Background. The interplay between smoking, oxidized low-density lipoprotein cholesterol (ox-LDL) and gonadal hormones has been scarcely investigated.
Aim. To investigate associations in ox-LDL and ...gonadal hormones in smokers and non-smokers
Methods. Participants (n=164) were obtained from a population cohort of Finnish men aged 40-70 years. The subjects answered a detailed questionnaire on their health behaviour, medication, diseases, and different symptoms, and the hormonal and lipid profiles were measured.
Results. Smokers (n=33) had higher levels of ox-LDL (21%) and more free testosterone (12%) (P<0.01 for all) than non-smokers (n=131). The difference between smokers and non-smokers in ox-LDL persisted after controlling for possible confounding factors. When the smokers were divided into two subgroups (n=16 and n=17) according to total testosterone (≤15 and >15 nmol/L), the ox-LDL in the low-testosterone subgroup was significantly higher (30%) than in the high-testosterone group (P=0.006). Similarly in the corresponding non-smoking subgroups (n=72 and n=59), ox-LDL was significantly higher (11%) in the low-testosterone subgroup than in the high-testosterone subgroup (P=0.012).
Conclusions. Smoking men have significantly more ox-LDL than non-smoking men. Furthermore, if smoking is combined with a low serum testosterone, ox-LDL is even higher. This may suggest a higher risk for atherosclerosis.
Objectives The deterioration of sexual, physical, and mental performance in aging men has been used to measure the clinical manifestations of androgen decrement. However, their prevalence and ...relation to coexisting morbidities are unknown. Methods All men in Turku, Finland, aged 40 to 69 years (n = 28,622) in 2000 were mailed a questionnaire that included questions on general health, sociobehavioral factors, and the Aging Male Symptoms scale (17 questions, each yielded 1 to 5 points, from 1, no symptoms to 5, very severe). Results The participation rate was 54% (15,496 returned questionnaires). Moderate or severe sexual symptoms (decreased frequency of erections, libido, and potency) were observed in 20% of men of the youngest age group of 40 to 44 years. The proportion of men with significant symptoms increased linearly with age up to 67% in the oldest age group (65 to 69 years). Other symptoms did not show a similar age trend. On multifactor analysis, sexual symptoms were independently associated with decreased life satisfaction and increased visits to the physician after adjustment for coexisting morbidities. Visits to the physician were up to three times more frequent among men with moderate to severe sexual symptoms than among those with mild or no symptoms. Conclusions Sexual symptoms in aging men are common and associated with decreased life satisfaction and an increased number of visits to the physician. These symptoms deserve more attention in the workup of aging male patients, because they offer a simple screening tool to detect impaired well-being associated with increased consumption of health services.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
33.
Announcement on NCE2013 Mäkinen, Juha
Acta obstetricia et gynecologica Scandinavica,
05/2013, Volume:
92, Issue:
5
Journal Article
Peer reviewed
Open access
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
34.
Announcement on NCE 2013 Mäkinen, Juha
Acta obstetricia et gynecologica Scandinavica,
05/2013, Volume:
92, Issue:
5
Journal Article
Peer reviewed
Full text
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
35.
Announcement on NCE 2013 Mäkinen, Juha
Acta obstetricia et gynecologica Scandinavica,
04/2013, Volume:
92, Issue:
4
Journal Article
Peer reviewed
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Background. Surgical treatment and staging of ovarian borderline tumors have been reported to be often suboptimal and differ considerably. We evaluated the extent of surgical treatment of these ...tumors in different hospital categories. Material and methods. A prospective survey performed in 1999 included 65 patients operated on for borderline ovarian tumors and covered 78% of such patients reported to the Finnish Cancer Registry. Detailed information of demographic data and surgical treatment was reported by the responsible physicians using a special questionnaire after confirmation of histopathology. Results. Fifty-eight patients (89%) had stage I tumor, only two patients (3%) had stage II disease and five patients (8%) had stage III disease with peritoneal implants. The majority of the patients underwent bilateral salpingo-oophorectomy (66%) and hysterectomy (58%). Unilateral salpingo-oophorectomy was performed for 21 (32%) and omentectomy for 22 (34%) patients. Ten out of the 16 women under 40 years of age had fertility-sparing surgery. Peritoneal biopsies were taken in 16 (25%) women and lymphadenectomy was performed for 9 (14%) patients with clinical suspicion of invasive ovarian carcinoma. Frozen section was taken in half of the patients and the histology remained the same in 72% of the final pathology reports. No clear differences of the extent of surgical treatment were detected between different hospital categories. Overall cumulative 5-year relative survival rate was 96%. Conclusions. Bilateral salpingo-oophorectomy and hysterectomy was performed for the majority of patients with borderline ovarian tumor. More attention should be paid to adequate staging of borderline tumors in all hospital categories.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
In this paper the formative intervention conducted since 2000 at the Finnish National Defence University (FNDU) will be reflected on. In other words, this period covers the FNDU’s application of the ...principles crystallised in the European Bologna Process. Consequently, in the triple-hermeneutic inquiry process, prevalent basic cultural assumptions, paradoxes and problems were identified, but even more interestingly, for the aims of the paper, a few key educational questions were put forward for the future. Every soldier is expected to be a leader and a manager of violence, as well as being a teacher and an educator. It follows that every teacher and manager at the FNDU has deal with key educational questions. Such educational questions resemble sticking points for the actors involved in continuously reproducing and potentially revolutionising the social systems, for example of the FNDU, in the continuity of praxis.
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