Stringent nonpharmaceutical interventions (NPIs) such as lockdowns and border closures are not currently recommended for pandemic influenza control. New Zealand used these NPIs to eliminate ...coronavirus disease 2019 during its first wave. Using multiple surveillance systems, we observed a parallel and unprecedented reduction of influenza and other respiratory viral infections in 2020. This finding supports the use of these NPIs for controlling pandemic influenza and other severe respiratory viral threats.
Objective: To assess the impact of survival of cryopreservation and thawing with all blastomeres intact on the outcome of multicell frozen ET.
Design: Retrospective study.
Setting: Academic assisted ...reproductive technology program.
Patient(s): One hundred sixteen exclusively multicell frozen ETs in 78 patients.
Intervention(s): Frozen ET.
Main Outcome Measure(s): Relation of embryonic blastomere survival to the outcome of frozen ET (i.e., pregnancy).
Result(s): When at least one embryo survived with all blastomeres intact, the total pregnancy rate (biochemical, clinical, or delivered) was 37.7%, the clinical pregnancy rate was 24.6%, and the delivered pregnancy rate was 18.8%. When no embryo survived with all blastomeres intact, the corresponding rates were 10.6%, 8.5%, and 6.4%. The differences in the total pregnancy rate and the clinical pregnancy rate were statistically significant. The delivered pregnancy rates approached statistical significance.
Conclusion(s): Multicell embryonic survival of cryopreservation and thawing with all blastomeres intact identifies embryos with superior developmental potential.
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To assess the effect of an elevated serum P level on the day of hCG administration in an IVF cycle on resulting embryos by evaluating their performance at subsequent frozen ET.
A retrospective study.
...Ninety-six consecutive patients undergoing frozen ET cycles were studied in a tertiary care center.
Serum obtained on the day of hCG administration in an IVF cycle was assayed for E2 and P by RIA. The main outcome measured was the development of a clinical pregnancy in a subsequent frozen ET cycle.
Using a previously described breakpoint in serum P concentration of 0.9 ng/mL (2.86 nmol/L), 8 of 69 (11.6%) frozen ETs in which embryos from low P level IVF cycles were transferred and 7 of 27 (25.9%) frozen ETs of embryos from elevated P level IVF cycles were transferred resulted in the development of clinical pregnancies. Although this does not clearly demonstrate superiority of embryos obtained from elevated P cycles, employing a power calculation, the probability that the pregnancy rate in the elevated serum P group is at least equal to the observed rate in the low P group is 92.8%.
These data suggest that an elevated serum P level on the day of hCG administration does not adversely affect the quality of oocytes or resulting embryos.
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This study examines the impact of campus environment, cost, convenience, curriculum, socioeconomic status, and academic achievement on whether or not Black students graduated or left college before ...graduating from the College of Charleston between 1983-1989. The data were gathered through a survey of 391 Black graduates and non-graduates enrolled between 1983-1989 at the College of Charleston. Responses from 40 graduates and 50 non-graduates from this group were compared for statistical analysis purposes. The instrument had six subscales including: (1) campus environment, (2) convenience, (3) cost, (4) curriculum, (5) socioeconomic status, and (6) academic achievement. Internal consistency reliability coefficients were computed for each of the six subscales from the data gathered in the questionnaire using the Statistical Package for Social Sciences (SPSS-X) mainframe computer package application. The reliability coefficients for each subset and the composite instrument were reported in the discussion of the findings. Descriptive statistics were computed to define the characteristics of the data to facilitate subsequent comparisons. Comparative statistics were employed to contrast the two groups identified in each of the six subsets of the instrument. The 95 percent confidence level was established as the criterion for determination of the significant variation among groups. The major conclusion of this study is that no significant differences were found between graduates and non-graduates in relation to four of the six variables examined: (1) campus environment, (2) cost, (3) convenience, and (4) socioeconomic status. With the other two variables, two minor factors were different in aspects of curriculum to include: (1) fairness of grading and treatment of faculty toward Black students, and (2) lack of explanations by professors of difficult concepts to Black students. There was also a significant difference in the GPAs of graduates which was greater than that of non-graduates. The findings reveal a need to probe this area further with additional questioning and formulating strategies to address the problem of Black student retention in predominantly White colleges, particularly in the areas of campus environment, cost, and curriculum (courses, faculty, issues, and relationships with students).
Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell ...transcriptomes of human renal tumors and normal tissue from fetal, pediatric, and adult kidneys. We matched childhood Wilms tumor with specific fetal cell types, thus providing evidence for the hypothesis that Wilms tumor cells are aberrant fetal cells. In adult renal cell carcinoma, we identified a canonical cancer transcriptome that matched a little-known subtype of proximal convoluted tubular cell. Analyses of the tumor composition defined cancer-associated normal cells and delineated a complex vascular endothelial growth factor (VEGF) signaling circuit. Our findings reveal the precise cellular identities and compositions of human kidney tumors.
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As new techniques and approaches to supervision attract interest within therapy-related professions, the contributors to this informative book consider the nature of a supervision and examine the ...ways in which it can be further defined and developed. Drawing together practical and theoretical perspectives, Integrative Approaches to Supervision examines the contribution that supervision can make within both organisational and individual settings. The book covers frameworks and models for supervision, supervision in clinical practice and issues within integrative supervision. Topics include: different models of the supervision practice; anti-oppressive practice; spirituality and supervision; counselling supervision in health care; supervision of organisations; self-protection for supervisors from complaints and litigation. Wide in scope but rich in detail, this book is essential reading for psychotherapists, counsellors, consultants and students involved in the supervision process.
Women use technology to mediate numerous aspects of their professional and personal lives. Yet, few design and create these technologies given that women, especially women of color, are grossly ...underrepresented in computer science and engineering courses. Decisions about participation in STEM are frequently made prior to high school, and these decisions are impacted by prior experience, interest, and sense of fit with community. Digital Youth Divas is an out-of-school program that uses narrative stories to launch the creation of digital artifacts and support non-dominant middle school girls' STEM interests and identities through virtual and real-world community. In this article, we discuss the framework of the Digital Youth Divas environment, including our approach to blending narratives into project-based design challenges through on- and offline mechanisms. Results from our pilot year, including the co-design process with the middle school participants, suggest that our narrative-centered, blended learning program design sparks non-dominant girls' interests in STEM activities and disciplinary identification, and has the potential to mediate girls' sense of STEM agency, identities, and interests.
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