Latent blood fingerprints (LBFPs) can provide critical information of foul play and help identify the suspects at violent crime scenes. The current methods for LBFP visualization are still not ...satisfactory because of the low sensitivity or complicated protocol. This study demonstrates a simple and effective LBFP visualization strategy by integrating a new amphiphilic fluorescent amino-functionalized conjugated polymer with the cotton-pad developing protocol. LBFPs on various substrates are visualized by simply covering them with the polymer solution-soaked cotton pads. The images display clear fingerprint patterns, ridge details, and sweat pores, even on very challenging substrates such as painted wood and multicolored can. The gray value analysis confirms semiquantitatively the enhancement of the contrast between ridges and furrows. Even LBFPs with various contaminations or aged for more than 600 days are effectively developed and visualized. The developed fingerprint images show superior stability over long storage time and against solvent washing. Moreover, the polymer causes no degradation of DNAs in the blood, suggesting the possibility of further DNA profiling and identification after development. The mechanistic investigation suggests that the formation of positive or inverted images can be attributed to the synergistic effects from the affinity between polymer and blood, and the affinity betwen polymer and substrate, as well as the slight quenching of polymer fluorescence by blood. Furthermore, the covalent bonding between the protonated primary amino group and proteins in blood endows the stability of the developed fingerprints. The result rationalizes the molecular design of the fluorescent polymer and sheds new light on the future strategies to effective LBFP visualization in practical applications.
Full text
Available for:
IJS, KILJ, NUK, PNG, UL, UM
Lead-free perovskite materials for capacitors have been recognized worldwide attention in recent times with high storage energy density and efficiency. A series of (Bi
0.50
Na
0.40
K
0.10
)
0.94
Ba
...0.06
Ti
(1−
x
)
(Al
0.50
Ta
0.50
)
x
O
3
ceramics are synthesized using traditional mixed oxide route. All ceramics are in single-phase perovskite-like structure. At room temperature, high storage energy density,
W
r
~ 1.67 J/cm
3
, and conversion efficiency,
η
~ 81.46%, are perceived for
x
= 0.06 composition at 115 kV/cm. Temperature-dependent study obtains
W
r
~ 1.21 J/cm
3
and
η
~ 84.96% at 80 °C with 80 kV/cm field. In addition, composition
x
= 0.06 is fatigue-free from 1 to 10
5
cycles measured at 80 kV/cm field. Furthermore, ceramic
x
= 0.04 is obtained a high bipolar strain ~ 0.31% at 80 kV/cm compared to other compositions. Hence, the compositions
x
= 0.06 for high energy density and
x
= 0.04 for strain might be useable in many electronic components.
Full text
Available for:
DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, SIK, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Toolface adjustment methods for directional drilling in oil and gas drilling currently rely heavily on manual real-time interventions for continuous adjustment. However, due to the influence of ...manual experience, these existing methods suffer from unstable effects and high labor costs. As energy consumption continues to rise, the demand for intelligent directional drilling is becoming increasingly pressing. To address the challenges posed by automatic adjustment issues encountered in actual drilling operations under various complex downhole environments, this study presents a model-free online learning adaptive decision strategy for cross-well intelligent adjustment and toolface stabilization, which is applicable for both slide and rotatory steerable systems. A reward function embedded with expert operating experience is developed to learn the orientation strategy from the driller's corrective actions. Additionally, a priority-based experience replay mechanism is introduced to enhance online learning efficiency. To accurately simulate the directional drilling process and pre-train the orientation strategy, a data-driven directional drilling simulation environment is proposed. With the aim of facilitating implementation and widespread adoption in practical engineering, this study also involves the migration of a strategic model, integration of a real-time interaction module, and encapsulation of algorithms for field applications. Simulations and field experiments are conducted to validate the effectiveness of the proposed strategy. The experimental results demonstrate that the strategy can achieve decision-making goals in a short period of time.
•Model-free toolface control strategy is set up for directional drilling systems.•Multi-head attention LSTM is used to construct directional drilling system model.•Decision algorithm is verified in real directional drilling scenarios.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Metal semiconductor oxides are widely used in the field of gas sensors in recent years due to the advantages of good gas sensitivity, low raw material cost and facile preparation. To achieve more ...sensitive, accurate and rapid detection of ethanol gas, tetrakaidecahedral ZnSnO
3
nanoparticles were successfully synthesized by means of a facile template-free co-precipitation method. The nano-Ag particles were decorated evenly on the surface of the ZnSnO
3
particles with a heat treatment at 250 °C. The as-synthesized products were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDS) and X-ray photoelectron spectroscopy (XPS). The results of gas sensing test experiment show that the tetrakaidecahedral ZnSnO
3
decorated by nano-Ag (Ag@ZnSnO
3
) sample has excellent gas sensitivity properties to ethanol at 220 °C. In particular, the composite Ag@ZnSnO
3
material gas sensor has a short response time of 2 s and recovery time of 23 s as the nano-Ag modification ratio is 5%. The responsivity of the Ag@ZnSnO
3
gas sensor with a modification ratio of 5% to the 500 ppm ethanol is 258 at 220 °C, which is 2.83 times of the pristine ZnSnO
3
gas sensor. The minimum limit detection of the sensor to ethanol is 2 ppm. The research in this paper confirms that Ag@ZnSnO
3
composite material has potential application prospects in the manufacture of high-performance ethanol sensors.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Owing to the attractive energy band properties, a black phosphorus (BP)-analogue semiconductor, germanium selenide (GeSe), shows a promising potential applied for optoelectronic devices. Herein, ...ultrathin GeSe nanosheets were systematically prepared via a facile liquid-phase exfoliation approach, with controllable nanoscale thickness. Different from BP, ultrathin GeSe nanosheets exhibit good stability under both liquid and ambient conditions. Besides, its ultrafast carrier dynamics was probed by transient absorption spectroscopy. We showed that the GeSe nanosheet-based photodetector exhibits excellent photoresponse behaviors ranging from ultraviolet (UV) to the visible regime, with high responsivity and low dark current. Furthermore, the detective ability of such a device can be effectively modulated by varying the applied bias potential, light intensity, and concentration of the electrolyte. Generally, our present contribution could not only supply fundamental knowledge of a GeSe nanosheet-based photoelectrochemical (PEC)-type device, but also offer guidance to extend other possible semiconductor materials in the application of the PEC-type photodetector.
Full text
Available for:
IJS, KILJ, NUK, PNG, UL, UM
Aberrant protein post-translational modification is a hallmark of malignant tumors. Lysine succinylation (Ksucc) plays a vital role in cell energy metabolism in various cancers. However, whether ...succinylation can be catalyzed by acetyltransferase p300 remains unclear. In this study, we unveiled that p300 is a "writer" for succinylation, and p300-mediated Ksucc promotes cell glycometabolism in lung adenocarcinoma (LUAD). Specifically, our succinylome data revealed that
deficiency leads to the systemic reduction of Ksucc, and 79.55% of the p300-succinylated proteins were found in the cytoplasm, which were primarily enriched in the carbohydrate metabolism process. Interestingly, deleting
led to a notable decrease in Ksucc levels on several glycolytic enzymes, especially Phosphoglycerate Kinase 1 (
). Mutation of the succinylated site of
notably hindered cell glycolysis and lactic acid excretion. Metabolomics in vivo indicated that p300-caused metabolic reprogramming was mainly attributed to the altered carbohydrate metabolism. In addition, 89.35% of LUAD patients exhibited cytoplasmic localization of p300, with higher levels in tumor tissues than adjacent normal tissues. High levels of p300 correlated with advanced tumor stages and poor prognosis of LUAD patients. Briefly, we disclose the activity of p300 to catalyze succinylation, which contributes to cell glucose metabolic reprogramming and malignant progression of lung cancer.
Full text
Available for:
IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
This research deals with tensile properties and deformation behavior of Fe-xMn-1.2C (wt.%, x = 7, 11, 15 and 19) steels. The effect of Mn content and strain rate on mechanical properties is analyzed ...considering deformation microstructure observation. Results show that the strength and plasticity of the test steels increase either with the increase of Mn content or strain rate. The increased Mn content enhances the stacking fault energy (SFE) of the test steel, but also aggravates the dynamic strain aging (DSA) effect, which promotes the formation of deformation twins and work hardening characteristic instead. The increased strain rate is also noted conducive for the formation of deformation twins. Consequently, the deformation strain prolongs, and desired strength and plasticity are obtained. At high strain rate of 2 × 10−2 s−1, the strength and plasticity of the 120Mn15 and 120Mn19 steels are observed approximately the same, which can be explained by the combined influences of strain rate and Mn element on the deformation twins and the DSA effect. Moreover, a moderate but stable strain hardening rate during plastic deformation is proved to be a key parameter to achieve excellent strength and plasticity in high-C high-Mn steel. The presented research provides an economical method for the selection of high-C high-Mn steel, i.e., reducing the Mn content, under different service environments.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
p300 acts as a transcription coactivator and an acetyltransferase that plays an important role in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is an important ...regulator in regulating the evolution of malignant tumours and it also has extensive functions. From the perspective of non-posttranslational modification, it has been proven that p300 can participate in regulating many pathophysiological processes, such as activating oncogene transcription, promoting tumour cell growth, inducing apoptosis, regulating immune function and affecting embryo development. In recent years, p300 has been found to act as an acetyltransferase that catalyses a variety of protein modification types, such as acetylation, propanylation, butyylation, 2-hydroxyisobutyration, and lactylation. Under the catalysis of this acetyltransferase, it plays its crucial tumourigenic driving role in many malignant tumours. Therefore, the function of p300 acetyltransferase has gradually become a research hotspot. From a posttranslational modification perspective, p300 is involved in the activation of multiple transcription factors and additional processes that promote malignant biological behaviours, such as tumour cell proliferation, migration, and invasion, as well as tumour cell apoptosis, drug resistance, and metabolism. Inhibitors of p300 have been developed and are expected to become novel anticancer drugs for several malignancies. We review the characteristics of the p300 protein and its functional role in tumour from the posttranslational modification perspective, as well as the current status of p300-related inhibitor research, with a view to gaining a comprehensive understanding of p300.
Full text
Available for:
IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
3D porous flower-like ZnO microstructures loaded by large-size Ag were successfully synthesized via a simple two-stage method. XRD and XPS results proved that the synthesized Ag/ZnO was a pure phase. ...SEM and TEM results showed that the Ag nanoparticles with large size (about 400 nm) were successfully loaded on the porous flower-like ZnO. The sensitivity of Ag/ZnO was 268 to 200 ppm ethanol at 300 °C, which was 6 times higher than that of pure ZnO. In addition, the sensor of Ag/ZnO exhibited a faster response/recovery behavior and a lower detection limit. The enhanced gas sensing performance of Ag/ZnO has been explained from three aspects: the “spillover effect” of Ag, the formation of metal-semiconductor heterojunction and the role of “electronic sensitization”.
•A new method to synthesize large-size Ag nanoparticles (400 nm) and loaded it on 3D porous flower-like ZnO.•Ag/ZnO gas sensor displays higher gas response and faster response/recover time.•This paper explains the enhanced gas sensing mechanism from three aspects.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
PDF
