The majority of OA journals appear to be gratis rather than libre--as of August 2011 only 1,549 (22%) of the 6,922 journals in the Directory of Open Access Journals (DOAJ) were licensed under ...Creative Commons, and some of these licenses contained non-commercial or non-derivative clauses. ...the reader may not be free to do what they wish with the text or data as per the OKD. In terms of our primary aim of providing tools, apps, and datasets for generating, discovering, and reusing open data, ideas are flowing continuously but require the input of the wider scientific community in identifying the problems they face in publishing, discovering, and reusing data online and requesting assistance in solving them.
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With the current rapid spread of COVID-19, global health systems are increasingly overburdened by the sheer number of people that need diagnosis, isolation and treatment. Shortcomings are evident ...across the board, from staffing, facilities for rapid and reliable testing to availability of hospital beds and key medical-grade equipment. The scale and breadth of the problem calls for an equally substantive response not only from frontline workers such as medical staff and scientists, but from skilled members of the public who have the time, facilities and knowledge to meaningfully contribute to a consolidated global response. Here, we summarise community-driven approaches based on Free and Open Source scientific and medical Hardware (FOSH) as well as personal protective equipment (PPE) currently being developed and deployed to support the global response for COVID-19 prevention, patient treatment and diagnostics.
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Epidemiological research has shown that hallucinations and delusions, the classic symptoms of psychosis, are far more prevalent in the population than actual psychotic disorder. These symptoms are ...especially prevalent in childhood and adolescence. Longitudinal research has demonstrated that psychotic symptoms in adolescence increase the risk of psychotic disorder in adulthood. There has been a lack of research, however, on the immediate clinicopathological significance of psychotic symptoms in adolescence.
To investigate the relationship between psychotic symptoms and non-psychotic psychopathology in community samples of adolescents in terms of prevalence, co-occurring disorders, comorbid (multiple) psychopathology and variation across early v. middle adolescence.
Data from four population studies were used: two early adolescence studies (ages 11-13 years) and two mid-adolescence studies (ages 13-16 years). Studies 1 and 2 involved school-based surveys of 2243 children aged 11-16 years for psychotic symptoms and for emotional and behavioural symptoms of psychopathology. Studies 3 and 4 involved in-depth diagnostic interview assessments of psychotic symptoms and lifetime psychiatric disorders in community samples of 423 children aged 11-15 years.
Younger adolescents had a higher prevalence (21-23%) of psychotic symptoms than older adolescents (7%). In both age groups the majority of adolescents who reported psychotic symptoms had at least one diagnosable non-psychotic psychiatric disorder, although associations with psychopathology increased with age: nearly 80% of the mid-adolescence sample who reported psychotic symptoms had at least one diagnosis, compared with 57% of the early adolescence sample. Adolescents who reported psychotic symptoms were at particularly high risk of having multiple co-occurring diagnoses.
Psychotic symptoms are important risk markers for a wide range of non-psychotic psychopathological disorders, in particular for severe psychopathology characterised by multiple co-occurring diagnoses. These symptoms should be carefully assessed in all patients.
Certain strains of the intracellular endosymbiont Wolbachia can strongly inhibit or block the transmission of viruses such as dengue virus (DENV) by Aedes mosquitoes, and the mechanisms responsible ...are still not well understood. Direct infusion and liquid chromatography-Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry-based lipidomics analyses were conducted using Aedes albopictus Aa23 cells that were infected with the wMel and wMelPop strains of Wolbachia in comparison to uninfected Aa23-T cells. Substantial shifts in the cellular lipid profile were apparent in the presence of Wolbachia Most significantly, almost all sphingolipid classes were depleted, and some reductions in diacylglycerols and phosphatidylcholines were also observed. These lipid classes have previously been shown to be selectively enriched in DENV-infected mosquito cells, suggesting that Wolbachia may produce a cellular lipid environment that is antagonistic to viral replication. The data improve our understanding of the intracellular interactions between Wolbachia and mosquitoes.
Mosquitoes transmit a variety of important viruses to humans, such as dengue virus and Zika virus. Certain strains of the intracellular bacterial genus called Wolbachia found in or introduced into mosquitoes can block the transmission of viruses, including dengue virus, but the mechanisms responsible are not well understood. We found substantial shifts in the cellular lipid profiles in the presence of these bacteria. Some lipid classes previously shown to be enriched in dengue virus-infected mosquito cells were depleted in the presence of Wolbachia, suggesting that Wolbachia may produce a cellular lipid environment that inhibits mosquito-borne viruses.
We clarify that management scholars do not have a shared conceptualization of what the terms micro and macro mean. Therefore, there is not one, but rather there are multiple micro—macro divides ...within management. Specifically, there are three micro—macro divides that separate scholarship at three levels of the social and economic systems that management scholars study. These system levels include individuals and groups, organizations, and the broader social and economic systems (which contain individuals and organizations—such as industries, labor markets, and societies). Scholarship at these three system levels is often based in different disciplines. For example, scholarship on individuals and groups is often based in psychology whereas scholarship regarding organizations and social and economic systems is often based in economics or sociology. Yet there are fundamental differences in the theoretical assumptions and methodological traditions underlying these disciplines. We call these differences disciplinary divides and argue that because disciplinary divides oftentimes coexist with system-level divides, scholars bridging system levels need to be cognizant of disciplinary divides. The purpose of this article is to help scholars bridge these divides. To this end, we first identify the nature and specific types of divides. We then present a content analysis of 300 articles as a snapshot of the extent to which bridging scholarship is conducted. Finally, we provide a road-map that details the specific intellectual steps required to bridge system-level and disciplinary divides and make one’s scholarship more accessible to scholars from other disciplines and management subdomains.
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The search for biomarkers for autism spectrum disorder (henceforth autism) has received a lot of attention due to their potential clinical relevance. The clinical and aetiological heterogeneity of ...autism suggests the presence of subgroups. The lack of identification of a valid diagnostic biomarker for autism, and the inconsistencies seen in studies assessing differences between autism and typically developing control groups, may be partially explained by the vast heterogeneity observed in autism. The focus now is to better understand the clinical and biological heterogeneity and identify stratification biomarkers, which are measures that describe subgroups of individuals with shared biology. Using stratification approaches to assess treatment within pre-defined subgroups could clarify who may benefit from different treatments and therapies, and ultimately lead to more effective individualised treatment plans.
Nanostructured composites of inorganic and organic materials are attracting extensive interest for electronic and optoelectronic device applications. In this paper, we introduce a general method for ...the fabrication of metal sulfide nanoparticle/polymer films employing a low-cost and low temperature route compatible with large-scale device manufacturing. Our approach is based upon the controlled in situ thermal decomposition of a solution processable metal xanthate precursor complex in a semiconducting polymer film. To demonstrate the versatility of our method, we fabricate a CdS/P3HT nanocomposite film and show that the metal sulfide network inside the polymer film assists in the absorption of visible light and enables the achievement of high yields of charge photogeneration at the CdS/P3HT heterojunction. Photovoltaic devices based upon such nanocomposite films show solar light to electrical energy conversion efficiencies of 0.7% under full AM1.5 illumination and 1.2% under 10% incident power, demonstrating the potential of such nanocomposite films for low-cost photovoltaic devices.
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Nine new transition‐metal dithiocarbamates involving ferrocene (Fc), namely, M(FcCH2Bzdtc)2 (M=NiII (1), CuII (2), CdII (3), HgII (4), PdII (5), PtII (6) and PbII (7); Bzdtc=N‐benzyl dithiocarbamate) ...and M(FcCH2Bzdtc)3 (M=CoII (8) and UO2VI (9)), have been synthesised and characterised by micro analyses, IR spectroscopy, 1H and 13C NMR spectroscopy, and in three cases by single‐crystal X‐ray analysis. The peak broadening in the 1H spectrum of the copper complex indicates the paramagnetic behaviour of this compound. A square‐planar geometry around the nickel and copper complexes and distorted linear geometry around the mercury complex have been found. The latter geometry is attributed to the bulkiness of the methylferrocenyl and benzyl groups. The observed single quasi‐reversible cyclic voltammograms for complexes 2, 8 and 9 indicate the stabilisation of a metal centre other than Fe in their characteristic oxidation state. These complexes have been used as a photosensitiser in dye‐sensitised solar cells.
Making light work: Nine transition‐metal dithiocarbamate complexes possessing ferrocenyl groups have been synthesised and their electrochemical and light‐harvesting properties studied. The square‐planar complexes containing NiII, CuII and PtII show the best performance for use in dye‐sensitised solar cells (see picture).
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Traumatic brain injury (TBI) is known to lead to a range of adverse psychiatric sequelae but the question of whether TBI is a risk factor for psychosis and, in particular, schizophrenia remains ...unclear. Studies examining this issue have yielded conflicting results. We carried out a systematic review of the literature on TBI and psychosis in order to identify all population-based controlled studies which provide estimates of risk for schizophrenia following TBI. Odds ratios (ORs) were combined using random effects meta-analysis. Our literature search yielded 172 studies which were considered to be potentially relevant. From these, we identified 9 studies that could provide estimates of risk in the form of ORs. The pooled analysis revealed a significant association between TBI and schizophrenia (OR = 1.65; 95% CI = 1.17-2.32), with significant heterogeneity between the studies. Estimates from the family studies (OR = 2.8: 95% CI =1.76-4.47) were higher than those from the cohort/nested case-control studies (OR = 1.42: 95% CI = 1.02-1.97) by a factor of almost 2. There did not appear to be a dose-response relationship between severity of head injury and subsequent risk of schizophrenia. This meta-analysis supports an increased risk of schizophrenia following TBI, with a larger effect in those with a genetic predisposition to psychosis. Further epidemiological and neuroscientific studies to elucidate the mechanisms underlying this association are warranted.
When firms create value with employees' human capital, who captures this value—employees or their employing firms? This paper explains that the answer to this question depends both on the type of ...human capital deployed and characteristics of the labor market from which the firm hired the employees. When labor markets are highly competitive, individuals will capture more of the value their general human capital and discretionary firm-specific human capital creates, and firms and individuals will share the value created by required firm-specific and co-specialized human capital. When labor markets are less competitive, who captures the value created with a particular type of human capital depends on the reasons why the labor market is less competitive and each party's bargaining power and negotiation skill. The paper closes with the implications of the theory developed in this paper for human resources, organizational behavior, and strategic management scholarship and practice.
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