Abstract
Monovalent SARS-CoV-2 Prototype (Wuhan-Hu-1) and bivalent (Prototype + BA.4/5) COVID-19 vaccines have demonstrated a waning of vaccine-mediated immunity highlighted by lower neutralizing ...antibody responses against SARS-CoV-2 Omicron XBB sub-variants. The reduction of humoral immunity due to the rapid evolution of SARS-CoV-2 has signaled the need for an update to vaccine composition. A strain change for all authorized/approved vaccines to a monovalent composition with Omicron subvariant XBB.1.5 has been supported by the WHO, EMA, and FDA. Here, we demonstrate that immunization with a monovalent recombinant spike protein COVID-19 vaccine (Novavax, Inc.) based on the subvariant XBB.1.5 induces neutralizing antibodies against XBB.1.5, XBB.1.16, XBB.2.3, EG.5.1, and XBB.1.16.6 subvariants, promotes higher pseudovirus neutralizing antibody titers than bivalent (Prototype + XBB.1.5) vaccine, induces SARS-CoV-2 spike-specific Th1-biased CD4 + T-cell responses against XBB subvariants, and robustly boosts antibody responses in mice and nonhuman primates primed with a variety of monovalent and bivalent vaccines. Together, these data support updating the Novavax vaccine to a monovalent XBB.1.5 formulation for the 2023–2024 COVID-19 vaccination campaign.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The records of 104 patients who underwent reconstructive foot and ankle surgery for deformities secondary to rheumatoid arthritis were reviewed. The use of rheumatoid chemotherapeutic agents, age, ...sex, rheumatoid nodule status, and the number of concurrent surgical procedures performed was analyzed to determine any association with the postoperative outcome for wound healing and infectious complications. The 104 patients, ranging in age from 23 to 83 years, underwent 725 operative procedures. An overall 32% complication rate was recorded. Analysis of five specific rheumatoid chemotherapeutic agents (NSAIDs, steroids, methotrexate, hydroxychloroquine, gold), age, sex, number of operative procedures performed, and presence of rheumatoid nodules, either alone or in combination, failed to prove a statistical association with either a healing or infectious postoperative complication.
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NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
In this paper, we present the design and characterization of a novel platform for mechanical cell lysis of even the most difficult to lyse cell types on a micro or nanoscale (maximum 70
μL total ...volume). The system incorporates a machined plastic circular disk assembly, magnetic field actuated microfluidics, centrifugal cells and tissue homogenizer and centrifugation system. The mechanism of tissue disruption of this novel cell homogenization apparatus derives from the relative motion of ferromagnetic metal disks and grinding matrices in a liquid medium within individual chambers of the disk in the presence of an oscillating magnetic field. The oscillation of the ferromagnetic disks or blades produces mechanical impaction and shear forces capable of disrupting cells within the chamber both by direct action of the blade and by the motion of the surrounding lysis matrix, and by motion induced vortexing of buffer fluid. Glass beads or other grinding media are integrated into each lysis chamber within the disk to enhance the transfer of energy from the oscillating metal blade to the cells. The system also achieves the centrifugal elimination of solids from each liquid sample and allows the elution of clarified supernatants via siphoning into a collection chamber fabricated into the plastic disk assembly. This article describes system design, implementation and validation of proof of concept on two samples—
Escherichia coli and
Saccharomyces cerevisiae representing model systems for cells that are easy and difficult to lyse, respectively.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
In a first of its kind authentic clinical interprofessional education (IPE) experience, University of Kentucky (UK) health profession students joined dental students to implement a pilot program to ...promote oral health and wellness with children living in underserved Appalachian communities. Known as hCATS (Health Colleges Advancing Team Skills) to Appalachia, a total of 113 students participated in interprofessional teams of 48 health profession students paired with 65 dentistry students to provide health services. Although the UK College of Dentistry has provided sealant services (tooth decay prevention) to elementary school children for several decades in eastern Kentucky counties, funding through the UK Women and Philanthropy Network allowed services to expand to include general health screening and age-appropriate education on oral health, nutrition, exercise, and prevention of substance abuse. The UK Center for Interprofessional Health Education (CIHE) coordinated the efforts for students from the colleges of Communication and Information Sciences, Health Sciences, Nursing, Pharmacy, Public Health, and Social Work. In addition to the clinical experience in the elementary schools, nursing and other health profession students explored the health resources of the communities visited and reflected on their experience in collaborative practice that the program was designed to encourage. The authors noted positive outcomes with interprofessional education competencies, although more structure for collaboration is required to ensure students who work with other professions in an authentic clinical setting can gain early relevant practice in, and experience the benefits of, collaborative patient care.
•Kentucky ranks among the highest for oral health disparities.•Students reported gains in the perception of their own collaborative skills and knowledge of community characteristics.•Students also reported improvement with interprofessional competencies over the course of the rural health clinical experience.•Underserved communities offer a rich learning environment for authentic clinical and collaborative practice.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
For 20 years, FBI forensic experts gave flawed testimony regarding microscopic hair analysis. Jim Norton, William Anderson and George Divine unpick their mistakes
For 20 years, FBI forensic experts ...gave flawed testimony regarding microscopic hair analysis. Jim Norton, William Anderson and George Divine unpick their mistakes
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BFBNIB, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
6.
UNNECESSARY Norton, Jim
Railroad history,
04/2006
194
Journal Article
Peer reviewed
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BFBNIB, NMLJ, NUK, PNG, UL, UM, UPUK
Rimac Seguros es la empresa aseguradora líder en el mercado peruano, con más de 120 años ofreciendo seguros de vida, salud, vehicular y riesgos generales, tanto para empresas como para personas ...naturales. La visión de Rimac es la de ser una empresa socialmente responsable, centrada en el cliente y de clase mundial, por lo que su gestión no solamente se preocupa por su crecimiento financiero, sino también por su desarrollo como una empresa sostenible. Para ello, la empresa viene trabajando en diversas iniciativas que ayuden a reducir sus emisiones de dióxido de carbono (CO2) al ambiente, las cuales son medidas anualmente través de huella de carbono. Sin embargo, el equipo de Sostenibilidad sigue teniendo dificultades para reducir la contaminación generada por el transporte diario de los colaboradores hacia sus centros de trabajo.El objetivo de la consultoría fue identificar la causa raíz del problema en el comportamiento de dichos colaboradores, de modo que se pueda proponer un plan que ayude a motivar un cambio en su medio de transporte por uno que no emita dióxido de carbono, como bicicletas, scooters o caminar. Para ello se realizó un análisis, mediante una técnica de diseño de comportamientos, y se encontró que el principal problema radica en la alta percepción de inseguridad que existe hacia el uso de dichos medios de transporte, especialmente por la carencia de vías seguras o la mala condición en la que se encuentran. En base a este diagnóstico, se propone un plan con 10 iniciativas enfocadas en aumentar la percepción de seguridad hacia el uso de medios de transporte sostenible. La implementación de dicho plan ayudaría a aumentar en 50% la cantidad de colaboradores que utilizaría movilidad sostenible, con lo cual se alcanzaría la meta de reducción de dióxido de carbono, así como generar otros beneficios como reducir el estrés percibido por los colaboradores debido al tiempo invertido en el tráfico limeño, y mejorar el posicionamiento de la marca al ser asociada como una marca eco-amigable, tanto ante los clientes como sus colaboradores.
