Palladium allylic systems containing modular chiral dithioether ligands were chosen as catalysts for a systematic study of homodonor ligands in allylic alkylation reactions. For this purpose, new ...type-DMPS (4−6) and -DEGUS (8, 9) ligands were synthesized. Dithioethers 4−6 afforded high activities and excellent selectivities in all Pd-catalyzed allylic reactions. Particularly the Pd/6 catalytic system provided b-VIII with an ee > 99% and a regioselectivity l/b (VIII) = 1/1.6. A family of intermediate complexes containing several allyl groups (symmetrical, 13−16 and 20, and nonsymmetrical, 17−19, moieties) and dithioether ligands (4−6, 8, 9, 11, and 12) is described. The complexes were fully characterized both in solution and in the solid state. X-ray structures of four of these complexes (16−18 and 20) were determined. The diastereomers present in solution were studied by NMR spectroscopy, and in some cases it was possible to establish a relationship between the diastereomeric excesses and the selectivities found in the catalytic process.
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IJS, KILJ, NUK, PNG, UL, UM
492.
Femmes à risque Cohen, M.; Jacquemier, J.; Maestro, C. ...
Oncologie (Paris),
10/2011, Volume:
13, Issue:
10-11
Journal Article, Conference Proceeding
Peer reviewed
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Introduction: Bloodstream infection (BSI) due to extended-spectrum β-lactamase-producing Gram-negative bacilli (ESBL-GNB) is increasing at an alarming pace worldwide. Although β-lactam/β-lactamase ...inhibitor (BLBLI) combinations have been suggested as an alternative to carbapenems for the treatment of BSI due to these resistant organisms in the general population, their usefulness for the treatment of BSI due to ESBL-GNB in haematological patients with neutropaenia is yet to be elucidated. The aim of the BICAR study is to compare the efficacy of BLBLI combinations with that of carbapenems for the treatment of BSI due to an ESBL-GNB in this population. Methods and analysis: A multinational, multicentre, observational retrospective study. Episodes of BSI due to ESBL-GNB occurring in haematological patients and haematopoietic stem cell transplant recipients with neutropaenia from 1 January 2006 to 31 March 2015 will be analysed. The primary end point will be case-fatality rate within 30 days of onset of BSI. The secondary end points will be 7-day and 14-day case-fatality rates, microbiological failure, colonisation/infection by resistant bacteria, superinfection, intensive care unit admission and development of adverse events. Sample size: The number of expected episodes of BSI due to ESBL-GNB in the participant centres will be 260 with a ratio of control to experimental participants of 2. Ethics and dissemination: The protocol of the study was approved at the first site by the Research Ethics Committee (REC) of Hospital Universitari de Bellvitge. Approval will be also sought from all relevant RECs. Any formal presentation or publication of data from this study will be considered as a joint publication by the participating investigators and will follow the recommendations of the International Committee of Medical Journal Editors (ICMJE). The study has been endorsed by the European Study Group for Bloodstream Infection and Sepsis (ESGBIS) and the European Study Group for Infections in Compromised Hosts (ESGICH).
In 2011, a round robin test was initiated within the group of CIRP Research Affiliates. The aim was to establish a platform for linking interdisciplinary research in order to share the expertise and ...experiences of participants all over the world. This paper introduces a testpart which has been designed to allow an analysis of different manufacturing technologies, simulation methods, machinery and metrology as well as process and production planning aspects. Current investigations are presented focusing on the machining and additive processes to produce the geometry, simulation approaches, machine analysis, and a comparison of measuring technologies. Challenges and limitations regarding the manufacturing and evaluation of the testpart features by the applied methods are discussed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Insulin and insulin-like growth factor-I (IGF-I) receptors were characterized in glycoprotein fractions prepared by wheat
germ agglutinin-agarose affinity chromatography from the ovaries of carp. ...Insulin-specific overall binding in carp ovaries
was 6- to 11-fold lower than IGF-I binding (2.7 +/- 0.48% vs. 22.8 +/- 3.6% per 20 microg glycoprotein). Cold IGF-I displaced
radiolabeled IGF-I binding in doses 1000- to 3000-fold lower than cold insulin. On the other hand, cold insulin displaced
radiolabeled insulin binding at concentrations 5- to 30-fold lower than cold IGF-I. The alpha-subunit molecular masses of
carp insulin and IGF-I receptors were smaller than the alpha-subunit molecular mass of rat insulin receptor (125 and 120 vs.
135 kDa, respectively). Autophosphorylation of carp beta-subunit insulin and IGF-I receptors showed similar molecular masses
that did not differ from the molecular mass of rat insulin beta subunit. Receptor tyrosine kinase activity was stimulated
in a dose-dependent manner by insulin and IGF-I. Insulin and IGF-I stimulated tyrosine kinase activity and reached a maximum,
respectively, of 224 +/- 14% and 279 +/- 7% of basal phosphorylation. Insulin and IGF-I binding characteristics were measured
through different stages of follicular development. High specific binding of both peptides in primary oocyte growth (5.6 +/-
0.8% and 50 +/- 10% per 20 microg glycoprotein for insulin and IGF-I, respectively) decreased to a minimum at the end of vitellogenesis,
followed by a slight increase later, in the preovulatory stage. The presence of insulin and IGF-I receptors in carp ovaries
and the changes in percentage of binding throughout the reproductive cycle suggest that, in carp, the roles of insulin and
IGF-I depend on the ovarian maturation stage.
Atypical fibroxanthoma (AFX) is an uncommon neoplasm of the superficial soft tissue occurring in actinically damaged skin of elderly patients. Sun-exposed skin also represents the main site of ...squamous and basal cell carcinomas and malignant melanoma, and a key role for ultraviolet (UV) radiation in their pathogenesis has long been suspected. UV-related mutations of the p53 gene have been identified in human skin cancers. To verify whether the pathogenesis of AFX is related to the effect of sunlight, p53 protein and gene status have been investigated in a series of 10 cases of AFX. Seven of 10 showed p53 immunoreactivity in most of the neoplastic cells. Molecular analysis of the p53 gene revealed an abnormal single strand conformation polymorphism pattern in all the p53 positive cases. Polymerase chain reaction direct sequencing revealed that all the mutations involved cytosine bases. Four cases showed C to T transitions (including two CC-TT double base substitutions) and two cases showed C to G transversion. All but one mutation took place at dipyrimidine sites. These findings provide the first objective evidence for the central role of UV radiation in the development of AFX and also represent the first in vivo demonstration of solar UV-induced mutations in a human mesenchymal neoplasm.
Cyber security threats are an ever increasing, frequent and complex issue in the modern information era. With the advent of big data, incremental increase of huge amounts of data has further ...increased the security problems. Intrusion Detection Systems (IDS) were been developed to monitor and secure the cyber data systems and networks from any intrusions. However, the intrusion detection is difficult due to the rapid evolution of security attacks and the high volume, variety and speed of big data. In addition, the shallow architectures of existing IDS models lead to high computation cost and high memory requirements, thus further diminishing the efficiency of intrusion detection. The recent studies have suggested the use of data analytics and the deep learning algorithms can be effective in improving the IDS. An efficient IDS model is developed in this study by using the improved Elman-type Recurrent Neural Networks (RNN) in which the Improved Chicken Swarm Optimization (ICSO) optimally determines RNN parameters. RNN is an efficient method for classifying network traffic data but its traditional training algorithms are slow in convergence and faces local optimum problem. The introduction of ICSO with enhanced global search ability significantly avoids those limitations and improves the training process of RNN. This optimized deep learning algorithm of RNN, named as ICSO-RNN, is employed in the IDS with Intuitionistic Fuzzy Mutual Information feature selection to analyze larger network traffic datasets. The proposed IDS model using ICSO-RNN is tested on UNSW NB15 dataset. The final outcomes suggested that ICSO-RNN model has high performance in intrusion detection, with minimum training time and is proficient for big data.
This paper is focused on reviewing previously carried out work and written in literature. Non- conventional abrasive water jet technology is being utilized to machine variety of metals, their ...respective alloys and nonmetals. Mainly concentrated on Titanium alloys and difficulty in its machining. Numerous variables associated with the technology and their consequence on response variable were analyzed and summarized in this review. Paper conclude numerous gaps in research along with future scope.
To prospectively evaluate a compact portable 10-gauge handheld battery-operated biopsy system for stereotactic biopsy of microcalcifications. The ethics committee of the hospital approved this ...prospective multicentric study, and informed consent was obtained. Biopsy under stereotactic guidance was performed in 215 patients for 219 lesions consisting of microcalcifications without mass. The feasibility and the tolerance of the procedure were evaluated. The mean weight of the specimen was calculated. In patients with surgical diagnoses, the underestimation rate in biopsy diagnoses of atypical ductal hyperplasia and ductal carcinoma in situ were evaluated. The sampled specimens were separated according to the presence of calcifications on magnified specimen radiographs and to the probe the rotation number in order to evaluate the contribution of each rotation and the contribution of the specimen with and without calcifications on the radiographs. The macrobiopsy was feasible in 98.5% of the patients and was well tolerated in 82% of patients. It identified 4.6% invasive carcinomas, 18.5% ductal carcinomas in situ, 14.8% atypical ductal hyperplasias, 22.2% benign proliferative mastopathies and 39.8% benign non-proliferative mastopathies. The underestimation rate was 26.6% when an atypical ductal hyperplasia was diagnosed at biopsy, and 7.7% when a ductal carcinoma in situ was diagnosed. In the 77 patients with surgical correlation, the accurate diagnosis was obtained in specimens sampled during the first, second, and third in 69%, 9%, and 4% of the biopsies, respectively, and the analysis of specimens without microcalcification had an added value in 8% of patients. The compact portable battery-operated biopsy system can be used successfully for stereotactic biopsy of microcalcifications and constitutes a valid alternative to current systems.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, VSZLJ, ZAGLJ
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