We have assessed, by means of the methods of statistics, the compliance of the treatment facilities of the Dnieper waterworks in Kiev with the state-of-the-art in the quality the Dnieper River water ...and, in the first place, with that of the organic component, which determines its color.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The most investigations of the biomarkers of renal allograft dysfunction (RAD) are limited by early post-operational period and are aimed at diagnosis of acute rejection of renal transplant. This ...work has aimed to establish additional characteristics of chronic RAD by using non-invasive biomarkers of the blood serum and urine.Materials and methods. 79 patients aged 16 to 59 years (47 men and 32 women) took part in our retrospective study. The alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamil transferase (GGT), alkaline phosphatase (ALP), N-acetyl-β-D-glucosaminidase (NAG); interleukins (IL-2, IL-8, IL-10) and beta-2-microglobulin were evaluated.Results. Increased IL-10 and β2-MG serum concentration, and increased urinary concentration and activity of β2-MG, IL-2, IL-8, NAG, AP, AST, GGT were typical for chronic RAD. Only NAG was independently significantly associated with chronic RAD in multivariate regression. From the area under ROC-curves were derived, that β2-MG level in serum and urine, and the activity of NAG in urine had the excellent and good power to classify patients with satisfactory function and chronic RAD.Conclusions. The increase of β2-MG in serum and urine may indicate glomerular and tubular dysfunction, respectively. An increase of urinary NAG indicates the ongoing damage of the tubules. The increase of IL-2 and IL-8 in the urine and IL-10 in serum may indicate the etiology of chronic RAD.
The retrospective analysis of the influence of histological changes in donor kidneys on the KAG function during first year was conducted in 75 recipients of a cadaveric kidney. The state of tubuli, ...glomeruli, interstitium, vessels was assessed semiquantitatively in the material of «0»-biopsies. The endpoints were serum creatinine and glomerular filtration rate at 3, 6 and 12 months. KAG function in the first year is programmed by histological changes in all compartments of donor kidney. Influence of histological changes is time-dependent: the effect of ischemic damage shows up quickly, but disappeared after 6 months; the effect of arteriolohyalinosis and arteriosclerosis begins to show up later – since 6 months; changes in glomeruli have influence on a KAG function in 3 months and 1 year; interstitial fibrosis in cortex and medulla negatively influences KAG function on the extent of all first year. Our data argue for the necessity of «0»-biopsies examination for the prediction of KAG subsequent function.
The study was organized to provide additional characteristic of chronic dysfunction of renal allo-transplant using such biomarkers of serum and urine as enzymes (alanine aminotransferase), aspartate ...aminotransferase, gamma- glutamiltransferase, alkaline phosphatase, N-acetyl-β-D-glucosaminidase, interleukins (IL-2, IL-8, IL-10), beta-2- microglobulin. The chronic dysfunction of renal allo-transplant is characterized by increasing of concentration of IL-10 and beta-2-microglobulin in serum and increasing of concentration of beta-2-microglobulin, IL-2, IL-8 in urine and increasing of activity of N-acetyl-β-D-glucosaminidase, alkaline phosphatase, aspartate aminotransferase, gamma-glutamiltransferase as compared with patients with satisfactory function of renal allo-transplant. The multivariant logistic regression analysis established that only activity of N-acetyl-β-D-glucosaminidase in urine was reliably independently related to chronic dysfunction of renal allo-transplant. It is assumed that increasing of concentration of beta-2-microglobulin in serum testifies glomerular dysfunction and in urine--tubular dysfunction of renal allo-transplant. The enzymeuria indicates continuing damage of epithelium of proximal tubules of nephron. The classification of patients with satisfactory function and chronic dysfunction of renal allo-transplant established that the highest indicators of square under ROC-curves had concentration of beta-2-microglobulin in serum (0.858 ± 0.061) and urine (0.733 ± 0.079) and activity of N-acetyl-β-D-glucosaminidase in urine (0.701 ± 0.061). To specify diagnosis of chronic dysfunction of renal allo-transplant the most useful (ratio of likelihood of positive result 10 and 11 correspondingly) are tests of beta-2- microglobulin in serum (more than 8.55 mkg/ml) and N-acetyl-β-D-glucosaminidase/creatinine in urine (more than 34 nmol/(sl)/ mmol/l). These discoveries require further validation and confirmation by implementation of morphological analysis of bioptat of renal allo-transplant.
We demonstrate an unusually strong magneto-optical response of elongated plate-shaped pigment particles in magnetic fields ranging from 0 to 25 T. In a weak field, the particles align perpendicular ...to the field and the dispersions exhibit the Cotton-Mouton effect. In a strong magnetic field, the magneto-optical behaviour is nonlinear and cannot be explained by a simple model of non-interacting diamagnetic rods in a thermal equilibrium. We also demonstrate that the addition of a small amount of magnetic particles results in a complex magneto-optical response, where the particles align parallel to a weak magnetic field and perpendicular to a strong one.
We demonstrate an unusually strong magneto-optical response of elongated plate-shaped pigment particles in magnetic fields ranging from 0 to 25 T.
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IJS, KILJ, NUK, UL, UM, UPUK
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