Motivated by observational studies that report associations between schizophrenia and traits, such as poor diet, increased body mass index and metabolic disease, we investigated the genetic ...contribution to dietary intake in a sample of 335,576 individuals from the UK Biobank study. A principal component analysis applied to diet question item responses generated two components: Diet Component 1 (DC1) represented a meat-related diet and Diet Component 2 (DC2) a fish and plant-related diet. Genome-wide association analysis identified 29 independent single-nucleotide polymorphisms (SNPs) associated with DC1 and 63 SNPs with DC2. Estimated from over 35,000 3rd-degree relative pairs that are unlikely to share close family environments, heritabilities for both DC1 and DC2 were 0.16 (standard error (s.e.) = 0.05). SNP-based heritability was 0.06 (s.e. = 0.003) for DC1 and 0.08 (s.e = 0.004) for DC2. We estimated significant genetic correlations between both DCs and schizophrenia, and several other traits. Mendelian randomisation analyses indicated a negative uni-directional relationship between liability to schizophrenia and tendency towards selecting a meat-based diet (which could be direct or via unidentified correlated variables), but a bi-directional relationship between liability to schizophrenia and tendency towards selecting a fish and plant-based diet consistent with genetic pleiotropy.
When a distance relay protects a transmission line located on a dual circuit tower, a coupling effect will occur between the two circuits. Transposition of the circuits can reduce the mutual ...impedances, but this does not cater to the zero-sequence mutual coupling impedance during earth faults. As a result, the impedance measured by a distance relay under phase-to-earth fault conditions in these circumstances will not represent the correct impedance to the fault point unless these effects are taken into account. On multi-circuit lines, primarily if they operate in parallel, a zero-sequence mutual coupling should be considered when calculating settings for distance protection function. A 220 kV parallel line sharing the same tower was analysed using DigSilent Power Factory in the simulations. Phase-to-earth faults in different configurations were analysed on this system, and the reach of the protection relay was then estimated for operation. The results confirm how a protection relay can overreach and underreach in a distance protection scheme due to the influence of mutual coupling.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The aim of this study was to develop near infrared spectroscopy (NIRS) calibrations to predict quality parameters, dry matter (DM, g kg−1) and crude protein (CP, g kg−1 DM), in fresh un-dried grass. ...Knowledge of these parameters would enable more precise allocation of quality herbage to grazing livestock. Perennial ryegrass samples (n = 1 615) were collected over the 2017 and 2018 grazing seasons at Teagasc Moorepark to develop a NIRS calibration dataset. Additional samples were collected for an independent validation dataset (n = 197) during the 2019 grazing season. Samples were scanned using a FOSS 6500 spectrometer at 2 nm intervals in the range of 1 100 ~ 2 500 nm and absorption was recorded as log 1/Reflectance. Reference wet chemistry analysis was carried out for both parameters and the resultant data were calibrated against spectral data by means of modified partial least squares regression. A range of mathematical spectral treatments were examined for each calibration, which were ranked in order of standard error of prediction (SEP) and ratio of percent deviation (RPD). Best performing calibrations achieved high predictive precision for DM (R2 = 0.86 SEP = 9.46 g kg−1, RPD = 2.60) and moderate precision for CP (R2 = 0.84 SEP = 20.38 g kg−1 DM, RPD = 2.37). These calibrations will aid the optimisation of grassland management and the development of precision agricultural technologies.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The increasing integration of inverter-based resources, such as wind and photovoltaic systems, poses significant challenges for protection devices. Reduction in fault current is expected to ...compromise power system protection performance. Traditional overhead line protection schemes have primarily been designed focusing on the dynamic behaviour of rotating machines as the primary generation sources, neglecting the unique dynamic response of inverter-based resources governed by inverters. Consequently, the effectiveness of distance or impedance relays in safeguarding lines with inverter-based resources requires special attention. This study developed a comprehensive model of a 110 kV network comprising traditional and inverter-based resources using DigSilent PowerFactory. Electromagnetic transients (EMT) analysis is conducted on distance protection devices within the network. The findings presented in this paper highlight the complex challenges encountered when employing distance relay protection in the presence of inverter-based resources.
Substation Automation Systems are commonly used to control, protect and monitor substations in a power system. Many existing substation automation systems use proprietary protocols, which are no ...longer supported. Therefore, expensive and complex solutions are often required when automation equipment fails or reaches the end of life (15/20 years), or a substation extension is required. Older proprietary-based protocols in substation automation systems are being updated and replaced by introducing the IEC 61850 standard series.IEC 61850 brings significant changes to how Intelligent Electronic Devices used for protection are to be tested. The introduction of non-traditional relay signals resulted in the need for new tools and processes regarding commissioning, testing and maintenance.This paper provides an overview of existing proprietary protocols and outlines the IEC 61850 standard. The challenges in testing IEC 61850 protection equipment are investigated. Finally, a power utility approach for extending existing legacy substation automation systems is demonstrated in a lab-based trial. The comparison illustrated the many benefits of installing and extending substations using IEC 61850 rather than reengineering the proprietary systems.
The objective of this study was to investigate the effect of level of pre-grazing herbage mass (HM) and daily herbage allowance (DHA) on the fatty acid (FA) intake and composition of ruminal content ...of grazing dairy cows. Four rumen fistulated Holstein-Friesian dairy cows were allocated to either a high or low HM (1700 vs 2600 kg DM ha-1) and within herbage mass treatment further allocated to a high or low DHA (20 vs 16 kg of DM cow-1 day-1) in a 4 × 4 Latin square design. Total FA intake and linolenic acid (LNA) intake was higher for cows on high DHA (p<0.05). Ruminal oleic acid, linoleic and LNA were not affected by treatments. Ruminal stearic acid (C18:0) and vaccenic acid (VA) concentrations were higher at low HM (43.6 and 14.8 g/100 gof FA respectively; p<0.01) compared to high HM (42.0 and 12.5 g/100 gof FA respectively for C18:0 and VA). Cows grazing high DHA had higher ruminal concentration of VA (15.3 g/100 gof FA; p<0.01) than low DHA (12.1 g/100 gof FA). Regarding milk FA composition, only some of the milk FA varied across treatments, being the VA and LNA concentrations higher at low HM (p<0.05). These data suggest that low HM and high DHA, at least within the range studied here, promotes the accumulation of ruminal VA which could be available for subsequent conversion within the mammary gland to the human health promoting c9,t11 isomer of conjugated linoleic acid.
Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the ...causality of these associations is unclear. We sought to assess the causal nature of these associations using Mendelian randomization (MR).
We used SNPs associated with each risk factor as instrumental variables in MR analyses. We considered type 2 diabetes (T2D, NSNPs = 49), fasting glucose (NSNPs = 36), insulin resistance (NSNPs = 10), body mass index (BMI, NSNPs = 32), total cholesterol (NSNPs = 73), HDL-cholesterol (NSNPs = 71), LDL-cholesterol (NSNPs = 57), triglycerides (NSNPs = 39), systolic blood pressure (SBP, NSNPs = 24), smoking initiation (NSNPs = 1), smoking quantity (NSNPs = 3), university completion (NSNPs = 2), and years of education (NSNPs = 1). We calculated MR estimates of associations between each exposure and AD risk using an inverse-variance weighted approach, with summary statistics of SNP-AD associations from the International Genomics of Alzheimer's Project, comprising a total of 17,008 individuals with AD and 37,154 cognitively normal elderly controls. We found that genetically predicted higher SBP was associated with lower AD risk (odds ratio OR per standard deviation 15.4 mm Hg of SBP 95% CI: 0.75 0.62-0.91; p = 3.4 × 10(-3)). Genetically predicted higher SBP was also associated with a higher probability of taking antihypertensive medication (p = 6.7 × 10(-8)). Genetically predicted smoking quantity was associated with lower AD risk (OR per ten cigarettes per day 95% CI: 0.67 0.51-0.89; p = 6.5 × 10(-3)), although we were unable to stratify by smoking history; genetically predicted smoking initiation was not associated with AD risk (OR = 0.70 0.37, 1.33; p = 0.28). We saw no evidence of causal associations between glycemic traits, T2D, BMI, or educational attainment and risk of AD (all p > 0.1). Potential limitations of this study include the small proportion of intermediate trait variance explained by genetic variants and other implicit limitations of MR analyses.
Inherited lifetime exposure to higher SBP is associated with lower AD risk. These findings suggest that higher blood pressure--or some environmental exposure associated with higher blood pressure, such as use of antihypertensive medications--may reduce AD risk.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
•Cheddar cheese was more yellow in colour from a 95% Grass-fed system vs. a total mixed ration (TMR) feeding system.•Bovine diet affected Cheddar cheese texture both from texture profile analysis, ...and as perceived by a consumer panel.•Bovine diet did not influence consumer liking of Cheddar cheese at an overall group level.•Clear consumer segmentation was evident for feeding system preferences, with 42 consumers preferring Cheddar cheese from a GF system vs TMR.•In all consumer groups, taste was the main overall driver of liking.
This study investigated the effects of diet and stage of lactation (SOL) on sensory profiles, texture, volatile profiles, and colour of Cheddar cheese. Cheddar cheese was manufactured from early-, mid-, and late-lactation milk obtained from seasonally calved cows (n = 54). Cows were assigned a diet; group 1: perennial ryegrass (GRS), group 2: total mixed ration (TMR), and group 3: partial mixed ration (PMR). Instrumental analysis was performed at 270 days (mature Cheddar). Sensory evaluation took place after 548 days (extra mature Cheddar).
Toluene was the only volatile compound that was significantly influenced by diet. The trained panel rated early-lactation cheese as stronger than mid- and late- for cowy/barny flavour and late-lactation cheese as sweeter than early- and mid-lactation cheese. Mid-lactation cheese was liked least overall. Early-lactation cheeses were rated higher for ‘crumbly’ texture than mid- and late. Diet affected consumer ratings, with GRS and PMR cheese rated as more intense than TMR for flavour, aftertaste, and saltiness. Consumers reported that TMR cheese was lighter in colour compared to GRS cheese, which was supported by instrumental analysis. Consumers perceived GRS as more springy and less crumbly than TMR and PMR, while Texture Profile Analysis indicated that TMR was harder than GRS. Consumer segmentation was observed with two clear preference groups, one preferring GRS and one preferring TMR. For both groups, ‘taste’ seemed to be the main driver of liking, highlighting that consumer preference is most impacted by individual taste preferences.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
10.
Analysis of a Midpoint Series Compensated Line Donovan, Michael O; Barry, Noel; Connell, Joe ...
2021 56th International Universities Power Engineering Conference (UPEC),
2021-Aug.-31
Conference Proceeding
Many electrical utilities worldwide are increasingly using series compensation to meet the need to add large amounts of renewable energy resources such as wind and solar to the existing power system ...network. In series compensated lines, the effective line inductive reactance becomes small due to the capacitive compensation. This can lead to voltage and current inversion and subsynchronous oscillations during disturbances along the series compensated line. For distance relays, special consideration must be taken for series compensated, and adjacent lines due to the series capacitor bank (SCB) alters the line impedance. This can cause a protection relay to operate for faults beyond its normal reach. A 400 kV series compensated network is modelled using DigSilent Power Factory. Electromagnetic transients (EMT) analysis was performed on distance protection devices on the network. The results presented in this paper show that a series compensated line presents challenges for setting distance relay protection where a three-phase fault can lead to overreach, voltage, or current inversion at different network locations.
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