Close Reading with Computers Eve, Martin Paul
Metacritic Journal for Comparative Studies and Theory,
2019, 2019-06-04, 20201201, Volume:
6, Issue:
2
eBook, Book Review
Peer reviewed
Open access
Rather than working at the usual scales of distant reading, this book shows what happens when we bring techniques from the digital humanities to bear on a single novel for close readings.
Steroid-resistant or steroid-refractory acute graft-versus-host disease (SR-aGVHD) poses one of the most vexing challenges faced by providers who care for patients after allogeneic hematopoietic cell ...transplantation. For the past 4 decades, research in the field has been driven by the premise that persistent graft-versus-host disease (GVHD) results from inadequate immunosuppression. Accordingly, most efforts to solve this problem have relied on retrospective or prospective studies testing agents that have direct or indirect immunosuppressive effects. Retrospective studies far outnumber prospective studies, and no controlled prospective trial has shown superior results for any agent over others. Truth be told, I do not know how to treat SR-aGVHD. Preclinical work during the past decade has provided fresh insights into the pathogenesis of acute GVHD, and translation of these insights toward development of more effective treatments for patients with SR-aGVHD has at last begun. Given the limited state of current knowledge, this “How I Treat” review highlights the overriding imperative to avoid harm in caring for patients with SR-aGVHD. Prospective trials that are widely available are urgently needed to advance the field.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
This review summarizes our current knowledge of primate including human retina focusing on bipolar, amacrine and ganglion cells and their connectivity. We have two main motivations in writing. ...Firstly, recent progress in non-invasive imaging methods to study retinal diseases mean that better understanding of the primate retina is becoming an important goal both for basic and for clinical sciences. Secondly, genetically modified mice are increasingly used as animal models for human retinal diseases. Thus, it is important to understand to which extent the retinas of primates and rodents are comparable. We first compare cell populations in primate and rodent retinas, with emphasis on how the fovea (despite its small size) dominates the neural landscape of primate retina. We next summarise what is known, and what is not known, about the postreceptoral neurone populations in primate retina. The inventories of bipolar and ganglion cells in primates are now nearing completion, comprising ~12 types of bipolar cell and at least 17 types of ganglion cell. Primate ganglion cells show clear differences in dendritic field size across the retina, and their morphology differs clearly from that of mouse retinal ganglion cells. Compared to bipolar and ganglion cells, amacrine cells show even higher morphological diversity: they could comprise over 40 types. Many amacrine types appear conserved between primates and mice, but functions of only a few types are understood in any primate or non-primate retina. Amacrine cells appear as the final frontier for retinal research in monkeys and mice alike.
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In this book, Chris Collins and Paul Postal consider examples such the one below on the interpretation where Nancy thinks that this course is not interesting:Nancy doesn't think this course is ...interesting.They argue such examples instantiate a kind of syntactic raising that they term Classical NEG Raising. This involves the raising of a NEG (negation) from the embedded clause to the matrix clause. Collins and Postal develop three main arguments to support their claim. First, they show that Classical NEG Raising obeys island constraints. Second, they document that a syntactic raising analysis predicts both the grammaticality and particular properties of what they term Horn clauses (named for Laurence Horn, who discovered them). Finally, they argue that the properties of certainparentheticalstructures strongly support the syntactic character of Classical NEG Raising. Collins and Postal also offer a detailed analysis of the main argument in the literature against a syntactic raising analysis (which they call the Composed Quantifier Argument). They show that the facts appealed to in this argument not only fail to conflict with their approach but actually support a syntactic view. In the course of their argument, Collins and Postal touch on a variety of related topics, including the syntax of negative polarity items, the status of sequential negation, and the scope of negative quantifiers.
Neurons share an intense load Martin, Paul R
Science (American Association for the Advancement of Science),
01/2023, Volume:
379, Issue:
6630
Journal Article
Peer reviewed
Time-of-day-detecting cells in the eye give customized responses to light intensity.
The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, ...acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body's natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue regeneration and repair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.
"This is a book about the power game currently being played out between two symbiotic cultural institutions: the university and the novel. As the number of hyper-knowledgeable literary fans grows, ...students and researchers in English departments waiver between dismissing and harnessing voices outside the academy. Meanwhile, the role that the university plays in contemporary literary fiction is becoming increasingly complex and metafictional, moving far beyond the ‘campus novel’ of the mid-twentieth century. Martin Paul Eve’s engaging and far-reaching study explores the novel's contribution to the ongoing displacement of cultural authority away from university English. Spanning the works of Jennifer Egan, Ishmael Reed, Tom McCarthy, Sarah Waters, Percival Everett, Roberto Bolaño and many others, Literature Against Criticism forces us to re-think our previous notions about the relationship between those who write literary fiction and those who critique it. "
The transition of farmers from subsistence to market-oriented agriculture is meant to reduce hunger, increase wellbeing and accelerate rural economic progress. While an impressive extant literature ...has analysed agricultural commercialisation effects on welfare from an income, expenditure and consumption perspective, authors place less attention on the implications on asset holdings, which is a more robust long-term measure of welfare. Using chickpea production in Ethiopia as a case, we assess the effects of chickpea commercialisation on household asset ownership and livestock holdings of smallholder farmers. We employ a household fixed-effects estimator to control for time-invariant unobserved heterogeneity and account for possible endogeneity using an instrumental variable approach. For comparison purposes, we also evaluate the income effects of chickpea and examine impact heterogeneity using quantile regressions. Our results indicate a positive impact of agricultural commercialisation on assets, livestock ownership and income. We found commercialisation to benefit all farmers in terms of impact heterogeneity, though with higher gains for asset-rich households. Despite this rising asset inequality, we conclude that increased agricultural commercialisation can contribute to economic development of households and reduce rural poverty.
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Chronic graft-versus-host disease (GVHD) remains a common and potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation (HCT). The 2-year cumulative incidence of ...chronic GVHD requiring systemic treatment is ∼30% to 40% by National Institutes of Health criteria. The risk of chronic GVHD is higher and the duration of treatment is longer after HCT with mobilized blood cells than with marrow cells. Clinical manifestations can impair activities of daily living and often linger for years. Hematology and oncology specialists who refer patients to centers for HCT are often subsequently involved in the management of chronic GVHD when patients return to their care after HCT. Treatment of these patients can be optimized under shared care arrangements that enable referring physicians to manage long-term administration of immunosuppressive medications and supportive care with guidance from transplant center experts. Keys to successful collaborative management include early recognition in making the diagnosis of chronic GVHD, comprehensive evaluation at the onset and periodically during the course of the disease, prompt institution of systemic and topical treatment, appropriate monitoring of the response, calibration of treatment intensity over time in order to avoid overtreatment or undertreatment, and the use of supportive care to prevent complications and disability.
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