Schistosomiasis affects millions globally. There is no vaccine, and treatment depends entirely on praziquantel (PZQ). Field isolates exhibit reduced susceptibility to PZQ, and resistance has been ...experimentally induced, suggesting that reliance on a single treatment is particularly dangerous. The present study investigated the value of cinnarizine and griseofulvin against Schistosoma mansoni through their in vitro effects on adult worms and oviposition as well as in vivo evaluation in early and late infection, compared to PZQ, in a preliminary experimental model. In vitro, both cinnarizine and griseofulvin showed uncoupling, sluggish worm movement and complete absence of ova at 100 μg/ml. In early infection, cinnarizine showed a significant reduction in the number of porto-mesenteric couples compared to the griseofulvin and control groups, a finding similar to PZQ. Remarkably, cinnarizine significantly exceeded PZQ and griseofulvin in reducing the total worm burden. In late infection, cinnarizine and griseofulvin showed results similar to PZQ by significantly reducing the numbers of hepatic and porto-mesenteric couples and total worm burden compared to controls. Cinnarizine performed better than griseofulvin by reducing hepatic and intestinal ovum counts, and it led to complete disappearance of the first two immature stages. The current work suggests the possibility of using cinnarizine and griseofulvin, mainly in late S. mansoni infection, especially cinnarizine, which showed similar results to PZQ and surpassed it in early infection. Further studies are required to elucidate their exact mechanisms of action and particularly their synergistic effect with PZQ.
Abstract
The search for a dark photon holds considerable interest in the physics community. Such a force carrier would begin to illuminate the dark sector. Many experiments have searched for such a ...particle, but so far it has proven elusive. In recent years the concept of a low mass dark photon has gained popularity in the physics community. Of particular recent interest is the
8
Be and
4
He anomaly, which could be explained by a new fifth force carrier with a mass of 17 MeV/
c
2
. The proposed Darklight experiment would search for this potential low mass force carrier at ARIEL in the 10-20 MeV/
c
2
e
+
e
−
invariant mass range. This proceeding will focus on the experimental design and physics case of the Darklight experiment.
Elastic electron-proton scattering (e-p) and the spectroscopy of hydrogen atoms are the two methods traditionally used to determine the proton charge radius, r
. In 2010, a new method using muonic ...hydrogen atoms
found a substantial discrepancy compared with previous results
, which became known as the 'proton radius puzzle'. Despite experimental and theoretical efforts, the puzzle remains unresolved. In fact, there is a discrepancy between the two most recent spectroscopic measurements conducted on ordinary hydrogen
. Here we report on the proton charge radius experiment at Jefferson Laboratory (PRad), a high-precision e-p experiment that was established after the discrepancy was identified. We used a magnetic-spectrometer-free method along with a windowless hydrogen gas target, which overcame several limitations of previous e-p experiments and enabled measurements at very small forward-scattering angles. Our result, r
= 0.831 ± 0.007
± 0.012
femtometres, is smaller than the most recent high-precision e-p measurement
and 2.7 standard deviations smaller than the average of all e-p experimental results
. The smaller r
we have now measured supports the value found by two previous muonic hydrogen experiments
. In addition, our finding agrees with the revised value (announced in 2019) for the Rydberg constant
-one of the most accurately evaluated fundamental constants in physics.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The two-photon exchange experiment at DESY Alarcon, R.; Beck, R.; Bernauer, J. C. ...
The European physical journal. A, Hadrons and nuclei,
04/2024, Volume:
60, Issue:
4
Journal Article
Peer reviewed
Open access
We propose a new measurement of the ratio of positron-proton to electron-proton elastic scattering at DESY. The purpose is to determine the contributions beyond single-photon exchange, which are ...essential for the Quantum Electrodynamic (QED) description of the most fundamental process in hadronic physics. By utilizing a 20 cm long liquid hydrogen target in conjunction with the extracted beam from the DESY synchrotron, we can achieve an average luminosity of
2.12
×
10
35
cm
-
2
·
s
-
1
(
≈
200
times the luminosity achieved by OLYMPUS). The proposed two-photon exchange experiment (TPEX) entails a commissioning run at a beam energy of 2 GeV, followed by measurements at 3 GeV, thereby providing new data up to
Q
2
=
4.6
(GeV/
c
)
2
(twice the range of current measurements). We present and discuss the proposed experimental setup, run plan, and expectations.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
5.
Timing detectors with SiPM read-out for the MUSE experiment at PSI Rostomyan, T.; Cline, E.; Lavrukhin, I. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
01/2021, Volume:
986, Issue:
C
Journal Article
Peer reviewed
Open access
The Muon Scattering Experiment at the Paul Scherrer Institute uses a mixed beam of electrons, muons, and pions, necessitating precise timing to identify the beam particles and reactions they cause. ...We describe the design and performance of three timing detectors using plastic scintillator read out with silicon photomultipliers that have been built for the experiment. The Beam Hodoscope, upstream of the scattering target, counts the beam flux and precisely times beam particles both to identify species and provide a starting time for time-of-flight measurements. The Beam Monitor, downstream of the scattering target, counts the unscattered beam flux, helps identify background in scattering events, and precisely times beam particles for time-of-flight measurements. The Beam Focus Monitor, mounted on the target ladder under the liquid hydrogen target inside the target vacuum chamber, is used in dedicated runs to sample the beam spot at three points near the target center, where the beam should be focused.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
A windowless hydrogen gas target of nominal thickness 1019 cm−2 is an essential component of the DarkLight experiment, which is designed to utilize the megawatt electron beam at an Energy Recovery ...Linac (ERL). The design of such a target is challenging because the pressure drops by many orders of magnitude between the central, high-density section of the target and the surrounding beamline, resulting in laminar, transitional, and finally molecular flow regimes. The target system was assembled and operated at Jefferson Lab’s Low Energy Recirculator Facility (LERF) in 2016, and subsequently underwent several revisions and calibration tests at MIT Bates in 2017. The system at dynamic equilibrium was simulated in COMSOL to provide a better understanding of its optimal operation at other working points. We have determined that a windowless gas target with sufficiently high density for DarkLight’s experimental needs is feasible in an ERL environment.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Positron beams, both polarized and unpolarized, are identified as essential ingredients for the experimental programs at the next generation of lepton accelerators. In the context of the hadronic ...physics program at Jefferson Lab (JLab), positron beams are complementary, even essential, tools for a precise understanding of the electromagnetic structure of nucleons and nuclei, in both the elastic and deep-inelastic regimes. For instance, elastic scattering of polarized and unpolarized electrons and positrons from the nucleon enables a model independent determination of its electromagnetic form factors. Also, the deeply-virtual scattering of polarized and unpolarized electrons and positrons allows unambiguous separation of the different contributions to the cross section of the lepto-production of photons and of lepton-pairs, enabling an accurate determination of the nucleons and nuclei generalized parton distributions, and providing an access to the gravitational form factors. Furthermore, positron beams offer the possibility of alternative tests of the Standard Model of particle physics through the search of a dark photon, the precise measurement of electroweak couplings, and the investigation of charged lepton flavor violation. This document discusses the perspectives of an experimental program with high duty-cycle positron beams at JLab.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, SIK, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
We present new precision measurements of the elastic electron-proton scattering cross section for momentum transfer (Q^{2}) up to 15.75 (GeV/c)^{2}. Combined with existing data, these provide an ...improved extraction of the proton magnetic form factor at high Q^{2} and double the range over which a longitudinal or transverse separation of the cross section can be performed. The difference between our results and polarization data agrees with that observed at lower Q^{2} and attributed to hard two-photon exchange (TPE) effects, extending to 8 (GeV/c)^{2} the range of Q^{2} for which a discrepancy is established at >95% confidence. We use the discrepancy to quantify the size of TPE contributions needed to explain the cross section at high Q^{2}.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM
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