Our objective of this study is to design and develop a polyethylene glycol (PEG2000)-modified multiwall carbon nanotube (PEGylated MWCNT) formulation for oral controlled metronomic chemotherapeutic ...drug delivery. Multiwall carbon nanotubes undergo various chemical modifications including oxidation with strong acids, conjugation of polyethylene glycol, and coating with cellulose acetate phthalate which resulted in the formation of aqueous dispersion and prevention of drug degradation in acidic environment. Advanced analytical procedure such as Fourier transform infra-red, X-ray diffraction, differential scanning calorimetry, thermal gravimetric analysis, transmission electron microscopy, and dynamic light scattering techniques were used to evaluate physicochemical characterization. We also performed in vitro cytotoxic study by MTT assay and results revealed that carboplatin-loaded PEGylated MWCNTs did not show significant detrimental effect on the viability of MDA-MB-231 (human breast cancer) cells. The maximum encapsulation and drug-loading capacity were determined to be 71.58 ± 0.04 and 39.62 ± 0.07%, respectively. The release of carboplatin from PEGylated MWCNTs was investigated at simulated intestinal fluid (SIF), pH 6.8, after optimizing at simulated gastric fluid (SGF), pH 1.2, by enteric coating. Enteric-coated PEGylated MWCNTs exhibit pH-responsive drug activity in a sustained manner especially at pH 6.8. This surface modification strongly suggests that PEGylated MWCNTs could be a potential carrier for metronomic chemotherapeutic agent for high drug resistance, drug with maximum adverse effect and poorly oral bioavailable drugs.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Chitosan (CS) is one of the most successfully developed biodegradable polymers. Among the numerous polymers developed to formulate polymeric nanoparticles, CS has fascinated considerable attention ...due to its appealing properties: (i) biodegradability and biocompatibility, (ii) FDA approval for wound dressings as well as in dietary application, (iii) non-toxicity, (v) scope of sustained release, (vi) probability to modify surface properties and (vii) scope of target nanoparticles (NPs) to particular organs or cells. This review presents different preparation methods of chitosan nanoparticles (CSNPs) from the methodological and mechanistic point of view. The crosslinking agent including aldehyde, tripolyphosphate (TPP), genipin and other cross linkers and the physicochemical behaviour of CSNPs including drug loading, drug release, particles size, zeta-potential and stability are briefly discussed. This review also presents why CS has been chosen to design nanoparticles (NPs) as drug delivery systems in various pharmaceutical applications.
Display omitted
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Chitosan (CS) is one of the most functional natural biopolymer widely used in the pharmaceutical field due to its biocompatibility and biodegradability. These privileges lead to its application in ...the synthesis of nanoparticles for the drug during the last two decades. This article gives rise to a general review of the different chitosan nanoparticles (CSNPs) preparation techniques: Ionic gelation, emulsion cross-linking, spray-drying, emulsion-droplet coalescence method, nanoprecipitation, reverse micellar method, desolvation method, modified ionic gelation with radial polymerisation and emulsion solvent diffusion, from the point of view of the methodological and mechanistic aspects involved. The physicochemical behaviour of CSNPs including drug loading, drug release, particles size, zeta potential and stability are briefly discussed. This review also directs to bring an outline of the major applications of CSNPs in drug delivery according to drug and route of administration. Finally, derivatives of CSNPs and CS nano-complexes are also discussed.
Full text
Available for:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Carbon Nanotubes (CNTs) have been frequently acquired as one of the fascinating and advanced nanocarriers for drug delivery and many potential applications due to its unique physicochemical ...properties. CNTs provided the high surface area for maximum drug loading capacity and ability to cross mammalian cell membranes and allow flexible nature through incorporating assorted functional groups and focused molecules at the constant time. However, an excessive amount of CNTs trigger undesirable toxicity at the sub-atomic cell and animal species which have been reported by many researchers. Despite that, available toxicological concerning about CNTs remains contradictory. Consequently, a systematic understanding of CNT toxicity is required. This review highlighted how several important factors (such as length, diameter, impurities, aggregation, protein corona, and surface modification) that can influence possible toxicological implications. In addition, we conclude the paper by outlining the development of various CNTs conjugated platinum (anti-cancer) drug, profitable for biomedical application and challenges involving CNTs based formulations.
Display omitted
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The purpose of this study was to develop and evaluate of gelatin nanoparticles (GNPs) by nanoprecipitation method to increase metoprolol succinate (MES) peroral bioavailability. Prepared GNPs were ...evaluated in terms of its properties such as particle size, zeta potential, entrapment efficiency, drug loading, in vitro drug release, morphologyand in-vivo pharmacokinetic studies. The GNPs showed sustain drug release in phosphate buffer (pH 7.4) while less release in the 0.1 N HCl as compared to plain MES. The in vivo pharmacokinetics study on rabbits showed a rise in the bioavailability of the GNPs by 2.27 folds as compared to marketed formulation. FTIR studies performed on the GNPs indicated no drug-polymer interaction. Nanoparticles (NPs) prepared by nanoprecipitation method were found to be clear (through SEM) and their mean particle size was in the range of 59.83±0.14 to156.41±0.19 nm. The F-3 formulation exhibited the highest entrapment of 98.07±0.53. Zeta potential of all GNPs was in the range of 11.66 to 14.50 mV which indicates that they are moderately stable. Release study revealed that GNPs release drug at a sustained rate which assists in the absorption of MES through the blood. Further, in vivo studies induced in increased bioavailability of the MES which established the potential of developed carrier systems. Thus, it can be concluded that these prepared NPs might be one of the best preparation for the delivery of MES for better therapeutic efficacy.
Display omitted
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Load filters
No result was selected!
Please select the results that you wish to export.
The search was successfully saved.
Editing
The search could not be saved.
Saved searches can be viewed in the list My searches.
The changes made to the saved search were saved successfully.
Save search
Shelf entry
No result was selected!
Adding material to shelf was successful.
Adding material to shelf was partly successful.
Adding material to shelf failed completely.
It was not necessary to add the material to the shelf.
Please select the results that you want to put on shelf!
On shelf the following records have been successfully added:
On shelf the following records have been successfully added:
