With the gradual deepening of China’s aging population, the status quo of “getting old before getting rich” has brought great challenges to the problem of elderly care. In this paper, we take the ...supply chain management of elderly services as the core and optimize the service cost and service quality through a two-layer planning model to obtain the best decision-making scheme. A particle Swarm Algorithm (PSO) is proposed to solve the model with intelligent evolution, and an incentive mechanism is established on the basis of the senior care supply chain, which maximizes its revenue by relying on the contract. Finally, by improving the SCORE model, data analysis and dynamic simulation of the senior care service supply chain can be carried out. The results show that the supply chain of senior care service reaches the optimization when the ratio of the capital input of community, institution and home is 0.2:0.2:0.6, and its equilibrium ratio stabilizes at about 96.0%:4%, which effectively alleviates the current pressure of senior care service. This study realizes the coordination of information and interests in the supply chain of community senior care service, which is of great practical significance for the innovation of healthy senior care service.
Twist is a critical epithelial-mesenchymal transition (EMT)-inducing transcription factor that increases expression of vimentin. How Twist1 regulates this expression remains unclear. Here, we report ...that Twist1 regulates Cullin2 (Cul2) circular RNA to increase expression of vimentin in EMT. Twist1 bound the Cul2 promoter to activate its transcription and to selectively promote expression of Cul2 circular RNA (circ-10720), but not mRNA. circ-10720 positively correlated with Twist1, tumor malignance, and poor prognosis in hepatocellular carcinoma (HCC). Twist1 promoted vimentin expression by increasing levels of circ-10720, which can absorb miRNAs that target vimentin. circ-10720 knockdown counteracted the tumor-promoting activity of Twist1
and in patient-derived xenograft and diethylnitrosamine-induced TetOn-Twist1 transgenic mouse HCC models. These data unveil a mechanism by which Twist1 regulates vimentin during EMT. They also provide potential therapeutic targets for HCC treatment and provide new insight for circular RNA (circRNA)-based diagnostic and therapeutic strategies.
A circRNA-based mechanism drives Twist1-mediated regulation of vimentin during EMT and provides potential therapeutic targets for treatment of HCC.
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The decarbonisation of the iron and steel industry, contributing approximately 8% of current global anthropogenic CO
emissions, is challenged by the persistently growing global steel demand and ...limitations of techno-economically feasible options for low-carbon steelmaking. Here we explore the inherent potential of recovering energy and re-using materials from waste streams, high-temperature slag, and re-investing the revenues for carbon capture and storage. In a pathway based on energy recovery and resource recycling of glassy blast furnace slag and crystalline steel slag, we show that a reduction of 28.5 ± 5.7% CO
emissions to the sectoral 2 °C target requirements in the iron and steel industry could be realized in 2050 under strong decarbonization policy consistent with low warming targets. The technological schemes applied to engineer this high-potential pathway could generate a revenue of US$35 ± 16 and US$40 ± 18 billion globally in 2035 and 2050, respectively. If this revenue is used for carbon capture and storage implementation, equivalent CO
emission to the 2 °C sectoral target requirements is expected to be reduced before 2050, without any external investments.
Measurement of the energy use dispersed through international trade is crucial in the age of global value chains. This study traces international energy flows, presents the stylized facts, and ...analyses the major driving factors of energy flows. The findings of this study show that 20% of global energy is transmitted through global value chains and there is large energy imbalance between economies. The gravity model illustrates that energy transfers between home and host countries increase with economic size, a shared border, a same language, and a similar legal system, and decrease with geographic distance. However, distance is becoming less significant in transmitting energy due to the increasing complexity of global value chains. Global value chains have altered how the world consumes energy directly and indirectly, thus must be taken into consideration by both environmental and trade policies aiming at encouraging sustainable development, equity, and energy conservation.
•World energy use is redistributed via international trade in the global value chains (GVCs) era.•Energy embodied in GVCs has increased rapidly in recent decades.•The net energy transfer of developed economies is positive while that of developing economies is negative.•The patterns of energy flow vary across different trading routes in GVCs.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Given the aim of maintaining global warming below 2 °C, carbon emission reduction has become a global top priority. Since the Belt and Road Initiative has increasing influence on ...manufacturing-oriented developing countries, more attention should be paid to carbon emission reduction in these regions. This study conducts a comprehensive analysis by analyzing the carbon inequality and regional development and compares the carbon emissions driven by final demand among countries in and outside the Belt and Road area from 1990 to 2015. It is found that the majority of the Belt and Road regions achieved a rapid GDP growth rate with increasing carbon emissions, in which the investment-driven type demonstrated a significant growth. In contrast, the developed countries outside the Belt and Road area maintained their economic growth while decreasing the carbon emissions owed to the declining of investment-driven emissions; however the consumption-driven emissions stably remained a relatively high level. Our results showed that the inequality of carbon emission within Belt and Road regions is lower than the global average, while the inequality of the investment-driven emissions showed an obviously increasing trend. By discussing the carbon inequality and regional development, rational and feasible strategies for countries and regions within and outside the Belt and Road area are essential, and different types of strategies such as low-carbon technologies transfers and overseas financial cooperation are suggested for regional carbon emission reduction and sustainable regional development under the Belt and Road Initiative.
•The per capita carbon emissions driven by final demand from 1990 to 2015 are analyzed.•The countries and regions within and outside the Belt and Road area are compared.•Three types of regions are identified in consideration of economic development and carbon emissions.•Consumption-driven carbon emissions contribute approximately 70% in Belt and Region regions.•Investment-driven carbon emissions increase significantly within Belt and Region area.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Rational design of optimal bifunctional oxygen electrocatalyst with low cost and high activity is greatly desired for realization of rechargeable Zn–air batteries. Herein, we fabricate mesoporous ...thin-walled CuCo2O4@C with abundant nitrogen-doped nanotubes via coaxial electrospinning technique. Benefiting from high catalytic activity of ultrasmall CuCo2O4 particles, double active specific surface area of mesoporous nanotubes, and strong coupling with N-doped carbon matrix, the obtained CuCo2O4@C exhibits outstanding oxygen electrocatalytic activity and stability, in terms of a positive onset potential (0.951 V) for oxygen reduction reaction (ORR) and a low overpotential (327 mV at 10 mA cm–2) for oxygen evolution reaction (OER). Significantly, when used as cathode catalyst for Zn-air batteries, CuCo2O4@C also displays a low charge–discharge voltage gap (0.79 V at 10 mA cm–2) and a long cycling life (up to 160 cycles for 80 h). With desirable architecture and excellent electrocatalytic properties, the CuCo2O4@C is considered a promising electrocatalyst for Zn–air batteries.
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IJS, KILJ, NUK, PNG, UL, UM
In this study, we investigated the effects of exogenous calcium nitrate on photoinhibition and thylakoid protein level in peanut plants under heat （40 ℃） and high irradiance （HI） （1,200 mmol/m2 per ...s） stress. Compared with control seedlings （cultivated in 0 mmol/L Ca（NO3）2 medium）, the maximal photochemical efficiency of photosystem II （PSII） in Ca2t‐treated plants showed a slight decrease after 5 h stress, accompanied by lower degree of PSII closure （1‐qP）, higher non‐photochemical quenching, and lower level of membrane damage. Ca2t inhibitors were used to analyze the varieties of antioxidant enzymes activity and PSII proteins. These results indicated that Ca2t could protect the subunits of PSII reaction centers from photoinhibition by reducing the generation of reactive oxygen species. In the presence of both ethyleneglycol‐bis（2‐aminoethylether）‐tetraacetic acid and ascorbic acid （AsA）, the net degradation of the damaged D1 protein was faster than that only treated with AsA. Our previous study showed that either the transcriptional or the translational level of calmodulin was obviously higher in Ca2t‐treated plants. These results suggested that, under＆amp;nbsp;heat and HI stress, the Ca2t signal transduction pathway can al eviate the photoinhibition through regulating the protein repair process besides an enhanced capacity for scavenging reactive oxygen species.
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FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
Aptamers are single stranded DNA or RNA molecules that have been selected using in vitro techniques to bind target molecules with high affinity and selectivity, rivaling antibodies in many ways. In ...order to use aptamers in research and clinical applications, a thorough understanding of aptamer–target binding is necessary. In this article, we review methods for assessing aptamer–protein binding using separation based techniques such as dialysis, ultrafiltration, gel and capillary electrophoresis, and HPLC; as well as mixture based techniques such as fluorescence intensity and anisotropy, UV–vis absorption and circular dichroism, surface plasmon resonance, and isothermal titration calorimetry. For each method the principle, range of application and important features, such as sample consumption, experimental time and complexity, are summarized and compared.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A ...systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV.
An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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