Abstract Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's disease (AD). Yet, not much is known about the molecular alterations underlying this reactive phenotype. ...To get an insight into the molecular changes underlying AD induced astrocyte and microglia reactivity, we performed a transcriptional analysis on acutely isolated astrocytes and microglia from the cortex of aged controls and APPswe/PS1dE9 AD mice. As expected, both cell types acquired a proinflammatory phenotype, which confirms the validity of our approach. Interestingly, we observed that the immune alteration in astrocytes was relatively more pronounced than in microglia. Concurrently, our data reveal that astrocytes display a reduced expression of neuronal support genes and genes involved in neuronal communication. The microglia showed a reduced expression of phagocytosis and/or endocytosis genes. Co-expression analysis of a human AD expression data set and the astrocyte and microglia data sets revealed that the inflammatory changes in astrocytes were remarkably comparable in mouse and human AD, whereas the microglia changes showed less similarity. Based on these findings we argue that chronically proinflammatory astrocyte and microglia phenotypes, showing a reduction of genes involved in neuronal support and neuronal signaling, are likely to contribute to the neuronal dysfunction and cognitive decline in AD.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
We are entering an era of unprecedented quantities of data from current and planned survey telescopes. To maximize the potential of such surveys, automated data analysis techniques are required. Here ...we implement a new methodology for variable star classification, through the combination of Kohonen Self-Organizing Maps (SOMs, an unsupervised machine learning algorithm) and the more common Random Forest (RF) supervised machine learning technique. We apply this method to data from the K2 mission fields 0–4, finding 154 ab-type RR Lyraes (10 newly discovered), 377 δ Scuti pulsators, 133 γ Doradus pulsators, 183 detached eclipsing binaries, 290 semidetached or contact eclipsing binaries and 9399 other periodic (mostly spot-modulated) sources, once class significance cuts are taken into account. We present light-curve features for all K2 stellar targets, including their three strongest detected frequencies, which can be used to study stellar rotation periods where the observed variability arises from spot modulation. The resulting catalogue of variable stars, classes, and associated data features are made available online. We publish our SOM code in python as part of the open source pymvpa package, which in combination with already available RF modules can be easily used to recreate the method.
Photometric surveys such as Kepler have the precision to identify exoplanet and eclipsing binary candidates from only a single transit. K2, with its 75 d campaign duration, is ideally suited to ...detect significant numbers of single-eclipsing objects. Here we develop a Bayesian transit-fitting tool (‘Namaste: An Mcmc Analysis of Single Transit Exoplanets’) to extract orbital information from single transit events. We achieve favourable results testing this technique on known Kepler planets, and apply the technique to seven candidates identified from a targeted search of K2 campaigns 1, 2 and 3. We find EPIC203311200 to host an excellent exoplanet candidate with a period, assuming zero eccentricity, of
$540 ^{+410}_{-230}$
d and a radius of 0.51 ± 0.05R
Jup. We also find six further transit candidates for which more follow-up is required to determine a planetary origin. Such a technique could be used in the future with TESS, PLATO and ground-based photometric surveys such as NGTS, potentially allowing the detection of planets in reach of confirmation by Gaia.
Determining the architecture of multi-planetary systems is one of the cornerstones of understanding planet formation and evolution. Resonant systems are especially important as the fragility of their ...orbital configuration ensures that no significant scattering or collisional event has taken place since the earliest formation phase when the parent protoplanetary disc was still present. In this context, TOI-178 has been the subject of particular attention since the first TESS observations hinted at the possible presence of a near 2:3:3 resonant chain. Here we report the results of observations from CHEOPS, ESPRESSO, NGTS, and SPECULOOS with the aim of deciphering the peculiar orbital architecture of the system. We show that TOI-178 harbours at least six planets in the super-Earth to mini-Neptune regimes, with radii ranging from 1.152
−0.070
+0.073
to 2.87
−0.13
+0.14
Earth radii and periods of 1.91, 3.24, 6.56, 9.96, 15.23, and 20.71 days. All planets but the innermost one form a 2:4:6:9:12 chain of Laplace resonances, and the planetary densities show important variations from planet to planet, jumping from 1.02
−0.23
+0.28
to 0.177
−0.061
+0.055
times the Earth’s density between planets
c
and
d
. Using Bayesian interior structure retrieval models, we show that the amount of gas in the planets does not vary in a monotonous way, contrary to what one would expect from simple formation and evolution models and unlike other known systems in a chain of Laplace resonances. The brightness of TOI-178 (
H
= 8.76 mag,
J
= 9.37 mag,
V
= 11.95 mag) allows for a precise characterisation of its orbital architecture as well as of the physical nature of the six presently known transiting planets it harbours. The peculiar orbital configuration and the diversity in average density among the planets in the system will enable the study of interior planetary structures and atmospheric evolution, providing important clues on the formation of super-Earths and mini-Neptunes.
Full text
Available for:
FMFMET, NUK, UL, UM, UPUK
On the abundance of circumbinary planets Armstrong, D. J; Osborn, H. P; Brown, D. J. A ...
Monthly Notices of the Royal Astronomical Society,
10/2014, Volume:
444, Issue:
2
Journal Article
Peer reviewed
Open access
We present here the first observationally based determination of the rate of occurrence of circumbinary planets. This is derived from the publicly available Kepler data, using an automated search ...algorithm and debiasing process to produce occurrence rates implied by the seven systems already known. These rates depend critically on the planetary inclination distribution: if circumbinary planets are preferentially coplanar with their host binaries, as has been suggested, then the rate of occurrence of planets with Rp
> 6R⊕ orbiting with P
p
< 300 d is
$10.0 ^{+18}_{-6.5}$
per cent (95 per cent confidence limits), higher than but consistent with single star rates. If on the other hand the underlying planetary inclination distribution is isotropic, then this occurrence rate rises dramatically, to give a lower limit of 47 per cent. This implies that formation and subsequent dynamical evolution in circumbinary discs must either lead to largely coplanar planets, or proceed with significantly greater ease than in circumstellar discs. As a result of this investigation, we also show that giant planets ( > 10R⊕) are significantly less common in circumbinary orbits than their smaller siblings, and confirm that the proposed shortfall of circumbinary planets orbiting the shorter period binaries in the Kepler sample is a real effect.
Context.
The detection of a super-Earth and three mini-Neptunes transiting the bright (
V
= 9.2 mag) star HD 108236 (also known as TOI-1233) was recently reported on the basis of TESS and ...ground-based light curves.
Aims.
We perform a first characterisation of the HD 108236 planetary system through high-precision CHEOPS photometry and improve the transit ephemerides and system parameters.
Methods.
We characterise the host star through spectroscopic analysis and derive the radius with the infrared flux method. We constrain the stellar mass and age by combining the results obtained from two sets of stellar evolutionary tracks. We analyse the available TESS light curves and one CHEOPS transit light curve for each known planet in the system.
Results.
We find that HD 108236 is a Sun-like star with
R
⋆
= 0.877 ± 0.008
R
⊙
,
M
⋆
= 0.869
−0.048
+0.050
M
⊙
, and an age of 6.7
−5.1
+4.0
Gyr. We report the serendipitous detection of an additional planet, HD 108236 f, in one of the CHEOPS light curves. For this planet, the combined analysis of the TESS and CHEOPS light curves leads to a tentative orbital period of about 29.5 days. From the light curve analysis, we obtain radii of 1.615 ± 0.051, 2.071 ± 0.052, 2.539
−0.065
+0.062
, 3.083 ± 0.052, and 2.017
−0.057
+0.052
R
⊕
for planets HD 108236 b to HD 108236 f, respectively. These values are in agreement with previous TESS-based estimates, but with an improved precision of about a factor of two. We perform a stability analysis of the system, concluding that the planetary orbits most likely have eccentricities smaller than 0.1. We also employ a planetary atmospheric evolution framework to constrain the masses of the five planets, concluding that HD 108236 b and HD 108236 c should have an Earth-like density, while the outer planets should host a low mean molecular weight envelope.
Conclusions.
The detection of the fifth planet makes HD 108236 the third system brighter than
V
= 10 mag to host more than four transiting planets. The longer time span enables us to significantly improve the orbital ephemerides such that the uncertainty on the transit times will be of the order of minutes for the years to come. A comparison of the results obtained from the TESS and CHEOPS light curves indicates that for a
V
~ 9 mag solar-like star and a transit signal of ~500 ppm, one CHEOPS transit light curve ensures the same level of photometric precision as eight TESS transits combined, although this conclusion depends on the length and position of the gaps in the light curve.
Full text
Available for:
FMFMET, NUK, UL, UM, UPUK
Abstract
The relative rarity of giant planets around low-mass stars compared with solar-type stars is a key prediction from the core-accretion planet formation theory. In this paper we report on the ...discovery of four gas giant planets that transit low-mass late K and early M dwarfs. The planets HATS-74Ab (TOI 737b), HATS-75b (TOI 552b), HATS-76b (TOI 555b), and HATS-77b (TOI 730b) were all discovered from the HATSouth photometric survey and follow-up using TESS and other photometric facilities. We use the new ESPRESSO facility at the VLT to confirm systems and measure their masses. We find that these planets have masses of 1.46 ± 0.14
M
J, 0.491 ± 0.039
M
J, 2.629 ± 0.089
M
J, and
1.374
−
0.074
+
0.100
M
J, respectively, and radii of 1.032 ± 0.021
R
J, 0.884 ± 0.013
R
J, 1.079 ± 0.031
R
J, and 1.165 ± 0.021
R
J, respectively. The planets all orbit close to their host stars with orbital periods ranging from 1.7319 days to 3.0876 days. With further work, we aim to test core-accretion theory by using these and further discoveries to quantify the occurrence rate of giant planets around low-mass host stars.
To investigate the origin of the features discovered in the exoplanet population, the knowledge of exoplanets' mass and radius with a good precision (≲10%) is essential. To achieve this purpose the ...discovery of transiting exoplanets around bright stars is of prime interest. In this paper, we report the discovery of three transiting exoplanets by the SuperWASP survey and the SOPHIE spectrograph with mass and radius determined with a precision better than 15%. WASP-151b and WASP-153b are two hot Saturns with masses, radii, densities and equilibrium temperatures of 0.31−0.03+0.04 MJ$0.31_{-0.03}^{+0.04}\,{M_{\textrm{J}}}$0.31−0.03+0.04 MJ, 1.13−0.03+0.03 RJ$1.13_{-0.03}^{+0.03}\,{R_{\textrm{J}}}$1.13−0.03+0.03 RJ, 0.22−0.02+0.03 ρJ$0.22_{-0.02}^{+0.03}\,\rho_{\mathrm{J}}$0.22−0.02+0.03 ρJ and 1290−10+20 K$1290_{-10}^{+20}~\mathrm{K}$1290−10+20 K, and 0.39−0.02+0.02 MJ$0.39_{-0.02}^{+0.02}\,{M_{\textrm{J}}}$0.39−0.02+0.02 MJ, 1.55−0.08+0.10 RJ$1.55_{-0.08}^{+0.10}\,{R_{\textrm{J}}}$1.55−0.08+0.10 RJ, 0.11−0.02+0.02 ρJ$0.11_{-0.02}^{+0.02}\,\rho_{\mathrm{J}}$0.11−0.02+0.02 ρJ and 1700−0.40+0.40 K$1700_{-40}^{+40}~\mathrm{K}$1700−40+40 K, respectively. Their host stars are early G type stars (with mag V ~ 13) and their orbital periods are 4.53 and 3.33 days, respectively. WASP-156b is a super-Neptune orbiting a K type star (mag V = 11.6). It has a mass of $0.128_{-0.009}^{+0.010}\,{M_{\rm J}}$0.128−0.009+0.010 MJ0.128-0.009+0.010MJ, a radius of $0.51_{-0.02}^{+0.02}\,{R_{\rm J}}$0.51−0.02+0.02 RJ0.51-0.02+0.02RJ, a density of 1.0−0.1+0.1 ρJ$1.0_{-0.1}^{+0.1}\,\rho_{\mathrm{J}}$1.0−0.1+0.1 ρJ, an equilibrium temperature of 970−20+30 K$970_{-20}^{+30}~\mathrm{K}$970−20+30 K and an orbital period of 3.83 days. The radius of WASP-151b appears to be only slightly inflated, while WASP-153b presents a significant radius anomaly compared to a recently published model. WASP-156b, being one of the few well characterized super-Neptunes, will help to constrain the still debated formation of Neptune size planets and the transition between gas and ice giants. The estimates of the age of these three stars confirms an already observed tendency for some stars to have gyrochronological ages significantly lower than their isochronal ages. We propose that high eccentricity migration could partially explain this behavior for stars hosting a short period planet. Finally, these three planets also lie close to (WASP-151b and WASP-153b) or below (WASP-156b) the upper boundary of the Neptunian desert. Their characteristics support that the ultra-violet irradiation plays an important role in this depletion of planets observed in the exoplanet population.
Full text
Available for:
FMFMET, NUK, UL, UM, UPUK
AU Mic is a young planetary system with a resolved debris disc showing signs of planet formation and two transiting warm Neptunes near mean-motion resonances. Here we analyse three transits of AU Mic ...b observed with the CHaracterising ExOPlanet Satellite (CHEOPS), supplemented with sector 1 and 27 Transiting Exoplanet Survey Satellite (TESS) photometry, and the All-Sky Automated Survey from the ground. The refined orbital period of AU Mic b is 8.462995 ± 0.000003 d, whereas the stellar rotational period is
P
rot
= 4.8367 ± 0.0006 d. The two periods indicate a 7:4 spin–orbit commensurability at a precision of 0.1%. Therefore, all transits are observed in front of one of the four possible stellar central longitudes. This is strongly supported by the observation that the same complex star-spot pattern is seen in the second and third CHEOPS visits that were separated by four orbits (and seven stellar rotations). Using a bootstrap analysis we find that flares and star spots reduce the accuracy of transit parameters by up to 10% in the planet-to-star radius ratio and the accuracy on transit time by 3–4 min. Nevertheless, occulted stellar spot features independently confirm the presence of transit timing variations (TTVs) with an amplitude of at least 4 min. We find that the outer companion, AU Mic c, may cause the observed TTVs.
Full text
Available for:
FMFMET, NUK, UL, UM, UPUK
The Transiting Exoplanet Survey Satellite, TESS, is currently carrying out an all-sky search for small planets transiting bright stars. In the first year of the TESS survey, a steady progress was ...made in achieving the mission’s primary science goal of establishing bulk densities for 50 planets smaller than Neptune. During that year, the TESS’s observations were focused on the southern ecliptic hemisphere, resulting in the discovery of three mini-Neptunes orbiting the star TOI-125, a V = 11.0 K0 dwarf. We present intensive HARPS radial velocity observations, yielding precise mass measurements for TOI-125b, TOI-125c, and TOI-125d. TOI-125b has an orbital period of 4.65 d, a radius of 2.726 ± 0.075 R(E), a mass of 9.50 ± 0.88 M(E), and is near the 2:1 mean motion resonance with TOI-125c at 9.15 d. TOI-125c has a similar radius of 2.759 ± 0.10 R(E) and a mass of 6.63 ± 0.99 M(E), being the puffiest of the three planets. TOI-125d has an orbital period of 19.98 d and a radius of 2.93 ± 0.17 R(E) and mass 13.6 ± 1.2 M(E). For TOI-125b and d, we find unusual high eccentricities of 0.19 ± 0.04 and 0.17(sup +0.08, sub −0.06), respectively. Our analysis also provides upper mass limits for the two low-SNR planet candidates in the system; for TOI-125.04 (R(P) = 1.36 R(E), P = 0.53 d), we find a 2σ upper mass limit of 1.6 M(E), whereas TOI-125.05 (R(P) = 4.2(sup +2.4, sub −1.4 R(E), P = 13.28 d) is unlikely a viable planet candidate with an upper mass limit of 2.7 M(E). We discuss the internal structure of the three confirmed planets, as well as dynamical stability and system architecture for this intriguing exoplanet system.
PDF
