To investigate the health-related quality of life (HRQoL) of patients receiving allogeneic hematopoietic SCT (allo-HSCT) from HLA-haploidentical/partially matched related donors (HID/PMRD) and to ...compare this value with that of patients receiving allo-HSCT from HLA-identical sibling donor (ISD), a total of 350 patients receiving allo-HSCT were enrolled in a study (ISD: 173; HID/PMRD: 177). HRQoL post transplantation was evaluated by an SF-36 questionnaire. The effect of various factors on the HRQoL was analyzed through COX regression. Compared with the ISD group, patients in the HID/PMRD group had higher scores in physical functioning, general health, bodily pain, vitality and emotional role functioning, and these patients functioned significantly better on the physical and mental component summaries. Also, long-term survivors exhibit better HRQoL. Measured by multivariate analysis, extensive chronic GVHD was observed to have a strongly negative impact on patients' HRQoL, while male gender status, lower age when receiving allo-HSCT and returning to work or school were associated with positive impacts on at least one subscale. These results showed that the HRQoL of patients receiving HID/PMRD hematopoietic SCT (HSCT) is comparable to that of patients receiving ISD HSCT, and HLA disparity is not the factor affecting the HRQoL.
Full text
Available for:
DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The aim of this study was to investigate the impact of occurrence of chronic GVHD (cGVHD) and its severity on transplantation outcomes in a consecutive cohort of AML and myelodysplastic syndrome ...(MDS) patients who received unmanipulated haploidentical hematopoietic SCT (haplo-HSCT; n=324). The cumulative incidence of relapse was significantly decreased in patients with cGVHD compared with the non-cGVHD group (1 year: 3.2% vs 11.9%, P=0.002; 3 years: 6.0% vs 16.3%, P=0.002), particularly in those with mild cGVHD. The cumulative incidence of non-relapse mortality was comparable between patients with and without cGVHD. The probabilities of disease-free survival (DFS) were significantly better in patients with cGVHD than in those in the non-cGVHD group (1 year: 90.5% vs 78.5%, P=0.002; 3 years: 86.5% vs 71.5%, P<0.001), particularly in those with mild or moderate cGVHD; however, no significant impact of severe cGVHD on DFS was seen. Our findings highlight the close relationship between cGVHD and the immune-mediated GVL effect in patients with AML and MDS receiving unmanipulated haplo-HSCT; however, only mild or moderate cGVHD was associated with a lower risk of relapse translating into improved DFS.
Full text
Available for:
DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Techniques for haploidentical hematopoietic stem cell transplantation (haplo-HSCT) to treat severe aplastic anemia (SAA) have recently improved, but no protocol has been evaluated in a large number ...of pediatric patients. Fifty-two children with SAA received haplo-HSCT in our center. The treatment protocol used G-CSF-primed bone marrow with G-CSF-mobilized PBSCs without in vitro T-cell depletion. The conditioning regimen included busulfan/cyclophosphamide and antithymocyte globulin. Fifty-one patients achieved primary engraftment; one child died of regimen-related toxicity on the day +1. Secondary graft failure occurred in three patients. The cumulative incidences of aGVHD grade II-IV and grade III-IV were 39.2±0.5 and 13.7±0.2%, respectively. The cumulative incidence of cGVHD was 34.2±0.5%. The 3-year overall and failure-free survival rates were 84.5±5.0 and 82.7±5.2%, respectively, with a median follow-up time of 744.5 days (100-3294) for surviving patients. The Eastern Cooperative Oncology Group score was the only predictor of overall and failure-free survival rates. Clinical outcomes were similar between the upfront and salvage group. This result suggests that both newly diagnosed and refractory pediatric SAA patients benefit from haplo-HSCT, especially when patients are in good general condition. Therefore, haplo-HSCT might be an alternative therapy for pediatric SAA patients without HLA-matched sibling donors.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
•We proposed an electromagnetic incremental forming (EMIF) method.•Simulation the electromagnetic incremental forming process by remeshing the air meshes.•The simulation method considers the effect ...of the workpiece deformation and movement of coil on magnetic analysis.•Two consecutive discharges in a fixed position are needed to produce large parts using EMIF technology.•There exists suitable overlap ratio in two adjacent discharge regions, which corresponds to best forming quality.
Large parts cannot be shaped by conventional electromagnetic forming method due to the limitation of the strength of working coil and the capacity of capacitor bank. In this paper, based on the principle of single point incremental forming, a new method named electromagnetic incremental forming (EMIF) has been proposed. The method makes use of a small coil and small discharge energy to cause workpiece local deformation in a high speed. Finally, all local deformations accumulate into large parts. For the electromagnetic incremental sheet forming, the effect factors of processing parameters namely discharge voltage, vent hole, discharging times in a fixed position and the number of discharge region, on final sheet shape are investigated by using AA3003 aluminum alloy parts. In addition, two different simulation strategies are proposed to predict electromagnetic incremental sheet and tube forming process. For method 1: the technology like “birth–death element” is used to indirectly describe the movement of the coil and the morphing technology is used to make the air change with the workpiece deformation. For method 2: the coil can directly move to a special position and the remesh technology is used to consider the effect of the workpiece deformation and the movement of coil on magnetic analysis. It is found that method 1 cannot be used for electromagnetic incremental sheet forming process if overlap region exists in two adjacent discharge regions. However, method 1 can successfully predict electromagnetic incremental tube forming. And method 2 can be used for electromagnetic incremental sheet or tube forming. Both of the experimental and simulation results demonstrate that this new technology is feasible to produce large part.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The decay $D^+_s$ → $π^+π^+π^-η$ is observed for the first time, using e+e- collision data corresponding to an integrated luminosity of 6.32 fb-1 collected by the BESIII detector at center-of-mass ...energies between 4.178 and 4.226 GeV. The absolute branching fraction for this decay is measured to be $\mathscr{B}$($D^+_s$ → $π^+π^+π^-η$) = (3.12 ± 0.13stat ± 0.90syst)%. The first amplitude analysis of this decay reveals the substructures in $D^+_s$ → $π^+π^+π^-η$ nd determines the relative fractions and the phases among these substructures. The dominant intermediate process is $D^+_s$ → $a_1$(1260)+$η,a_1$(1260)+ → ρ(770)0$π^+$ with a branching fraction of (1.73 ± 0.14stat ±0.08syst)%. We also observe the W-annihilation process $D^+_s$ → $a_0$(980)+ ρ(770)0, $a_0$(980)+ → $π^+η$ with a branching fraction of (0.21 ± 0.08stat ± 0.05syst)%, which is larger than the branching fractions of other measured pure W-annihilation decays by 1 order of magnitude.
Full text
Available for:
CMK, CTK, FMFMET, IJS, NUK, PNG, UM
Abstract Using a sample of $$1.31\times 10^{9} ~J/\psi $$ 1.31×109J/ψ events collected with the BESIII detector, we perform a study of $$J/\psi \rightarrow \gamma K{\bar{K}}\eta '$$ J/ψ→γKK¯η′ . ...X(2370) is observed in the $$K{\bar{K}}\eta '$$ KK¯η′ invariant-mass distribution with a statistical significance of $$8.3\sigma $$ 8.3σ . Its resonance parameters are measured to be $$M=2341.6\pm 6.5 \, \text {(stat.)} \pm 5.7 \, \text {(syst.)}~ \hbox {MeV}/c^{2}$$ M=2341.6±6.5(stat.)±5.7(syst.)MeV/c2 and $$\Gamma = 117\pm 10 \, \text {(stat.)}\pm 8 \, \text {(syst.)}~\hbox {MeV}$$ Γ=117±10(stat.)±8(syst.)MeV . The product branching fractions for $$J/\psi \rightarrow \gamma X(2370),X(2370)\rightarrow K^{+}K^{-}\eta '$$ J/ψ→γX(2370),X(2370)→K+K-η′ and $$J/\psi \rightarrow \gamma X(2370),X(2370)\rightarrow K_{S}^{0}K_{S}^{0}\eta '$$ J/ψ→γX(2370),X(2370)→KS0KS0η′ are determined to be $$(1.79\pm 0.23\, \text {(stat.)}\pm 0.65\,\text {(syst.)})\times 10^{-5}$$ (1.79±0.23(stat.)±0.65(syst.))×10-5 and $$(1.18\pm 0.32\, \text {(stat.)}\pm 0.39\, \text {(syst.)})\times 10^{-5}$$ (1.18±0.32(stat.)±0.39(syst.))×10-5 , respectively. No evident signal for X(2120) is observed in the $$K{\bar{K}}\eta '$$ KK¯η′ invariant-mass distribution. The upper limits for the product branching fractions of $${\mathcal {B}}(J/\psi \rightarrow \gamma X(2120)\rightarrow \gamma K^{+} K^{-} \eta ')$$ B(J/ψ→γX(2120)→γK+K-η′) and $${\mathcal {B}}(J/\psi \rightarrow \gamma X(2120)\rightarrow \gamma K_{S}^{0} K_{S}^{0} \eta ')$$ B(J/ψ→γX(2120)→γKS0KS0η′) are determined to be $$1.49\times 10^{-5}$$ 1.49×10-5 and $$6.38\times 10^{-6}$$ 6.38×10-6 at the 90% confidence level, respectively.
Full text
Available for:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Forbidden hugs in pandemic times Cai, Y.-Z.; Pastorello, A.; Fraser, M. ...
Astronomy and astrophysics (Berlin),
11/2022, Volume:
667
Journal Article
Peer reviewed
Open access
We present an observational study of the luminous red nova (LRN) AT 2021biy in the nearby galaxy NGC 4631. The field of the object was routinely imaged during the pre-eruptive stage by synoptic ...surveys, but the transient was detected only at a few epochs from ∼231 days before maximum brightness. The LRN outburst was monitored with unprecedented cadence both photometrically and spectroscopically. AT 2021biy shows a short-duration blue peak, with a bolometric luminosity of ∼1.6 × 10
41
erg s
−1
, followed by the longest plateau among LRNe to date, with a duration of 210 days. A late-time hump in the light curve was also observed, possibly produced by a shell-shell collision. AT 2021biy exhibits the typical spectral evolution of LRNe. Early-time spectra are characterised by a blue continuum and prominent H emission lines. Then, the continuum becomes redder, resembling that of a K-type star with a forest of metal absorption lines during the plateau phase. Finally, late-time spectra show a very red continuum (
T
BB
≈ 2050 K) with molecular features (e.g., TiO) resembling those of M-type stars. Spectropolarimetric analysis indicates that AT 2021biy has local dust properties similar to those of V838 Mon in the Milky Way Galaxy. Inspection of archival
Hubble
Space Telescope data taken on 2003 August 3 reveals a ∼20
M
⊙
progenitor candidate with log (
L
/
L
⊙
) = 5.0 dex and
T
eff
= 5900 K at solar metallicity. The above luminosity and colour match those of a luminous yellow supergiant. Most likely, this source is a close binary, with a 17–24
M
⊙
primary component.
Full text
Available for:
FMFMET, NUK, UL, UM, UPUK
The rare decay η ′ → π+ π− e+ e− is studied using a sample of 1.3 × 109 J / ψ events collected with the BESIII detector at BEPCII in 2009 and 2012. The branching fraction is measured with improved ...precision to be ( 2.42 ± 0.0 5stat ± 0.0 8syst) × 10−3. Due to the inclusion of new data, this result supersedes the last BESIII result on this branching fraction. In addition, the C P -violating asymmetry in the angle between the decay planes of the π+π− -pair and the e+e− -pair is investigated. A measurable value would indicate physics beyond the standard model; the result is ACP = ( 2.9 ± 3. 7stat ± 1. 1syst) % , which is consistent with the standard model expectation of no C P -violation. The precision is comparable to the asymmetry measurement in the K0L → π+π− e+e− decay where the observed (14 ± 2) % effect is driven by a standard model mechanism.
Full text
Available for:
CMK, CTK, FMFMET, IJS, NUK, PNG, UM
ABSTRACT
We present the Global Rapid Advanced Network Devoted to the Multi-messenger Addicts (GRANDMA). The network consists of 21 telescopes with both photometric and spectroscopic facilities. They ...are connected together thanks to a dedicated infrastructure. The network aims at coordinating the observations of large sky position estimates of transient events to enhance their follow-up and reduce the delay between the initial detection and optical confirmation. The GRANDMA programme mainly focuses on follow-up of gravitational-wave alerts to find and characterize the electromagnetic counterpart during the third observational campaign of the Advanced LIGO and Advanced Virgo detectors. But it allows for follow-up of any transient alerts involving neutrinos or gamma-ray bursts, even those with poor spatial localization. We present the different facilities, tools, and methods we developed for this network and show its efficiency using observations of LIGO/Virgo S190425z, a binary neutron star merger candidate. We furthermore report on all GRANDMA follow-up observations performed during the first six months of the LIGO–Virgo observational campaign, and we derive constraints on the kilonova properties assuming that the events’ locations were imaged by our telescopes.
PDF
