Summary
Genes encoding antigen‐presenting molecules within the human major histocompatibility complex (MHC) account for the highest component of genetic risk for many neurological diseases, such as ...multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. Myriad genetic, immunological and environmental factors may contribute to an individual's susceptibility to neurological disease. Here, we review and discuss the decades long research on the influence of genetic variation at the MHC locus and the role of immunogenetic killer cell immunoglobulin‐like receptor (KIR) loci in neurological diseases, including multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. The findings of immunogenetic association studies are consistent with a polygenic model of inheritance in the heterogeneous and multifactorial nature of complex traits in various neurological diseases. Future investigation is highly recommended to evaluate both coding and non‐coding variation in immunogenetic loci using high‐throughput high‐resolution next‐generation sequencing technologies in diverse ethnic groups to fully appreciate their role in neurological diseases.
Genes encoding antigen‐presenting molecules within the human major histocompatibility complex (MHC) account for the highest component of genetic risk for many neurological diseases, such as multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. Myriad genetic, immunological and environmental factors may contribute to an individual's susceptibility to neurological disease. Here, we review and discuss the decades long research on the influence of genetic variation at the MHC locus and the role of immunogenetic killer cell immunoglobulin‐like receptor (KIR) loci in neurological diseases, including multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK
Cortisol has been identified as a biomarker in saliva to monitor psychological stress. In this work, we report a label-free paper-based electrical biosensor chip to quantify salivary cortisol at a ...point-of-care (POC) level. A high specificity of the sensor chip to detect cortisol with a detection limit of 3 pg/mL was achieved by conjugating anticortisol antibody (anti-CAB) on top of gold (Au) microelectrodes using 3,3′-dithiodipropionic acid di(N-hydroxysuccinimide ester (DTSP) as a self-assembled monolayer (SAM) agent. The electrode design utilized poly(styrene)-block-poly(acrylic acid) (PS67-b-PAA27) polymer and graphene nanoplatelets (GP) suspension coated on filter paper to increase the sensitivity of the immune response. A biosensor chip was then integrated with a lab-built low-cost miniaturized printed circuit board (PCB) to provide an electrical connection and to wirelessly transmit/receive electrical signals using MATLAB. This fully integrated proposed hand-held device successfully exhibited a wide cortisol-detection range from 3 pg/mL to 10 μg/mL, with a sensitivity of 50 Ω (pg mL–1)−1. The performance of the proposed cortisol sensor chip was validated using an enzyme-linked immunosorbent assay (ELISA) technique with a regression value of 0.9951. The advantages of the newly developed cortisol immune biosensor over previously reported chips include an improved limit of detection, no need for additional redox medium for electron exchange, faster response to achieve stable data, excellent shelf life, and its economical production.
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IJS, KILJ, NUK, PNG, UL, UM
The short gamma-ray burst (GRB) 170817A was the first GRB associated with a gravitational-wave event. Due to the exceptionally low luminosity of the prompt γ-ray and the afterglow emission, the ...origin of both radiation components is highly debated. The most discussed models for the burst and the afterglow include a regular GRB jet seen off-axis and the emission from the cocoon encompassing a "choked" jet. Here, we report low radio frequency observations at 610 and 1390 MHz obtained with the Giant Metrewave Radio Telescope. Our observations span a range of ∼7 to ∼152 days after the burst. The afterglow started to emerge at these low frequencies about 60 days after the burst. The 1390 MHz light curve barely evolved between 60 and 150 days, but its evolution is also marginally consistent with an F ∝ t0.8 rise seen in higher frequencies. We model the radio data and archival X-ray, optical, and high-frequency radio data with models of top-hat and Gaussian structured GRB jets. We performed a Markov Chain Monte Carlo analysis of the structured-jet parameter space. Though highly degenerate, useful bounds on the posterior probability distributions can be obtained. Our bounds of the viewing angle are consistent with that inferred from the gravitational-wave signal. We estimate the energy budget in prompt emission to be an order of magnitude lower than that in the afterglow blast wave.
Diabetic neuropathy Bansal, V; Kalita, J; Misra, U K
Postgraduate Medical Journal,
02/2006, Volume:
82, Issue:
964
Journal Article, Book Review
Peer reviewed
Open access
Diabetic neuropathy (DN) refers to symptoms and signs of neuropathy in a patient with diabetes in whom other causes of neuropathy have been excluded. Distal symmetrical neuropathy is the commonest ...accounting for 75% DN. Asymmetrical neuropathies may involve cranial nerves, thoracic or limb nerves; are of acute onset resulting from ischaemic infarction of vasa nervosa. Asymmetric neuropathies in diabetic patients should be investigated for entrapment neuropathy. Diabetic amyotrophy, initially considered to result from metabolic changes, and later ischaemia, is now attributed to immunological changes. For diagnosis of DN, symptoms, signs, quantitative sensory testing, nerve conduction study, and autonomic testing are used; and two of these five are recommended for clinical diagnosis. Management of DN includes control of hyperglycaemia, other cardiovascular risk factors; α lipoic acid and L carnitine. For neuropathic pain, analgesics, non-steroidal anti-inflammatory drugs, antidepressants, and anticonvulsants are recommended. The treatment of autonomic neuropathy is symptomatic.
ABSTRACT
We present radio and optical afterglow observations of the TeV-bright long gamma-ray burst 190114C at a redshift of z = 0.425, which was detected by the Major Atmospheric Gamma Imaging ...Cherenkov telescope. Our observations with Atacama Large Millimeter/submillitmeter Array, Australia Telescope Compact Array, and upgraded Giant Metre-wave Radio Telescope were obtained by our low frequency observing campaign and range from ∼1 to ∼140 d after the burst and the optical observations were done with three optical telescopes spanning up to ∼25 d after the burst. Long-term radio/mm observations reveal the complex nature of the afterglow, which does not follow the spectral and temporal closure relations expected from the standard afterglow model. We find that the microphysical parameters of the external forward shock, representing the share of shock-created energy in the non-thermal electron population and magnetic field, are evolving with time. The inferred kinetic energy in the blast-wave depends strongly on the assumed ambient medium density profile, with a constant density medium demanding almost an order of magnitude higher energy than in the prompt emission, while a stellar wind-driven medium requires approximately the same amount energy as in prompt emission.
Abstract
Rapidly evolving transients, or objects that rise and fade in brightness on timescales two to three times shorter than those of typical Type Ia or Type II supernovae (SNe), have uncertain ...progenitor systems and powering mechanisms. Recent studies have noted similarities between rapidly evolving transients and Type Ibn SNe, which are powered by ejecta interacting with He-rich circumstellar material (CSM). In this work we present multiband photometric and spectroscopic observations from Las Cumbres Observatory and Swift of four fast-evolving Type Ibn SNe. We compare these observations with those of rapidly evolving transients identified in the literature. We discuss several common characteristics between these two samples, including their light curve and color evolution as well as their spectral features. To investigate a common powering mechanism we construct a grid of analytical model light curves with luminosity inputs from CSM interaction as well as
56
Ni radioactive decay. We find that models with ejecta masses of ≈1–3
M
⊙
, CSM masses of ≈0.2–1
M
⊙
, and CSM radii of ≈20–65 au can explain the diversity of peak luminosities, rise times, and decline rates observed in Type Ibn SNe and rapidly evolving transients. This suggests that a common progenitor system—the core collapse of a high-mass star within a dense CSM shell—can reproduce the light curves of even the most luminous and fast-evolving objects, such as AT 2018cow. This work is one of the first to reproduce the light curves of both SNe Ibn and other rapidly evolving transients with a single model.
Sixty-eight patients with convulsive status epilepticus (SE) were randomly assigned to two groups to study the efficacy of sodium valproate (VPA) and phenytoin (PHT). Seizures were aborted in 66% in ...the VPA group and 42% in the PHT group. As a second choice in refractory patients, VPA was effective in 79% and PHT was effective in 25%. The side effects in the two groups did not differ. Sodium valproate may be preferred in convulsive SE because of its higher efficacy.
Iminodiacetic acid functionality has been introduced on styrene–divinyl benzene co-polymeric beads and characterized by FT-IR in order to develop weak acid based cation exchange resin. This resin was ...evaluated for the removal of different heavy metal ions namely Cd(II), Cr(VI), Ni(II) and Pb(II) from their aqueous solutions. The results showed greater affinity of resin towards Cr(VI) for which 99.7% removal achieved in optimal conditions following the order Ni(II)
>
Pb(II)
>
Cd(II) with 65%, 59% and 28% removal. Experiments were also directed towards kinetic studies of adsorption and found to follow first order reversible kinetic model with the overall rate constants 0.3250, 0.2393, 0.4290 and 0.2968 for Cr(VI), Ni(II), Pb(II) and Cd(II) removal respectively. Detailed studies of Cr(VI) removal has been carried out to see the effect of pH, resin dose and metal ion concentration on adsorption and concluded that complexation enhanced the chromium removal efficacy of resin drastically, which is strongly pH dependent. The findings were also supported by the comparison of FT-IR spectra of neat resin with the chromium-adsorbed resin.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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