In this paper, the issue of adaptive event‐triggered output‐feedback control for a class of switched nonlinear systems with time‐varying delays is investigated. By adopting the mode‐dependent average ...dwell time (MDADT) method and the backstepping technique, an adaptive neural output‐feedback control strategy is proposed for the switched system with event‐triggered mechanism. In the process of controller design, an intelligent approximation technique and a switched filter are introduced to overcome the difficulties caused by the unknown nonlinear functions and the immeasurable states, respectively. Moreover, the appropriate Lyapunov–Krasovskii functionals are designed to compensate the effects of time delays. It is proved that the proposed control strategy guarantees that all the signals in the switched closed‐loop systems are bounded under arbitrary switchings with MDADT. In the end, two simulation examples are provided to illustrate the feasibility of the developed control strategy.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
This article proposes two adaptive asymptotic tracking control schemes for a class of interconnected systems with unmodeled dynamics and prescribed performance. By applying an inherent property of ...radial basis function (RBF) neural networks (NNs), the design difficulties aroused from the unknown interactions among subsystems and unmodeled dynamics are overcome. Then, in order to ensure that the tracking errors can be suppressed in the specified range, the constrained control problem is transformed into the stabilization problem by using an auxiliary function. Based on the adaptive backstepping method, a time-triggered controller is constructed. It is proven that under the framework of Barbalat's lemma, all the variables in the closed-loop system are bounded and the tracking errors are further ensured to converge to zero asymptotically. Furthermore, the event-triggered strategy with a variable threshold is adopted to make more precise control such that the better system performance can be obtained, which reduces the system communication burden under the condition of limited communication resources. Finally, an illustrative example is provided to demonstrate the effectiveness of the proposed control scheme.
The lattice parameter of platinum-based intermetallic compounds (IMCs), which correlates with the intrinsic activity of the oxygen reduction reaction (ORR), can be modulated by crystal phase ...engineering. However, the controlled preparation of IMCs with unconventional crystal structures remains highly challenging. Here, we demonstrate the synthesis of carbon-supported PtCu-based IMC catalysts with an unconventional L10 structure by a composition-regulated strategy. Experiment and machine learning reveal that the thermodynamically favorable structure changes from L11 to L10 when slight Cu atoms are substituted with Co. Benefiting from crystal-phase-induced strain enhancement, the prepared L10-type PtCu0.8Co0.2 catalyst exhibits much-enhanced mass and specific activities of 1.82 A mgPt –1 and 3.27 mA cmPt –2, which are 1.91 and 1.73 times higher than those of the L11-type PtCu catalyst, respectively. Our work highlights the important role of crystal phase in determining the surface strain of IMCs, and opens a promising avenue for the rational preparation of IMCs with different crystal phases by doping.
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IJS, KILJ, NUK, PNG, UL, UM
•Trim14 overexpression in serum from patients with knee osteoarthritis.•Trim14 was highly expressed in the L3-5 DRG and SDH of CFA rats.•Trim14 was mainly expressed in CGRP and IB4 neurons but not ...glial cells.•Trim14 knockdown increased IκBα expression and inhibited NF-κB phosphorylation.•Trim14 knockdown relieved chronic inflammatory pain and anxiety in CFA rats.
Chronic inflammatory pain is the highest priority for people with osteoarthritis when seeking medical attention. Despite the availability of NSAIDs and glucocorticoids, central sensitization and peripheral sensitization make pain increasingly difficult to control. Previous studies have identified the ubiquitination system as an important role in the chronic inflammatory pain. Our study displayed that the E3 ubiquitin ligase tripartite motif-containing 14 (Trim14) was abnormally elevated in the serum of patients with osteoarthritis and pain, and the degree of pain was positively correlated with the degree of Trim14 elevation. Furthermore, CFA-induced inflammatory pain rat model showed that Trim14 was significantly increased in the L3-5 spinal dorsal horn (SDH) and dorsal root ganglion (DRG), and in turn the inhibitor of nuclear factor Kappa-B isoform α (IκBα) was decreased after Trim14 elevation. After intrathecal injection of Trim14 siRNA to inhibit Trim14 expression, IκBα expression was reversed and increased, and the pain behaviors and anxiety behaviors of rats were significantly relieved. Overall, these findings suggested that Trim14 may contribute to chronic inflammatory pain by degrading IκBα, and that Trim14 may become a novel therapeutic target for chronic inflammatory pain.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Crustal delamination induced by eclogitization of orogenic roots, in addition to plate subduction, is an important process that transfers crustal materials back into the mantle. Many previous studies ...have demonstrated a causal link between crustal delamination and eclogitization, but actual magmatic records of the process are rarely documented. Here we present detailed studies on two distinct late Paleozoic adakite suites in the Awulale Mountains (Chinese Western Tianshan), that is, the suites with high (HN) and low (LN) Nb/Ta ratios, to constrain the regional crustal delamination. Both igneous suites have adakitic affinity and formed by partial melting of the juvenile thickened lower crust with different residual mineral assemblages in their source regions. The late Carboniferous HN adakite has superchondritic Nb/Ta (21.4–23.3) and high Dy/Yb (2.66–2.88) ratios and may have formed via rutile‐bearing, eclogite‐controlled melting of the lower crust, implying crustal thickening and eclogitization. In contrast, the Permian LN adakites have varying and lower ranges of Nb/Ta (12.9–20.0) and Dy/Yb ratios (1.35–2.53), which were probably derived from mixing of garnet‐bearing amphibolite with minor rutile‐bearing, eclogite‐controlled melts, implying crustal thinning and the end of eclogitization. The succession of these two adakite suites suggests that during the late Carboniferous to early Permian, eclogitization of the orogenic root, accompanying successive crustal delaminations, occurred in this region. Accordingly, our results imply that adakites with different geochemical features are potential tracers for the mineralogy of orogenic roots and, importantly, provide convincing evidence for eclogitization‐induced crustal delamination in orogenic belts.
Key Points
Two distinct adakite groups (with super/subchondritic Nb/Ta ratios) are present in the Awulale Mountains (Chinese Western Tianshan)
Adakite geochemical features are controlled by the residual mineral assemblages in the magma sources
Adakites in orogenic belts could be used to trace eclogitization‐induced crustal delamination events
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
BACKGROUNDPrimary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) are two unexplained immune diseases. The golden standard for diagnosis of these diseases requires a liver biopsy. Liver ...biopsy is not widely accepted by patients because of its invasive nature, and atypical liver histology can confuse diagnosis. In view of the lack of effective diagnostic markers for PBC and AIH, combined with the increasingly mature metabolomics technologies, including full-contour metabolomics and target. AIMTo determine non-invasive, reliable, and sensitive biochemical markers for the differential diagnosis of PBC and AIH. METHODSSerum samples from 54 patients with PBC, 26 patients with AIH and 30 healthy controls were analyzed by Ultra-high performance liquid chromatography-tandem mass spectrometry serum metabolomics. The metabolites and metabolic pathways were identified, and the metabolic changes, metabolic pathways and inter-group differences between PBC and AIH were analyzed. Fifteen kinds of target metabolites of bile acids (BAs) were quantitatively analyzed by SRM, and the differential metabolites related to the diagnosis of PBC were screened by receiver operating characteristic curve analysis. RESULTSWe found the changes in the levels of amino acids, BAs, organic acids, phospholipids, choline, sugar, and sugar alcohols in patients with PBC and AIH. Furthermore, the SRM assay of BAs revealed the increased levels of chenodeoxycholic acid, lithocholic acid (LCA), taurolithocholic acid (TLCA), and LCA + TLCA in the PBC group compared with those in the AIH group. The levels of BAs may be used as biomarkers to differentiate PBC from AIH diseases. The levels of glycochenodeoxycholic acid, glycochenodeoxycholic sulfate, and taurodeoxycholic acid were gradually elevated with the increase of Child-Pugh class, which was correlated with the severity of disease. CONCLUSIONThe results demonstrated that the levels of BAs could serve as potential biomarkers for the early diagnosis and assessment of the severity of PBC and AIH.
Polyploidy (genome duplication) is a pivotal force in evolution. However, the interactions between parental genomes in a polyploid nucleus, frequently involving subgenome dominance, are poorly ...understood. Here we showcase analyses of a bamboo system (Poaceae: Bambusoideae) comprising a series of lineages from diploid (herbaceous) to tetraploid and hexaploid (woody), with 11 chromosome-level de novo genome assemblies and 476 transcriptome samples. We find that woody bamboo subgenomes exhibit stunning karyotype stability, with parallel subgenome dominance in the two tetraploid clades and a gradual shift of dominance in the hexaploid clade. Allopolyploidization and subgenome dominance have shaped the evolution of tree-like lignified culms, rapid growth and synchronous flowering characteristic of woody bamboos as large grasses. Our work provides insights into genome dominance in a remarkable polyploid system, including its dependence on genomic context and its ability to switch which subgenomes are dominant over evolutionary time.
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GEOZS, IJS, IMTLJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK, ZAGLJ
This study presents major, trace element and Li-B-Sr–Nd–Pb-Hf isotope compositions of post-collisional (Permian) shoshonitic volcanic rocks (SVRs) from West Tianshan, NW China. Zircon UPb dating ...indicates that the West Tianshan SVRs were mainly formed in the late Early Permian (272–279 Ma). They include absarokites, shoshonites and banakites, which have variable SiO2 (46–63 wt%) and K2O (2.12–8.12 wt%) contents. They display enrichment in light rare earth elements (LREE) and depletion in heavy rare earth elements. They are enriched in large ion lithophile elements (e.g., La, Rb and Ba) and depleted in high field strength elements (e.g., Nb, Ta and Ti) with slightly negative to negligible Eu anomalies, pronounced positive Pb anomalies and low Nb/U (9.32 ± 6.54), Ce/Pb (0.14–10.0, average 5.03 ± 3.02), relatively high Nb/Ta (16.74 ± 2.72) and Zr/Hf (39.56 ± 6.06) ratios. They have relatively high Li contents (26.0–93.0 ppm) and B contents (6.19–84.7 ppm), and low but variable δ7Li (−4.0‰ to +2.4‰). They are characterized by low (87Sr/86Sr)i (0.7045–0.7068), positive εNd(t) values (+0.31 − +5.53), relatively low 206Pb/204Pb (18.16–18.65), 207Pb/204Pb (15.51–15.63) and 208Pb/204Pb (37.97–39.22) and positive εHf(t) (+5.4 − +12.5). These features consistently suggest a metasomatized enriched mantle source having affinities with an EM I-like reservoir for the SVRs. Source enrichment was generated dominantly by subducted slab related aqueous fluid and altered oceanic crust (AOC) melts. Dehydration modeling of Li and B isotopes and Li, Y, B, Nb trace element fractionation collectively show that the flat, deeply subducted and stagnated, eclogitic slab suffered progressive dehydration(~5–12%)and was distinctly 7Li-depleted. Based on these compositional features and model calculations, we suggest that West Tianshan SVRs had an enriched mantle source metasomatised by aqueous fluid and hydrous slab melt, and their parental magmas were derived from variable mixing of spinel and garnet peridotite (60Gt:40Sp − 80Gt:20Sp). Taking into account petrogenetic and regional tectonic data, we suggest that the West Tianshan SVRs developed in an intraplate setting during the late Early Permian. It is most probable that the Early Permian Tarim mantle plume, located in the south side of the study area, promoted Early Permian asthenospheric upwelling that resulted in melting of a fossil subduction-enriched source to produce shoshonitic volcanic rocks in the West Tianshan.
•Lower δ7Li and wider range are evidently lighter than most volcanic suites world-wide.•A deeply subducted and stagnated eclogitic slab is one end-member of enriched source.•Parental magmas were from mixing of garnet and spinel peridotite (60/40–80/20).•SVRs formed in post-collision transition from subduction-related to intraplate setting.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Although bioactive sphingolipids have been shown to regulate cardiometabolic homeostasis and inflammatory signaling pathways in rodents, population-based longitudinal studies of relationships between ...sphingolipids and onset of metabolic syndrome (MetS) are sparse. We aimed to determine associations of circulating sphingolipids with inflammatory markers, adipokines, and incidence of MetS. Among 1242 Chinese people aged 50–70 years who completed the 6-year resurvey, 76 baseline plasma sphingolipids were quantified by high-throughput liquid chromatography-tandem mass spectrometry. There were 431 incident MetS cases at 6-year revisit. After multivariable adjustment including lifestyle characteristics and BMI, 21 sphingolipids mainly from ceramide and hydroxysphingomyelin subclasses were significantly associated with incident MetS. Meanwhile, the baseline ceramide score was positively associated (RRQ4 versus Q1 = 1.31; 95% CI 1.05, 1.63; ptrend = 0.010) and the hydroxysphingomyelin score was inversely associated (RRQ4 versus Q1 = 0.60; 95% CI 0.45, 0.79; ptrend < 0.001) with incident MetS. When further controlling for clinical lipids, both associations were attenuated but remained significant. Comparing extreme quartiles, RRs (95% CIs) of MetS risk were 1.34 (95% CI 1.06, 1.70; ptrend = 0.010) for ceramide score and 0.71 (95% CI 0.51, 0.97; ptrend = 0.018) for hydroxysphingomyelin score, respectively. Furthermore, a stronger association between ceramide score and incidence of MetS was evidenced in those having higher inflammation levels (RRQ4 versus Q1 1.57; 95% CI 1.16, 2.12; pinteraction = 0.004). Our data suggested that elevated ceramide concentrations were associated with a higher MetS risk, whereas raised hydroxysphingomyelin levels were associated with a lower MetS risk beyond traditional clinical lipids.
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