Recent studies have suggested the possibility of significantly obscuring supersoft X-ray sources in relatively modest amounts of local matter lost from the binaries themselves. If correct, then this ...would have explained the paucity of observed supersoft X-ray sources and would have significance for the search for single-degenerate Type Ia supernova progenitors. We point out that earlier studies of circumbinary obscuration ignored photoionizations of the gas by the emission from the supersoft X-ray source. We revisit the problem using a full, self-consistent calculation of the ionization state of the circumbinary material photoionized by the radiation of the central source. Our results show that the circumstellar mass-loss rates required for obscuration of supersoft X-ray sources is about an order of magnitude larger than those reported in earlier studies, for comparable model parameters. While this does not entirely rule out the possibility of circumstellar material obscuring supersoft X-ray sources, it makes it unlikely that this effect alone can account for the majority of the missing supersoft X-ray sources. We discuss the observational appearance of hypothetical obscured nuclear-burning white dwarfs and show that they have signatures making them distinct from photoionized nebulae around supersoft X-ray sources imbedded in the low-density interstellar medium.
Critically ill patients with severe infections are at high risk of suboptimal antimicrobial dosing. The pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobials in these patients differ ...significantly from the patient groups from whose data the conventional dosing regimens were developed. Use of such regimens often results in inadequate antimicrobial concentrations at the site of infection and is associated with poor patient outcomes. In this article, we describe the potential of in vitro and in vivo infection models, clinical pharmacokinetic data and pharmacokinetic/pharmacodynamic models to guide the design of more effective antimicrobial dosing regimens. Individualised dosing, based on population PK models and patient factors (e.g. renal function and weight) known to influence antimicrobial PK, increases the probability of achieving therapeutic drug exposures while at the same time avoiding toxic concentrations. When therapeutic drug monitoring (TDM) is applied, early dose adaptation to the needs of the individual patient is possible. TDM is likely to be of particular importance for infected critically ill patients, where profound PK changes are present and prompt appropriate antibiotic therapy is crucial. In the light of the continued high mortality rates in critically ill patients with severe infections, a paradigm shift to refined dosing strategies for antimicrobials is warranted to enhance the probability of achieving drug concentrations that increase the likelihood of clinical success.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
We analysed archival data of Chandra pre-explosion observations of the position of SN 2014J in M82. No X-ray source at this position was detected in the data, and we calculated upper limits on the ...luminosities of the progenitor. These upper limits allow us to firmly rule out an unobscured supersoft X-ray source progenitor with a photospheric radius comparable to the radius of white dwarf near the Chandrasekhar mass (∼1.38 M⊙) and mass accretion rate in the interval where stable nuclear burning can occur. However, due to a relatively large hydrogen column density implied by optical observations of the supernova, we cannot exclude a supersoft source with lower temperatures, kT ≲ 70 eV. We find that the supernova is located in the centre of a large structure of soft diffuse emission, about 200 pc across. The mass, ∼3 × 104 M⊙ and short cooling time of the gas, τcool ∼ 8 Myr, suggest that it is a supernova-inflated superbubble, associated with the region of recent star formation. If SN 2014J is indeed located inside the bubble, it likely belongs to the prompt population of Type Ia supernovae, with a delay time as short as ∼50 Myr. Finally, we analysed the one existing post-supernova Chandra observation and placed upper limit of ∼(1–2) × 1037 erg s−1 on the X-ray luminosity of the supernova itself.
Seagrass meadows store globally-significant quantities of organic ‘blue’ carbon. These blue carbon stocks are potentially vulnerable to anthropogenic stressors (e.g. coastal development, climate ...change). Here, we tested the impact of oxygen exposure and warming (major consequences of human disturbance) on rates of microbial carbon break-down in seagrass sediments. Active microbes occurred throughout seagrass sediment profiles, but deep, ancient sediments (~5000 yrs. old) contained only 3% of the abundance of active microbes as young, surface sediments (<2 yrs. old). Metagenomic analysis revealed that microbial community structure and function changed with depth, with a shift from proteobacteria and high levels of genes involved in sulfur cycling in the near surface samples, to a higher proportion of firmicutes and euraracheota and genes involved in methanogenesis at depth. Ancient carbon consisted almost entirely (97%) of carbon considered ‘thermally recalcitrant’, and therefore presumably inaccessible to microbial attack. Experimental warming had little impact on carbon; however, exposure of ancient sediments to oxygen increased microbial abundance, carbon uptake and sediment carbon turnover (34–38 fold). Overall, this study provides detailed characterization of seagrass blue carbon (chemical stability, age, associated microbes) and suggests that environmental disturbances that expose coastal sediments to oxygen (e.g. dredging) have the capacity to diminish seagrass sediment carbon stocks by facilitating microbial remineralisation.
Display omitted
•Seagrass ecosystems store globally-significant amounts of blue carbon•Mechanisms underpinning blue carbon destabilisation are largely unknown•Exposure of blue carbon to oxygen triggered microbial remineralization•Sediment carbon turnover increased 34–38-fold following oxygen exposure•Activities that expose seagrass sediments to oxygen threaten blue carbon stability
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Quinones represent an important group of highly structurally diverse, mainly polyketide-derived secondary metabolites widely distributed among filamentous fungi. Many quinones have been reported to ...have important biological functions such as inhibition of bacteria or repression of the immune response in insects. Other quinones, such as ubiquinones are known to be essential molecules in cellular respiration, and many quinones are known to protect their producing organisms from exposure to sunlight. Most recently, quinones have also attracted a lot of industrial interest since their electron-donating and -accepting properties make them good candidates as electrolytes in redox flow batteries, like their often highly conjugated double bond systems make them attractive as pigments. On an industrial level, quinones are mainly synthesized from raw components in coal tar. However, the possibility of producing quinones by fungal cultivation has great prospects since fungi can often be grown in industrially scaled bioreactors, producing valuable metabolites on cheap substrates. In order to give a better overview of the secondary metabolite quinones produced by and shared between various fungi, mainly belonging to the genera
Aspergillus
,
Penicillium
,
Talaromyces
,
Fusarium
, and
Arthrinium
, this review categorizes quinones into families such as emodins, fumigatins, sorbicillinoids, yanuthones, and xanthomegnins, depending on structural similarities and information about the biosynthetic pathway from which they are derived, whenever applicable. The production of these quinone families is compared between the different genera, based on recently revised taxonomy.
Key points
•
Quinones represent an important group of secondary metabolites widely distributed in important fungal genera such as Aspergillus, Penicillium, Talaromyces, Fusarium, and Arthrinium.
•
Quinones are of industrial interest and can be used in pharmacology, as colorants and pigments, and as electrolytes in redox flow batteries.
•
Quinones are grouped into families and compared between genera according to the revised taxonomy.
Full text
Available for:
CEKLJ, DOBA, EMUNI, FZAB, GEOZS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Stereotactic body radiation therapy of thoracic tumors close to the central airways implies risk of severe toxicity. We report a prospective multicenter phase 2 trial for tumors located less than or ...equal to 1 cm from the proximal bronchial tree with primary end point of local control and secondary end point of toxicity.
Stereotactic body radiation therapy with 7 Gy × 8 was prescribed to the 67% isodose encompassing the planning target volume. The patients were stratified to group A (tumors ≤ 1 cm from the main bronchi and trachea) or group B (all other tumors). Risk factors for treatment-related death were tested in univariate analysis, and a logistic regression model was developed for fatal bronchopulmonary bleeding versus dose to the main bronchi and trachea.
A total of 65 patients (group A/group B, n = 39/26) were evaluated. The median distance between the tumor and the proximal bronchial tree was 0 mm (0–10 mm). The 2-year local control was 83%. Grade 3 to 5 toxicity was noted in 22 patients, including 10 cases of treatment-related death (bronchopulmonary hemorrhage, n = 8; pneumonitis, n = 1; fistula, n = 1). Dose to the combined structure main bronchi and trachea and tumor distance to the main bronchi were important risk factors. Dose modeling revealed minimum dose to the “hottest” 0.2 cc to the structure main bronchi and trachea as the strongest predictor for lethal bronchopulmonary hemorrhage.
On the basis of the presented data, 7 Gy × 8, prescribed to the planning target volume-encompassing isodose, should not be used for tumors located within 1 cm from the main bronchi and trachea. Group B-type tumors may be considered for the treatment on the basis of an individual risk-benefit assessment and a maximum dose to the main bronchi and trachea in the order of 70 to 80 Gy (equivalent dose in 2 Gy fractions).
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
A synthesis of phenotypic and quantitative genomic traits is provided for bacteria and archaea, in the form of a scripted, reproducible workflow that standardizes and merges 26 sources. The resulting ...unified dataset covers 14 phenotypic traits, 5 quantitative genomic traits, and 4 environmental characteristics for approximately 170,000 strain-level and 15,000 species-aggregated records. It spans all habitats including soils, marine and fresh waters and sediments, host-associated and thermal. Trait data can find use in clarifying major dimensions of ecological strategy variation across species. They can also be used in conjunction with species and abundance sampling to characterize trait mixtures in communities and responses of traits along environmental gradients.
We present an early-phase g-band light curve and visual-wavelength spectra of the normal Type Ia supernova (SN) 2013gy. The light curve is constructed by determining the appropriate S-corrections to ...transform KAIT natural-system B- and V-band photometry and Carnegie Supernova Project natural-system g-band photometry to the Pan-STARRS1 g-band natural photometric system. A Markov chain Monte Carlo calculation provides a best-fit single power-law function to the first ten epochs of photometry described by an exponent of 2.16+0.06−0.06 2 . 16 − 0.06 + 0.06 $ 2.16^{+0.06}_{-0.06} $ and a time of first light of MJD 56629.4+0.1−0.1 56629 . 4 − 0.1 + 0.1 $ 56629.4^{+0.1}_{-0.1} $ , which is 1.93+0.12−0.13 1 . 93 − 0.13 + 0.12 $ 1.93^{+0.12}_{-0.13} $ days (i.e., < 48 h) before the discovery date (2013 December 4.84 UT) and −19.10+0.12−0.13 − 19 . 10 − 0.13 + 0.12 $ -19.10^{+0.12}_{-0.13} $ days before the time of B-band maximum (MJD 56648.5 ± 0.1). The estimate of the time of first light is consistent with the explosion time inferred from the evolution of the Si IIλ6355 Doppler velocity. Furthermore, discovery photometry and previous nondetection limits enable us to constrain the companion radius down to Rc ≤ 4 R⊙. In addition to our early-time constraints, we used a deep +235 day nebular-phase spectrum from Magellan/IMACS to place a stripped H-mass limit of < 0.018 M⊙. Combined, these limits effectively rule out H-rich nondegenerate companions.
Full text
Available for:
FMFMET, NUK, UL, UM, UPUK
The death of massive stars produces a variety of supernovae, which are linked to the structure of the exploding stars. The detection of several precursor stars of type II supernovae has been reported ...(see, for example, ref. 3), but we do not yet have direct information on the progenitors of the hydrogen-deficient type Ib and Ic supernovae. Here we report that the peculiar type Ib supernova SN 2006jc is spatially coincident with a bright optical transient that occurred in 2004. Spectroscopic and photometric monitoring of the supernova leads us to suggest that the progenitor was a carbon-oxygen Wolf-Rayet star embedded within a helium-rich circumstellar medium. There are different possible explanations for this pre-explosion transient. It appears similar to the giant outbursts of luminous blue variable stars (LBVs) of 60-100 solar masses, but the progenitor of SN 2006jc was helium- and hydrogen-deficient (unlike LBVs). An LBV-like outburst of a Wolf-Rayet star could be invoked, but this would be the first observational evidence of such a phenomenon. Alternatively, a massive binary system composed of an LBV that erupted in 2004, and a Wolf-Rayet star exploding as SN 2006jc, could explain the observations.
Full text
Available for:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
•Report on an extensive QA-programme for an SBRT trial for central lung tumours.•Small variations in OAR delineation potentially leads to large OAR over-dosage.•Extensive QA decreases variability in ...OAR delineation and treatment planning.•QA of OAR delineations may lead to a more coherent interpretation of trial outcome.
SBRT of central lung tumours implies significant risk of toxicity. We are initiating two phase II trials prescribing 56 Gy/eight fractions to PTV, allowing for dose escalation of GTV. We prioritize organs at risk (OAR) constraints over target coverage, making the treatment plans very sensitive to OAR delineation variations. The aim of this study is to quantify the dosimetric impact of contouring variations and to provide a thorough description of pre-trial quality assurance to be used in upcoming trials to provide consistent clinical care.
Delineation: Seven physicians delineated OAR in three rounds, with evaluations in-between. For each patient case, seven treatment plans, repeatedly using each of the OAR structure sets from the seven physicians, were made and compared to evaluate the dosimetric effect of delineation variability.
Treatment planning: Treatment plans for seven cases were made at six departments in two rounds, with discussion in-between.
OAR delineation variation between centres resulted in high variabilities in OAR dose for simulated plans and led to potential overdosage of the lobar bronchus (constraint: D0.03cc < 45 Gy), with maximum doses ranging between 58 Gy (first round), and 50 Gy (third round). For mediastinal tissue, the constraint (D0.03cc < 45 Gy) was violated for the majority of the delineations in all three rounds, with maximum doses of 84 Gy (first round), and 72 Gy (third round).For the treatment planning study, the range of the standard deviation for GTV mean dose was 12.8–18.5 Gy (first round) and 2.8–3.5 Gy (second round).
Even small variations in OAR delineation led to high OAR overdosage. The study demonstrates the importance of having extensive QA procedures in place before initiating clinical trials on dose escalation in SBRT.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
PDF
