Therapeutic anticoagulation showed inconsistent results in hospitalized patients with COVID-19 and selection of the best patients to use this strategy still a challenge balancing the risk of ...thrombotic and hemorrhagic outcomes. The present post-hoc analysis of the ACTION trial evaluated the variables independently associated with both bleeding events (major bleeding or clinically relevant non-major bleeding) and the composite outcomes thrombotic events (venous thromboembolism, myocardial infarction, stroke, systemic embolism, or major adverse limb events). Variables were assessed one by one with independent logistic regressions and final models were chosen based on Akaike information criteria. The model for bleeding events showed an area under the curve of 0.63 (95% confidence interval CI 0.53 to 0.73), while the model for thrombotic events had an area under the curve of 0.72 (95% CI 0.65 to 0.79). Non-invasive respiratory support was associated with thrombotic but not bleeding events, while invasive ventilation was associated with both outcomes (Odds Ratio of 7.03 95 CI% 1.95 to 25.18 for thrombotic and 3.14 95% CI 1.11 to 8.84 for bleeding events). Beyond respiratory support, creatinine level (Odds Ratio OR 1.01 95% CI 1.00 to 1.02 for every 1.0 mg/dL) and history of coronary disease (OR 3.67; 95% CI 1.32 to 10.29) were also independently associated to the risk of thrombotic events. Non-invasive respiratory support, history of coronary disease, and creatinine level may help to identify hospitalized COVID-19 patients at higher risk of thrombotic complications.ClinicalTrials.gov: NCT04394377.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Abstract The KM3NeT neutrino telescope is currently being deployed at two different sites in the Mediterranean Sea. First searches for astrophysical neutrinos have been performed using data taken ...with the partial detector configuration already in operation. The paper presents the results of two independent searches for neutrinos from compact binary mergers detected during the third observing run of the LIGO and Virgo gravitational wave interferometers. The first search looks for a global increase in the detector counting rates that could be associated with inverse beta decay events generated by MeV-scale electron anti-neutrinos. The second one focuses on upgoing track-like events mainly induced by muon (anti-)neutrinos in the GeV–TeV energy range. Both searches yield no significant excess for the sources in the gravitational wave catalogs. For each source, upper limits on the neutrino flux and on the total energy emitted in neutrinos in the respective energy ranges have been set. Stacking analyses of binary black hole mergers and neutron star-black hole mergers have also been performed to constrain the characteristic neutrino emission from these categories.
Many remote sensing-based evapotranspiration (RSBET) algorithms have been proposed in the past decades and evaluated using flux tower data, mainly over North America and Europe. Model evaluation ...across South America has been done locally or using only a single algorithm at a time. Here, we provide the first evaluation of multiple RSBET models, at a daily scale, across a wide variety of biomes, climate zones, and land uses in South America. We used meteorological data from 25 flux towers to force four remote sensing based ET models: Priestley & Taylor Jet Propulsion Laboratory (PT-JPL), Global Land Evaporation Amsterdam Model (GLEAM), Penman-Monteith Mu model (PM-MOD), and Penman-Monteith Nagler model (PM-VI). ET was predicted satisfactorily by all four models, with correlations consistently higher (R²>0.6) for GLEAM and PT-JPL, and PM-MOD and PM-VI presenting overall better responses in terms of PBIAS (-10<PBIAS<10%). As for PM-VI, this outcome is expected, given the model requires calibration with local data. Model skill seems to be unrelated to land-use type but instead presented a certain level of dependency on biome and climate, with the models producing the best results for wet to moderately wet environments. Our findings show the suitability of individual models for a number of combinations of land cover types, biomes, and climates. At the same time, no model outperformed the other for all conditions, and all models presented poor skills for sites in certain conditions, which emphasizes the need of adapting individual algorithms to take into account intrinsic characteristics of climates and ecosystems in South America.
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► The immobilization of EDTA on Si–APTS composite was observed to occur in a stoichiometric relation of 2(APTS):1(EDTA). ► IR and NMR data suggest a cavity-like structure with four ...nitrogen atoms inside and two carboxylate groups outside. ► Adsorption assays for ions indicated a potential applicability of the Si–APTS–EDTA spheres as a bifunctional material.
The immobilization of EDTA on Si–APTS composite was observed to occur in a stoichiometric relation of 2(APTS):1(EDTA) with a degree of functionalization of 0.56mmolg−1. Based on IR and NMR data it was suggested that the immobilization results in a cavity with four nitrogen atoms inside and two carboxylate groups outside. Surface area, total pore volume and average pore diameter, of the Si–APTS–EDTA spheres were determined, respectively, as 177.6m2g−1, 0.35cm3g−1 and 73.6Å. Zeta potential (PZC=5.0) and adsorption assays indicated a potential applicability of the Si–APTS–EDTA spheres as a bifunctional material since it was observed the adsorption of cations and anions.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor-positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study ...(ClinicalTrials.gov identifier: NCT04576455).
Post-/pre-/perimenopausal women, or men, age 18 years or older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines of systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly assigned 1:1 to giredestrant (30 mg oral once daily) or fulvestrant/aromatase inhibitor per local guidelines (+luteinizing hormone-releasing hormone agonist in pre-/perimenopausal women, and men) until disease progression/unacceptable toxicity. Stratification was by visceral versus nonvisceral disease, prior cyclin-dependent kinase 4/6 inhibitor, and prior fulvestrant. The primary end point was investigator-assessed progression-free survival (INV-PFS).
At clinical cutoff (February 18, 2022; median follow-up: 7.9 months; N = 303), the INV-PFS hazard ratio (HR) was 0.81 (95% CI, 0.60 to 1.10;
= .1757). In the prespecified secondary end point analysis of INV-PFS by
mutation (m) status in circulating tumor DNA-evaluable patients (n = 232), the HR in patients with a detectable
m (n = 90) was 0.60 (95% CI, 0.35 to 1.03) versus 0.88 (95% CI, 0.54 to 1.42) in patients with no
m detected (n = 142). Related grade 3-4 adverse events (AEs), serious AEs, and discontinuations due to AEs were balanced across arms.
Although the acelERA BC study did not reach statistical significance for its primary INV-PFS end point, there was a consistent treatment effect with giredestrant across most key subgroups and a trend toward favorable benefit among patients with
-mutated tumors. Giredestrant was well tolerated, with a safety profile comparable to PCET and consistent with known endocrine therapy risks. Overall, these data support the continued investigation of giredestrant in other studies.
Penile cancer has a high incidence in developing countries. The gold standard treatment is penectomy, however, due to its mutilating nature, organ-preserving techniques such as Mohs' micrography have ...been developed. This is indicated in small and low-grade invasive tumors, as well as in situ neoplasia. In this regard, we report the case of a young patient with a neoplastic injury in the glans, who had undergone Mohs' micrographic surgery and who achieved satisfactory aesthetic, functional, and oncological results. Despite the recurrence, he had a new surgery by the same method with good outcomes.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
This study reports the results of ab initio and density functional theory (DFT) electronic structure calculations as well as 3 J HH experimental and calculated coupling constant data obtained in the ...investigation of the conformational equilibrium of 3-halo-derivatives of 1-methylpyrrolidin-2-one. The five-membered ring assumes an envelope conformation owing to the plane of formation of the OC–N–R bond, with C4 forming the “envelope lid”. When the conformation changes, the “lid” alternates between positions above and below the amide plane. The α-carbonyl halogen assumes two positions: a pseudo-axial and a pseudo-equatorial. In the gaseous phase, the calculations indicate that the pseudo-axial conformer is more stable and preferable going down the halogen family. Natural bond orbital analysis showed that electronic delocalization is significant only for the iodo derivative. In the other derivatives, the electrostatic repulsion between oxygen and the halogen determines the conformational equilibrium. When the solvated molecule was taken into account, the pseudo-equatorial conformer population increased with the relative permittivity of the solvent. This variation was strong in the fluoro derivative, and the preference was inverted. In the chlorine derivative, the two populations became closer in methanol and acetonitrile. In the bromine and iodine derivatives, the percentage of pseudo-equatorial conformer increased only slightly owing to the dipole moment of the conformation: the pseudo-equatorial conformation has a greater dipole moment and thus is stable in media with high relative permittivity.
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IJS, KILJ, NUK, PNG, UL, UM
Perfumes are products mainly consisting of ethyl alcohol, water and fragrance. These fragrances are responsible for characterizing the pleasant and unique odor of each perfume. Among the fragrances, ...we highlight a group of fragrances which can cause contact allergy, leading to dermatitis. Brazilian and the European law state that when these concentrations of allergenic fragrances exceed the limit of 0.01% for non-rinse products and 0.001% for products with rinsing, the manufacturer is obliged to discriminate on its label their presence. This work aims to quantify allergic fragrances in original and Brazilian perfume using solid-phase microextraction and analyze by gas chromatography-mass detector.
Los planes de Alfonso VII para Zafadola La idea que rondaba en la cabeza de Alfonso VII era convencer a los andalusíes de que únicamente en sus manos estaba la garantía de la paz y del respeto hacia ...las formas de vida andalusíes, y que ninguna de estas era posible con la presencia de los almorávides en la Península. Hogendijk, Jan., "Discovery of an 11th-Century geometrical Compilation: The istikmal of Yusuf al-Mu'taman ibn Hud, King of Saragossa", Historia Mathematica, N°13, Ginebra, 1986, pp. 43-52. Ibn al Kardabus: "Y en ese año Enrique e Ibn Ramiro con ejércitos, innumerables por su multitud, se dirigieron con al-Musta'in ibn Hud, entonces él salió al encuentro de ellos dos, pero el enemigo lo engañó y fue muerto como mártir en Cámara", Bosh Vila, 1960, op. cit., p. 143. 17 Ibn al Kardabus nos refiere lo siguiente: "Y cuando él (Alfonso), maldígale Dios, entró en ella (zaragoza) Imad al-Dawla ibn al-Musta'in ibn Hud huyó a Rueda, que era una fortaleza cercana a Zaragoza equiparable a los extremos visibles del cielo, extremadamente inaccesible y elevada.
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