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  • Allosteric activation of ba... Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation
    Trajtenberg, Felipe; Albanesi, Daniela; Ruétalo, Natalia ... MBio, 11/2014, Volume: 5, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Response regulators are proteins that undergo transient phosphorylation, connecting specific signals to adaptive responses. Remarkably, the molecular mechanism of response regulator activation ...
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  • High prognostic value of me... High prognostic value of measurable residual disease detection by flow cytometry in chronic lymphocytic leukemia patients treated with front-line fludarabine, cyclophosphamide, and rituximab, followed by three years of rituximab maintenance
    García-Marco, José A; Jiménez, Javier López; Recasens, Valle ... Haematologica, 11/2019, Volume: 104, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    It has been postulated that monitoring measurable residual disease (MRD) could be used as a surrogate marker of progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) patients after ...
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  • Structural features of sensory two component systems: a synthetic biology perspective
    Nieves, Marcos; Buschiazzo, Alejandro; Trajtenberg, Felipe Biochemical journal, 01/2023, Volume: 480, Issue: 2
    Journal Article
    Peer reviewed

    All living organisms include a set of signaling devices that confer the ability to dynamically perceive and adapt to the fluctuating environment. Two-component systems are part of this sensory ...
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  • Clinical impact of gastric ... Clinical impact of gastric acid suppressing medication on the effectiveness of tyrosine kinase inhibitors in lung cancer patients
    Nieves Sedano, Marcos; Manuel Caro Teller, José; García Muñoz, Carmen ... Journal of B.U. ON., 2018 May-Jun, 20180501, Volume: 23, Issue: 3
    Journal Article

    Erlotinib and gefitinib are both tyrosine kinase inhibitors (TKIs) approved for the treatment of non-small cell lung cancer (NSCLC). Although it is well known that the increase of gastric pH may ...
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  • An allosteric switch ensures efficient unidirectional information transmission by the histidine kinase DesK from Bacillus subtilis
    Lima, Sofía; Blanco, Juan; Olivieri, Federico ... Science signaling, 01/2023, Volume: 16, Issue: 769
    Journal Article
    Peer reviewed

    Phosphorylation carries chemical information in biological systems. In two-component systems (TCSs), the sensor histidine kinase and the response regulator are connected through phosphoryl transfer ...
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  • Chemosensitizer effect of c... Chemosensitizer effect of cisplatin-treated bladder cancer cells by phenazine-5,10-dioxides
    Hernández, Paola; Alem, Diego; Nieves, Marcos ... Environmental toxicology and pharmacology, 07/2019, Volume: 69
    Journal Article
    Peer reviewed

    •Phenazines 2c and 3a emerged as chemosensitizer agents to bladder cancer cells.•The HDAC inhibitory activity appears as one of the mechanism of action of 2c.•Phenazine dioxide 3a induced a ...
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  • Structural modifications on... Structural modifications on the phenazine N, N′-dioxide-scaffold looking for new selective hypoxic cytotoxins
    Lavaggi, María Laura; Nieves, Marcos; Cabrera, Mauricio ... European journal of medicinal chemistry, 11/2010, Volume: 45, Issue: 11
    Journal Article
    Peer reviewed

    We have identified phenazine 5,10-dioxides as prodrugs for antitumour therapy that undergo hypoxic-selective bioreduction to form cytotoxic species. Here, we investigated some structural ...
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