Immunization with a synthetic HIV-1 p17 peptide analog (HGP-30; aa 85-115 of HIV p17), coupled to a carrier protein (KLH, keyhole limpet hemocyanin) given with alum as the adjuvant induces antibodies ...which cross-react with both HGP-30 and HIV p17 and clones of cytotoxic and helper T-cells which recognize HGP-30 and HIV p17. Proliferation of lymphocytes in response to HGP-30 has been observed in mice, in HIV-infected individuals and in healthy HIV-seronegative volunteers vaccinated with the p17-based synthetic peptide construct. Cytotoxic T-cell responses against EBV transformed, recombinant p17 pulsed targets were observed using antigen-expanded PBLs from HGP-30-KLH immunized individuals. These results are consistent with predictions that the HGP-30 domain of HIV p17 contains both T- and B-cell epitopes that are recognized by animals and humans. In preclinical toxicology studies in animals and in initial clinical trials in humans the synthetic peptide construct (HGP-30-KLH/alum) has been shown to be safe. This paper summarizes the preclinical immunogenicity and safety data for HGP-30-KLH and presents the initial results from the first Phase 1 clinical trial.
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Reviews of Books Maiolo, Joseph A.; William, Glyndwr; Zohar, Noam J. ...
International history review,
12/1999, Volume:
21, Issue:
4
Journal Article
Peer reviewed
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Glacial ogives are transverse topographic, wave-like surface features that form below icefalls on some alpine glaciers. Ground-penetrating radar surveys from the Gorner glacier system in the Swiss ...Alps reveal an along-flow periodicity in scattering intensity that correlates with ogives. The scattering appears in the ablation zone and occurs at 5-20 m depth. The geometry of the scattering mimics that of the ogives, although exaggerated in amplitude. We interpret the scattering to represent lateral variations in water content. We propose that as glacial ice accelerated and stretched through the icefall, seasonal fluctuations occurred in water infiltration to crevasses during the summer and subsequent freezing of that water in the crevasses in the winter. This seasonally varying infilling and freezing locally altered the distribution of temperature, creating zones of temperate ice with water inclusions that preferentially scatter radar energy. In addition to the scattering pattern, highly reflective planar features associated with these periodic regions of temperate ice are interpreted as water-filled fractures. A three-dimensional rendering of the orientation of these planar features precludes a "fold-and-thrust" hypothesis for the formation of the ogives.
Book reviews Kyle, Donald G.; Steinberg, Jonathan; Voigt, David Q. ...
The International Journal of the History of Sport,
04/1997, Volume:
14, Issue:
1
Book Review
Peer reviewed
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118.
Book reviews Kyle, Donald G.; Steinberg, Jonathan; Voigt, David Q. ...
The International Journal of the History of Sport,
19/4/1/, Volume:
14, Issue:
1
Book Review
Peer reviewed
Audrey Briers, Sporting Success in Ancient Greece and Rome (Oxford: Ashmolean Museum, 1994). Pp.48, illustrations, further reading. $8.95 (paper). ISBN 1-85444-055-1.
Roger Morgan, Tennis: The ...Development of the European Ball Game. Foreword by H.R.H. Prince Edward (Oxford: Ronaldson Publications, 1995). Pp.xi + 259, £45. ISBN 0-9501251-7-1.
Christy Mathewson, Pitching in a Pinch: Baseball From the Inside (University of Nebraska Press, 1994). Pp.322. $12.00. ISBN 0-8032-8212-5); Harry Samuel 'Steamboat' Johnson, Standing the Gaff: The Life and Hard Times of a Minor League Umpire (University of Nebraska Press, 1994). Pp.194. $6.95. ISBN 0-8032-7579-X); Larry R. Gerlach, The Men in Blue: Conversations With Umpires (University of Nebraska Press, 1994). Pp.310. $11.95. ISBN 0-8032-7045-3.
Robin Lester, Stagg's University: The Rise, Decline, and Fall of Big-Time Football at Chicago (Urbana and Chicago: University of Illinois Press, 1995). Pp.301, b&w photographs, appendices. ISBN 0-252-02128-2.
Murray Sperber, Shake Down the Thunder: The Creation of Notre Dame Football (New York, Henry Holt & Co., 1993). Pp.xxii + 634. $25. ISBN 0-8050-1874-3.
Larry K. Menna, Sports in North America: A Documentary History -- Volume 2, Origins of Modern Sports, 1820-1840 (Gulf Breeze, Florida: Academic International Press). Pp.xvii + 405. Selected bibliography, 145 documents, and indexes. $75 (cloth) subscription/$95 non-subscription. ISBN 0-87569-136-6.
Richard Cashman, Paradise of Sport: The Rise of Organised Sport in Australia. (Melbourne: Oxford University Press, 1995). Illustrations, bibliography, index.. A$24.95.
John McI. Davidson, International Rugby Union - A Compendium of Scotland's Matches. (Edinburgh: Polygon, 1994). Pp. xii + 295, 12 appendices, 15 photographs, no index. $12.95 (paper). ISBN 0-7486-6186-7.
John Wilson, Playing by the Rules: Sport, Society, and the State (Detroit: Wayne State University Press. May, 1994). Pp.427. US$39.95. ISBN 0-8143-2107-0.
Richard, Cox The Internet as a Resource for the Sports Historian. (Frodsham, UK: Sports History Publishing in association with the British Society of Sports History, 1995). Pp. vi + 62, no price given. ISBN 1-898010-05-6.
Robert C. Post, High Performance: The Culture and Technology of Drag Racing 1950-1990, (Baltimore and London: The John Hopkins Press, 1994). Pp xxiii + 416. £30. ISBN 0-8018-4654-4.
Leif Yttergren: Competition is Life. The organisation and sportification of the sports in Stockholm 1860-1898 (1996).
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Reviews of Books Maiolo, Joseph A.; William, Glyndwr; Zohar, Noam J. ...
The International History Review,
12/1/1999, Volume:
21, Issue:
4
Book Review
Peer reviewed
CLARK G. REYNOLDS. Navies in History. Annapolis: Naval Institute Press, 1998. Pp. xi, 267. $24.95 (US), paper. Reviewed by Joseph A. Maiolo
PETER WHITFIELD. New Found Lands: Maps in the History of ...Exploration. London and New York: Routledge, 1998. Pp. viii, 200. $40.00 (US). Reviewed by Glyndwr William
A. J. COATES. The Ethics of War. Manchester: Manchester University Press, 1997; dist. Vancouver: University of British Columbia Press. Pp. 314. $24.95 (US), paper. Reviewed by Noam J. Zohar
JEREMY BLACK. Why Wars Happen. New York: New York University Press, 1998. Pp. 271. $30.00 (US); JEREMY BLACK. War and the World: Military Power and the Fate of Continents, 1450-2000. New Haven and London: Yale University Press, 1998. Pp. 334. $35.00 (US). Reviewed by Roger Beaumont
ROBERT E. A. PALMER. Rome and Carthage at Peace. Stuttgart: Franz Steiner Verlag, 1997. Pp. 152. DM 68. Reviewed by Hans-Friedrich Mueller
ROGER COLLINS. Charlemagne. Toronto: University of Toronto Press, 1998. Pp. xv, 234. $55.00 (CDN), cloth; $19.95 (CDN), paper. Reviewed by John J. Contreni
JEAN FAVIER. Gold and Spices: The Rise of Commerce in the Middle Ages, trans. Caroline Higgitt. New York and London: Holmes & Meier, 1998. Pp. 390. $39.95 (US). Reviewed by John H. Munro
JOHANNA MARIA VAN WINTER, compiler. Sources Concerning the Hospitallers of St John in the Netherlands, 14th-18th Centuries. Leiden: E.J. Brill, 1998. Pp. viii, 821. NLG 450. Reviewed by David F. Allen
DENIS TWITCHETT and FREDERICK W. MOTE, eds. The Cambridge History of China: VIII: The Ming Dynasty, 1368-1644, Part 2. New York: Cambridge University Press, 1998. Pp. xxi, 1203. $130.00 (US). Reviewed by Richard von Glahn
RICHARD W. UNGER. Ships and Shipping in the North Sea and Atlantic, 1400-1800. Aldershot: Variorum, 1997; dist. Brookfield: Ashgate. Pp. xii, 316. $89.95 (US). Reviewed by Timothy J. Runyan
OM PRAKASH. The New Cambridge History of India: II.5: European Commercial Enterprise in Pre-Colonial India. New York: Cambridge University Press, 1998. Pp.xviii,377. $54.95(US). Reviewed by Blair B. Kling
M. W. DALY, ed. The Cambridge History of Egypt: II: Modern Egypt, from 1517 to the End of the Twentieth Century. New York: Cambridge University Press, 1998. Pp. xiv, 463. $100.00 (US). Reviewed by Afaf Lutfi al-Sayyid Marsot
JAROSLAW PELENSKI. The Contest for the Legacy of Kievan Rus'. Boulder: East European Monographs, 1998; dist. New York: Columbia University Press. Pp. xxiii, 325. $48.00 (US). Reviewed by Paul Bushkovitch
NICHOLAS CANNY, ed. The Oxford History of the British Empire: I: The Origins of Empire: British Overseas Enterprise to the Close of the Seventeenth Century. New York: Oxford University Press, 1998. Pp. xix, 533. $59.50 (CDN). Reviewed by Simon Adams
PHILIP LAWSON. A Taste for Empire and Glory: Studies in British Overseas Expansion, 1660-1800. Aldershot: Variorum, 1997; dist. Brookfield: Ashgate. Pp. xiv, 298. $89.95 (US). Reviewed by Kenneth Morgan
HARRY LIEBERSOHN. Aristocratic Encounters: European Travelers and North American Indians. New York: Cambridge University Press, 1998. Pp. xi, 179. $49.95 (US). Reviewed by Ian K. Steele
SYLVIANE A. DIOUF. Servants of Allah: African Muslims Enslaved in the Americas. New York: New York University Press, 1998. Pp. ix, 254. $18.50 (US), paper. Reviewed by Paul E. Lovejoy
DESMOND GREGORY. No Ordinary General: Lt General Sir Henry Bunbury (1778-1860): The Best Soldier Historian. Cranbury: Fairleigh Dickinson University Press, 1999. Pp. 144. $32.50 (US). Reviewed by Neville Thompson
JOHN GASCOIGNE. Science in the Service of the Empire: Joseph Banks, the British State, and the Uses of Science in the Age of Revolution. New York: Cambridge University Press, 1998. Pp. vii, 247. $64.95 (US). Reviewed by Larry Stewart
PAUL WEBER. On the Road to Rebellion: The United Irishmen and Hamburg, 1796-1803. Dublin: Four Courts Press, 1997; dist. Portland: ISBS. Pp. 205. $45.00 (US). Reviewed by Daire Keogh
JAC WELLER. On Wellington: The Duke and His Art of War, ed. Andrew Uffindell. London and Mechanicsburg: Greenhill Books and Stackpole Books, 1998. Pp. 191. £19.99. Reviewed by Brian M. de Toy
LAWRENCE S. KAPLAN. Thomas Jefferson: Westward the Course of Empire. Wilmington: Scholarly Resources, 1999. Pp. xvii, 198. $50.00 (US), cloth; $17.95 (US)) paper. Reviewed by Reginald C. Stuart
I. C. CAMPBELL. 'Gone Native' in Polynesia: Captivity Narratives and Experiences from the South Pacific. Westport: Greenwood Press, 1998. Pp. xi, 167. $55.00 (US). Reviewed by David A. Chappell
NICHOLAS TARLING. Nations and States in Southeast Asia. New York: Cambridge University Press, 1998. Pp. x, 136. $59.95 (US), cloth; $17.95 (US), paper. Reviewed by A.J. Stockwell
JAMES CABLE. The Political Influence of Naval Force in History. New York: St Martin's Press, 1998. Pp. viii, 213. $59.95 (US). Reviewed by George W. Baer
NELIDA FUCCARO. The Other Kurds: Yazidis in Colonial Iraq. London and New York: I. B. Tauris, 1999; dist. New York: St Martin's Press. Pp. xiii, 230. $55.00 (US). Reviewed by Robert Olson
MARTIN A. KLEIN. Slavery and Colonial Rule in French West Africa. New York: Cambridge University Press, 1998. Pp. xxi, 354. $54.95 (US), cloth; $19.95 (US), paper. Reviewed by William B. Cohen
JAIME E. RODRÍGUEZ O. The Independence of Spanish America. New York: Cambridge University Press, 1998. Pp. xiii, 274. $59.95 (US). Reviewed by Timothy E. Anna
CARL BENN. The Iroquois in the War of 1812. Toronto: University of Toronto Press, 1998. Pp. xi, 272. $21.95 (CDN), paper. Reviewed by K. David Milobar
PHILIP D. CURTIN. Disease and Empire: The Health of European Troops in the Conquest of Africa. New York: Cambridge University Press, 1998. Pp. xiii, 256. $64.95 (US), cloth; $19.95 (US), paper. Reviewed by Daniel R. Headrick
TIMOTHY E. ANNA. Forging Mexico, 1821-1835. Lincoln and London: University of Nebraska Press, 1998. Pp. xiii, 330. $40.00 (US). Reviewed by Claudia Agostoni
GERALD STUDDERT-KENNEDY. Providence and the Raj: Imperial Mission and Missionary Imperialism. Walnut Creek, Calif.: AltaMira Press, 1998. Pp. 273. $44.95 (US). Reviewed by Penelope Carson
JANE SAMSON. Imperial Benevolence: Making British Authority in the Pacific Islands. Honolulu: University of Hawaii Press, 1998. Pp. xv, 240. $35.00 (US). Reviewed by Hugh Laracy
J. Y. WONG. Deadly Dreams: Opium, Imperialism, and the Arrow War (1856-1860) in China. New York: Cambridge University Press, 1998. Pp. xxx, 542. $69.95 (US). Reviewed by D. W. Clayton
ELLIOTT WEST. The Contested Plains: Indians, Goldseekers, and the Rush to Colorado. Lawrence: University Press of Kansas, 1998. Pp. xxiv, 422. $34.95 (US). Reviewed by Francis Paul Prucha
JACK L. HAMMERSMITH. Spoilsmen in a 'Flowery Fairyland': The Development of the US Legation in Japan, 1859-1906. Kent: Kent State University Press, 1998. Pp. xiv, 368. $49.00 (US). Reviewed by Antony Best
PETER STANLEY. White Mutiny: British Military Culture in India. New York: New York University Press, 1998. Pp. xiv, 314. $40.00 (US). Reviewed by Hew Strachan
JOHN C. G. RÖHL. Young Wilhelm: The Kaiser's Early Life, 1859-1888, trans. Jeremy Gaines and Rebecca Wallach. New York: Cambridge University Press, 1998. Pp. xxv, 979. $74.95 (US). Reviewed by Lamar Cecil
DAVID MAYERS. Wars and Peace: The Future Americans Envisioned, 1861-1991. New York: St Martin's Press, 1998. Pp. viii, 184. $45.00 (US). Reviewed by Eileen P. Scully
SAMUEL L. BAILY. Immigrants in the Lands of Promise: Italians in Buenos Aires and New York City, 1870-1914. Ithaca and London: Cornell University Press, 1999. Pp. xvii, 308. $45.00 (US). Reviewed by Donald S. Castro
HIROAKI KUROMIYA. Freedom and Terror in the Donbas: A Ukrainian-Russian Borderland, 1870s-1990s. New York: Cambridge University Press, 1998. Pp. xiv, 357. $44.95 (US). Reviewed by David Saunders
ANDREW LAMBERT. The Foundations of Naval History: John Knox Laughton, the Royal Navy, and the Historical Profession. London: Chatham Publishing, 1998. Pp. 256. £30.00. Reviewed by C. I. Hamilton
H. RAHMAN. The Making of the Gulf War: Origins of Kuwait's Long-Standing Territorial Dispute with Iraq. Reading: Ithaca Press, 1997. Pp. xv, 378. £35.00. Reviewed by Peter Sluglett
ROY MACLAREN, ed. African Exploits: The Diaries of William Stairs, 1887-1892. Montreal and Kingston: McGill-Queen's University Press, 1998. Pp. vi, 423. $49.95 (CDN); PETER HARRINGTON and FREDERIC A. SHARF, eds. Omdurman 1898: The Eye-Witnesses Speak: The British Conquest of the Sudan as Described by Participants in Letters, Diaries, Photos, and Drawings. London and Mechanicsburg: Greenhill Books and Stackpole Books, 1998. Pp. 236. £20.00. Reviewed by Philip Stigger
MATTHEW S. SELIGMANN. Rivalry in Southern Africa, 1893-99: The Transformation of German Colonial Policy. New York: St Martin's Press, 1998. Pp. vii, 200. $65.00 (US). Reviewed by Robert Kubicek
SALWA ALGHANIM. The Reign of Mubarak al-Sabah: Shaikh of Kuwait, 1896-1915. London and New York: I. B. Tauris, 1998; dist. New York: St Martin's Press. Pp. xiii, 242. $59.50 (US). Reviewed by Frederick F. Anscombe
RISTO MARJOMAA. War on the Savannah: The Military Collapse of the Sokoto Caliphate under the Invasion of the British Empire, 1897-1903. Helsinki: Finnish Academy of Science and Letters, 1998. Pp. 305. FIM 140; $28.00 (US). Reviewed by A. S. Kanya-Forstner
LOUIS A. PÉREZ, JR. The War of 1898: The United States and Cuba in History and Historiography. Chapel Hill and London: University of North Carolina Press, 1998. Pp. xvi, 171. $16.95 (US), paper. Reviewed by David Healy
MARK MAZOWER. Dark Continent: Europe's Twentieth Century. London: Allen Lane, The Penguin Press, 1998. Pp. xv, 495. £20.00. Reviewed by William R. Keylor
GUIDO MÜLLER, ed. Deutschland und der Westen: Internationale Beziehungen im 20. Jahrhundert: Festschrift fiir Klaus Schwabe zum 65. Geburtstag. Stuttgart: Franz Steiner Verlag, 1998. Pp. 381. DM 138, paper. Reviewed by Rennie W. Brantz
NIALL FERGUSON. The Pity of War. New York: Basic Bo
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