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  • Maintenance Olaparib for Ge... Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer
    Golan, Talia; Hammel, Pascal; Reni, Michele ... The New England journal of medicine, 07/2019, Volume: 381, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    Approximately 7% of pancreatic cancers occur in patients with a germline mutation in BRCA1 or BRCA2 , an alteration that compromises DNA repair. In a randomized trial in patients with metastatic ...
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  • A combination of resveratro... A combination of resveratrol and quercetin induces browning in white adipose tissue of rats fed an obesogenic diet
    Arias, Noemí; Picó, Catalina; Teresa Macarulla, M. ... Obesity (Silver Spring, Md.), January 2017, Volume: 25, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Objective To analyze whether a combination of quercetin (Q) and resveratrol (RSV) would induce a white adipose tissue (WAT) browning effect. Methods Thirty‐six rats were fed an obesogenic diet and ...
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  • Hepatic lipid metabolic pat... Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet
    Alberdi, Goiuri, D.S; Rodríguez, Víctor M., Ph.D; Macarulla, M. Teresa, Ph.D ... Nutrition (Burbank, Los Angeles County, Calif.), 03/2013, Volume: 29, Issue: 3
    Journal Article
    Peer reviewed

    Abstract Objective The scientific community is on the look-out for safe biomolecules useful in the prevention of obesity and related aberrations such as fatty liver. This study analyzed the influence ...
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  • BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial
    Bockorny, Bruno; Semenisty, Valerya; Macarulla, Teresa ... Nature medicine, 06/2020, Volume: 26, Issue: 6
    Journal Article
    Peer reviewed

    Programmed cell death 1 (PD-1) inhibitors have limited effect in pancreatic ductal adenocarcinoma (PDAC), underscoring the need to co-target alternative pathways. CXC chemokine receptor 4 (CXCR4) ...
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  • A First-in-Human, Phase I, ... A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies
    Juric, Dejan; de Bono, Johann S; LoRusso, Patricia M ... Clinical cancer research, 09/2017, Volume: 23, Issue: 17
    Journal Article
    Peer reviewed
    Open access

    To evaluate the safety, MTD, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of TAK-117 (MLN1117/INK1117), an investigational PI3Kα-selective inhibitor, in patients with ...
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  • Addition of Aflibercept to ... Addition of Aflibercept to Fluorouracil, Leucovorin, and Irinotecan Improves Survival in a Phase III Randomized Trial in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen
    VAN CUTSEM, Eric; TABERNERO, Josep; MCKENDRICK, Joe ... Journal of clinical oncology, 10/2012, Volume: 30, Issue: 28
    Journal Article
    Peer reviewed
    Open access

    Treatment for metastatic colorectal cancer (mCRC) commonly involves a fluoropyrimidine-based chemotherapy regimen such as infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) or ...
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  • Ramucirumab in metastatic c... Ramucirumab in metastatic colorectal cancer: evidence to date and place in therapy
    Verdaguer, Helena; Tabernero, Josep; Macarulla, Teresa Therapeutic Advances in Medical Oncology, 05/2016, Volume: 8, Issue: 3
    Book Review, Journal Article
    Peer reviewed
    Open access

    Colorectal cancer is the third most frequent cancer worldwide. Overall survival rates have improved greatly over the last few years due, at least in part, to the addition of targeted therapies to ...
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  • Thermogenesis is involved i... Thermogenesis is involved in the body-fat lowering effects of resveratrol in rats
    Alberdi, Goiuri; Rodríguez, Víctor M.; Miranda, Jonatan ... Food chemistry, 11/2013, Volume: 141, Issue: 2
    Journal Article
    Peer reviewed

    •Proposals for the thermogenic pathways of resveratrol.•Resveratrol increased gene expression of mitochondriogenic markers, COX2 and TFAM.•Resveratrol increased expression of UCP1 and UCP3 in two ...
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  • Colorectal cancer intrinsic... Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial‐to‐mesenchymal transition
    Roepman, Paul; Schlicker, Andreas; Tabernero, Josep ... International journal of cancer, 1 February 2014, Volume: 134, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    In most colorectal cancer (CRC) patients, outcome cannot be predicted because tumors with similar clinicopathological features can have differences in disease progression and treatment response. ...
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