Our previous studies suggest that the SNARE protein synaptosomal-associated protein of 23 kDa (SNAP23) is involved in the link between increased lipid levels and insulin resistance in cardiomyocytes. ...The objective was to determine whether SNAP23 may also be involved in the known association between lipid accumulation in skeletal muscle and insulin resistance/type 2 diabetes in humans, as well as to identify a potential regulator of SNAP23.
We analyzed skeletal muscle biopsies from patients with type 2 diabetes and healthy, insulin-sensitive control subjects for expression (mRNA and protein) and intracellular localization (subcellular fractionation and immunohistochemistry) of SNAP23, and for expression of proteins known to interact with SNARE proteins. Insulin resistance was determined by a euglycemic hyperinsulinemic clamp. Potential mechanisms for regulation of SNAP23 were also investigated in the skeletal muscle cell line L6.
We showed increased SNAP23 levels in skeletal muscle from patients with type 2 diabetes compared with that from lean control subjects. Moreover, SNAP23 was redistributed from the plasma membrane to the microsomal/cytosolic compartment in the patients with the type 2 diabetes. Expression of the SNARE-interacting protein Munc18c was higher in skeletal muscle from patients with type 2 diabetes. Studies in L6 cells showed that Munc18c promoted the expression of SNAP23.
We have translated our previous in vitro results into humans by showing that there is a change in the distribution of SNAP23 to the interior of the cell in skeletal muscle from patients with type 2 diabetes. We also showed that Munc18c is a potential regulator of SNAP23.
The Aurora space launcher concept Kopp, Alexander; Stappert, Sven; Mattsson, David ...
CEAS space journal,
06/2018, Volume:
10, Issue:
2
Journal Article
Peer reviewed
Open access
This paper gives an overview about the Aurora reusable space launcher concept study that was initiated in late-2015/early-2016. Within the Aurora study, several spaceplane-like vehicle configurations ...with different geometries, propulsion systems and mission profiles will be designed, investigated and evaluated with respect to their technical and economic feasibility. The first part of this paper will discuss the study logic and the current status of the Aurora studies and introduces the first vehicle configurations and their system design status. As the identification of highly efficient structural designs is of particular interest for Aurora, the structural design and analysis approach will be discussed in higher level of detail. A special design feature of the Aurora vehicle configurations is the utilization of the novel thin-ply composite material technology for structural mass reductions. Therefore, the second part of this paper will briefly discuss this technology and investigate the application and potential mass savings on vehicle level within simplified structural analysis studies. The results indicate that significant mass savings could be possible. Finally, an outlook on the next steps is provided.
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In between Science, Class and Society and The Killing Fields of Inequality Göran Therborn has consistently challenged received wisdom in politics and the social sciences. This book is a critical ...appraisal of the themes Therborn has pursued up till now. It is introduced by Robin Blackburn, for almost twenty years his editor at New Left Review.
A brief review of lipoprotein metabolism Vissers, Maud N; Stroes, Erik S; Kastelein, John JP
Evidence-Based Management of Lipid Disorders,
2010, 2009
Book Chapter
Anders Olofsson, fogde på Skånes landsting, Sven S [...] Anders Olofsson, fogde på Skånes landsting, Sven Saxtorp och Klemens Nilsson, kaniker i Lund, väpnarna Martin Bug, Johan Lund och Johan Jakobsson, prästerna Peter Jönsson, sakristan i Lunds domkyrkas kor, och Erik Jönsson vid S:t Botulfs kyrka, samt Eskil Nilsson, borgare i Lund
01/1371
Web Resource
Provider: - Institution: - Data provided by Europeana Collections- Anders Olofsson, fogde på Skånes landsting, Sven Saxtorp och Klemens Nilsson, kaniker i Lund, väpnarna Martin Bug, Johan Lund och ...Johan Jakobsson, prästerna Peter Jönsson, sakristan i Lunds domkyrkas kor, och Erik Jönsson vid S:t Botulfs kyrka, samt Eskil Nilsson, borgare i Lund, intygar att fru Marina Jönsdotter till Borrsjö, änka efter framlidne riddaren Nils Hak till Hyby, på Skånes landsting 18/1 1371 i närvaro av utfärdarna och andra trovärdiga vittnen genom skötning överlåtit all sin rörliga och fasta egendom i Saxtorp i Harjagers härad, nämligen tre gårdar, en huvudgård, där en viss Paul bor, och två andra gårdar i anslutning till huvudgården, till brevvisaren herr Johan Sommar, kanik i Lund. Marina Jönsdotter intygar att hon erhållit full betalning för egendomarna av Johan Sommar och förbinder sig och sina arvingar att åt honom och hans arvingar överlåta äganderätten samt lämna egendomarna fria från rättsanspråk och klander.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Anders Olofsson, fogde på Skånes landsting, Sven S [...] Anders Olofsson, fogde på Skånes landsting, Sven Saxtorp och Klemens Nilsson, kaniker i Lund, väpnarna Martin Bug, Johan Lund och Johan Jakobsson, prästerna Peter Jönsson, sakristan i Lunds domkyrkas kor, och Erik Jönsson vid S:t Botulfs kyrka, samt Eskil Nilsson, borgare i Lund
01/1371
Web Resource
Provider: - Institution: - Data provided by Europeana Collections- Anders Olofsson, fogde på Skånes landsting, Sven Saxtorp och Klemens Nilsson, kaniker i Lund, väpnarna Martin Bug, Johan Lund och ...Johan Jakobsson, prästerna Peter Jönsson, sakristan i Lunds domkyrkas kor, och Erik Jönsson vid S:t Botulfs kyrka, samt Eskil Nilsson, borgare i Lund, intygar att fru Marina Jönsdotter till Borrsjö, änka efter framlidne riddaren Nils Hak till Hyby, på Skånes landsting 18/1 1371 i närvaro av utfärdarna och andra trovärdiga vittnen genom skötning överlåtit all sin rörliga och fasta egendom i Saxtorp i Harjagers härad, nämligen tre gårdar, en huvudgård, där en viss Paul bor, och två andra gårdar i anslutning till huvudgården, till brevvisaren herr Johan Sommar, kanik i Lund. Marina Jönsdotter intygar att hon erhållit full betalning för egendomarna av Johan Sommar och förbinder sig och sina arvingar att åt honom och hans arvingar överlåta äganderätten samt lämna egendomarna fria från rättsanspråk och klander.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
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