A therapeutic carrier in the second near‐infrared (NIR) window is created that features magnetic target, magnetic resonance imaging (MRI) diagnosis, and photothermal therapy functions through the ...manipulation of a magnet and NIR laser. A covellite‐based CuS in the form of rattle‐type Fe3O4@CuS nanoparticles is developed to conduct photoinduced hyperthermia at 808 and 1064 nm of the first and second NIR windows, respectively. The Fe3O4@CuS nanoparticles exhibit broad NIR absorption from 700 to 1300 nm. The in vitro photothermal results show that the laser intensity obtained using 808 nm irradiation required a twofold increase in its magnitude to achieve the same damage in cells as that obtained using 1064 nm irradiation. Because of the favorable magnetic property of Fe3O4, magnetically guided photothermal tumor ablation is performed for assessing both laser exposures. According to the results under the fixed laser intensity and irradiation spot, exposure to 1064 nm completely removed tumors showing no signs of relapse. On the other hand, 808 nm irradiation leads to effective inhibition of growth that remained nearly unchanged for up to 30 d, but the tumors are not completely eliminated. In addition, MRI is performed to monitor rattle‐type Fe3O4@CuS localization in the tumor following magnetic attraction.
An effective, near‐infrared (NIR)‐responsive rattle‐type Fe3O4@CuS nanoparticle is developed to conduct magnetically guided photothermal tumor ablation and magnetic resonance imaging diagnosis through magnetic targeting. Based on the broad NIR absorption from 700 to 1300 nm, photothermal tumor ablation is evaluated by radiation at 808 and 1064 nm of the first and second NIR windows, respectively.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
The electrochemical nitrogen reduction reaction (NRR) process usually suffers extremely low Faradaic efficiency and ammonia yields due to sluggish NN dissociation. Herein, single‐atomic ruthenium ...modified Mo2CTX MXene nanosheets as an efficient electrocatalyst for nitrogen fixation at ambient conditions are reported. The catalyst achieves a Faradaic efficiency of 25.77% and ammonia yield rate of 40.57 µg h−1 mg−1 at ‐0.3 V versus the reversible hydrogen electrode in 0.5 m K2SO4 solution. Operando X‐ray absorption spectroscopy studies and density functional theory calculations reveal that single‐atomic Ru anchored on MXene nanosheets act as important electron back‐donation centers for N2 activation, which can not only promote nitrogen adsorption and activation behavior of the catalyst, but also lower the thermodynamic energy barrier of the first hydrogenation step. This work opens up a promising avenue to manipulate catalytic performance of electrocatalysts utilizing an atomic‐level engineering strategy.
Single‐atomic ruthenium modified Mo2CTX MXene nanosheets are developed as an efficient electrocatalyst for nitrogen fixation under ambient conditions. The catalyst achieves a high Faradaic efficiency and a large ammonia yield rate in 0.5 m K2SO4 solution, outperforming many previous reported nitrogen reduction reaction electrocatalysts. The high activity and durability enable the single‐atomic Ru‐Mo2CTX to be a promising electrocatalyst for artificial nitrogen fixation.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Circular RNAs (circRNAs) belong to an abundant category of non-coding RNAs that are stable and specific, and thus have great potential in cancer treatment. However, little is known about the role of ...circRNAs during radiotherapy in lung adenocarcinoma (LUAD). Here, we established the expression profiles of 1,875 dysregulated circRNAs in non-irradiated and irradiated A549 cells and identified circNEIL3 as a significantly downregulated circRNA in A549 cells treated with 0, 2, or 4 Gy of radiation, respectively. Functional assays demonstrated that circNEIL3 knockdown promoted radiation-induced cell pyroptosis, whereas circNEIL3 overexpression had the opposite effects. Importantly, the effects of circNEIL3 overexpression on inhibiting pyroptosis were reversed by PIF1 knockdown. Mechanistically, circNEIL3-mediated pyroptosis was achieved through directly binding to miR-1184 as a sponge, thereby releasing the inhibition of miR-1184 on PIF1, which ultimately induces DNA damage and triggers AIM2 inflammasome activation. In vivo, circNEIL3 knockdown significantly enhanced the efficacy of radiotherapy as evidenced by decreases in tumor volume and weight. Collectively, the circNEIL3/miR-1184/PIF1 axis that mediate pyroptosis induction may be a novel, promising therapeutic strategy for the clinical treatment of lung cancer.
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•Reduced graphene oxide film is prepared by a static self-assembly method.•The reduced graphene oxide film accounting for only 30 wt% of the entire pole piece.•The flexible ...supercapacitor based on the FeCo2S4/RGOF shows stable electrochemical performance.•The synergistic effect of reduced graphene oxide film and bimetallic sulphides enhanced the electrochemical performance.
With the aim of developing sustainable energy storage and a flexible device exhibiting excellent electrochemical performance, a supercapacitor system comprising a highly reduced graphene oxide film (RGOF) as substrate and a spinel flower-like FeCo2S4 array as the active material is fabricated. The specific capacitance of the FeCo2S4/RGOF electrode reaches 2487.97 F g−1 at a current density of 5 mA cm−2 while maintaining superior stability with 95.9% capacitance retention after 5000 cycles, thereby surpassing that of previously reported Fe-Co bimetallic sulfides. This is ascribed to the synergistic effect between conductive RGOF and active FeCO2S4, which are rich in redox reactions. The fabricated FeCo2S4/RGOF is utilized as a positive electrode in an asymmetric supercapacitor, delivering a high energy density of 88.2 W h kg−1 at 800 W kg−1. Furthermore, the supercapacitor exhibits excellent cycling stability with 85.1% capacitance retention after 5000 cycles at 5 A g−1 and outstanding persistence after different deformation conditions. Thus, the FeCo2S4 hybrid film electrode with specific flexibility shows potential applicability in portable and wearable energy storage devices.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
In this paper, a new aromatic diamine monomer 4,4'-(2,6-naphthalenediyl)bisbenzenamine) (NADA) was synthesized and a series of modified PI films containing naphthalene ring structure obtained by ...controlling the molar ratio of NADA monomer, ternary polymerization with 4,4'-oxydianiline (ODA), and pyromellitic dianhydride (PMDA). The effects of the introduction of the naphthalene ring on the free volume and various properties of PI were investigated by molecular dynamic simulations. The results show that the comprehensive properties of the modified films are all improved to some extent, with 5% thermal weight loss temperature (T
) of 569 °C, glass transition temperature (Tg) of 381 °C, tensile strength of 96.41 MPa, and modulus of elasticity of 2.45 GPa. Dielectric property test results show that the dielectric constant (Dk) of the film at 1 MHz is reduced from 3.21 to 2.82 and dielectric loss (Df) reduced from 0.0091 to 0.0065. It is noteworthy that the PI-1 dielectric constant is reduced from 3.26 to 3.01 at 10 GHz with only 5% NADA doping, which is expected to yield the best ratio and provide the possibility of industrial production.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Fibromyalgia is a chronic pain syndrome characterized by persistent and widespread musculoskeletal pain. Telerehabilitation is a promising treatment for patients with fibromyalgia through long-term ...monitoring, intervention, supervision, consultation, and education.
This study aimed to perform a comprehensive systematic review and meta-analysis of the efficacy and safety of telerehabilitation in patients with fibromyalgia.
Randomized controlled trials (RCTs) related to fibromyalgia and telerehabilitation were systematically searched in the PubMed, PEDro, Cochrane Library, ScienceDirect, Ovid MEDLINE, Embase, and Web of Science databases from inception to November 13, 2022. Two independent researchers screened the literatures and evaluated the methodological quality using the Cochrane Risk of Bias Tool. The outcome measures included the Fibromyalgia Impact Questionnaire scale, pain intensity, depression, pain catastrophizing, quality of life (QoL), and adverse events. Pooled effect sizes were calculated by Stata SE 15.1; a fixed effects model was used when I
<50%, whereas a random effects model was used when I
≥50%.
A total of 14 RCTs with 1242 participants were included in this meta-analysis. The pooled results indicated that the telerehabilitation improved the Fibromyalgia Impact Questionnaire score (weighted mean difference -8.32, 95% CI -11.72 to -4.91; P<.001), pain intensity (standardized mean difference SMD -0.62, 95% CI -0.76 to -0.47; P<.001), depression levels (SMD -0.42, 95% CI -0.62 to -0.22; P<.001), pain catastrophizing (weighted mean difference -5.81, 95% CI -9.40 to -2.23; P=.001), and QoL (SMD 0.32, 95% CI 0.18 to 0.47; P<.001) in patients with fibromyalgia compared to control interventions. Only 1 RCT reported a mild adverse event of telerehabilitation; the other 13 RCTs did not mention this.
Telerehabilitation can improve the symptoms and QoL of fibromyalgia. However, the safety of telerehabilitation remains uncertain due to the lack of sufficient evidence for the management of fibromyalgia. More rigorously designed trials are needed in the future to verify the safety and efficacy of telerehabilitation in fibromyalgia.
PROSPERO CRD42022338200; https://tinyurl.com/322keukv.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Circular RNAs (circRNAs), a novel class of widespread and diverse endogenous RNAs, can regulate gene expression in mammals. CircRNAs have recently been identified as microRNA sponges and involved in ...the development of some human diseases. However, the role of circRNAs in the process of tumorigenesis and development of lung cancer remains vague. The purpose of this study is to investigate the role of circRNAs in the lung cancer. In this study, we chose hsa_circ_0000064 as a targeted circRNA to investigate its clinical significances in lung cancer patients. The result indicated that hsa_circ_0000064 was up-regulated in lung cancer tissues and lung cancer cell lines (A549 and H1229). Moreover, its aberrant expression was correlated with several clinical characteristics, including T stage, lymphatic metastasis, and TNM stage. Fluorescence in situ hybridization detected that hsa_circ_0000064 was mostly located in the cytoplasm in A549 and H1229 cells. In addition, knockdown of hsa_circ_0000064 with siRNA dramatically attenuated the proliferation, blocked cell cycle progression, and promoted cell apoptosis. Western blot analysis showed that the protein levels of caspase-3, caspase-9, bax, p21, CDK6 and cyclin D1 significantly restrained by si-hsa_circ_0000064, while the expression of bcl-2 notably increased in A549 and H1229 cells. Further, si-hsa_circ_0000064 also abated migration and invasion activities of A549 and H1229 cells, which may be associated with reduced expressions of MMP-2 and MMP-9. In general, our data suggest that hsa_circ_0000064 represents a novel potential biomarker and therapeutic target of lung cancer.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Hydrogen production from electrochemical water splitting is a promising route to pursue clean and sustainable energy sources. Here, a three-dimensional nanoporous Cu–Ru alloy is prepared as a ...high-performance platinum-free catalyst for hydrogen evolution reaction (HER) by a dealloying process. Significantly, the optimized nanoporous alloy Cu53Ru47 exhibits remarkable catalytic activity for HER with nearly zero onset overpotential and ultralow Tafel slopes (∼30 and ∼35 mV dec–1) in both alkaline and neutral electrolytes, achieving a catalytic current density of 10 mA cm–2 at low overpotentials of ∼15 and ∼41 mV, respectively. Operando X-ray absorption spectroscopy experiments, in conjunction with DFT simulations, reveal that the incorporation of Ru atoms into the Cu matrix not only accelerates the reaction step rates of water adsorption and activation but also optimizes the hydrogen bonding energy on Cu and Ru active sites, improving the intrinsic activity for HER.
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IJS, KILJ, NUK, PNG, UL, UM
Prussian blue analogs (PBAs) are especially investigated as superior cathodes for sodium‐ion batteries (SIBs) due to high theoretical capacity (≈170 mA h g−1) with 2‐Na storage and low cost. However, ...PBAs suffer poor cyclability due to irreversible phase transition in deep charge/discharge states. PBAs also suffer low crystallinity, with considerable Fe(CN)6 vacancies, and coordinated water in crystal frameworks. Presently, a new chelating agent/surfactant coassisted crystallization method is developed to prepare high‐quality (HQ) ternary‐metal NixCo1−xFe(CN)6 PBAs. By introducing inactive metal Ni to suppress capacity fading caused by excessive lattice distortion, these PBAs have tunable limits on depth of charge/discharge. HQ‐NixCo1−xFe(CN)6 (x = 0.3) demonstrates the best reversible Na‐storage behavior with a specific capacity of ≈145 mA h g−1 and a remarkably improved cycle performance, with ≈90% capacity retention over 600 cycles at 5 C. Furthermore, a dual‐insertion full cell on the cathode and NaTi2(PO4)3 anode delivers reversible capacity of ≈110 mA h g−1 at a current rate of 1.0 C without capacity fading over 300 cycles, showing promise as a high‐performance SIB for large‐scale energy‐storage systems. The ultrastable cyclability achieved in the lab and explained herein is far beyond that of any previously reported PBA‐based full cells.
A high rate and long‐life dual‐insertion sodium‐ion full cell is successfully fabricated without noticeable capacity fading over 300 cycles by using high‐quality ternary‐metal Prussian blue analogs with large structural strain‐suppression, which can extend a new avenue toward practical application of sodium‐ion batteries for large‐scale energy‐storage systems.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
This study aimed to explore the possible mechanism of trauma-induced laryngotracheal stenosis and potential protective and therapeutic efficacy of quercetin on trauma-induced laryngotracheal ...stenosis.
The expression and activity of fibrotic factors interleukin (IL)-6, IL-8, autophagy related 5 (ATG5), collagen (COL)-1, tumor growth factor (TGF)-β COL-3, microtubule-associated proteins 1A/1B light chain 3A (LC3), and vascular endothelial growth factor (VEGF) and fibrotic signaling mediators mammalian target of rapamycin (mTOR) and phosphorylated AKT (pAKT) were detected by real-time quantitative PCR (qRT-PCR), ELISA, Western blot, and immunohistochemical staining, respectively, in the lipopolysaccharide (LPS)-induced WI-38 (a human embryonic lung fibroblast cell line) cellular fibrotic model and a trauma-induced rabbit tracheal stenosis model, with and without quercetin treatment.
Pre-treatment with quercetin significantly reversed the LPS-induced upregulation of pro-fibrotic factors (IL-6, IL-8, COL-1, COL-3, LC3) and fibrotic signaling mediators (mTOR and AKT), and it induced the downregulation of ATG5 in the WI-38 cells. Furthermore, the anti-fibrotic activity of quercetin was confirmed in the trauma-induced rabbit tracheal stenosis model. Thus, the nasogastric administration of quercetin attenuated the tracheal stenosis of the rabbit tracheal stenosis model, in addition to effectively reversing an increase in pro-fibrotic factors (VEGF, IL-6, TGF-β, COL-1, and COL-3) and fibrotic signaling mediators (mTOR and AKT), as well as downregulating ATG5 of the rabbit tracheal stenosis model.
Quercetin exhibits anti-fibrotic activity by inhibiting pro-fibrotic factors and AKT/mTOR signaling pathway, in addition to activating autophagy activity. This study provided experimental evidence supporting the application of quercetin in tracheal stenosis, clinically.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
