Given the manifold ways that depression impairs Darwinian fitness, the persistence in the human genome of risk alleles for the disorder remains a much debated mystery. Evolutionary theories that view ...depressive symptoms as adaptive fail to provide parsimonious explanations for why even mild depressive symptoms impair fitness-relevant social functioning, whereas theories that suggest that depression is maladaptive fail to account for the high prevalence of depression risk alleles in human populations. These limitations warrant novel explanations for the origin and persistence of depression risk alleles. Accordingly, studies on risk alleles for depression were identified using PubMed and Ovid MEDLINE to examine data supporting the hypothesis that risk alleles for depression originated and have been retained in the human genome because these alleles promote pathogen host defense, which includes an integrated suite of immunological and behavioral responses to infection. Depression risk alleles identified by both candidate gene and genome-wide association study (GWAS) methodologies were found to be regularly associated with immune responses to infection that were likely to enhance survival in the ancestral environment. Moreover, data support the role of specific depressive symptoms in pathogen host defense including hyperthermia, reduced bodily iron stores, conservation/withdrawal behavior, hypervigilance and anorexia. By shifting the adaptive context of depression risk alleles from relations with conspecifics to relations with the microbial world, the Pathogen Host Defense (PATHOS-D) hypothesis provides a novel explanation for how depression can be nonadaptive in the social realm, whereas its risk alleles are nonetheless represented at prevalence rates that bespeak an adaptive function.
Full text
Available for:
DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
We hypothesized that chemoprophylaxis with the echinocandin micafungin would be an effective agent for antifungal prophylaxis during neutropenia in patients undergoing hematopoietic stem cell ...transplantation (HSCT). We therefore conducted a randomized, double-blind, multi-institutional, comparative phase III trial, involving 882 adult and pediatric patients, of 50 mg of micafungin (1 mg/kg for patients weighing <50 kg) and 400 mg of fluconazole (8 mg/kg for patients weighing <50 kg) administered once per day. Success was defined as the absence of suspected, proven, or probable invasive fungal infection (IFI) through the end of therapy and as the absence of proven or probable IFI through the end of the 4-week period after treatment. The overall efficacy of micafungin was superior to that of fluconazole as antifungal prophylaxis during the neutropenic phase after HSCT (80.0% in the micafungin arm vs. 73.5% in the fluconazole arm difference, 6.5%; 95% confidence interval, 0.9%-12%; P = .03). This randomized trial demonstrates the efficacy of an echinocandin for antifungal prophylaxis in neutropenic patients.
Full text
Available for:
BFBNIB, NUK, PNG, UL, UM, UPUK
Context. The Kilo-Degree Survey (KiDS) is an ongoing optical wide-field imaging survey with the OmegaCAM camera at the VLT Survey Telescope, specifically designed for measuring weak gravitational ...lensing by galaxies and large-scale structure. When completed it will consist of 1350 square degrees imaged in four filters (ugri). Aims. Here we present the fourth public data release which more than doubles the area of sky covered by data release 3. We also include aperture-matched ZYJHKs photometry from our partner VIKING survey on the VISTA telescope in the photometry catalogue. We illustrate the data quality and describe the catalogue content. Methods. Two dedicated pipelines are used for the production of the optical data. The ASTRO-WISE information system is used for the production of co-added images in the four survey bands, while a separate reduction of the r-band images using the THELI pipeline is used to provide a source catalogue suitable for the core weak lensing science case. All data have been re-reduced for this data release using the latest versions of the pipelines. The VIKING photometry is obtained as forced photometry on the THELI sources, using a re-reduction of the VIKING data that starts from the VISTA pawprints. Modifications to the pipelines with respect to earlier releases are described in detail. The photometry is calibrated to the Gaia DR2 G band using stellar locus regression. Results. In this data release a total of 1006 square-degree survey tiles with stacked ugri images are made available, accompanied by weight maps, masks, and single-band source lists. We also provide a multi-band catalogue based on r-band detections, including homogenized photometry and photometric redshifts, for the whole dataset. Mean limiting magnitudes (5σ in a 2″ aperture) and the tile-to-tile rms scatter are 24.23 ± 0.12, 25.12 ± 0.14, 25.02 ± 0.13, 23.68 ± 0.27 in ugri, respectively, and the mean r-band seeing is 0.″70.
Full text
Available for:
FMFMET, NUK, UL, UM, UPUK
Sea otters in California are commonly infected with
Toxoplasma gondii. A unique Type X strain is responsible for 72% of otter infections, but its prevalence in terrestrial animals and marine ...invertebrates inhabiting the same area was unknown. Between 2000 and 2005, 45 terrestrial carnivores (lions, bobcats, domestic cats and foxes) and 1396 invertebrates (mussels, clams and worms) were screened for
T. gondii using PCR and DNA sequencing to determine the phylogeographic distribution of
T. gondii archetypal I, II, III and Type X genotypes. Marine bivalves have been shown to concentrate
T. gondii oocysts in the laboratory, but a comprehensive survey of wild invertebrates has not been reported. A California mussel from an estuary draining into Monterey Bay was confirmed positive for Type X
T. gondii by multilocus PCR and DNA sequencing at the
B1 and
SAG1 loci. This mussel was collected from nearshore marine waters just after the first significant rainfall event in the fall of 2002. Of 45 carnivores tested at the
B1,
SAG1, and
GRA6 typing loci, 15 had PCR-confirmed
T. gondii infection; 11 possessed alleles consistent with infection by archetypal Type I, II or III strains and 4 possessed alleles consistent with Type X
T. gondii infection. No non-canonical alleles were identified. The four
T. gondii strains with Type X alleles were identified from two mountain lions, a bobcat and a fox residing in coastal watersheds adjacent to sea otter habitat near Monterey Bay and Estero Bay. Confirmation of Type X
T. gondii in coastal-dwelling felids, canids, a marine bivalve and nearshore-dwelling sea otters supports the hypotheses that feline faecal contamination is flowing from land to sea through surface runoff, and that otters can be infected with
T. gondii via consumption of filter-feeding marine invertebrates.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
5.
New Cooling Sequences for Old White Dwarfs Renedo, I; Althaus, L. G; Miller Bertolami, M. M ...
The Astrophysical journal,
07/2010, Volume:
717, Issue:
1
Journal Article
Peer reviewed
Open access
We present full evolutionary calculations appropriate for the study of hydrogen-rich DA white dwarfs. This is done by evolving white dwarf progenitors from the zero-age main sequence, through the ...core hydrogen-burning phase, the helium-burning phase, and the thermally pulsing asymptotic giant branch phase to the white dwarf stage. Complete evolutionary sequences are computed for a wide range of stellar masses and for two different metallicities, Z = 0.01, which is representative of the solar neighborhood, and Z = 0.001, which is appropriate for the study of old stellar systems, like globular clusters. During the white dwarf cooling stage, we self-consistently compute the phase in which nuclear reactions are still important, the diffusive evolution of the elements in the outer layers and, finally, we also take into account all the relevant energy sources in the deep interior of the white dwarf, such as the release of latent heat and the release of gravitational energy due to carbon-oxygen phase separation upon crystallization. We also provide colors and magnitudes for these sequences, based on a new set of improved non-gray white dwarf model atmospheres, which include the most up-to-date physical inputs like the Ly{alpha} quasi-molecular opacity. The calculations are extended down to an effective temperature of 2500 K. Our calculations provide a homogeneous set of evolutionary cooling tracks appropriate for mass and age determinations of old DA white dwarfs and for white dwarf cosmochronology of the different Galactic populations.
We present a combined tomographic weak gravitational lensing analysis of the Kilo Degree Survey (KV450) and the Dark Energy Survey (DES-Y1). We homogenize the analysis of these two public cosmic ...shear datasets by adopting consistent priors and modeling of nonlinear scales, and determine new redshift distributions for DES-Y1 based on deep public spectroscopic surveys. Adopting these revised redshifts results in a 0.8 σ reduction in the DES-inferred value for S 8 , which decreases to a 0.5 σ reduction when including a systematic redshift calibration error model from mock DES data based on the MICE2 simulation. The combined KV450+DES-Y1 constraint on S 8 = 0.762 −0.024 +0.025 is in tension with the Planck 2018 constraint from the cosmic microwave background at the level of 2.5 σ . This result highlights the importance of developing methods to provide accurate redshift calibration for current and future weak-lensing surveys.
Full text
Available for:
FMFMET, NUK, UL, UM, UPUK
The energetic convenience of electrolytic water splitting is limited by thermodynamics. Consequently, significant levels of hydrogen production can only be obtained with an electrical energy ...consumption exceeding 45 kWh kg(-1)H2. Electrochemical reforming allows the overcoming of such thermodynamic limitations by replacing oxygen evolution with the oxidation of biomass-derived alcohols. Here we show that the use of an original anode material consisting of palladium nanoparticles deposited on to a three-dimensional architecture of titania nanotubes allows electrical energy savings up to 26.5 kWh kg(-1)H2 as compared with proton electrolyte membrane water electrolysis. A net energy analysis shows that for bio-ethanol with energy return of the invested energy larger than 5.1 (for example, cellulose), the electrochemical reforming energy balance is advantageous over proton electrolyte membrane water electrolysis.
Galaxies grow inefficiently, with only a small percentage of the available gas converted into stars each free-fall time. Feedback processes, such as outflowing winds driven by radiation pressure, ...supernovae, or supermassive black hole accretion, can act to halt star formation if they heat or expel the gas supply. We report a molecular outflow launched from a dust-rich star-forming galaxy at redshift 5.3, 1 billion years after the Big Bang. The outflow reaches velocities up to 800 kilometers per second relative to the galaxy, is resolved into multiple clumps, and carries mass at a rate within a factor of 2 of the star formation rate. Our results show that molecular outflows can remove a large fraction of the gas available for star formation from galaxies at high redshift.
Full text
Available for:
BFBNIB, NMLJ, NUK, ODKLJ, PNG, SAZU, UL, UM, UPUK
2020 marks 25 years since Olivier Guillitte defined the term ‘bioreceptivity’, to describe the ability of a building material to be colonised by living organisms. Although Guillitte noted in his 1995 ...paper that several issues required further investigation, to the best of our knowledge the bioreceptivity concept has not been restated, reviewed, reanalysed or updated since then. The present paper provides an opinionated exposition of the status and utility of the bioreceptivity concept for built heritage science and conservation in the light of current knowledge, aimed to stimulate further discussion. A bibliometric analysis highlights the key dimensions of the past 25 years of published research, showing that the term bioreceptivity has been widely used in the field of built cultural heritage. In our reanalysis of the concept, special attention is devoted to the six types of bioreceptivity (primary, secondary, tertiary, intrinsic, extrinsic and semi-extrinsic) articulated by Guillitte in 1995. We propose that field-based studies of bioreceptivity are urgently needed, and that the intrinsic, extrinsic and semi-extrinsic types of bioreceptivity should be dropped, and a new category (quaternary bioreceptivity) added. Additionally, we propose that bioreceptivity in submerged and subsoil environments should also be considered. Bioreceptivity remains an important concept for managing both new build and built heritage, as it provides the key to understanding the drivers and patterns of biological colonisation of building materials.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
PDF
