Introduction: In the field of industrial manufacturing, accurate inspection of mechanical components such as gears and bearings is of Paramount importance. However, the traditional mechanical testing ...methods are often disturbed by human factors, which not only affects the stability of the test results, but also leads to low efficiency and large error. In order to solve these problems, this research focuses on developing a new edge detection model. Methods: A novel edge detection model based on field-programmable gate array image processing technology was used in this study. The model uses adaptive threshold multi-directional edge detection technology to identify the edge features of mechanical gears and bearings, aiming at improving the precision of detection. Results and Discussion: After performance verification, the running time of the model was controlled within 11 s, and the detection error was limited to less than 9%. Compared with the control group and the experimental group, their performance was superior. Further analysis data show that the detection accuracy of this model is as high as 0.9004, its internal resource utilization rate is 88%, and the detection rate is as high as 91%, which are better than the comparison model. Conclusion: The proposed test model not only significantly improves the efficiency and accuracy of the test, but also fully meets the requirements of the test. This new edge detection model has potential application value in industrial manufacturing field, and provides a new solution for industrial manufacturing quality inspection.
The transcription factor nuclear factor erythroid-derived 2-like 2 (NRF2) participates in the activation of the antioxidant cytoprotective pathway and other important physiological processes to ...maintain cellular homeostasis. The dysregulation of NRF2 activity plays a role in various diseases, such as cardiovascular diseases, neurodegenerative diseases, and cancer. Thus, NRF2 activity is tightly regulated through multiple mechanisms, among which phosphorylation by kinases is critical in the posttranslational regulation of NRF2. For instance, PKC, casein kinase 2, and AMP-activated kinase positively, while GSK-3 negatively regulates NRF2 activity through phosphorylation of different sites. Here, we provide an overview of the phosphorylation regulation pattern of NRF2 and discuss the therapeutic potential of interventions targeting NRF2 phosphorylation.
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•Protein kinases phosphorylate Nrf2 to modulate its stability and/or activity.•Phosphorylation regulation of NRF2 bridges NRF2 activity to a series of biological events.•Targeting NRF2 phosphorylation regulation shows therapeutic potential for multiple inflammation-related diseases.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Herein, we present a novel strategy based on a “turn-on” persistent luminescence imaging chemical system of graphitic carbon nitride for detecting biothiols in biological fluids. Graphitic carbon ...nitride (g-C3N4) as persistent luminescence probe is fabricated via a new procedure based on pyrolysis of guanidine hydrochloride under ambient atmospheric conditions. The prepared g-C3N4 nanosheets give intensively long-persistent luminescence that can avoid interference from biological media such as tissue autofluorescence and scattering light. The original persistent luminescence of g-C3N4 turns off due to the adsorption of silver ion (Ag+) onto g-C3N4 materials with an electron transfer process. The presence of biothiols induces the onset of persistent luminescence emission by interrupting the quenching interaction, thereby turning on the imaging probe. The approach exhibits high specificity and high sensitivity to biothiols with low detection limit for cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) with 6.4, 8.1, and 9.6 nM, respectively. It is also successfully applied for imaging detection of biothiols in human urine, plasma, and cell lysates, demonstrating its great value of practical application in biological systems.
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IJS, KILJ, NUK, PNG, UL, UM
•The effects of amplitude and wavelength on heat transfer behavior are investigated.•9 different wavy channel configurations and 1 straight channel configuration are considered.•In different ...perspectives, comparisons on heat transfer performance are made among different cases.•Optimum wavy parameters are selected.
Performance enhancement of printed circuit heat exchanger (PCHE) is of great importance to the thermal efficiency improvement of supercritical CO2 Brayton cycle. In this paper, the heat transfer performance and flow characteristics of a sinusoidal wavy channel PCHE are numerically investigated. The effects of the amplitude and wavelength parameters are discussed under different mass flow conditions with inlet Re = 5210.8−13026.9 on the hot side. It’s found that the increase of amplitude and decrease of wavelength result in larger flow length and heat transfer area of the wavy channel, as well as higher heat transfer rate. The use of wavy channel instead of straight channel enhances heat transfer. Because of the complicated flow fields in the wavy channels affected by thermophysical property changes and centrifugal forces, the shapes and locations of high heat flux zones shift with different configurations. The secondary flow and heat transfer area change both contribute to the change of heat transfer characteristics. The resulting complicated heat transfer performance variation of different configurations are illustrated and discussed. Based on the overall performance evaluation results, the best performance is obtained with an amplitude of 3 mm and a wavelength of 50 mm or 75 mm.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Perovskite structure compounds are significant candidates for designing new optical function materials due to their structural variability. Here, an inorganic tetravalent cerium fluoride, Na2CeF6, is ...derived from the perovskite structure through double‐site cation co‐substitution. Na2CeF6 crystalizes in the non‐centrosymmetric space group P6¯2m${P}^{\bar{6}}2m$. Edge‐sharing connected NaF9 and CeF9 polyhedra build the whole 3D structure of Na2CeF6. Importantly, it represents the first Ce(IV) fluoride nonlinear optical (NLO) crystal and can produce a strong and phase‐matchable second‐harmonic generation (SHG) effect of ≈2.1 times that of KH2PO4 (KDP), making it the strongest among non‐lone pair electron metal fluoride system. Further, it exhibits a high laser‐induced damage threshold (LIDT) of 74.65–76.25 MW cm−2, which is over 20 times that of AgGaS2. It also exhibits a wide transparent region (0.5−14.3 µm). This work provides a facile route for exploring high‐performance halide NLO materials.
Here, an inorganic tetravalent cerium fluoride, Na2CeF6, is derived from the perovskite structure by double site cation substitution. It represents the first Ce(IV) fluoride nonlinear optical crystal and demonstrates a strong and phase‐matchable second‐harmonic generation effect (2.1 × KH2PO4). It also exhibits large laser‐induced damage threshold (over 20 × AgGaS2).
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Highlights
A series of novel injectable pH-responsive self-healing hydrogels with enhanced adhesive strength were prepared.
The hydrogels showed good gastric hemostasis property in a swine gastric ...hemorrhage model.
The hydrogels greatly enhanced gastric wound healing in a swine gastric wound model.
Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are well-established therapeutics for gastrointestinal neoplasias, but complications after EMR/ESD, including bleeding and perforation, result in additional treatment morbidity and even threaten the lives of patients. Thus, designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a challenge. Herein, a series of injectable pH-responsive self-healing adhesive hydrogels based on acryloyl-6-aminocaproic acid (AA) and AA-g-N-hydroxysuccinimide (AA-NHS) were developed, and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model. The hydrogels showed a suitable gelation time, an autonomous and efficient self-healing capacity, hemostatic properties, and good biocompatibility. With the introduction of AA-NHS as a micro-cross-linker, the hydrogels exhibited enhanced adhesive strength. A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding. A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition, α-SMA expression, and blood vessel formation. These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Alcohol use disorder (AUD) is an important brain disease. It alters the brain structure. Recently, scholars tend to use computer vision based techniques to detect AUD. We collected 235 subjects, 114 ...alcoholic and 121 non-alcoholic. Among the 235 image, 100 images were used as training set, and data augmentation method was used. The rest 135 images were used as test set. Further, we chose the latest powerful technique—convolutional neural network (CNN) based on convolutional layer, rectified linear unit layer, pooling layer, fully connected layer, and softmax layer. We also compared three different pooling techniques: max pooling, average pooling, and stochastic pooling. The results showed that our method achieved a sensitivity of 96.88%, a specificity of 97.18%, and an accuracy of 97.04%. Our method was better than three state-of-the-art approaches. Besides, stochastic pooling performed better than other max pooling and average pooling. We validated CNN with five convolution layers and two fully connected layers performed the best. The GPU yielded a 149× acceleration in training and a 166× acceleration in test, compared to CPU.
DNAzymes, screened through
in vitro
selection, have shown great promise as molecular tools in the design of biosensors and nanodevices. The catalytic activities of DNAzymes depend specifically on ...cofactors and show multiple enzymatic turnover properties, which make DNAzymes both versatile recognition elements and outstanding signal amplifiers. Combining nanomaterials with unique optical, magnetic and electronic properties, DNAzymes may yield novel fluorescent, colorimetric, surface-enhanced Raman scattering (SERS), electrochemical and chemiluminescent biosensors. Moreover, some DNAzymes have been utilized as functional components to perform arithmetic operations or as "walkers" to move along DNA tracks. DNAzymes can also function as promising therapeutics, when designed to complement target mRNAs or viral RNAs, and consequently lead to down-regulation of protein expression. This feature article focuses on the most significant achievements in using DNAzymes as recognition elements and signal amplifiers for biosensors, and highlights the applications of DNAzymes in logic gates, DNA walkers and nanotherapeutics.
DNAzymes, screened through
in vitro
selection, have shown great promise as molecular tools in the design of biosensors and nanodevices.
Thiols play vital roles in mediating physiological processes. However, it is difficult to discriminate one thiol from another because of the similarities among structures and reactivities of thiols. ...In light of the ultralow background and impressive discrimination power, a persistent luminescence-based sensing array has attracted increasing attention but still remains a huge challenge. Herein, we have thoroughly studied the chemistry involving dual-emission persistent luminescence nanoparticles (D-PLNPs) with metal ions (MIs) and for the first time proposed an MIs-triggered ratiometric persistent luminescence (R-PersL) sensor array for the discrimination of six thiols. To extract data-rich outputs from a single sensor element, three representative D-PLNPs with a core–shell structure and subsequent carboxyl functionalizations (CSD-PLNPs) were rationally fabricated. Interestingly, MIs revealed the different regulating efficiencies for the two main emission bands of CSD-PLNPs, resulting from MI-triggered R-PersL signal transductions. Inspired by the crucial roles of thiols in vivo, a proof-of-concept sensor array through the ensemble of CSD-PLNPs-COOH and certain MIs was developed and demonstrated aR-PersL “fingerprint“ pattern identification for six thiols. Remarkably, because of the autofluorescence-free background and high-throughput signal output, this sensing array system enabled a highly sensitive and differentiable detection of thiols at various concentrations in human blood serums, paving a new way to develop multiparameters sensing for complex analytes.
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IJS, KILJ, NUK, PNG, UL, UM
Quantum dots (QDs), especially metal-free QDs with their unique optoelectronic properties, environmental friendliness, and excellent biocompatibility, have opened a new avenue to explore novel ...chemiluminescence (CL) systems for analytical applications. However, the unknown CL properties, relatively weak emission, and instability of some of them in water (e.g., black phosphorus QDs) often seriously hinder their further practical applications. Chemical modification trends have offered new properties for materials and have been proved to be desirable ways to establish sensing platforms with improved sensitivity and stability. Herein, oleic acid capped black phosphorus QDs (OA-BP QDs) with improved stability and optical properties were successfully synthesized. More importantly, an extraordinary CL emission when OA-BP QDs reacted with SO3 2– was first observed. In the CL process, OA-BP QDs acted as the catalyst to trigger singlet oxygen (1O2) generation in NaHSO3, and then a chemiluminescence resonance energy transfer (CRET) between (1O2)2* (1O2 dimeric aggregate) and OA-BP QDs was produced. On this basis, a new CL system for directly monitoring SO3 2– in airborne fine particulate matter (PM2.5) was fabricated. The study opens attractive perspectives of modified metal-free QDs for the practice of CL in monitoring the chemical species in PM2.5.
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IJS, KILJ, NUK, PNG, UL, UM
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