Abstract
Background
Previous studies have reported ongoing cardiac inflammation as assessed by cardiac magnetic resonance imaging (CMR) in a significant proportion of patients several months after ...recovery from SARS-CoV-2 infection, many of whom had no or minimal symptoms at the time of infection.
Purpose
The aim of SETANTA was to investigate the prevalence of cardiac abnormalities by CMR in unselected patients in Ireland after acute SARS-CoV-2 infection and the correlation with immunological response and biomarkers of coagulation.
Methods
This was a prospective, observational, community-based study (clinicaltrials.gov identifier NCT04823182). Consecutive patients recovered from recent SARS-CoV-2 infection at 3 primary care sites were invited to participate. Key inclusion/exclusion criteria and outcomes of interest are shown in Figure 1.
Results
100 participants were enrolled (Feb-Sept 2021) at a median of 188 (IQR, 125, 246) days after positive SARS-CoV-2 swab. At index infection, 18% and 35% reported severe and moderate symptoms, respectively; 14% were hospitalized; 3% were admitted to intensive care for ventilatory support. At enrolment, 83% had ongoing symptoms. 85% had detectable SARS-CoV-2 antigens. CMR and laboratory findings are shown in Figure 1.
Conclusion
Among an unselected cohort of patients recovered from acute SARS-CoV2 infection, we report a low prevalence of cardiac abnormalities by CMR, despite a high prevalence of moderate/severe symptoms at presentation and a high prevalence of persistent symptoms. Correlation with biomarkers of immunity and coagulation will be available at ESC 2022.
Funding Acknowledgement
Type of funding sources: Foundation. Main funding source(s): WomenAsOne
British and Irish diasporas MacRaild, Donald; Bueltmann, Tanja; Clark, J. C. D
2019, 20190301, 2018, 2019-01-07
eBook
People from the British and Irish Isles have, for centuries, migrated to all corners of the globe.Wherever they went, the English, Irish, Scots, Welsh, and and even sub-national, supra-regional ...groups like the Cornish, co-mingled, blended and blurred. Yet while they gradually integrated into new lives in far-flung places, British and Irish Isle emigrants often maintained elements of their distinctive national cultures, which is an important foundation of diasporas. Within this wider context, this volume seeks to explore the nature and characteristics of the British and Irish diasporas, stressing their varying origins and evolution, the developing attachments to them, and the differences in each nation’s recognition of their own diaspora. The volume thus offers the first integrated study of the formation of diasporas from the islands of Ireland and Britain, with a particular view to scrutinizing the similarities, differences, tensions and possibilities of this approach.People from the British and Irish Isles have, for centuries, migrated to all corners of the globe.Wherever they went, the English, Irish, Scots, Welsh, and and even sub-national, supra-regional groups like the Cornish, co-mingled, blended and blurred. Yet while they gradually integrated into new lives in far-flung places, British and Irish Isle emigrants often maintained elements of their distinctive national cultures, which is an important foundation of diasporas. Within this wider context, this volume seeks to explore the nature and characteristics of the British and Irish diasporas, stressing their varying origins and evolution, the developing attachments to them, and the differences in each nation’s recognition of their own diaspora. The volume thus offers the first integrated study of the formation of diasporas from the islands of Ireland and Britain, with a particular view to scrutinizing the similarities, differences, tensions and possibilities of this approach.
