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  • Anti-tumor immunity in mism... Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN-driven CCL5 and CXCL10
    Mowat, Courtney; Mosley, Shayla R; Namdar, Afshin ... The Journal of experimental medicine, 09/2021, Volume: 218, Issue: 9
    Journal Article
    Peer reviewed
    Open access

    Colorectal cancers (CRCs) deficient in DNA mismatch repair (dMMR) contain abundant CD8+ tumor-infiltrating lymphocytes (TILs) responding to the abundant neoantigens from their unstable genomes. ...
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  • Prostaglandin E2 as a poten... Prostaglandin E2 as a potent therapeutic target for treatment of colon cancer
    Karpisheh, Vahid; Nikkhoo, Afshin; Hojjat-Farsangi, Mohammad ... Prostaglandins & other lipid mediators, 10/2019, Volume: 144
    Journal Article
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    •Colon cancer in one of the main health-related problems which is incurable particularly in advanced stages.•Prostanoids and particularly prostaglandin E2 (PGE2) are important inflammatory lipid ...
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  • Erythroid Suppressor Cells ... Erythroid Suppressor Cells Compromise Neonatal Immune Response against Bordetella pertussis
    Dunsmore, Garett; Bozorgmehr, Najmeh; Delyea, Cole ... The Journal of immunology (1950), 09/2017, Volume: 199, Issue: 6
    Journal Article
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    Open access

    Newborns are highly susceptible to infection. The underlying mechanism of neonatal infection susceptibility has generally been associated with neonatal immune cell immaturity. In this study, we ...
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  • CD71+VISTA+ erythroid cells... CD71+VISTA+ erythroid cells promote the development and function of regulatory T cells through TGF-β
    Shahbaz, Shima; Bozorgmehr, Najmeh; Koleva, Petya ... PLoS biology, 12/2018, Volume: 16, Issue: 12
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    Open access

    Cell-surface transferrin receptor (CD71+) erythroid cells are abundant in newborns with immunomodulatory properties. Here, we show that neonatal CD71+ erythroid cells express significant levels of ...
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  • Circular RNAs in cancer: ne... Circular RNAs in cancer: new insights into functions and implications in ovarian cancer
    Shabaninejad, Zahra; Vafadar, Asma; Movahedpour, Ahmad ... Journal of ovarian research, 09/2019, Volume: 12, Issue: 1
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    Circular RNAs (circRNAs) are a class of long non-coding RNAs (lncRNAs) which have a circular and closed loop structure. They are ubiquitous, stable, conserved and diverse RNA molecules with a range ...
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  • Circulating microRNAs in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers
    Mirzaei, Hamid Reza; Sahebkar, Amirhossein; Mohammadi, Mohsen ... Current pharmaceutical design, 01/2016, Volume: 22, Issue: 34
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    Peer reviewed

    Hepatocellular carcinoma (HCC) is one of the most common types of malignancies worldwide. There is little information on the mechanisms involved in the pathogenesis of this disease. Diagnosis of HCC ...
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7.
  • CD71 + erythroid suppressor... CD71 + erythroid suppressor cells impair adaptive immunity against Bordetella pertussis
    Namdar, Afshin; Koleva, Petya; Shahbaz, Shima ... Scientific reports, 08/2017, Volume: 7, Issue: 1
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    Infant's immune system cannot control infection or respond to vaccination as efficiently as older individuals, a phenomenon that has been attributed to immunological immaturity. Recently, we ...
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  • Differential expression of ... Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells
    Santer, Deanna M; Minty, Gillian E S; Golec, Dominic P ... PLOS pathogens, 04/2020, Volume: 16, Issue: 4
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    Type III interferons (IFN-lambdas(λ)) are important cytokines that inhibit viruses and modulate immune responses by acting through a unique IFN-λR1/IL-10RB heterodimeric receptor. Until now, the ...
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  • Increased efficacy of a den... Increased efficacy of a dendritic cell–based therapeutic cancer vaccine with adenosine receptor antagonist and CD73 inhibitor
    Arab, Samaneh; Kheshtchin, Nasim; Ajami, Maryam ... Tumor biology, 03/2017, Volume: 39, Issue: 3
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    Dendritic cells are important in initiating immune responses; therefore, a range of dendritic cell–based approaches have been established to induce immune response against cancer cells. However, the ...
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  • The prognostic and therapeu... The prognostic and therapeutic potential of HO-1 in leukemia and MDS
    Sadeghi, Mohammad; Fathi, Mehrdad; Gholizadeh Navashenaq, Jamshid ... Cell communication and signaling, 03/2023, Volume: 21, Issue: 1
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    Heme oxygenase-1 (HO-1), a heme-degrading enzyme, is proven to have anti-apoptotic effects in several malignancies. In addition, HO-1 is reported to cause chemoresistance and increase cell survival. ...
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