We present the first study of the evolution of the galaxy luminosity and
stellar-mass functions (GLF and GSMF) carried out by the Dark Energy Survey
(DES). We describe the COMMODORE galaxy catalogue ...selected from Science
Verification images. This catalogue is made of $\sim 4\times 10^{6}$ galaxies
at $0<z\lesssim1.3$ over a sky area of $\sim155\ {\rm sq. \ deg}$ with ${\it
i}$-band limiting magnitude ${\it i}=23\ {\rm mag}$. Such characteristics are
unprecedented for galaxy catalogues and they enable us to study the evolution
of GLF and GSMF at $0<z<1$ homogeneously with the same statistically-rich
data-set and free of cosmic variance effects. The aim of this study is twofold:
i) we want to test our method based on the use of photometric-redshift
probability density functions against literature results obtained with
spectroscopic redshifts; ii) we want to shed light on the way galaxies build up
their masses over cosmic time. We find that both the ${\it i}$-band galaxy
luminosity and stellar mass functions are characterised by a double-Schechter
shape at $z<0.2$. Both functions agree well with those based on spectroscopic
redshifts. The DES GSMF agrees especially with those measured for the GAlaxy
Mass Assembly and the PRism MUlti-object Survey out to $z\sim1$. At $0.2<z<1$,
we find the ${\it i}$-band luminosity and stellar-mass densities respectively
to be constant ($\rho_{\rm L}\propto (1+z)^{-0.12\pm0.11}$) and decreasing
($\rho_{\rm Mstar}\propto (1+z)^{-0.5\pm0.1}$) with $z$. This indicates that,
while at higher redshift galaxies have less stellar mass, their luminosities do
not change substantially because of their younger and brighter stellar
populations. Finally, we also find evidence for a top-down mass-dependent
evolution of the GSMF.
Purpose: We designed a prospective single arm Phase II study to evaluate the feasibility and mechanisms of apoptosis induction after
Ad-p53 ( INGN 201 ) gene transfer and radiation therapy in ...patients with non-small cell lung cancer.
Experimental Design: Nineteen patients with nonmetastatic non-small cell lung cancer who were not eligible for chemoradiation or surgery were
treated as outpatients with radiation therapy to 60 Gy over 6 weeks in conjunction with three intratumoral injections of Ad-p53 ( INGN 201 ) on days 1, 18, and 32.
Results: Seventeen of 19 patients completed all planned radiation and Ad-p53 ( INGN 201 ) gene therapy as outpatients. The most common adverse events were grade 1 or 2 fevers (79%) and chills (53%). Three months
after completion of therapy, pathologic biopsies of the primary tumor revealed no viable tumor (12 of 19 patients, 63%), viable
tumor (3 of 19 patients, 16%), and not assessed (4 of 19 patients, 21%). Computed tomography and bronchoscopic findings at
the primary injected tumor revealed complete response (1 of 19 patients, 5%), partial response (11 of 19 patients, 58%), stable
disease (3 of 19 patients, 16%), progressive disease (2 of 19 patients, 11%), and not evaluable (2 of 19 patients, 11%). Quantitative
reverse transcription-PCR analysis of the four p53 related genes p21 ( CDKN1A ), FAS , BAK , and MDM2 revealed that Bak expression was increased significantly 24 h after Ad-p53 ( INGN 201 ) injection and levels of CDKN1A and MDM2 expression were increased over the course of treatment.
Conclusions: Intratumoral injection of Ad-p53 ( INGN 201 ) in combination with radiation therapy is well tolerated and demonstrates evidence of tumor regression at the primary injected
tumor. Serial biopsies of the tumor suggest that BAK gene expression is most closely related to Ad-p53 ( INGN 201 ) gene transfer.
We present the first study of the evolution of the galaxy luminosity and stellar-mass functions (GLF and GSMF) carried out by the Dark Energy Survey (DES). We describe the COMMODORE galaxy catalogue ...selected from Science Verification images. This catalogue is made of \(\sim 4\times 10^{6}\) galaxies at \(0<z\lesssim1.3\) over a sky area of \(\sim155\ {\rm sq. \ deg}\) with \({\it i}\)-band limiting magnitude \({\it i}=23\ {\rm mag}\). Such characteristics are unprecedented for galaxy catalogues and they enable us to study the evolution of GLF and GSMF at \(0<z<1\) homogeneously with the same statistically-rich data-set and free of cosmic variance effects. The aim of this study is twofold: i) we want to test our method based on the use of photometric-redshift probability density functions against literature results obtained with spectroscopic redshifts; ii) we want to shed light on the way galaxies build up their masses over cosmic time. We find that both the \({\it i}\)-band galaxy luminosity and stellar mass functions are characterised by a double-Schechter shape at \(z<0.2\). Both functions agree well with those based on spectroscopic redshifts. The DES GSMF agrees especially with those measured for the GAlaxy Mass Assembly and the PRism MUlti-object Survey out to \(z\sim1\). At \(0.2<z<1\), we find the \({\it i}\)-band luminosity and stellar-mass densities respectively to be constant (\(\rho_{\rm L}\propto (1+z)^{-0.12\pm0.11}\)) and decreasing (\(\rho_{\rm Mstar}\propto (1+z)^{-0.5\pm0.1}\)) with \(z\). This indicates that, while at higher redshift galaxies have less stellar mass, their luminosities do not change substantially because of their younger and brighter stellar populations. Finally, we also find evidence for a top-down mass-dependent evolution of the GSMF.
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