Cilj. Cilj je rada dati prvi uvid u vrijednu knjižnu zbirku istarske obitelji De Franceschi i predstaviti godine rada na njezinu sređivanju u Nacionalnoj i sveučilišnoj knjižnici u Zagrebu u koju je ...vjerojatno dospjela 1949. godine te stajala neobrađena u kutijama na spremištu sve do početka ovoga stoljeća.
Pristup/metodologija/dizajn. Da bi predstavile razvoj i povijesni tijek zbirke autorice su se koristile povijesno-deskriptivnom metodom koristeći sve radove u kojima se spominje zbirka i obitelj De Franceschi. Kvantitativni rezultati o sadržaju, razdoblju i temi zbirke dobiveni su statističkom metodom, a u manjoj mjeri, pri usporedbi zbirke De Franceschi sa sličnim obiteljskim zbirkama, u radu se koristi i komparativna metoda.
Rezultati. Rekonstruiran je nastanak zbirke i njezin život nakon Drugoga svjetskog rata. Kvantitativnom analizom ustanovljeno je da se u zbirci nalazi 58 serijskih i 2338 monografskih publikacija u rasponu od 1503. do 1945. godine. Najviše je knjiga iz 19. i prve polovice 20. st., tematski prevladava povijest, a jezik talijanski. Uz materijalne karakteristike, važni su bibliofilski aspekti građe, poput potpisa članova obitelji i brojnih posveta, što zbirku čini vrijednom s kulturološkog i povijesnog aspekta.
Originalnost/vrijednost. U radu je prvi puta predstavljena zbirka De Franceschi koja je više od 75 godina stajala neobrađena na spremištima NSK. Tiskana monografska i serijska građa je obrađena i ponuđena svima zainteresiranima za korištenje i proučavanje u prostorima knjižnice.
Cilj. U članku je predstavljena radionica Ključni knjižničari za modul katalogizacije koja se održala na Stručnom skupu Knjižnični podaci: interoperabilnost, povezivanje i razmjena 28. i 29. ...studenog 2017. u Nacionalnoj i sveučilišnoj knjižnici u Zagrebu. Osnovne zadaće ključnih knjižničara jesu: stručna podrška redovnom radu knjižnica u sustavu, testiranje novih funkcionalnosti modula, praćenje i kontrola rada sustava temeljeni na izvještajima o radu, testiranje i analiza rada servisnih izvještaja na razini cijelog sustava, suradnja sa savjetnikom za integrirani knjižnični sustav, redaktorima baza, administratorom sustava, sistemskim i ključnim knjižničarima zaduženim za administrativno upravljanje sustavom te pružanje pomoći i edukacija sudionika u sustavu.
Metodologija. Polazeći od osnovnih aspekata uloge i rada ključnih knjižničara u okviru Integriranog knjižničnog sustava Nacionalne i sveučilišne knjižnice u Zagrebu te knjižnica iz sustava znanosti i visokog obrazovanja opisan je svaki aspekt rada u modulu katalogizacije.
Rezultati. Integrirani knjižnični sustav temelji se na primjeni zajedničkog programskog sustava Aleph, formata MARC 21, središnje normativne kontrole i nacionalnog predmetnog sustava. Nacionalna i sveučilišna knjižnica u Zagrebu, kao središnja knjižnica u sustavu, osigurava stručnu, tehničku i administrativnu podršku u radu zajedničkog informacijsko-knjižničnog sustava. Ključni knjižničari u modulu katalogizacije održavaju redovite tečajeve Osnove modula Katalogizacija, kao i demonstracijske vježbe. Knjižnice u sustavu zajednički koriste normativnu bazu Nacionalne i sveučilišne knjižnice i predloške za rad, dok se kataložni zapisi preuzimaju prema potrebi iz baza u sustavu ili se izrađuju novi. Putem Sustava za podršku https://iks.nsk.hr/podrska/ šalju se prijavnice u kojima se navode poteškoće s kojima se susreću knjižničari, a rješavaju ih redaktori, ključni i sistemski knjižničari.
Praktična primjena. Rezultati ovoga rada mogu pomoći knjižničarima iz knjižnica članica Integriranog sustava u njihovu svakodnevnom radu.
Originalnost. Široj se knjižničnoj zajednici nastoji približiti termin ključni knjižničari te njihova uloga u razvoju struke.
Izrada Hrvatske nacionalne bibliografije proizlazi iz zakonske obaveze i jedinstvene uloge Nacionalne i sveučilišne knjižnice u Zagrebu. Hrvatska retrospektivna bibliografija knjiga, kao dio hrvatske ...nacionalne bibliografije, sabire, vrednuje, odabire, sadržajno analizira i opisuje tiskane hrvatske knjige po jezičnom, nacionalnom, teritorijalnom i predmetnom načelu, od početka tiska (1483.) do granice s tekućom bibliografijom knjiga (1990). Knjige u elektroničkoj retrospektivnoj bibliografiji okupljene su u višegodišnje sveske, počevši od 1835. do 1990. godine, a uz njih se navode i kazala autora, naslova, nakladnika i predmeta. Kazalo nakladnika iz sveska koji obuhvaća razdoblje od 1900. do 1909. godine polazište je za analizu podataka o nakladništvu i tiskarstvu prve dekade 20. stoljeća. Cilj je utvrditi broj nakladnika koji je djelovao u tom razdoblju, opseg i vrste njihove nakladničke djelatnosti. U drugom dijelu rada, povezivanjem istraživanja povijesti nakladništva i rada na izradi normativne baze nakladnika, prikazat će se proces utvrđivanja jedinstvenog oblika i varijantnih oblika imena nakladnika koji se koriste u normativnoj bazi nakladnika digitalne knjižnice. Pri utvrđivanju jedinstvenog oblika prednost se daje nacionalnom obliku imena, zbog čega će se kao izvori koristiti i knjige ili članci o povijesti knjige, tiskarstva i nakladništva.
Several varicella vaccines are available worldwide. Countries with a varicella vaccination program use 1- or 2-dose schedules.
We examined postlicensure estimates of varicella vaccine effectiveness ...(VE) among healthy children.
Systematic review and descriptive and meta-analysis of Medline, Embase, Cochrane libraries, and CINAHL databases for reports published during 1995-2014.
Publications that reported original data on dose-specific varicella VE among immunocompetent children.
We used random effects meta-analysis models to obtain pooled one dose VE estimates by disease severity (all varicella and moderate/severe varicella). Within each severity category, we assessed pooled VE by vaccine and by study design. We used descriptive statistics to summarize 1-dose VE against severe disease. For 2-dose VE, we calculated pooled estimates against all varicella and by study design.
The pooled 1-dose VE was 81% (95% confidence interval CI: 78%-84%) against all varicella and 98% (95% CI: 97%-99%) against moderate/severe varicella with no significant association between VE and vaccine type or study design (P > .1). For 1 dose, median VE for prevention of severe disease was 100% (mean = 99.4%). The pooled 2-dose VE against all varicella was 92% (95% CI: 88%-95%), with similar estimates by study design.
VE was assessed primarily during outbreak investigations and using clinically diagnosed varicella.
One dose of varicella vaccine was moderately effective in preventing all varicella and highly effective in preventing moderate/severe varicella, with no differences by vaccine. The second dose adds improved protection against all varicella.
Parenting is essential for the survival and wellbeing of mammalian offspring. However, we lack a circuit-level understanding of how distinct components of this behaviour are coordinated. Here we ...investigate how galanin-expressing neurons in the medial preoptic area (MPOA
) of the hypothalamus coordinate motor, motivational, hormonal and social aspects of parenting in mice. These neurons integrate inputs from a large number of brain areas and the activation of these inputs depends on the animal's sex and reproductive state. Subsets of MPOA
neurons form discrete pools that are defined by their projection sites. While the MPOA
population is active during all episodes of parental behaviour, individual pools are tuned to characteristic aspects of parenting. Optogenetic manipulation of MPOA
projections mirrors this specificity, affecting discrete parenting components. This functional organization, reminiscent of the control of motor sequences by pools of spinal cord neurons, provides a new model for how discrete elements of a social behaviour are generated at the circuit level.
Full text
Available for:
KISLJ, NUK, SBMB, UL, UM, UPUK
The objective was to determine the range of hearing improvement (in dB) post ventilation tube insertion in children with chronic otitis media with effusion (COME), and whether there was a difference ...in hearing improvement between age groups and genders. This study also investigated whether there was a difference in the mean hearing improvement between the left and right ear, how many months passed before recovery of eustachian tube function, and how long the aeration of the middle ear lasted. The children included in the study were between six and twelve years of age, diagnosed with COME by audiological processing (type B tympanometric recording and conductive hearing loss up to 40 dB on pure tone audiometry) and underwent surgical insertion of ventilation tubes in both ears. Patient data included preoperative tympanometric records, preoperative and postoperative tone audiometry findings, tubometry findings 6 and 10 months after insertion of ventilation tubes, age and gender data, and length of time during which the tubes were in place. The mean hearing improvement of the included patients was 24.2 dB on the right ear and 24.5 dB on the left ear. There was no statistically significant difference between the left and right ear or between the genders. Older age groups had a higher mean hearing improvement compared with the younger age group. Younger age groups had a longer expected period of eustachian tube function recovery, and were expected to have ventilation tubes inserted for a longer period of time. Treatment with ventilation tube insertion resulted in significant improvement in hearing in children where previous conservative therapy failed to recover eustachian tube function and improve hearing. Although children of older age groups had greater preoperative hearing impairment, the recovery of both eustachian tube function and hearing improvement was faster, and the mean length of time that the ventilation tubes had to be inserted was shorter.
The expression pattern of the markers p19, Ki-67, MSX1, MSX2, PDL1, pRB, and CYCLINA2 was quantitatively and semiquantitatively analyzed in histologic sections of the developing and postnatal human ...eye at week 8, in retinoblastoma, and in various uveal melanomas post hoc studies by double immunofluorescence. The p19 immunoreactivity characterized retinal and/or choroidal cells in healthy and tumor tissues: expression was lower in the postnatal retina than in the developing retina and retinoblastoma, whereas it was high in epithelioid melanomas. Ki67 expression was high in the developing eye, retinoblastoma, and choroidal melanomas. MSX1 and MSX2 expression was similar in the developing eye and retinoblastoma, whereas it was absent in the postnatal eye. Their different expression was evident between epithelioid and myxoid melanomas. Similarly, PDL1 was absent in epithelioid melanomas, whereas it was highly expressed in developing and tumor tissues. Expression of pRB and CYCA2 was characteristic of developing and tumorous eye samples but not of the healthy postnatal eye. The observed expression differences of the analyzed markers correlate with the origin and stage of cell differentiation of the tissue samples. The fine balance of expression could play a role in both human eye development and ocular tumorigenesis. Therefore, understanding their relationship and interplay could open new avenues for potential therapeutic interventions and a better understanding of the mechanisms underlying the developmental plasticity of the eye and the development of neoplasms.
Full text
Available for:
IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
While recent studies have uncovered dedicated neural pathways mediating the positive control of parenting, the regulation of infant-directed aggression and how it relates to adult-adult aggression is ...poorly understood. Here we show that
(
)-expressing neurons in the hypothalamic perifornical area (PeFA
) are activated during infant-directed attacks in males and females, but not other behaviors. Functional manipulations of PeFA
neurons demonstrate the role of this population in the negative control of parenting in both sexes. PeFA
neurons receive input from areas associated with vomeronasal sensing, stress, and parenting, and send projections to hypothalamic and limbic areas. Optogenetic activation of PeFA
axon terminals in these regions triggers various aspects of infant-directed agonistic responses, such as neglect, repulsion, and aggression. Thus, PeFA
neurons emerge as a dedicated circuit component controlling infant-directed neglect and aggression, providing a new framework to understand the positive and negative regulation of parenting in health and disease.
This study aimed to measure the total arsenic content deposited in the ovaries of three consecutive generations of mice. The animals were treated with two different concentrations to determine ...whether histological changes were caused in the ovaries. The control group of mice received tap water, whereas the experimental groups were given different concentrations of dissolved arsenic (III)-oxide. The arsenic content in the ovaries in both experimental groups increased with each generation. The highest content was recorded in the third generation of the second experimental group. Between the two experimental groups in each generation, significant differences in the average number of
and ovarian follicles were identified. Arsenic caused structural changes in the ovaries in both experimental groups in all three consecutive generations.
Full text
Available for:
IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Contractors are facing an increasing degree of complexity in their construction projects. Due to inadequately prepared project plans, they have been suffering significant losses during the execution ...of construction projects. One of the key disadvantages of such plans is that during the planning process, a construction project is mostly defined as a linear rather than a dynamic and complex process with a high degree of uncertainty. Therefore, a contractor who is in the planning phase of a construction project should consider the impact of the project characteristics on its implementation according to the elements of project complexity. In this research, we therefore first made an overview of the existing research related to the elements of project complexity. Based on the frequency of their occurrence in existing surveys, this paper singled out eight groups of complexity characteristics that contractors should be aware of during construction projects. After that, based on the frequency of occurrence in the existing surveys, fifteen elements of complexity were classified for each project complexity group. The research conducted among construction project managers identified key complexity elements of the construction project from the contractor’s perspective. Thereby, the classification of groups with the associated key elements determining the complexity of a construction project from the perspective of the contractor was performed. By properly analyzing the impact of key elements of complexity on project flow during the planning phase, contractors can be more successful when planning the project objectives to be performed.
PDF
