This research examines the relationship between policy uncertainty and mergers and acquisitions (M&As). We find that policy uncertainty is negatively related to firm acquisitiveness and positively ...related to the time it takes to complete M&A deals. In addition, policy uncertainty motivates acquirers to use stock for payment and to pay lower bid premiums. Acquirers, on average, create larger shareholder value from M&A deals undertaken during periods of high policy uncertainty, which is attributable to their prudence as well as the wealth transfer from the financially constrained targets to acquirers.
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BFBNIB, CEKLJ, INZLJ, IZUM, KILJ, NMLJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK, ZRSKP
Fine-tuned ion transport across nanoscale pores is key to many biological processes, including neurotransmission. Recent advances have enabled the confinement of water and ions to two dimensions, ...unveiling transport properties inaccessible at larger scales and triggering hopes of reproducing the ionic machinery of biological systems. Here we report experiments demonstrating the emergence of memory in the transport of aqueous electrolytes across (sub)nanoscale channels. We unveil two types of nanofluidic memristors depending on channel material and confinement, with memory ranging from minutes to hours. We explain how large time scales could emerge from interfacial processes such as ionic self-assembly or surface adsorption. Such behavior allowed us to implement Hebbian learning with nanofluidic systems. This result lays the foundation for biomimetic computations on aqueous electrolytic chips.
Summary
Background
Transient receptor potential vanilloid subfamily, member 1 (TRPV1) may play an important role in pruritus and inflammation induction in atopic dermatitis (AD). The treatment effect ...of TRPV1 antagonist via topical application in patients with AD remains unknown.
Objectives
To assess the clinical efficacy and safety of PAC‐14028, a TRPV1 antagonist, via topical application in patients with AD.
Methods
In this 8‐week, phase IIb, randomized, double‐blind, multicentre, vehicle‐controlled study, patients with mild‐to‐moderate AD were randomized to receive PAC‐14028 cream 0·1%, 0·3%, 1·0% or vehicle cream twice daily. The primary efficacy end point was the Investigator's Global Assessment (IGA) success rate defined as the percentage of patients with an IGA score of 0 or 1 at week 8. The secondary efficacy end points included the severity Scoring of Atopic Dermatitis (SCORAD) index and Eczema Area and Severity Index (EASI) 75/90.
Results
A total of 194 patients were enrolled. IGA success rates at week 8 were 14·58% for vehicle cream, 42·55% for PAC‐14028 cream 0·1% (P = 0·0025 vs. vehicle), 38·30% for PAC‐14028 cream 0·3% (P = 0·0087 vs. vehicle) and 57·45% for PAC‐14028 cream 1·0% (P < 0·001 vs. vehicle). In particular, statistically significant differences were found between the vehicle and treatment groups in the IGA success rates with two‐grade improvement. The SCORAD index, EASI 75/90, sleep disturbance score and pruritus visual analogue scale showed a trend towards improvement. No significant safety issues were reported.
Conclusions
PAC‐14028 cream may be an effective and safe treatment modality for the treatment of patients with mild‐to‐moderate AD.
What is already known about this topic?
Atopic dermatitis (AD) is one of the most common inflammatory skin diseases characterized by pruritic erythematous skin lesions and barrier dysfunction.
Transient receptor potential vanilloid subfamily, member 1 (TRPV1) antagonists suppress the release of pruritic and proinflammatory mediators.
The preclinical results demonstrate the feasibility of TRPV1 as a potential therapeutic target for the treatment of AD.
What does this study add?
TRPV1 regulates inflammation and pruritus in patients with AD.
PAC‐14028 cream, a novel TRPV1 antagonist, was superior to vehicle in improving clinical symptoms and signs with a favourable safety profile in adults with mild‐to‐moderate AD.
TRPV1 antagonism may play a role as a promising nonsteroidal topical treatment target for AD with a new mechanism of action.
Linked Editorial: Song and Armstrong. Br J Dermatol 2019; 180:971–972.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
In this paper, we represent a resolution for the hierarchy problem where the inverse size of the extra dimension and the fundamental Planck scale would all be of the order of the TeV scale by ...proposing a fiber fabric of spacetime. The origin of the large hierarchy is essentially due to the
cosh
function which is physically originated from the dynamics of the horizontal metric in the vacuum of non-zero energy. In addition, the fiber fabric of spacetime allows us to resolve elegantly and naturally the problems of the chirality fermions and stabilizing potential for the size of the extra dimension, which are usually encountered in the higher dimensional theories. Then, we explore the inflation with the modulus of the extra dimension identified as the inflaton where our slow-roll inflationary model belongs to the E-model class with
n
=
1
. We calculate the main inflationary observables which are consistent with the present experiments. Finally, we study how the geodesic motion of neutral test particles gets modified from the extension of spacetime. We compute the radius of the photon sphere, the innermost stable circular orbit, the perihelion shift, the light bending angle, and the observables of the strong gravitational lensing and the retrolensing phenomenon. By comparing the predicted values with the experimental observations, we determine the constraints on the fiber fabric of spacetime.
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By applying the island rule proposed recently, we compute the entanglement entropy of Hawking radiation and study the Page curve for the eternal black holes in massive gravity. We investigate for ...both the neutral and charged black holes which the corresponding results of Schwarzschild and Reissner–Nordström black holes are restored in the limit of massless graviton. We show for the neutral and non-extremal charged black holes that the island is not formed at the early times of the evaporation and hence the entanglement entropy increases linearly in time. However, for the extremal charged black hole, the calculation of the entanglement entropy at the early times without the island is ill-defined because the metric is divergent at the curvature singularity. This implies that new physics in the UV region must be taken into account to make the metric behaving smoothly at the very short distances. At the late times, with the emergence of one island near the event horizon, the entanglement entropy is saturated by the Bekenstein–Hawking entropy of black holes. In addition, we analyze the impact of massive gravity parameters on the size of island, the entanglement entropy, the Page time, and the scrambling time in detail.
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An anomaly observed recently in the
8
Be
nuclear transition by the Atomki collaboration hints at a weakly-coupled, light new gauge boson with a mass of about 17 MeV. In this paper, we propose that ...this new gauge boson comes from a short-distance structure of the spacetime, rather than from an extension of the Standard Model through adding an extra
U
(
1
)
gauge symmetry. The dominant contribution to the relevant matrix element of the
8
Be
nuclear transition is given by the axial couplings. In order to account for the
8
Be
anomaly and satisfy the current experimental constraints, the coupling constant of the new gauge boson should be about
O
(
10
-
4
-
10
-
5
)
. Our theoretical model allows understanding the origin of the smallness of the coupling constant, which is still missing or being incompletely understood in the models at which the new gauge boson has the axial couplings.
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Optimization for structural crashworthiness and energy absorption has become an important topic of research attributable to its proven benefits to public safety and social economy. This paper ...provides a comprehensive review of the important studies on design optimization for structural crashworthiness and energy absorption. First, the design criteria used in crashworthiness and energy absorption are reviewed and the surrogate modeling to evaluate these criteria is discussed. Second, multiobjective optimization, optimization under uncertainties and topology optimization are reviewed from concepts, algorithms to applications in relation to crashworthiness. Third, the crashworthy structures are summarized, from generically novel structural configurations to industrial applications. Finally, some conclusions and recommendations are provided to enable academia and industry to become more aware of the available capabilities and recent developments in design optimization for structural crashworthiness and energy absorption.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
We have derived a non-linear charged black hole solution, in the AdS spacetime, which behaves asymptotically like the RN-AdS black hole but at the short distances like a dS geometry. Thus, the black ...hole is regular. The thermodynamic quantities of the black hole are derived. Also, we analyzed in details the phase transitions of the black hole by observing the discontinuity of the heat capacity at constant pressure and the cusp type double points in the Gibbs free energy-temperature graph. Furthermore, the thermodynamic phases and their stability are investigated relying on the off-sell Gibbs free energy. Finally, we calculated the critical exponents characterizing the behavior of the relevant thermodynamic quantities near the critical point.
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In this paper, we have constructed a bottom-up holographic model for the color superconductivity (CSC) of the Yang-Mills theory with including the higher derivative corrections which allow us to ...study the CSC phase with the color number Nc ≥ 2 . First, we consider the CSC phase transition in the context of Einstein-Gauss-Bonnet (EGB) gravity. We analyze the Cooper pair condensate in the deconfinement and confinement phases which are dual to the planar GB-RN-AdS black hole and GB-AdS soliton, respectively, where the backreaction of the matter part is taken into account. By examining the breakdown of the Breitenlohner-Freedman bound in the background of the planar GB-RN-AdS black hole, we find that the positive GB coupling parameter α > 0 leads to a lower upper bound of the color number in comparison to Einstein gravity where the CSC phase for Nc ≥ 2 is not realized. But, with the α < 0 case it is possible to observe the Cooper pair condensate for Nc ≥ 2 with the reasonable magnitude of α . This is confirmed and the corresponding phase diagram is found by solving numerically the equations of motion for the gravitational system. In addition, we show that the CSC phase disappears in the confinement phase for the magnitude of α below a certain value which means that beyond that value it might lead to the breakdown region of the EGB gravity in investigating the CSC phase. However, the CSC phase transition occurring with Nc ≥ 2 requires the magnitude of the GB coupling parameter to be rather large. As a result, the GB term would no longer be considered as the correction and it also violates the boundary causality bound. We resolve this problem by including additionally the higher derivative correction for the Maxwell electrodynamics and the nonminimal coupled Maxwell field. Figure
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From solving the equations of the motion for a system of Einstein gravity coupled to a non-linear electromagnetic field in the dS spacetime with two integral constants, we derived a static and ...spherical symmetric non-linear magnetic-charged black hole. It is indicated that this black hole solution behaves like a dS geometry in the short-distance regime. And, thus this black hole is regular. The structure of the black hole horizons is studied in detail. Also, we investigated the thermodynamics and the thermal phase transition of the black hole in both the local and global views. By observing the discontinuous change of the specific heat sign and the swallowtail structure of the free energy, we showed that the black hole can undergo a thermal phase transition between a thermodynamically unstable phase and a thermodynamically stable phase.
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