This updated version of Humanism and the Northern Renaissance now includes over 60 documents exploring humanist and Renaissance ideals, the zeal of religion, and the wealth of the new world. ...Together, the sources illuminate the chaos and brilliance of the historical period—as well as its failures and inconsistencies.
The reader has been thoroughly revised to meet the needs of the undergraduate classroom. Over 30 historical documents have been added, including material by Martin Luther, John Calvin, John Knox, William Shakespeare, Christopher Columbus, Miguel de Cervantes, and Galileo Galilei. In the introduction, Bartlett and McGlynn identify humanism as the central expression of the European Renaissance and explain how this idea migrated from Italy to northern Europe. The editors also emphasize the role of the church and Christianity in northern Europe and detail the events leading up to the Reformation. A short essay on how to read historical documents is included. Each reading is preceded by a short introduction and ancillary materials can be found on UTP's History Matters website (www.utphistorymatters.com).
The Investment Framework Enhanced (IFE) proposed in 2013 by the Joint United Nations Programme on HIV/AIDS (UNAIDS) explored how maximizing existing interventions and adding emerging prevention ...options, including a vaccine, could further reduce new HIV infections and AIDS-related deaths in low- and middle-income countries (LMICs). This article describes additional modeling which looks more closely at the potential health impact and cost-effectiveness of AIDS vaccination in LMICs as part of UNAIDS IFE.
An epidemiological model was used to explore the potential impact of AIDS vaccination in LMICs in combination with other interventions through 2070. Assumptions were based on perspectives from research, vaccination and public health experts, as well as observations from other HIV/AIDS interventions and vaccination programs. Sensitivity analyses varied vaccine efficacy, duration of protection, coverage, and cost.
If UNAIDS IFE goals were fully achieved, new annual HIV infections in LMICs would decline from 2.0 million in 2014 to 550,000 in 2070. A 70% efficacious vaccine introduced in 2027 with three doses, strong uptake and five years of protection would reduce annual new infections by 44% over the first decade, by 65% the first 25 years and by 78% to 122,000 in 2070. Vaccine impact would be much greater if the assumptions in UNAIDS IFE were not fully achieved. An AIDS vaccine would be cost-effective within a wide range of scenarios.
Even a modestly effective vaccine could contribute strongly to a sustainable response to HIV/AIDS and be cost-effective, even with optimistic assumptions about other interventions. Higher efficacy would provide even greater impact and cost-effectiveness, and would support broader access. Vaccine efficacy and cost per regimen are critical in achieving cost-effectiveness, with cost per regimen being particularly critical in low-income countries and at lower efficacy levels.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
This updated version of Humanism and the Northern
Renaissance now includes over 60 documents exploring humanist
and Renaissance ideals, the zeal of religion, and the wealth of the
new world.
Between the mid-fifteenth and mid-sixteenth century Prerogativa Regis, a central text of fiscal feudalism, was introduced into the curriculum of the Inns of Court, developed, and then abandoned. This ...2003 book argues that while lawyers often turned their attention to the text when political and financial issues brought it to the fore, they sought to maintain an intellectual consistency and coherence in the law. Discussions of both substance and procedure demonstrate how readers reflected the concerns of their time in the topics they chose to consider and how they drew on the learning of both their predecessors and their peers at the Inns. The first study based primarily on readings, this book threw light on legal education, early Tudor financial and administrative procedure, and the relationship between the ways that law was made, taught and used.
Abstract
In 1518 the chief justice of King’s Bench initiated an attempt to track successful claims of benefit of clergy on the assize circuits to ensure that laymen could make such claims only once, ...as mandated by a statute dating from 1490. By doing so he was the first to attempt to create a criminal record in England, where an individual felon’s crimes were recorded with the expectation that an earlier crime would have implications for the punishment of a subsequent one. Both this attempt and a later statutory attempt in 1543 were largely unsuccessful, however. They failed, not because of principled opposition or even inertia, but because the well-established bureaucratic structures of the early Tudor period struggled to keep up with the bureaucratic imagination of those who sought to reform or extend the reach of government. The failed attempt to construct a criminal record demonstrates that as the development of print changed information cultures, and the policies of the Tudors led to an intensification of governance, legal records remained profoundly limited by the intellectual and administrative structures within which they operated. Masters of the gathering of information, Tudor governors struggled to adapt old documents to new purposes or to manage information dynamically.
Abstract Purpose Desmoid fibromatosis is associated with frequent recurrence and significant morbidity, but no metastases. To examine the impact of initial non-operative management on event-free ...survival (EFS) in children, we reviewed our institutional experience with this tumor. Methods We retrospectively reviewed our institutional database for pediatric cases of desmoid fibromatosis treated between 1970 and 2010. Survival was analyzed using the Kaplan–Meier method and log-rank test. Results Ninety-three patients were identified, with a median follow-up of 6 years. Median age at diagnosis was 16 years. Forty-seven patients presented with primary tumors, and forty-six had recurrent or progressing disease. Five-year OS was 100%, and 5-year EFS was 31.8%, with a median time to event of 1.48 years. There was no significant difference in 5-year EFS between patients who were managed expectantly and those who initially received treatment (21% versus 34%, P = .09). Sex, race, history of trauma, or familial adenomatous polyposis, multifocality, tumor size, tumor location, and resection status did not correlate with EFS. Conclusion Our findings support a conservative initial approach in the management of desmoid fibromatosis. In patients at risk for morbid procedures, upfront resection should be reserved for select tumors that demonstrate aggressive growth or cause serious symptoms.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Highlights ► HIV, the etiologic agent that causes AIDS, is the fourth largest killer in the world today. ► The rate of new HIV infections continues to outpace efforts on HIV prevention and control. ► ...The development of a safe and effective vaccine for prevention and control of AIDS remains a global public health priority.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
After his appointment as chief justice of King's Bench in 1495, John Fyneux pressured the ecclesiastical hierarchy through indictments for escapes which explored which officials had responsibility ...for the prisons and how they were managed, and thereby successfully asserted the royal right of oversight. By the end of Henry VII's reign his bishops, faced with ruinous fines like other lords, had largely accepted their role as gaolers under royal authority, and thus contributed to the bureaucratisation of the hierarchy which Henry VIII would exploit to such good effect.
Purpose
To highlight changing features over time within a single static image through the auto‐alignment and subtraction of serial optic nerve photographs.
Methods
Subtraction maps were generated ...from auto‐aligned (EyeIC, Narbeth, PA) baseline and follow‐up images using Adobe Photoshop software. They demonstrated progressive retinal nerve fibre layer (RNFL) defects, optic disc haemorrhage (DH), neuroretinal rim loss (RL) and peripapillary atrophy (PPA). A masked glaucoma specialist identified features of progression on subtraction map first, then assessed feature strength by comparison with original images using alternation flicker. Control images with no progression and parallax‐only images (as determined by flicker) were included.
Results
Eighty eyes of 67 patients were used to generate subtraction maps that detected glaucoma progression in 87% of DH (n = 28, sensitivity (Se) 82%, specificity (Sp) 98%) and 84% of PPA (n = 30, Se 80%, Sp 98%) cases. The lowest rate of detection was seen with RL at 67% (n = 31, Se 65%, Sp 100%). The subtraction technique was most sensitive for detecting parallax (n = 39, Se 98%, Sp 94%). Features of glaucoma progression appeared equally strong in flicker and subtraction images, but parallax was often enhanced on subtraction maps. Among control images selected for absence of features of glaucomatous change (n = 9) in original flicker images, no features were detected on subtraction maps.
Conclusions
Auto‐alignment and subtraction of serial optic nerve photographs reliably detects features of glaucoma progression with a single static image. Parallax identification may also be facilitated. Auto‐alignment and subtraction of serial optic nerve photographs may prove especially useful in education and printed publications when dynamic imaging is not feasible.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
Vascular risk factors have been associated with glaucomatous visual field progression.
We determined the relationship between vascular risk factors and structural glaucomatous progression using ...serial flicker chronoscopy images.
Two glaucoma fellowship-trained ophthalmologists, masked to temporal sequence, independently graded serial flicker chronoscopy images from one eye of a cohort of glaucoma patients for features of structural progression in this retrospective cohort study. After adjudication, simple and multiple logistic models were constructed to determine variables associated with increased odds of progression, including systolic blood pressure (BP), diastolic BP and mean ocular perfusion pressure.
Seventy-two eyes of 72 patients were analysed. Patients with any form of structural progression (n=40) were older (67.0 vs 58.8 years; p=0.005) and had lower diastolic BP (71.8 vs 76.5 mm Hg; p=0.02) than patients without progression (n=32). In the univariable model, diastolic BP was associated with progressive retinal nerve fibre layer (RNFL) loss (OR=0.2 per 10 mm Hg, 95% CI 0.1 to 0.6, p<0.006) and neuroretinal rim loss (OR=0.4 per 10 mm Hg, 95% CI 0.2 to 0.8, p<0.01). Diastolic BP was also significant in the multivariable model for RNFL loss (p=0.009) and neuroretinal rim loss (p=0.003).
This study is the first to use structural progression and flicker chronoscopy to identify vascular glaucoma risk factors. Older age and lower diastolic BP were associated with progression. By multivariable analysis diastolic BP was associated with RNFL and neuroretinal rim loss. These findings suggest that diastolic BP is associated with structural glaucomatous progression which may have implications for management.
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