This book is the long-awaited successor to Owen Phillips's classic textbook, Flow and Reactions in Permeable Rocks, published in 1991. In the intervening 18 years between the two, significant ...advances have been made to our understanding of subterranean flow, especially through the vast amount of research into underground storage of nuclear waste and aquifer pollution. This new book integrates and extends these modern ideas and techniques and applies them to the physics and chemistry of sub-surface flows in water-saturated, sandy and rocky media. It describes essential scientific concepts and tools for hydrologists and public health ecologists concerned with present day flow and transport, and also for geologists who interpret present day patterns of mineralization in terms of fluid flow in the distant past. The book is ideal for graduate students and professionals in hydrology, water resources, and aqueous geochemistry.
Some blame the violence and unrest in the Muslim world on Islam itself, arguing that the religion and its history is inherently bloody. Others blame the United States, arguing that American attempts ...to spread democracy by force have destabilized the region, and that these efforts are somehow radical or unique. Challenging these views, The Clash of Ideas in World Politics reveals how the Muslim world is in the throes of an ideological struggle that extends far beyond the Middle East, and how struggles like it have been a recurring feature of international relations since the dawn of the modern European state.
The Great Recession, institutional dysfunction, a growing divide between urban and rural prospects, and failed efforts to effectively address immigration have paved the way for a populist backlash ...that disrupts the postwar bargain between political elites and citizens. Whether today's populism represents a corrective to unfair and obsolete policies or a threat to liberal democracy itself remains up for debate. Yet this much is clear: these challenges indict the triumphalism that accompanied liberal democratic consolidation after the collapse of the Soviet Union. To respond to today's crisis, good leaders must strive for inclusive economic growth while addressing fraught social and cultural issues, including demographic anxiety, with frank attention. Although reforms may stem the populist tide, liberal democratic life will always leave some citizens unsatisfied. This is a permanent source of vulnerability, but liberal democracy will endure so long as citizens believe it is worth fighting for.
"One of the most important political books of 2018."-Rod Dreher,American ConservativeOf the three dominant ideologies of the twentieth century-fascism, communism, and liberalism-only the last ...remains. This has created a peculiar situation in which liberalism's proponents tend to forget that itisan ideology and not the natural end-state of human political evolution. As Patrick Deneen argues in this provocative book, liberalism is built on a foundation of contradictions: it trumpets equal rights while fostering incomparable material inequality; its legitimacy rests on consent, yet it discourages civic commitments in favor of privatism; and in its pursuit of individual autonomy, it has given rise to the most far-reaching, comprehensive state system in human history. Here, Deneen offers an astringent warning that the centripetal forces now at work on our political culture are not superficial flaws but inherent features of a system whose success is generating its own failure.
Improvements in microscopy software and hardware have dramatically increased the pace of image acquisition, making analysis a major bottleneck in generating quantitative, single-cell data. Although ...tools for segmenting and tracking bacteria within time-lapse images exist, most require human input, are specialized to the experimental set up, or lack accuracy. Here, we introduce DeLTA 2.0, a purely Python workflow that can rapidly and accurately analyze images of single cells on two-dimensional surfaces to quantify gene expression and cell growth. The algorithm uses deep convolutional neural networks to extract single-cell information from time-lapse images, requiring no human input after training. DeLTA 2.0 retains all the functionality of the original version, which was optimized for bacteria growing in the mother machine microfluidic device, but extends results to two-dimensional growth environments. Two-dimensional environments represent an important class of data because they are more straightforward to implement experimentally, they offer the potential for studies using co-cultures of cells, and they can be used to quantify spatial effects and multi-generational phenomena. However, segmentation and tracking are significantly more challenging tasks in two-dimensions due to exponential increases in the number of cells. To showcase this new functionality, we analyze mixed populations of antibiotic resistant and susceptible cells, and also track pole age and growth rate across generations. In addition to the two-dimensional capabilities, we also introduce several major improvements to the code that increase accessibility, including the ability to accept many standard microscopy file formats as inputs and the introduction of a Google Colab notebook so users can try the software without installing the code on their local machine. DeLTA 2.0 is rapid, with run times of less than 10 minutes for complete movies with hundreds of cells, and is highly accurate, with error rates around 1%, making it a powerful tool for analyzing time-lapse microscopy data.
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Pseudosection modelling is rapidly becoming an essential part of a petrologist＇s toolkit and often forms the basis of interpreting the tectonothermal evolution of a rock sample, outcrop, or ...geological region. Of the several factors that can affect the accuracy and precision of such calculated phase diagrams, ＂geological＂ uncertainty related to natural petrographic variation at the hand sample- and/or thin section-scale is rarely considered. Such uncertainty influences the sample＇s bulk composition, which is the primary control on its equilibrium phase relationships and thus the interpreted pressure-temper- ature （P-T） conditions of formation. Two case study examples--a garnet-cordierite granofels and a garnet-staurolite-kyanite schist--are used to compare the relative importance that geological uncer- tainty has on bulk compositions determined via （1） X-ray fluorescence （XRF） or （2） point counting techniques. We show that only minor mineralogical variation at the thin-section scale propagates through the phase equilibria modelling procedure and affects the absolute P-T conditions at which key assemblages are stable. Absolute displacements of equilibria can approach ＋l kbar for only a moderate degree of modal proportion uncertainty, thus being essentially similar to the magnitudes reported for analytical uncertainties in conventional thermobarometry. Bulk compositions determined from multiple thin sections of a heterogeneous garnet-staurolite-kyanite schist show a wide range in major-element oxides, owing to notable variation in mineral proportions. Pseudosections constructed for individual point count-derived bulks accurately reproduce this variability on a case-by-case basis, though averaged proportions do not correlate with those calculated at equivalent peak P-T conditions for a whole-rock XRF-derived bulk composition. The main discrepancies relate to varying proportions of matrix phases （primarily mica） relative to porphyroblasts （primarily staurolite and kyanite）, indicating that point counting preserves small-scale petrographic features that are otherwise averaged out in XRF analysis of a larger sample. Careful consideration of the size of the equilibration volume, the constituents that comprise the effective bulk composition, and the best technique to employ for its determination based on rock type and petrographic character, offer the best chance to produce trustworthy data from pseudosection analysis.
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The pharmaceutical industry remains under huge pressure to address the high attrition rates in drug development. Attempts to reduce the number of efficacy- and safety-related failures by analysing ...possible links to the physicochemical properties of small-molecule drug candidates have been inconclusive because of the limited size of data sets from individual companies. Here, we describe the compilation and analysis of combined data on the attrition of drug candidates from AstraZeneca, Eli Lilly and Company, GlaxoSmithKline and Pfizer. The analysis reaffirms that control of physicochemical properties during compound optimization is beneficial in identifying compounds of candidate drug quality and indicates for the first time a link between the physicochemical properties of compounds and clinical failure due to safety issues. The results also suggest that further control of physicochemical properties is unlikely to have a significant effect on attrition rates and that additional work is required to address safety-related failures. Further cross-company collaborations will be crucial to future progress in this area.
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Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the current status of 25 historical candidate ...genes for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1). The initial study for 24 of these genes explicitly evaluated common variant hypotheses about schizophrenia. Our evaluation included a meta-analysis of the candidate gene literature, incorporation of the results of the largest genomic study yet published for schizophrenia, ratings from informed researchers who have published on these genes, and ratings from 24 schizophrenia geneticists. On the basis of current empirical evidence and mostly consensual assessments of informed opinion, it appears that the historical candidate gene literature did not yield clear insights into the genetic basis of schizophrenia. A likely reason why historical candidate gene studies did not achieve their primary aims is inadequate statistical power. However, the considerable efforts embodied in these early studies unquestionably set the stage for current successes in genomic approaches to schizophrenia.
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How should the Western world today respond to the challenges of political Islam? Taking an original approach to answer this question,Confronting Political Islamcompares Islamism's struggle with ...secularism to other prolonged ideological clashes in Western history. By examining the past conflicts that have torn Europe and the Americas-and how they have been supported by underground networks, fomented radicalism and revolution, and triggered foreign interventions and international conflicts-John Owen draws six major lessons to demonstrate that much of what we think about political Islam is wrong.
Owen focuses on the origins and dynamics of twentieth-century struggles among Communism, Fascism, and liberal democracy; the late eighteenth- and nineteenth-century contests between monarchism and republicanism; and the sixteenth- and seventeenth-century wars of religion between Catholics, Lutherans, Calvinists, and others. Owen then applies principles learned from the successes and mistakes of governments during these conflicts to the contemporary debates embroiling the Middle East. He concludes that ideological struggles last longer than most people presume; ideologies are not monolithic; foreign interventions are the norm; a state may be both rational and ideological; an ideology wins when states that exemplify it outperform other states across a range of measures; and the ideology that wins may be a surprise.
Looking at the history of the Western world itself and the fraught questions over how societies should be ordered,Confronting Political Islamupends some of the conventional wisdom about the current upheavals in the Muslim world.
Posttraumatic stress disorder (PTSD) is defined by classic psychological manifestations, although among the characteristics are significantly increased rates of serious somatic comorbidities, such as ...cardiovascular disease, immune dysfunction, and metabolic syndrome. In this review, we assess the evidence for disturbances that may contribute to somatic pathology in inflammation, metabolic syndrome, and circulating metabolites (implicating mitochondrial dysfunction) in individuals with PTSD and in animal models simulating features of PTSD. The clinical and preclinical data highlight probable interrelated features of PTSD pathophysiology, including a proinflammatory milieu, metabolomic changes (implicating mitochondrial and other processes), and metabolic dysregulation. These data suggest that PTSD may be a systemic illness, or that it at least has systemic manifestations, and the behavioral manifestations are those most easily discerned. Whether somatic pathology precedes the development of PTSD (and thus may be a risk factor) or follows the development of PTSD (as a result of either shared pathophysiologies or lifestyle adaptations), comorbid PTSD and somatic illness is a potent combination placing affected individuals at increased physical as well as mental health risk. We conclude with directions for future research and novel treatment approaches based on these abnormalities.
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