Despite the great demand on and attempts at package express shipping services, online retailers have not yet had a practical solution to make such services profitable. In this paper, we propose an ...economical approach to express package delivery, i.e., exploiting relays of taxis with passengers to help transport package collectively, without degrading the quality of passenger services. Specifically, we propose a two-phase framework called crowddeliver for the package delivery path planning. In the first phase, we mine the historical taxi trajectory data offline to identify the shortest package delivery paths with estimated travel time given any Origin-Destination pairs. Using the paths and travel time as the reference, in the second phase we develop an online adaptive taxi scheduling algorithm to find the near-optimal delivery paths iteratively upon real-time requests and direct the package routing accordingly. Finally, we evaluate the two-phase framework using the real-world data sets, which consist of a point of interest, a road network, and the large-scale trajectory data, respectively, that are generated by 7614 taxis in a month in the city of Hangzhou, China. Results show that over 85% of packages can be delivered within 8 hours, with around 4.2 relays of taxis on average.
•AmimCl and BmimCl was more suitable for preparing quality film.•A decrease of DP resulted in a higher crystallinity index.•Crystal structure governs the properties of the film.
Three ionic liquids ...(ILs) with increasing dissolution power, 1-butyl-3-methylimidazolium chloride (BmimCl), 1-allyl-3-methylimidazolium chloride (AmimCl), and 1-ethyl-3-methylimidazolium acetate (EmimAc), were selected for cellulose dissolution and film preparation through regeneration. The physical properties of the films were investigated, and the correlation between the IL used and the film properties was evaluated. The results indicated that the superior cellulose dissolution system, EmimAc, had the most difficult regeneration process (i.e., more time was required for gel formation), followed by AmimCl, and BmimCl. On the other hand, the film produced from AmimCl had the highest crystallinity, transparency, and tensile strength, followed by the films produced from BmimCl and EmimAc. It was inferred that stronger and more ordered molecular arrangements and inter-molecular interactions preferentially occurred during cellulose regeneration from AmimCl than during cellulose regeneration from BmimCl and EmimAc.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPUK, ZAGLJ, ZRSKP
Oesophageal cancer is one of the most aggressive cancers and is the sixth leading cause of cancer death worldwide. Approximately 70% of global oesophageal cancer cases occur in China, with ...oesophageal squamous cell carcinoma (ESCC) being the histopathological form in the vast majority of cases (>90%). Currently, there are limited clinical approaches for the early diagnosis and treatment of ESCC, resulting in a 10% five-year survival rate for patients. However, the full repertoire of genomic events leading to the pathogenesis of ESCC remains unclear. Here we describe a comprehensive genomic analysis of 158 ESCC cases, as part of the International Cancer Genome Consortium research project. We conducted whole-genome sequencing in 17 ESCC cases and whole-exome sequencing in 71 cases, of which 53 cases, plus an additional 70 ESCC cases not used in the whole-genome and whole-exome sequencing, were subjected to array comparative genomic hybridization analysis. We identified eight significantly mutated genes, of which six are well known tumour-associated genes (TP53, RB1, CDKN2A, PIK3CA, NOTCH1, NFE2L2), and two have not previously been described in ESCC (ADAM29 and FAM135B). Notably, FAM135B is identified as a novel cancer-implicated gene as assayed for its ability to promote malignancy of ESCC cells. Additionally, MIR548K, a microRNA encoded in the amplified 11q13.3-13.4 region, is characterized as a novel oncogene, and functional assays demonstrate that MIR548K enhances malignant phenotypes of ESCC cells. Moreover, we have found that several important histone regulator genes (MLL2 (also called KMT2D), ASH1L, MLL3 (KMT2C), SETD1B, CREBBP and EP300) are frequently altered in ESCC. Pathway assessment reveals that somatic aberrations are mainly involved in the Wnt, cell cycle and Notch pathways. Genomic analyses suggest that ESCC and head and neck squamous cell carcinoma share some common pathogenic mechanisms, and ESCC development is associated with alcohol drinking. This study has explored novel biological markers and tumorigenic pathways that would greatly improve therapeutic strategies for ESCC.
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DOBA, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
This paper presents a group-aware mobile crowd sensing system called MobiGroup, which supports group activity organization in real-world settings. Acknowledging the complexity and diversity of group ...activities, this paper introduces a formal concept model to characterize group activities and classifies them into four organizational stages. We then present an intelligent approach to support group activity preparation, including a heuristic rule-based mechanism for advertising public activity and a context-based method for private group formation. In addition, we leverage features extracted from both online and offline communities to recommend ongoing events to attendees with different needs. Compared with the baseline method, people preferred public activities suggested by our heuristic rule-based method. Using a dataset collected from 45 participants, we found that the context-based approach for private group formation can attain a precision and recall of over 80%, and the usage of spatial-temporal contexts and group computing can have more than a 30% performance improvement over considering the interaction frequency between a user and related groups. A case study revealed that, by extracting the features such as dynamic intimacy and static intimacy, our cross-community approach for ongoing event recommendation can meet different user needs.
The intrusion detection systems, firewalls and other security devices provide a guarantee for the safe operation of the network, but with the wide application of network, virus, hackers and other ...security incidents are increasing, these security devices will send tens of thousands of a warning in a very short period of time, the network management personnel is difficult to find useful information from these massive alarms. In addition, with the increasingly large scale network, mobile network, data management, data related to SMS, MMS message service system, single security device cannot detect all intrusions, so we must consider how to make these equipments work harmoniously. In this paper, based on the above problems, the mobile data network security integrated management system is studied, and the research and implementation of security event management mechanism is discussed in detail. The event management proposed in this paper can be regarded as an extension of the concept of network management, which enriches the content of the five functions of network management. In addition, the traditional network management and system management are two independent concepts. The two management systems can be combined together through the event management, so that the network security operation can be further improved. The purpose of security event modeling is to format the events from different event sources to facilitate subsequent processing. In this paper, the object oriented modeling method is adopted, which is scalable, and at the same time, the difference of all kinds of events is fully considered. For the description of the model, this paper uses the XML language, which is universal. Harm of computer virus on the network security management is more and more big, the characteristics of computer virus and the typical symptoms and its harmfulness are analyzed, and the security of mobile communication network is analyzed. The proposed system modification virus prevention. Implementation of general security management system in mobile data network is the focus of this article, mainly from the three aspects of the audit log management, security event monitor and account password management in the mobile data network involving multiple business systems in the implementation of integrated security management system. In this paper, we adopt rule based hierarchical system architecture, the coupling degree of each module is relatively loose, and it has great flexibility in the deployment.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPUK, ZAGLJ, ZRSKP
Lyocell fiber has emerged as an important class of regenerated cellulose that is produced based on the N-methyl morpholine-N-oxide (NMMO) dissolution method, and it has unique properties compared to ...viscose fiber. The NMMO technology provides a simple, resource-conserving, and environmentally friendly method for producing regenerated cellulose fiber. In this paper, the manufacturing process, environmental impact, and product quality of lyocell fiber are reviewed and compared with those of the conventional viscose fiber.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Planning an itinerary before traveling to a city is one of the most important travel preparation activities. In this paper, we propose a novel framework called TripPlanner, leveraging a combination ...of location-based social network (i.e., LBSN) and taxi GPS digital footprints to achieve personalized, interactive, and traffic-aware trip planning. First, we construct a dynamic point-of-interest network model by extracting relevant information from crowdsourced LBSN and taxi GPS traces. Then, we propose a two-phase approach for personalized trip planning. In the route search phase, TripPlanner works interactively with users to generate candidate routes with specified venues. In the route augmentation phase, TripPlanner applies heuristic algorithms to add user's preferred venues iteratively to the candidate routes, with the objective of maximizing the route score while satisfying both the venue visiting time and total travel time constraints. To validate the efficiency and effectiveness of the proposed approach, extensive empirical studies were performed on two real-world data sets from the city of San Francisco, which contain more than 391 900 passenger delivery trips generated by 536 taxis in a month and 110 214 check-ins left by 15 680 Foursquare users in six months.
Container ports are generally measured and compared using performance indicators such as container throughput and facility productivity. Being able to measure the performance of container ports ...quantitatively is of great importance for researchers to design models for port operation and container logistics. Instead of relying on the manually collected statistical information from different port authorities and shipping companies, we propose to leverage the pervasive ship GPS traces and maritime open data to derive port performance indicators, including ship traffic, container throughput, berth utilization, and terminal productivity. These performance indicators are found to be directly related to the number of container ships arriving at the terminals and the number of containers handled at each ship. Therefore, we propose a framework that takes the ships' container-handling events at terminals as the basis for port performance measurement. With the inferred port performance indicators, we further compare the strengths and weaknesses of different container ports at the terminal level, port level, and region level, which can potentially benefit terminal productivity improvement, liner schedule optimization, and regional economic development planning. In order to evaluate the proposed framework, we conduct extensive studies on large-scale real-world GPS traces of container ships collected from major container ports worldwide through the year, as well as various maritime open data sources concerning ships and ports. Evaluation results confirm that the proposed framework not only can accurately estimate various port performance indicators but also effectively produces port comparison results such as port performance ranking and port region comparison.
As the pathological basis of cardiovascular disease (CVD), atherosclerosis is featured as a chronic inflammation. Hypercholesterolemia is an independent risk factor for CVD. Accumulated studies have ...shown that hypercholesterolemia is associated with myeloid cell expansion, which stimulates innate and adaptive immune responses, strengthens inflammation, and accelerates atherosclerosis progression. Hematopoietic stem/progenitor cells (HSPC) in bone marrow (BM) expresses a panel of lipoprotein receptors to control cholesterol homeostasis. Deficiency of these receptors abrogates cellular cholesterol efflux, resulting in HSPC proliferation and differentiation in hypercholesterolemic mice. Reduction of the cholesterol level in the lipid rafts by infusion of reconstituted high-density lipoprotein (HDL) or its major apolipoprotein, apoA-I, reverses hypercholesterolemia-induced HSPC expansion. Apart from impaired cholesterol metabolism, inhibition of reactive oxygen species production suppresses HSPC activation and leukocytosis. These data indicate that the mechanisms underlying the effects of hypercholesterolemia on HSPC proliferation and differentiation could be multifaceted. Furthermore, dyslipidemia also regulates HSPC-neighboring cells, resulting in HSPC mobilization. In the article, we review how hypercholesterolemia evokes HSPC activation and mobilization directly or via its modification of BM microenvironment. We hope this review will bring light to finding key molecules to control HSPC expansion, inflammation, and atherosclerosis for the treatment of CVD.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
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