Background
This study marks the first epidemiological evaluation of the prevalence and burden of chronic neuropathic pain (NeP) in an Asian population. The objective of this nationwide ...cross‐sectional study was to identify the characteristics of individuals with NeP, detect the NeP features that affect their quality of life (QOL), and demonstrate the negative effects of NeP on social and daily living as well as comorbidities including depression, anxiety and sleep disorders.
Methods
We mailed a cross‐sectional, population‐based epidemiological survey to a random nationwide sample of 10,000 Japanese adults over 20 years old.
Results
The response rate was 54.4% (2445 men, 2992 women; mean age, 53.4 years). Prevalence of chronic pain was 16.6%, and prevalence of NeP was 3.2% as detected by the PainDETECT. Participants with NeP showed significantly lower quality of life according to scores on the EuroQol‐5 Dimensions scale (p < 0.001), higher levels of psychological distress on the Kessler 6‐item psychological distress scale (p < 0.001), poorer sleep quality (p < 0.001), and more workdays lost (p < 0.001) than did participants without NeP. Linear regression modelling showed that widespread pain, thermal hyperalgesia and pressure‐induced pain had strong associations with lower QOL, with regression coefficients of −0.046 (p < 0.001), −0.038 (p < 0.001), and −0.040 (p < 0.001), respectively.
Conclusions
This study is the first to report the prevalence of NeP in an Asian population using a validated questionnaire. This study provides compelling evidence that chronic NeP is more strongly associated with poorer QOL, mental health and social well‐being than CP without a neuropathic component.
Significance
This population‐based nationwide epidemiological study revealed the prevalence, characteristics, and negative effects of chronic pain with neuropathic components in Asian society. The prevalence of neuropathic pain was 3.2% with PainDETECT.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
We present Magnetospheric Multiscale observations of an electron‐scale reconnecting current sheet in the mixing region along the trailing edge of a Kelvin‐Helmholtz vortex during southward ...interplanetary magnetic field conditions. Within this region, we observe intense electrostatic wave activity, consistent with lower‐hybrid waves. These waves lead to the transport of high‐density magnetosheath plasma across the boundary layer into the magnetosphere and generate a mixing region with highly compressed magnetic field lines, leading to the formation of a thin current sheet associated with electron‐scale reconnection signatures. Consistencies between these reconnection signatures and a realistic, local, fully‐kinetic simulation modeling this current sheet indicate a temporal evolution of the observed electron‐scale reconnection current sheet. The multi‐scale and inter‐process character of this event can help us understand plasma mixing connected to the Kelvin‐Helmholtz instability and the temporal evolution of electron‐scale reconnection.
Plain Language Summary
Like wind blowing over water, the stream of ionized gas released from the Sun, called the solar wind, can lead to waves and rolled‐up vortex structures at the boundary of Earth's magnetosphere, called the magnetopause. These so‐called Kelvin‐Helmholtz waves have been shown to be connected to various different plasma processes on different scales. This multi‐scale and multi‐process character makes them an ideal candidate to study the relation between these processes from both spacecraft observations and simulations. By using spacecraft data from the Magnetospheric Multiscale mission, which was designed for the study of small‐scale plasma processes in Earth's magnetosphere, we show observations of electron‐scale magnetic reconnection, an explosive energy conversion process in plasmas, in a region along the trailing edge of these waves. These observations shed new light on the multi‐scale and multi‐process character of the Kelvin‐Helmholtz instability and the energy conversion processes along its boundary.
Key Points
A reconnecting electron‐scale current sheet is observed by Magnetospheric Multiscale (MMS) in mixing plasma along the trailing edge of a Kelvin‐Helmholtz vortex
Realistic 2.5D fully‐kinetic simulation shows reasonable agreement with MMS data
Consistencies between the simulation and MMS indicate a temporal evolution of the reconnecting current sheet
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
We present Very Long Baseline Array polarimetric observations of the innermost jet of 3C 84 (NGC 1275) at 43 GHz. A significant polarized emission is detected at the hotspot of the innermost ...restarted jet, which is located 1 pc south from the radio core. While the previous report presented a hotspot at the southern end of the western limb, the hotspot location has been moved to the southern end of the eastern limb. Faraday rotation is detected within an entire bandwidth of the 43 GHz band. The measured rotation measure (RM) is at most (6.3 1.9) × 105 rad m−2 and might be slightly time variable on the timescale of a month by a factor of a few. Our measured RM and the RM previously reported by the CARMA and SMA observations cannot be consistently explained by the spherical accretion flow with a power-law profile. We propose that a clumpy/inhomogeneous ambient medium is responsible for the observed RM. Using an equipartition magnetic field, we derive the electron density of 2 × 104 cm−3. Such an electron density is consistent with the cloud of the narrow line emission region around the central engine. We also discuss the magnetic field configuration from the black hole scale to the parsec scale and the origin of low polarization.
Longwave Infrared Camera (LIR) on board Akatsuki first revealed the global structure of the thermal tides in the upper cloud layer of Venus. The data were acquired over three Venusian years, and the ...analysis was done over the areas from the equator to the midlatitudes in both hemispheres and over the whole local time. Thermal tides at two vertical levels were analyzed by comparing data at two different emission angles. Dynamical wave modes consisting of tides were identified; the diurnal tide consisted mainly of Rossby‐wave and gravity‐wave modes, while the semidiurnal tide predominantly consisted of a gravity‐wave mode. The revealed vertical structures were roughly consistent with the above wave modes, but some discrepancy remained if the waves were supposed to be monochromatic. In turn, the heating profile that excites the tidal waves can be constrained to match this discrepancy, which would greatly advance the understanding of the Venusian atmosphere.
Plain Language Summary
On Venus, the atmosphere circulates 60 times faster than the solid body of Venus; this phenomenon is called “superrotation,” and it is one of the mysteries of the Venusian atmosphere. To maintain the fast circulation, thermal tides, which are global‐scale atmospheric waves excited by solar heating, have been considered a very important candidate because they have the ability of accelerating the atmosphere through propagating. A midinfrared camera onboard the Japanese Venus orbiter, Akatsuki, can capture temperature perturbations due to the thermal tides in the upper cloud level (60‐ to 70‐km altitude), and it revealed their global and vertical structures with a long‐term observation (more than three Venusian years) for the first time. Interestingly, we found that the location of the maximum temperature at the cloud top level was different from noon where solar energy input is at a maximum. In addition, the location was shifted toward the morning side as the sensing altitude increased. This finding is an evidence of the vertical traveling of the thermal tides, indicating the wave's atmospheric acceleration.
Key Points
Akatsuki/LIR revealed the global structures of thermal tides across the equator in the upper cloud layer of Venus for the first time
Using the emission angle dependence of LIR's sensing altitude, upward propagation of the semidiurnal tide was confirmed
Wave types consisting of the thermal tides were identified
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Summary
The objective of this study is to assess and quantify the risk for gestational diabetes mellitus (GDM) according to prepregnancy maternal body mass index (BMI). The design is a systematic ...review of observational studies published in the last 30 years. Four electronic databases were searched for publications (1977–2007). BMI was elected as the only measure of obesity, and all diagnostic criteria for GDM were accepted. Studies with selective screening for GDM were excluded. There were no language restrictions. The methodological quality of primary studies was assessed. Some 1745 citations were screened, and 70 studies (two unpublished) involving 671 945 women were included (59 cohorts and 11 case–controls). Most studies were of high or medium quality. Compared with women with a normal BMI, the unadjusted pooled odds ratio (OR) of an underweight woman developing GDM was 0.75 (95% confidence interval CI 0.69 to 0.82). The OR for overweight, moderately obese and morbidly obese women were 1.97 (95% CI 1.77 to 2.19), 3.01 (95% CI 2.34 to 3.87) and 5.55 (95% CI 4.27 to 7.21) respectively. For every 1 kg m−2 increase in BMI, the prevalence of GDM increased by 0.92% (95% CI 0.73 to 1.10). The risk of GDM is positively associated with prepregnancy BMI. This information is important when counselling women planning a pregnancy.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
When the interplanetary magnetic field (IMF) is strongly northward, a boundary layer that contains a considerable amount of plasma of magnetosheath origin is often observed along and earthward of the ...low‐latitude magnetopause. Such a preexisting boundary layer, with a higher density than observed in the adjacent magnetosphere, reduces the local Alfvén speed and allows the Kelvin–Helmholtz (KH) instability to grow more strongly. We employ a three‐dimensional fully kinetic simulation to model an event observed by the Magnetospheric Multiscale (MMS) mission in which the spacecraft detected substantial KH waves between a preexisting boundary layer and the magnetosheath during strong northward IMF. Initial results of this simulation have successfully demonstrated ion‐scale signatures of magnetic reconnection induced by the nonlinearly developed KH vortex, which are quantitatively consistent with MMS observations. We further quantify the simulated mass and energy transfer processes driven by this vortex‐induced reconnection (VIR) and show that during this particular MMS event, (i) mass enters a new mixing layer formed by the VIR more efficiently from the preexisting boundary layer side than from the magnetosheath side, (ii) mixed plasmas within the new mixing layer convect tailward along the magnetopause at more than half the magnetosheath flow speed, and (iii) energy dissipation in localized VIR dissipation regions results in a strong parallel electron heating within the mixing layer. The quantitative agreements between the simulation and MMS observations allow new predictions that elucidate how the mass and energy transfer processes occur near the magnetopause during strong northward IMF.
Key Points
A 3‐D fully kinetic simulation of an MMS vortex‐induced reconnection event is analyzed and compared with MMS observations
The simulation is in excellent agreement with the MMS observations on quantities of the electron‐scale reconnection dissipation region
The simulation predicts the formation of a new thick mixing layer with strong parallel electron heating along the flank magnetopause
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Telomerase is a reverse transcriptase complex that ensures stable maintenance of linear eukaryotic chromosome ends by overcoming the end replication problem, posed by the inability of replicative DNA ...polymerases to fully replicate linear DNA. The catalytic subunit TERT must be assembled properly with its telomerase RNA for telomerase to function, and studies in Tetrahymena have established that p65, a La-related protein 7 (LARP7) family protein, utilizes its C-terminal xRRM domain to promote assembly of the telomerase ribonucleoprotein (RNP) complex. However, LARP7-dependent telomerase complex assembly has been considered as unique to ciliates that utilize RNA polymerase III to transcribe telomerase RNA. Here we show evidence that fission yeast Schizosaccharomyces pombe utilizes the p65-related protein Pof8 and its xRRM domain to promote assembly of RNA polymerase II-encoded telomerase RNA with TERT. Furthermore, we show that Pof8 contributes to repression of the transcription of noncoding RNAs at telomeres.
We identify the electron diffusion region (EDR) of a guide field dayside reconnection site encountered by the Magnetospheric Multiscale (MMS) mission and estimate the terms in generalized Ohm's law ...that controlled energy conversion near the X‐point. MMS crossed the moderate‐shear (∼130°) magnetopause southward of the exact X‐point. MMS likely entered the magnetopause far from the X‐point, outside the EDR, as the size of the reconnection layer was less than but comparable to the magnetosheath proton gyroradius, and also as anisotropic gyrotropic “outflow” crescent electron distributions were observed. MMS then approached the X‐point, where all four spacecraft simultaneously observed signatures of the EDR, for example, an intense out‐of‐plane electron current, moderate electron agyrotropy, intense electron anisotropy, nonideal electric fields, and nonideal energy conversion. We find that the electric field associated with the nonideal energy conversion is (a) well described by the sum of the electron inertial and pressure divergence terms in generalized Ohms law though (b) the pressure divergence term dominates the inertial term by roughly a factor of 5:1, (c) both the gyrotropic and agyrotropic pressure forces contribute to energy conversion at the X‐point, and (d) both out‐of‐the‐reconnection‐plane gradients (∂/∂M) and in‐plane (∂/∂L,N) in the pressure tensor contribute to energy conversion near the X‐point. This indicates that this EDR had some electron‐scale structure in the out‐of‐plane direction during the time when (and at the location where) the reconnection site was observed.
Key Points
We analyze MMS data measured during a slow crossing of the density‐asymmetric magnetopause
Ion and electron dynamics are consistent with a normal crossing of an inner diffusion region
J→·E→′ appeared to result from in and out‐of‐plane gradients of gyrotropic and agyrotropic electron pressure tensor
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Strongly correlated electron systems often exhibit very strong interactions between structural and electronic degrees of freedom that lead to complex and interesting phase diagrams. For technological ...applications of these materials it is important to learn how to drive transitions from one phase to another. A key question here is the ultimate speed of such phase transitions, and to understand how a phase transition evolves in the time domain. Here we apply time-resolved X-ray diffraction to directly measure the changes in long-range order during ultrafast melting of the charge and orbitally ordered phase in a perovskite manganite. We find that although the actual change in crystal symmetry associated with this transition occurs over different timescales characteristic of the many electronic and vibrational coordinates of the system, the dynamics of the phase transformation can be well described using a single time-dependent 'order parameter' that depends exclusively on the electronic excitation.
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IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
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