To compare visual acuity and refractive results between topography-guided laser in situ keratomileusis (LASIK) planned with the Phorcides Analytic Engine (PAE) to results after wavefront-optimized ...(WFO) LASIK in subjects with preoperative oblique astigmatism in their manifest refraction.
This was a retrospective chart review of clinical results from eyes treated with topography-guided LASIK planned with PAE compared to eyes treated with WFO LASIK using the same Wavelight® excimer laser system. All included subjects had preoperative oblique astigmatism. Residual refractive error and visual acuity (uncorrected and corrected) were the measures of interest, at the visit closest to 90 days postoperative.
A matched data set from 100 WFO and 97 PAE eyes was extracted from clinical records. At the postoperative visit the PAE group showed lower residual refractive cylinder (p = 0.04), uncorrected distance visual acuity (UDVA) (-0.06 PAE vs. -0.02 WFO, p < 0.01) and distance corrected visual acuity (CDVA) (p < 0.01). The percentage of eyes with a mean refraction spherical equivalent (MRSE) magnitude within 0.25 D and 0.50 D of plano was statistically significantly higher in the PAE group (p = 0.04 and 0.01, respectively). A statistically significantly higher percentage of eyes in the PAE group had UDVA better than or equal to -0.10 logMAR (20/16 Snellen, 36% vs 22%, p = 0.04). More eyes gained CDVA after surgery in the PAE group (53% vs 32%, p < 0.01). There were five enhancements in the WFO group versus none in the PAE group, a statistically significant difference (p = 0.03).
Visual acuity and refractive outcomes after LASIK using PAE in eyes with oblique astigmatism in their preoperative refraction were statistically significantly better than those obtained when WFO treatment was used. The number of refractive outliers and the number of retreatments were also significantly lower with PAE treatment.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The 2–10‐km‐thick, mainly carbonate cap of the 14,000 km2 Bahamas carbonate platform (BCP) has impeded imaging of its underlying crustal structure. The deeper structure of the BCP records both its ...Mesozoic rift and hotspot history and its later deformation related to its Paleogene collision with the Great Arc of the Caribbean (GAC). We use regional gravity data to model the crustal structure, type, and deformational processes of the BCP by: (a) integrating publicly available seismic data; (b) inverting the Moho along 2D regional gravity transects across the collisional zone; (c) modeling flexural uplift of a forebulge that reflects the attempted subduction of the BCP beneath the GAC; and (d) using downhole temperatures and radiogenic heat production in 1D basin models to differentiate crustal types related to the Mesozoic rift history. We interpret three crustal domains underlying the BCP: (a) 27–12‐km‐thick, rifted, and thinned continental crust of the northern Bahamas between the Blake Plateau and Exuma Sound; (b) 24–12‐km‐thick, volcanically‐thickened oceanic crust related to the Triassic‐Jurassic Bahamas hotspot in the central Bahamas southeast of Long Island; and (c) 20–12‐km‐thick, thickened oceanic crust north of Hispaniola. We propose that these crustal types reflect northwest‐southeastward, Triassic‐Jurassic rifting of the Bahamas region during the breakup of Pangea and accompanying magmatic activity related to the Triassic‐Jurassic Bahamas hotspot and early oceanic spreading. Growth of the BCP during the Cretaceous in this area was followed by Late Cretaceous‐Paleogene subduction‐related flexure and terminal Paleogene collision between the GAC and the BCP.
Plain Language Summary
We investigate the thickly‐sedimented and difficult‐to‐image Bahamas carbonate platform (BCP) by generating different gravity‐based models of its sub‐surface crustal structure. These models help us better understand the crustal types extended and formed during Mesozoic rifting and hotspot activity and the later deformation of these crustal types during the Paleogene collision between the Cuban island arc and the BCP.
Key Points
Regional, gravity‐based crustal models are generated for the Paleogene collisional zone between the Bahamas carbonate platform and the Great Arc of the Caribbean
Flexural modeling of the basement beneath the Bahamas reveals a suture‐parallel, forearc bulge produced by Paleogene underthrusting
Burial plots of deep wells across the platform reveal the timing and extent of Mesozoic rift, passive margin, and collisional events
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
The 110,000 km2 Yucatan Basin in the northern Caribbean Sea is critical for understanding the Late Cretaceous to Recent tectonic evolution of the Caribbean‐North American plate boundary. This study ...integrates gravity, magnetic, and a 5,500 km grid of 2D seismic data to carry out a tectonostratigraphic analysis of the Yucatan Basin. These data provide the first recognition of 38–102 km‐long spreading ridges that constrain a SW‐NE opening direction in the western Yucatan Basin. The age of this oceanic crust is constrained to be late Paleocene‐middle Eocene (57–42 Ma) based on heat flow measurements, depth‐to‐seafloor, and three sedimentary sequences inferred to be Eocene—Recent in age based on stratigraphic correlations to distant wells. We interpret the Yucatan Basin as a back‐arc basin formed during the northeastward movement of the Caribbean volcanic arc that is now exposed in Cuba, evolved during the early Cretaceous to middle Eocene, and was terminated by collision with the Bahama carbonate platform during the late Paleocene to middle Eocene. We identify regional, left‐lateral strike‐slip faults that extend into the Cuban volcanic arc, as observed in other active back‐arc basins. We propose that the Yucatan back‐arc basin once formed the northwestern extension of age‐equivalent back‐arc basins in Hispaniola, where the basin is inverted, topographically elevated, and strongly shortened, and in the Lesser Antilles where the Paleogene back‐arc basin has remained undeformed and submarine. This once‐continuous back‐arc basin was disrupted and left‐laterally offset by ∼500 km during the Late Eocene‐Recent formation of the Cayman trough strike‐slip system.
Plain Language Summary
This study utilizes seismic reflection data to carry out a tectonostratigraphic analysis of the Yucatan Basin.
Key Points
We integrate gravimetric, magnetometric, and seismic reflection data to identify oceanic crust in the Yucatan back‐arc basin
Heat flow and depth to the seafloor constrain a Late Paleocene‐Middle Eocene age for the oceanic crust adjacent to the Cuban volcanic arc
Similar back‐arc basins nearby were inverted, subaerially exposed, and left‐laterally offset during the late Eocene‐Recent
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
To compare visual acuity and refractive results between topography-guided laser in situ keratomileusis (LASIK) planned with the Phorcides Analytic Engine (PAE) to results after wavefront-optimized ...(WFO) LASIK in subjects with preoperative oblique astigmatism in their manifest refraction. This was a retrospective chart review of clinical results from eyes treated with topography-guided LASIK planned with PAE compared to eyes treated with WFO LASIK using the same Wavelight.sup.® excimer laser system. All included subjects had preoperative oblique astigmatism. Residual refractive error and visual acuity (uncorrected and corrected) were the measures of interest, at the visit closest to 90 days postoperative. A matched data set from 100 WFO and 97 PAE eyes was extracted from clinical records. At the postoperative visit the PAE group showed lower residual refractive cylinder (p = 0.04), uncorrected distance visual acuity (UDVA) (-0.06 PAE vs. -0.02 WFO, p < 0.01) and distance corrected visual acuity (CDVA) (p < 0.01). The percentage of eyes with a mean refraction spherical equivalent (MRSE) magnitude within 0.25 D and 0.50 D of plano was statistically significantly higher in the PAE group (p = 0.04 and 0.01, respectively). A statistically significantly higher percentage of eyes in the PAE group had UDVA better than or equal to -0.10 logMAR (20/16 Snellen, 36% vs 22%, p = 0.04). More eyes gained CDVA after surgery in the PAE group (53% vs 32%, p < 0.01). There were five enhancements in the WFO group versus none in the PAE group, a statistically significant difference (p = 0.03). Visual acuity and refractive outcomes after LASIK using PAE in eyes with oblique astigmatism in their preoperative refraction were statistically significantly better than those obtained when WFO treatment was used. The number of refractive outliers and the number of retreatments were also significantly lower with PAE treatment.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
To evaluate prospectively the clinical outcomes of topography-guided laser in situ keratomileusis (LASIK) surgery performed with Contoura® Vision using the Wavelight® excimer laser and planned with ...the Phorcides Analytical Engine.
Four clinical practices in the USA.
Prospective, single-arm interventional study.
130 eyes of 65 patients with myopia and/or myopic astigmatism were enrolled in a prospective study of visual and refractive outcomes following treatment with Contoura® Vision using the Wavelight® EX500 excimer laser to achieve optimal distance vision. At 3 months postoperatively, uncorrected distance vision (UDVA), manifest refraction (MR), and corrected distance vision (CDVA) were measured and compared to historical controls.
At 3 months after surgery, 100%, 89% and 28% of eyes achieved UDVA of 20/20, 20/15/ and 20/10 or better, respectively. Ninety-two percent of eyes had postoperative UDVA equal to or better than their preoperative CDVA. Postoperative CDVA was equal to, 1 line better, or 2 lines better than the preoperative CDVA in 53%, 40%, and 6% of eyes, respectively. Only 1 eye lost 1 line of CDVA, and no eyes lost more than 1 line of CDVA. There was a significant decrease in subjective visual complaints, including glare, halos, difficulty driving at night, reading difficulty, starbursts, fluctuation in vision, and light sensitivity.
The Phorcides Analytical Engine can be used to optimize visual outcomes for the correction of myopia and myopic astigmatism.
The R132H isocitrate dehydrogenase one (IDH1) mutation is a prognostic biomarker present in a subset of gliomas and is associated with heightened survival when paired with aggressive surgical ...resection. In this study, we establish proof-of-principle for rapid colorimetric detection of the IDH1-R132H mutation in tumor samples in under 1 hour without the need for a nucleic acid extraction. Colorimetric peptide nucleic acid loop-mediated isothermal amplification (CPNA-LAMP) utilizes 4 conventional LAMP primers, a blocking PNA probe complementary to the wild-type sequence, and a self-annealing loop primer complementary to the single nucleotide variant to only amplify the DNA sequence containing the mutation. This assay was evaluated using IDH1-WT or IDH1-R132H mutant synthetic DNA, wild-type or IDH1-R132H mutant U87MG cell lysates, and tumor lysates from archived patient samples in which the IDH1 status was previously determined using immunohistochemistry (IHC). Reactions were performed using a hot water bath and visually interpreted as positive by a pink-to-yellow color change. Results were subsequently verified using agarose gel electrophoresis. CPNA-LAMP successfully detected the R132H single nucleotide variant, and results from tumor lysates yielded 100% concordance with IHC results, including instances when the single nucleotide variant was limited to a portion of the tumor. Importantly, when testing the tumor lysates, there were no false positive or false negative results.
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Using a mega-regional dataset that includes over 20,000
km of on- and offshore 2D seismic lines and 12 wells, we illustrate three different stages of fault formation and basin evolution in the ...Caribbean arc-South American continent collisional zone. Transpressional deformation associated with oblique collision of the Caribbean arc migrates diachronously over a distance of ∼1500
km from western Venezuela in Paleogene time (∼57
Ma) to a zone of active deformation in the eastern offshore Trinidad area. Each diachronous stage of pre-, syn-, and post-collisional basin formation is accompanied by distinct patterns of fault families. We use subsidence histories from wells to link patterns of long-term basinal subsidence to periods of activity of the fault families.
Initial collision is characterized by overthrusting of the south- and southeastward-facing Caribbean arc and forearc terranes onto the northward-subducting Mesozoic passive margin of northern South America. Northward flexure of the South American craton produces a foreland basin between the thrust front and the downward-flexed continental crust that is initially filled by clastic sediments shed both from the colliding arc and cratonic areas to the south. As the collision extends eastward towards Trinidad, this same process continues with progressively younger foreland basins formed to the east. On the overthrusting Caribbean arc and forearc terranes, north-south rifting adjacent to the collision zone initiates and is controlled by forward momentum of southward-thrusting arc terranes combined with slab pull of the underlying and subducting, north-dipping South American slab. Uplift of fold-thrust belts arc-continent suture induces rerouting of large continental drainages parallel to the collisional zone and to the axis of the foreland basins.
This late stage of arc-continent collision is characterized by termination of deformation in one segment of the fold-thrust belt as convergent deformation shifts eastward. Rebound of the collisional belt is produced as the north-dipping subducted oceanic crust breaks off from the passive margin, inducing inversion of preexisting normal faults as arc-continent convergence reaches a maximum. Strain partitioning also begins to play an important role as oblique convergence continues, accommodating deformation by the formation of parallel, strike-slip fault zones and backthrusting (southward subduction of the Caribbean plate beneath the South Caribbean deformed belt). As subsidence slows in the foreland basins, sedimentation transitions from a marine underfilled basin to an overfilled continental basin. Offshore, sedimentation is mostly marine, sourced by the collided Caribbean terranes, localized islands and carbonate deposition.
This final stage of arc-continent collision is characterized by: 1) complete slab breakoff of the northward-dipping South American slab; 2) east-west extension of the Caribbean arc as it elongates parallel to its strike forming oblique normal faults that produce deep rift and half-grabens; 3) continued strain partitioning (strike-slip faulting and folding). The subsidence pattern in the Caribbean basins is more complex than interpreted before, showing a succession of extensional and inversion events. The three tectonic stages closely control the structural styles and traps, source rock distribution, and stratigraphic traps for the abundant hydrocarbon resources of the on- and offshore areas of Venezuela and Trinidad.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Paul Michael Mann, 1 Paul M Mann II, 1 Phillip Brunson, 1 Richard Potvin 2 1Mann Eye Institute and Laser Centers, Houston, TX, USA; 2Science in Vision, Bend, OR, USACorrespondence: Phillip ...BrunsonMann Eye Institute and Laser Centers, 5115 Main Street, Suite #300, Houston, TX, 77002, USAEmail phillip.brunson@manneye.comWe thank Dr. Motwani for his interest in our study. While he mentions a secondstudy that follows the same "script", we would point out that data from our practicewas not included in that study. The similarity appears related to the fact that bothstudies were retrospective, where data are limited and the outcome measures arepatient-based, generally consisting of the postoperative refraction and visual acuitydata in the clinical records. Our primary goal was merely to determine if use of thePhorcides Analytical Engine (Phorcides) was improving outcomes in our practice.We do not believe LYRA was mischaracterized in the manuscript, as thecomment (reworded and slightly less clear in Dr. Motwani's letter) was meantonly to indicate that both topographic and refractive data were being used to planthe laser treatment. View the original paper byBrunson and colleagues This is in response to the Letter to the Editor
Climate change induced permafrost thaw in the Arctic is mobilizing ancient dissolved organic carbon (DOC) into headwater streams; however, DOC exported from the mouth of major arctic rivers appears ...predominantly modern. Here we highlight that ancient (>20,000 years B.P.) permafrost DOC is rapidly utilized by microbes (~50% DOC loss in <7 days) and that permafrost DOC decay rates (0.12 to 0.19 day−1) exceed those for DOC in a major arctic river (Kolyma: 0.09 day−1). Permafrost DOC exhibited unique molecular signatures, including high levels of aliphatics that were rapidly utilized by microbes. As microbes processed permafrost DOC, its distinctive chemical signatures were degraded and converged toward those of DOC in the Kolyma River. The extreme biolability of permafrost DOC and the rapid loss of its distinct molecular signature may explain the apparent contradiction between observed permafrost DOC release to headwaters and the lack of a permafrost signal in DOC exported via major arctic rivers to the ocean.
Key Points
Permafrost DOC microbial utilization is greater than modern DOC in arctic rivers
Permafrost DOM has unique molecular signatures (high levels of aliphatics)
Unique molecular signature of permafrost DOM lost on biodegradation
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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