La mer joue un rôle essentiel dans l’introduction du football à Dalmatie sous l’Empire austro-hongrois grâce aux bateaux britanniques qui y accostent. En 1911, des étudiants croates de Prague créent ...le club de Hajduk Split. Il se développe après la Grande Guerre en jouant des matchs contre les équipages des bateaux de l’Entente, même si les matelots italiens ne sont pas les bienvenus. Sous la direction de l’entraîneur Luka Kaliterna, l’équipe de jeunes joueurs propose un jeu technique qui brille une première fois lors d’une tournée en Afrique du Nord française (1923). Ils deviennent les « Maîtres de la mer », enchainent les tournées et gagnent deux titres de champions de Yougoslavie en 1927 et 1929. L’invasion allemande et le démantèlement de la Yougoslavie (1941) font disparaître le club transformé en AC Spalato par l’occupant italien. Il renaît en 1944 sur l’île de Vis et est refondé sous le nom de Hajduk NOVJ. L’équipe se produit dans des tournées de propagande dans le sud de l’Italie libérée et jusqu’au Proche-Orient. Redevenu civil, il obtient de nouveaux titres de champion dans la Yougoslavie de Tito avant d’être à nouveau pris dans la guerre en 1991. Jamais son lien indéfectible avec la mer n’a été rompu.
The sea played a key role in the introduction of football to Dalmatia under the Austro-Hungarian Empire, thanks to the British ships that docked in the Croatian port. In 1911, Croatian students of Praga founded the Hajduk Split club. After World War I, the team grew by playing matchs against the crews of Entente ships, although Italian crews were not welcome. Under the direction of coach Luka Kaliterna, the team of young players offered a technical game that shone for the first time during a tour of French North Africa (1923). They became the ‘Masters of the Sea’ and went on tour after tour, while winning two Yugoslavian championship titles in 1927 and 1929. The German invasion and dismantling of Yugoslavia (1941) led to the club’s demise, when it was transformed into AC Spalato by the Italian occupiers. It was reborn in 1944 on the island of Vis and re-founded as Hajduk NOVJ. The team performed on propaganda tours in the south of liberated Italy and as far afield as the Middle East. Having returned to civilian life, he won further championship titles in Tito’s Yugoslavia before being caught up in the war again in 1991. But his unfailing link with the sea was never broken.
Even before Tito's Communist Party established control over the war-ravaged territories which became socialist Yugoslavia, his partisan forces were using football as a revolutionary tool. In 1944 a ...team representing the incipient state was dispatched to play matches around the liberated Mediterranean. This consummated a deep relationship between football and communism that endured until this complex multi-ethnic polity tore itself apart in the 1990s. Starting with an exploration of the game in the short-lived interwar Kingdom, this book traces that liaison for the first time. Based on extensive archival research and interviews, it ventures across the former Yugoslavia to illustrate the myriad ways football was harnessed by an array of political forces.
Silver nanoparticles (AgNPs) are widely used in commercial applications as antimicrobial agents, but there have recently been increasing concerns raised about their possible environmental and health ...impacts. In this study, zebrafish embryos were exposed to two sizes of AgNP, 4 and 10 nm, through a continuous exposure from 4 to 96 h post-fertilisation (hpf), to study their uptake, impact and molecular defense responses. Results showed that zebrafish embryos were significantly impacted by 72 hpf when continuously exposed to 4 nm AgNPs. At concentrations above 0.963 mg/L, significant in vivo uptake and delayed yolk sac absorption was evident; at 1.925 mg/L, significantly reduced body length was recorded compared to control embryos. Additionally, 4 nm AgNP treatment at the same concentration resulted in significantly upregulated
4 (
) and
(
) mRNA expression in exposed embryos 96 hpf. In contrast, no significant differences in terms of larvae body length, yolk sac absorption or gene expression levels were observed following exposure to 10 nm AgNPs. These results demonstrated that S4 AgNPs are available for uptake, inducing developmental (measured as body length and yolk sac area) and transcriptional (specifically
and
) perturbations in developing embryos. This study suggests the importance of particle size as one possible factor in determining the developmental toxicity of AgNPs in fish embryos.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The adult human heart possesses a limited regenerative potential following an ischemic event, and undergoes a number of pathological changes in response to injury. Although cardiac regeneration has ...been documented in zebrafish and neonatal mouse hearts, it is currently unknown whether the immature human heart is capable of undergoing complete regeneration. Combined progress in pluripotent stem cell differentiation and tissue engineering has facilitated the development of human cardiac organoids (hCOs), which resemble fetal heart tissue and can be used to address this important knowledge gap. This study aimed to characterize the regenerative capacity of immature human heart tissue in response to injury. Following cryoinjury with a dry ice probe, hCOs exhibited an endogenous regenerative response with full functional recovery 2 weeks after acute injury. Cardiac functional recovery occurred in the absence of pathological fibrosis or cardiomyocyte hypertrophy. Consistent with regenerative organisms and neonatal human hearts, there was a high basal level of cardiomyocyte proliferation, which may be responsible for the regenerative capacity of the hCOs. This study suggests that immature human heart tissue has an intrinsic capacity to regenerate.
We have previously developed a high-throughput bioengineered human cardiac organoid (hCO) platform, which provides functional contractile tissue with biological properties similar to native heart ...tissue, including mature, cell-cycle-arrested cardiomyocytes. In this study, we perform functional screening of 105 small molecules with pro-regenerative potential. Our findings reveal surprising discordance between our hCO system and traditional 2D assays. In addition, functional analyses uncovered detrimental effects of many hit compounds. Two pro-proliferative small molecules without detrimental impacts on cardiac function were identified. High-throughput proteomics in hCO revealed synergistic activation of the mevalonate pathway and a cell-cycle network by the pro-proliferative compounds. Cell-cycle reentry in hCO and in vivo required the mevalonate pathway as inhibition of the mevalonate pathway with a statin attenuated pro-proliferative effects. This study highlights the utility of human cardiac organoids for pro-regenerative drug development, including identification of underlying biological mechanisms and minimization of adverse side effects.
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•Drug screening in human PSC-cardiac organoids for pro-proliferative compounds•Functional screening to identify compounds with side effects on contractility•Single-organoid proteomics to uncover biological mechanisms of compounds•Systems approaches to identify core CM proliferation signatures
Hudson, Porrello, et al. perform drug screening in human mini-hearts to identify compounds that promote human heart muscle cell proliferation. Drug screening also eliminated potential side effects on heart rhythm and function. Induction of heart muscle cell proliferation required activation of the cholesterol biosynthesis pathway.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Sex, death and nostalgia are among the impulses driving Beatles fandom: the metaphorical death of the Beatles after their break-up in 1970 has fueled the progressive nostalgia of fan conventions for ...48 years; the deaths of John Lennon and George Harrison have added pathos and drama to the Beatles’ story; Beatles Monthly was predicated on the Beatles’ good looks, and the letters page was a forum for euphemistically expressed sexuality. The Beatles and Fandom is the first book to discuss these fan subcultures. It combines academic theory on fandom with compelling original research material to tell an alternative history of the Beatles phenomenon: a fans’ history of the Beatles that runs concurrently with the popular story we all know.
Mad Dogs and Englishness connects English popular music with questions about English national identities, featuring essays that range across Bowie and Burial, PJ Harvey, Bishi and Tricky. The later ...years of the 20th century saw a resurgence of interest in cultural and political meanings of Englishness in ways that continue to resonate now. Pop music is simultaneously on the outside and inside of the ensuing debates. It can be used as a mode of commentary about how meanings of Englishness circulate socially. But it also produces those meanings, often underwriting claims about English national cultural distinctiveness and superiority. This book's expert contributors use trans-national and trans-disciplinary perspectives to provide historical and contemporary commentaries about pop's complex relationships with Englishness. Each chapter is based on original research, and the essays comprise the best single volume available on pop and the English imaginary.
This paper explores two reddit communities that supported Bernie Sanders and Donald Trump, respectively, in the run up to the 2016 US Presidential election campaign. Much of the paper is dedicated to ...explaining how reddit functions, describing the behaviour of the subreddit communities in question and then asking whether these demonstrated collective intelligence. Subreddit communities submit and vote on content, through their votes they make collective decisions about which content will be broadcast to their community. Large subreddit communities that formed rapidly to support a candidate in an election have not previously been observed on reddit—these offered an interesting context for the consideration of whether subreddit communities demonstrate collective intelligence. Voting is a key determinant of what happens on each subreddit and it is conducted anonymously, it is, therefore, not possible to understand the role(s) that every individual plays in the functioning of the subreddit. The behaviour of these subreddit communities can only be understood as a collective of submitting, commenting, voting and moderating participants. Whether these collectives behave intelligently is a matter of how one defines intelligence—but it is clear that they can be effective in pursuing certain ends. These collectives encounter and sometimes oppose each other on reddit. The community of Trump supporters in particular were in conflict with a number of other high-profile communities on the site, and also the platform’s administrators.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
It has been shown that large interdisciplinary teams working across geography are more likely to be impactful. We asked whether the physical proximity of collaborators remained a strong predictor of ...the scientific impact of their research as measured by citations of the resulting publications.
Articles published by Harvard investigators from 1993 to 2003 with at least two authors were identified in the domain of biomedical science. Each collaboration was geocoded to the precise three-dimensional location of its authors. Physical distances between any two coauthors were calculated and associated with corresponding citations. Relationship between distance of coauthors and citations for four author relationships (first-last, first-middle, last-middle, and middle-middle) were investigated at different spatial scales. At all sizes of collaborations (from two authors to dozens of authors), geographical proximity between first and last author is highly informative of impact at the microscale (i.e. within building) and beyond. The mean citation for first-last author relationship decreased as the distance between them increased in less than one km range as well as in the three categorized ranges (in the same building, same city, or different city). Such a trend was not seen in other three author relationships.
Despite the positive impact of emerging communication technologies on scientific research, our results provide striking evidence for the role of physical proximity as a predictor of the impact of collaborations.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The aims of this study were to (1) characterize anticipatory and reactive postural strategies in typically developing (TD) children and adolescents; (2) determine if TD youth shift from reactive to ...anticipatory mechanisms based on knowledge of platform movement; and (3) determine whether TD youth further modify postural strategies when additional information about the perturbation is provided. Sixteen typically developing youth aged 7–17 years stood with eyes open on a movable platform that progressively translated anteroposteriorly (20 cm peak-to-peak) through four speeds (0.1, 0.25, 0.5, and 0.61 Hz). Participants performed two trials each of experimenter-triggered and self-triggered perturbations. Postural muscle activity (1000 Hz) of the tibialis anterior, gastrocnemius, quadriceps and hamstrings and 3D whole body kinematics (100 Hz) were recorded. The Anchoring Index and marker-pair trajectory cross-correlations were calculated as indications of body stabilization. The number of steps taken to regain balance/avoid falling were counted. Transition states and steady states were analyzed separately. Generally, the higher frequencies resulted in more steps being taken, lower correlations coupled with greater temporal lags between marker trajectories, and postural muscle activity similar to older adults. The provision of self-triggered perturbations allowed participants to make the appropriate changes to their balance by use of anticipatory postural control mechanisms.
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