUK, PNG, UL, UM
Polymethacrylimide (PMI) foams own the highest specific stiffness and strength of all foams. In situ x-ray micro computed tomography (CT) is used to map three-dimensional (3D) microstructures of this ...representative closed-cell foam under quasi-static compression. The strain fields obtained via digital volume correlation reveal divergent types (discrete or spreading) of deformation banding for the PMI foam with different densities (52 or 75 kgm−3). Significant cell collapse occurs in the deformation bands, leading to ∼40% reduction of the mean cell size, and alignment of cell orientations. Microstructure-based finite element analysis confirms that elastic buckling of cell walls dominates cell collapse, and the buckling strength of walls depends highly on their thicknesses and inclination angles. An edge segmentation technique is then used to quantify the morphology and buckling strength index of cell walls. The spatial distribution of the weakest 3% cell walls correlates well with the modes of deformation banding. Based on elastic buckling of cell walls, new analytical models are developed to predict the strength–density scaling law and stress–strain curves of the PMI foam, which agree well with the experimental results.
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•In situ tomography and strain mapping in PMI foams under compression.•Initial density affects structural disorder and deformation banding.•Meso-FEM confirms elastic buckling of cell walls induces cell collapse.•New buckling-based density-scaling law and constitutive models derived.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The metabolic responses of cows undergo substantial changes during the transition from late pregnancy to early lactation. However, the molecular mechanisms associated with these changes in ...physiological metabolism have not been clearly elucidated. The objective of this study was to investigate metabolic changes in transition cows from the perspective of plasma metabolites. Plasma samples collected from 24 multiparous dairy cows on approximately d 21 prepartum and immediately postpartum were analyzed using ultra-high-performance liquid chromatography/time-of-flight mass spectrometry in positive and negative ion modes. In conjunction with multidimensional statistical methods (principal component analysis and orthogonal partial least squares discriminant analysis), differences in plasma metabolites were identified using the t-test and fold change analysis. Sixty-seven differential metabolites were identified consisting of AA, lipids, saccharides, and nucleotides. The levels of 32 plasma metabolites were significantly higher and those of 35 metabolites significantly lower after parturition than on d 21 prepartum. Pathway analysis indicated that the metabolites that increased from late pregnancy to early lactation were primarily involved in lipid metabolism and energy metabolism, whereas decreased metabolites were related to AA metabolism.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Cancer initiating cells (CICs) are responsible for the unrestrained cell growth and chemoresistance of malignant tumors. Histone demethylation has been shown to be crucial for ...self-renewal/differentiation of stem cells, but it remains elusive whether lysine-specific demethylase 1 (LSD1) regulates the stemness properties of CICs. Here we report that the abundant expression of leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) is associated with the progression of hepatocellular carcinoma (HCC). Lgr5(+) HCC cells behave similarly to CICs and are highly tumorigenic and resistant to chemotherapeutic agents. Importantly, Lgr5(+) cells express higher levels of LSD1, which in turn regulates Lgr5 expression and promotes the self-renewal and drug resistance of Lgr5(+) CICs. Mechanistically, LSD1 promotes β-catenin activation by inhibiting the expression of several suppressors of β-catenin signaling, especially Prickle1 and APC in Lgr5(+) CICs, by directly regulating the levels of mono- and di-methylation of histone H3 lysine-4 at the promoters of these genes. Furthermore, LSD1-associated activation of the β-catenin signaling is essential for maintaining the activity of Lgr5(+) CICs. Together, our findings unravel the LSD1/Prickle1/APC/β-catenin signaling axis as a novel molecular circuit regulating the stemness and chemoresistance of hepatic Lgr5(+) CICs and provide potential targets to improve chemotherapeutic efficacies against HCC.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Aims Visfatin is a newly discovered adipokine found in abundance in visceral fat. It lowers plasma glucose in humans and mice. In this study, we explored the relationships between the plasma level ...of visfatin and genetic single nucleotide polymorphisms (SNPs) and Type 2 diabetes mellitus (T2DM) and anthropometric and metabolic parameters in Chinese subjects.
Methods Oral glucose tolerance tests (OGTT) and biochemical assays for plasma insulin, lipid profiles and serum visfatin were performed in 241 newly diagnosed T2DM patients, subjects with impaired glucose regulation (IGR), and normal glucose tolerant subjects more than 40 years of age. Genotyping for three SNP loci: −1535C/T, rs2058539 and rs10953502 were performed using the allele‐specific real‐time PCR method.
Results Visfatin levels were similar in T2DM patients, IGR and normal glucose tolerant subjects. However, visfatin levels were significantly lower in obese than normal‐weight subjects (13.66 ± 0.87 vs. 15.46 ± 0.47 ng/ml, P = 0.03). There was suggestively significant correlation between visfatin level and body mass index (r = –0.17 P = 0.07) and waist–hip ratio (r = 0.16 P = 0.08) in male subjects, but not in female subjects. Allele and common haplotype frequencies of the three SNP loci were similar in T2DM patients, IGR and normal glucose tolerant subjects. However, significant associations were found between these three SNP loci and plasma glucose concentration at 0 and 120 min during OGTT, the area under the response curve for plasma glucose, and triglyceride and total cholesterol levels.
Conclusions Serum visfatin levels may be related to visceral obesity in men, and the visfatin gene may account for variation of glucose and lipid parameters in Chinese subjects.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
High-entropy alloys (HEAs) are considered as potential structural materials for aerospace and defense applications where impacts are recurrently encountered. The dynamic mechanical properties and the ...underlying deformation and damage mechanisms are significant for safety assessment and structural design optimization, but are underinvestigated. In this work, two types of plate impact experiments, i.e., shock compression and spallation, are performed on typical quaternary CoCrFeNi HEA (at%), to investigate its dynamic mechanical properties and microscopic deformation/damage mechanisms. Free-surface velocity histories are measured to evaluate the mechanical properties and damage processes, including the Hugoniot elastic limit (HEL; ∼0.8 GPa), spall strength (∼3.2 GPa) and pullback rates. The spall strength of the CoCrFeNi HEA is higher than those of most medium- and high-entropy alloys ever reported, except for the Al0.1CoCrFeNi HEA. The deformed samples are characterized with scanning electron microscopy, electron backscatter diffraction and transmission electron microscopy. Shock-induced dislocation slip and deformation twinning dominate plastic deformation. With increasing impact velocity, dislocation density increases significantly and twin bundles appear instead of individual twins. For incipient spallation, voids nucleate preferentially at grain boundaries, especially at grain boundary triple junctions. Damage in the CoCrFeNi HEA is ductile in nature.
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•CoCrFeNi HEA demonstrates an excellent spall strength-ductility combination.•Nano-twin bundles, rather than individual nano-twins, apper at uf = 901 m s−1.•Voids nucleate at grain boundaries, especially at grain boundary triple junctions.•Heterogeneous-structured dimples reveal ductile damage in CoCrFeNi HEA.
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GEOZS, IMTLJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Abstract Purpose Previously published literatures of acute studies on few subjects have shown contradictory evidences on the reproducibility and characteristics of the elicited phosphenes, despite ...using the same stimulating parameters with epiretinal electrode arrays. In this study, we set out to investigate the long-term repeatilibity and reproducibility of phosphenes in subjects chronically implanted with the Argus® II retinal prosthesis. Design Retrospective interventional case series and reliability study Methods Six Argus® II subjects of >5 years implantation from a single site participated. The 4-electrode cluster (“quad”) closest to fovea was stimulated in each subject with a fixed biphasic current. Perceived phosphenes were depicted relative to subjective visual field center. The stimulus was applied at reducing time intervals from 20min to 1second. Two sets of stimulations were performed on the same day and 2 further sets repeated on a separate visit >1 week apart. Results Phosphene Features Each subject depicted phosphenes of consistent shapes and sizes, and reported seeing the same colors with the fixed stimulating parameters, irrespective of the inter-stimuli intervals. However there is a wide inter-subject variation in the phosphene characteristics. Retinotopic Agreement Four subjects drew phosphenes in the same visual field quadrant as predicted by the quad-fovea location. Two subjects depicted phosphenes in the same hemi-field as the expected locations. Conclusion Phosphenes for each subject were consistently reproducible in all our chronically implanted subjects. This has important implication in the development of long-term pixelated prosthetic vision for future devices.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Yb-doped WO3 photocatalysts were prepared by co-sputtering WO3 and Yb, followed by annealing in air for water oxidation with visible light. All the obtained photocatalysts were monoclinic with ...sputtering power of Yb up to 10 W and displayed no optical absorption red shift. In photoelectrochemical (PEC) studies, the photocurrent densities were improved with up to 0.34 at.% Yb in WO3, with the highest photocurrent of 1.3 mA/cm2 (1.2 V vs. Ag/AgCl) achieved with <0.1 at.% Yb. Electrochemical impedance spectroscopy (EIS) measurements showed that optimized Yb doping reduced charge transfer resistance and increased donor density of WO3 photocatalyst. The improvement in photocurrent density was attributed to enhanced conductive carrier path, increased oxygen vacancies and 4f13 orbital configuration due to Yb3+ substitution of W6+.
•Yb-doped WO3 photocatalysts were prepared by co-sputtering WO3 and Yb.•The annealed photocatalysts were used for water oxidation under visible light.•Photocurrent densities were improved with up to 0.34 at.% Yb in WO3.•Highest photocurrent of 1.3 mA/cm2 (1.2 V vs. Ag/AgCl) achieved with <0.1 at.% Yb.•Optimized Yb doping reduced charge transfer resistance and increased donor density.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Background and objective
Preoperative acetabular cup templating has an important auxiliary effect on hip surgery. The traditional acetabular cup templating method requires the measuring person to ...have some experience in total hip replacement (THA) surgery since the measurement results vary from person to person with differences between different measuring persons. To obtain stable templating results, we designed a new acetabular cup templating method and tested the inter-person measuring differences and measurement accuracy of this method. Meanwhile, the clinical application of this method was preliminarily explored.
Materials and methods
The pattern of this new method was manual labeling of imaging characteristic points and then programmed automatic measurements. The measurement process was performed entirely by orthopedic graduate students without any experience in hip replacement surgery. The inter-person measuring difference was evaluated by comparing the templating results of three measuring persons. The accuracy of the templating was evaluated by comparing the templating results with the actual size of the prosthesis in the surgery. The correlation between the position of the acetabular cup and the templating error was analyzed to explore the clinical significance of the templating results. This study was a retrospective study which included templating in a total of 406 cases for total hip replacement with cementless cup prosthesis. Digital measurements were performed using the Matlab software from MathWorks. The statistical comparison was performed using Kendall’s
W
test.
Results
The results of the three measuring persons were completely identical in 61.8% (251/406) of cases, and the variation in 38.2% (155/406) of cases did not exceed one size of the acetabular cup. The Kendall’s
W
coefficient was 0.977, and
p
< 0.01. The measurement accuracy is not as good as the traditional method in exactly accurate measurement and ±1 cup size, but it is similar to the traditional method in the ±2 cup sizes. The correlation between the templating error and the position evaluation of the implanted acetabular cups reveals: (1) larger the templating error, larger the proportion of the acetabular cups with poor position; (2) the proportion of acetabular cup with poor position slowly increased when the templating error was from 0 to 1 size, and the proportion rapidly increased when the templating error was from 1 to 2 size.
Conclusion
All the patients with clear teardrop bottom and lateral superior edge of acetabulum were able to use our method to predict the size of the acetabular cup. The method has the following advantages: (1) it does not require the measuring person to have any previous experience of the THA surgery, which reduces the labor cost of the templating; (2) the differences between the measuring persons is small, the measurement result can be repeated; (3) it can predict the probability of acetabular cup with poor positioning according to the templating error, and thereby reminding the surgeon to recheck and correct the position of the acetabular cup in time during the surgery.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
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