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•Thienothiophene-based covalent organic framework is wrapped on the outer surface of CNT to form a nanocomposite as host material for Li-S battery.•B, O and S atoms on COF could ...uniformly distribute on CNT, which improves the electron transporting, and meanwhile has a strong tendency to capture polysulfides.•TT-BOST@CNT cathode show a high initial discharge specific capacity of 1545 mAh g−1 at 0.2 C and a small attenuation rate of 0.035% per cycle in 1000 cycles at 1 C.•The coexistence of B, O and S atoms endow the nanocomposite with good catalysis ability.
Lithium-sulfur batteries (LSBs) is a promising secondary battery system with high energy density and environment-friendly characteristics, however, the severe “shuttle effect” and poor conductivity usually lead to short service life and low initial capacity. Carbon Nanotubes (CNTs) with excellent conductivity and large quantity of cavities are promising host materials, whereas, the weak interaction between CNTs and polysulfides usually leads to serious shuttle effect in charge/discharge processes. Herein, thienothiophene-based covalent organic framework is uniformly wrapped on the outer surface of CNTs to form a nanocomposite TT-BOST@CNT. It is observed that the coexistence of the electron-rich S, O and the electron-deficient B atoms enables the effective adsorption of both Li+ and Sx2− in lithium polysulfides (LiPSs). Studies reveal that the B, O and S atoms endow the nanocomposite with good catalysis ability, whereby, conversion of the insoluble long-chain polysulfides to the soluble short-chain polysulfides is accelerated. Consequently, the TT-BOST@CNT/S cathode displays outstanding electrochemical performance, with a high discharge specific capacity of 1545 mAh g−1 at 0.2 C and a small attenuation rate of 0.035% per cycle in 1000 cycles at 1 C.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Organic electrode materials are promising to be applied in sodium ion batteries (SIBs) due to their low cost and easily modified molecular structures. Nevertheless, low conductivity and high ...solubility in electrolytes still limit the development of organic electrodes. In this work, a carboxylate small molecule (BDTTS) based on tetrathiafulvalene is developed as anode material for SIBs. BDTTS has a large rigid π-conjugated planar structure, which may reduce solubility in the electrolyte, meanwhile facilitating charge transporting. Experimental results and theoretical calculations both support that apart from the four carbonyl groups, the sulfur atoms on tetrathiafulvalene also provide additional active sites during the discharge/charge process. Therefore, the additional active sites can well compensate for the capacity loss caused by the large molecular weight. The as-synthesized BDTTS electrode renders an excellent capacity of 230 mAh g-1 at a current density of 50 mA g-1 and an excellent long-life performance of 128 mAh g-1 at 2C after 500 cycles. This work enriches the study on organic electrodes for high-performance SIBs and paves the way for further development and utilization of organic electrodes.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Abstract Background The emergence of plasmid-mediated mobile colistin resistance ( mcr ) gene poses a great challenge to the clinical application of polymyxins. To date, mcr-1 to mcr-10 have been ...found in animals, humans, and the environment. Among them, mcr-8 was first identified in Klebsiella pneumoniae ( K. pneumoniae ) of swine origin, and then mcr-8.1 to mcr-8.5 were successively identified. Notably, K. pneumoniae is the major host of the mcr-8 gene in both animals and humans. This study aims to explore the characteristics of K. pneumoniae strains carrying the mcr-8 gene and tmexCD1-toprJ1 gene cluster and investigate the correlation between these two antibiotic resistance genes. Methods The isolates from the poultry farms and the surrounding villages were identified by mass spectrometer, and the strains positive for mcr-1 to mcr-10 were screened by polymerase chain reaction (PCR). The size of the plasmid and the antimicrobial resistance genes carried were confirmed by S1-nuclease pulsed-field gel electrophoresis (S1-PFGE) and Southern hybridization, and the transferability of the plasmid was verified by conjugation experiments. Antimicrobial susceptibility testing (AST) and whole genome sequencing (WGS) were used to characterize the strains. Results Two K. pneumoniae isolates (KP26 and KP29) displaying polymyxin resistance were identified as mcr-8 gene carriers. Besides that, tigecycline-resistant gene cluster tmexCD1-toprJ1 was also found on the other plasmid which conferred strain resistance to tigecycline. Through epidemiological analysis, we found that the mcr-8 gene has dispersed globally, circulating in the human, animals, and the environment. Furthermore, our analysis suggests that the coexistence of mcr-8 and tmexCD1-toprJ1 on a single plasmid might evolved through plasmid recombination. Conclusions Although the mcr-8 and tmexCD1-toprJ1 gene clusters in the two strains of K. pneumoniae in this study were on two different plasmids, they still pose a potential threat to public health, requiring close monitoring and further study.
An organic small molecule PN with multiple carbonyl groups was used to form composite network with rGO, and the composite effectively reduce the shuttle effect of Li-S batteries.
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•The ...PN small molecule has multiple carbonyl groups, which is beneficial to the adsorption of polysulfide.•PN-rGO organic composite materials form conductive network as host for Li-S batteries.•The adsorption of polysulfide is enhanced and the shuttle effect is effectively alleviated.•The S/PN-rGO electrode as electrode delivers outstanding electrochemical performance.
The “shuttle effect” of polysulfide in the cycling process seriously hinders the practical application of lithium-sulfur batteries. Herein, a perylene-based organic molecule with multiple carbonyl groups (PN) was introduced to modify rGO and form a PN-rGO composite network. PN with large conjugated planar structure is potential to be highly distributed throughout the electrode. The large specific surface area of rGO provides a substrate for PN molecules and could avoid their aggregation. Moreover, PN-rGO can provide a rapid and continuous transporting path for lithium ions and electrons, thus improving conductivity and accelerating the electrochemical dynamics of the battery. At the same time, the carbonyl groups in PN can effectively adsorb polysulfide through SO interaction, and the shuttle effect of polysulfide could be alleviated. A high discharge specific capacity of 1071 mAh g−1 is retained after 200 cycles at 0.2C. In addition, the composite showed a higher rate performance of 589 mAh g−1 at 5C, compared to pristine rGO (283 mAh g−1). This work demonstrates that the rational design of organic small molecule to modify carbon materials is potential to inhibit the shuttle effect as well as to acquire stable cathode material. Our work may provide a foundation for the future design of functionalized organic molecules as energy storage materials.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Highly accurate observations at various scales on the land surface are urgently needed for the studies of many areas, such as hydrology, meteorology, and agriculture. With the rapid development of ...remote sensing techniques, remote sensing has had the capacity of monitoring many factors of the Earth＇s land surface. Especially, the space-borne microwave remote sensing systems have been widely used in the quantitative monitoring of global snow, soil moisture, and vegetation parameters with their all-weather, all-time observation capabilities and their sensitivities to the characteristics of land surface factors. Based on the electromagnetic theories and microwave radiative transfer equations, researchers have achieved great successes in the mi- crowave remote sensing studies for different sensors in recent years. This article has systematically reviewed the progresses on five research areas including microwave theoretical modeling, microwave inversion on soil moisture, snow, vegetation and land surface temperatures. Through the further enrichment of remote sensing datasets and the development of remote sensing theories and inversion techniques, remote sensing including microwave remote sensing will play a more important role in the studies and applications of the Earth systems.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Background
The pathogen responsible for tuberculosis is called Mycobacterium tuberculosis. Its interaction with macrophages has a significant impact on the onset and progression of the disease.
...Methods
The respiratory pathway allows Mycobacterium tuberculosis to enter the body's lungs where it battles immune cells before being infected latently or actively. In the progress of tuberculosis, Mycobacterium tuberculosis activates the body's immune system and creates inflammatory factors, which cause tissue inflammation to infiltrate and the creation of granulomas, which seriously harms the body. Toll-like receptors of macrophage can mediate host recognition of Mycobacterium tuberculosis, initiate immune responses, and participate in macrophage autophagy. New host-directed therapeutic approaches targeting autophagy for drug-resistant Mycobacterium tuberculosis have emerged, providing new ideas for the effective treatment of tuberculosis.
Conclusions
In-depth understanding of the mechanisms by which macrophage autophagy interacts with intracellular Mycobacterium tuberculosis, as well as the study of potent and specific autophagy-regulating molecules, will lead to much-needed advances in drug discovery and vaccine design, which will improve the prevention and treatment of human tuberculosis.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The mean-square stability of the θ-method for neutral stochastic delay integro-differential equations (NSDIDEs) is considered in this paper. We construct two classes of θ-methods, i.e. the stochastic ...linear theta (SLT) method and the split-step theta (SST) method for NSDIDEs. Under the one-sided growth condition and contractive condition, we show that both methods are mean-square exponentially stable. An example is given to illustrate the theoretical results.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Achieving zero energy consumption in buildings is one of the most effective ways of achieving ‘carbon neutrality’ and contributing to a green and sustainable global development. Currently, BIPV ...systems are one of the main approaches to achieving zero energy in buildings in many countries. This paper presents the evolution of BIPV systems and predicts their future trends by deriving a base sample of core papers on BIPV systems from 2012 to 2022 from the Web of Science core database and conducting a bibliometric study using CiteSpace scientific visualisation software. To gain a deeper understanding and grasp of the research progress of BIPV systems, research group discovery, research hotspot analysis, and research frontier detection of the relevant literature were conducted. (1) Research groups on the topic were summarised through author coupling network, publication distribution, and country mapping analysis; (2) Research hotspots on the topic were explored through keyword co-occurrence, keyword emergence, and time zone map analysis; (3) Research hotspots on the topic were explored through literature co-citation timeline maps, literature co-citation categories, and literature co-citation clustering analysis to detect the frontiers of research in the field. Finally, we conclude that research trends in BIPV systems are mainly in the areas of heat transfer, thermal performance, renewable energy, solar cell and renewable building materials, and evaluation systems. In the future, BIPV research and applications will move towards interdisciplinary and multinational cooperation, which will maximise the benefits of clean energy conversion in buildings. It will also provide researchers and practitioners with a clearer understanding of BIPV research trends and hotspots, and provide new directions for future research.
The rapid global dissemination of Salmonella enterica sequence type 34 (ST34) has sparked significant concern due to its resistance to critical antimicrobials and its ability to spread across various ...sectors. In order to investigate the evolution and transmission dynamics of this epidemic clonal lineage, as well as the horizontal transfer of mcr-carrying plasmids within the One Health framework, we conducted a comprehensive genomic epidemiological study. This study focused on the 11 mcr-carrying S. enterica isolates obtained from clinical settings in China, while also considering 2337 publicly available genomes of mcr-carrying S. enterica collected from 20 countries and diverse sources spanning over a 22-year period. Among the mcr-positive Salmonella isolates, ST34 was found to be the predominant lineage, comprising 30.12 % (704/2337) of the total collection. These isolates were identified as either serovar Typhimurium or its monophasic variant, which were obtained from both clinical and non-clinical sources. Phylogeographic analyses traced the global spread of the mcr-carrying ST34 lineage, which was divided into three distinct clusters, with 83.10 % of them carrying mcr-1 or/and mcr-9 genes. Notably, the mcr-1 positive ST34 isolates were primarily found in China (190/298, 63.76 %), with only four from the United States. Conversely, mcr-9 positive ST34 isolates were predominantly identified in the United States (261/293, 89.08 %), while none were observed in China. The mcr-1 positive ST34 isolates was predicted to have originated from clinical sources in United Kingdom, whereas mcr-9 positive ST34 isolates was likely derived from environmental sources in Germany. The most recent common ancestor for mcr-1 and mcr-9 carrying ST34 S. enterica was estimated to have emerged around 1983 and 1951. These findings provided thorough and intuitive insights into the intercontinental spread of mcr-carrying S. enterica ST34 lineage in a One Health context. Ongoing surveillance is crucial for effectively monitoring the worldwide dissemination of this multidrug-resistant high-risk clone.
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•mcr-carrying Salmonella ST34 exhibited global dissemination across various sectors.•China had 63.76 % of mcr-1-carrying ST34 isolates, whereas the US only had four.•The US had 89.08 % mcr-9-carrying ST34 isolates, whereas China had none.•mcr-1 and mcr-9-carrying ST34 were originated from UK and Germany, respectively.•Global surveillance of mcr-carrying Salmonella in One Health context is necessary.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Tricin, a natural nontoxic flavonoid distributed in grasses and euphorbia plants, has been reported to scavenge free radicals, possess anti-inflammatory and antioxidative effects. However, its ...autophagic effect on Parkinson's disease (PD) has not been elucidated. By adopting cellular and C. elegans models of PD, the autophagic effect of tricin was identified based on the level of autophagy markers (LC3-II and p62). Besides, the pharmacological effects on neurotransmitters (dopamine), inflammatory cytokines (IFN γ, TNFα, MCP-1, IL-10, IL-6 and IL-17A), histology (hematoxylin & eosin and Nissl staining) and behavioural pathology (open-field test, hindlimb clasping, Y-maze, Morris water-maze and nest building test) were also confirmed in the A53T-α-synuclein transgenic PD mouse model. Further experiments demonstrated that tricin induced autophagic flux and lowered the level of α-synuclein through AMPK-p70s6K- and ATG7-dependent mechanism. Compared to the existing clinical PD drugs, tricin mitigated pathogenesis and symptoms of PD with no observable side effects. In summary, tricin is proposed as a potential adjuvant remedy or nutraceutical for the prevention and treatment of PD.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
