Environmental tobacco smoke, inhaled by active firsthand smokers and their entourage, is associated with morbidity and mortality. Many children are passively exposed to secondhand smoke worldwide. ...Infants and young children account for the largest global disease burden associated with prenatal and postnatal secondhand smoke, probably due to underdeveloped neurological, immune, and respiro-circulatory systems. There is an increasingly robust association between tobacco smoke exposure, before and after birth, and executive function problems in children, adding to current and future disease burden estimates in public health. This review summarizes research advancements which address the link between environmental tobacco smoke and the development of attention deficits and hyperactive behavior, both as symptoms and as part of a mental health disorder in childhood. The multiple effects of tobacco smoke inhalation are best understood in terms of disruptions in normative processes involving cellular communication, structural development, and epigenetic influences which have the potential to become intergenerational. It is concluded that public health efforts be directed toward increasing parental awareness and compliance with existing guidelines that recommend no safe level of exposure.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
•3D numerical modeling of the wave generated by the Vajont rockslide.•Definition of the rocklide kinematics using a 3D approach.•Parallel 3D SPH numerical scheme obtained using the Compute Unified ...Device Architecture (CUDA) of nVidia devices.•Validation against data available in literature.
A 3D numerical modeling of the wave generated by the Vajont slide, one of the most destructive ever occurred, is presented in this paper. A meshless Lagrangian Smoothed Particle Hydrodynamics (SPH) technique was adopted to simulate the highly fragmented violent flow generated by the falling slide in the artificial reservoir. The speed-up achievable via General Purpose Graphic Processing Units (GP-GPU) allowed to adopt the adequate resolution to describe the phenomenon. The comparison with the data available in literature showed that the results of the numerical simulation reproduce satisfactorily the maximum run-up, also the water surface elevation in the residual lake after the event.
Moreover, the 3D velocity field of the flow during the event and the discharge hydrograph which overtopped the dam, were obtained.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
3.
School Readiness and Later Achievement Pagani, Linda S; Fitzpatrick, Caroline; Archambault, Isabelle ...
Developmental psychology,
09/2010, Volume:
46, Issue:
5
Journal Article
Peer reviewed
We first replicated the data analytic strategy used in
Duncan et al. (2007)
with a population-based data set of French-speaking children from Quebec (Canada). Prospective associations were examined ...between cognitive, attention, and socioemotional characteristics underlying kindergarten school readiness and second grade math, reading, and general achievement. We then extended this school readiness model by including motor skills as an additional element in the prediction equation and expanded the original strategy by including classroom engagement. The Montreal Longitudinal-Experimental Preschool Study, featured in Duncan et al., served as the Canadian reference group. In the replication model, kindergarten cognitive and attention characteristics predicted achievement by the end of 2nd grade. Although inconsistent across outcomes, behavioral problems and skills also emerged as predictors of some aspects of later achievement. Coefficients for kindergarten math skills were largest, followed by attention skills, receptive language skills, attention problems, and behavior. Most coefficients resembled those generated in the initial study. In our extension model, fine motor skills added their significant contribution to the prediction of later achievement above and beyond the original key elements of school readiness. Our extension model confirmed prospectively associations between kindergarten cognitive, attention, fine motor, and physical aggression characteristics and later achievement and classroom engagement by the end of 2nd grade. Although they comparatively showed better long-term benefits from stronger early attention skills, girls with less kindergarten cognitive skills were more vulnerable than boys with similar deficits when predicting 2nd grade math.
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CEKLJ, FFLJ, NUK, ODKLJ, PEFLJ, UPUK
Youth media guidelines in Canada and the United States recommend that bedrooms should remain screen-free zones. This study aims to verify whether bedroom screens at age 12 years prospectively predict ...academic and social impairment by age 17 years.
Participants were from the Quebec Longitudinal Study of Child Development birth cohort (661 girls and 686 boys). Linear regression analyses estimated associations between having a bedroom screen (television or computer) at age 12 years and selfreported overall grades, dropout risk, prosocial behaviour and likelihood of having experienced a dating relationship in the past 12 months at age 17 years, while adjusting for potential individual and family confounding factors.
For both girls and boys, bedroom screens at age 12 years predicted lower overall grades (B = -2.41, p ≤ 0.001 for boys; -1.61, p ≤ 0.05 for girls), higher dropout risk (B = 0.16, p ≤ 0.001 for boys; 0.17, p ≤ 0.001 for girls) and lower likelihood of having experienced a dating relationship (B = -0.13, p ≤ 0.001 for boys; -0.18, p ≤ 0.001 for girls) at age 17. Bedroom screens also predicted lower levels of prosocial behaviour (B = -0.52, p ≤ 0.001) at age 17 years for boys.
The bedroom as an early adolescent screen-based zone does not predict long-term positive health and well-being. Pediatric recommendations to parents and youth should be more resolute about bedrooms being screen-free zones and about unlimited access in private exposures in childhood.
Providing high-quality teaching practices is central to promote student engagement in school. High quality teaching is even more important in schools located in low socioeconomic neighborhoods, where ...a larger proportion of children present more important academic difficulties and lower classroom behavioural, affective, and cognitive engagement. The Self-System Model of Motivational Development posits that learner engagement is favored when teachers structure classroom activity, are involved with students, and support their autonomy. How these dimensions interact to create effective classroom contexts that foster student engagement remains less documented. The goal of the present study was to test additive and combined (interactive) multilevel longitudinal associations between teacher structure, autonomy-support, and involvement on students behavioral, affective, and cognitive engagement across one school year. Based on a sample of 696 low SES elementary school students, results of our path analysis revealed that teacher involvement and autonomy-support contributed to various dimensions of classroom engagement. Besides, structure was not directly to this outcome. Yet, a combined use of autonomy-support and structure or autonomy-support and involvement was associated with higher behavioral engagement among low-SES children. These results suggest that teacher practices cannot be interpreted in isolation as they add up and interact to contribute to elementary school student academic experience.
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BFBNIB, NUK, PILJ, SAZU, UL, UM, UPUK
Watching television is a common pastime for very young children. High exposure may negatively influence physical and mental health outcomes. Not much is known about how early exposure relates to ...lifestyle choices in adolescence.
To estimate how toddler televiewing is subsequently associated with lifestyle indicators at adolescence.
Participants are 986 girls and 999 boys from the Quebec Longitudinal Study of Child Development birth cohort (Canada). Child self-reports lifestyle habits at age 13 that were linearly regressed on parent-reported televiewing at age 2 while adjusting for potential confounders.
Every 1 h 13 m increase in daily televiewing was prospectively associated with a 8.2% increased risk of unhealthy eating habits (unstandardized b = 0.05; 95% CI, 0.02 to 0.07), 10.1% decrease in eating breakfast on weekdays (unstandardized b = −0.06; 95% CI, −0.09 to −0.04), 13.3% increase in BMI (unstandardized b = 0.38; 95% CI, 0.26 to 0.50), 4.7% decrease in student engagement (unstandardized b = −0.07; 95% CI, −0.14 to −0.004), and 5.8% increase in concurrent screen time (unstandardized b = 0.06; 95% CI, 0.02 to 0.11). Post hoc simulations of noncompliance with AAP recommendations support their implementation.
Excessive toddlerhood televiewing was prospectively associated with less optimal health and self-invested behavioral dispositions. Lifestyle habits not only affect metabolic risk but may also influence personal success outcomes. These independent relationships, observed more than a decade later, suggest a need for better parental awareness of the way children invest their limited waking hours could affect their long-term life course trajectories.
•Excessive early televiewing was associated with subsequent risks in adolescence.•Excessive early televiewing was associated with later risk of being overweight.•Excessive early televiewing was associated with later risk of poor eating habits.•Excessive early televiewing was associated with later risk of skipping breakfast.•Excessive early televiewing predicted a later risk of being less engaged at school.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Tyrosine kinase inhibitors (TKIs) have revolutionised the management of chronic myeloid leukaemia (CML), with the disease now having a five-year survival rate over 80%. The primary focus in the ...treatment of CML has been on improving the specificity and potency of TKIs to inhibit the activation of the BCR::ABL1 kinase and/or overcoming resistance driven by mutations in the BCR::ABL1 oncogene. However, this approach may be limited in a significant proportion of patients who develop TKI resistance despite the effective inhibition of BCR::ABL1. These patients may require novel therapeutic strategies that target both BCR::ABL1-dependent and BCR::ABL1-independent mechanisms of resistance. The combination treatment strategies that target alternative survival signalling, which may contribute towards BCR::ABL1-independent resistance, could be a successful strategy for eradicating residual leukaemic cells and consequently increasing the response rate in CML patients.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The growing incidence of degenerative musculoskeletal disorders as well as lifestyle changes has led to an increase in the surgical procedures involving implanted medical devices in orthopedics. When ...studying implant/tissue interface in hard materials (i.e., metals or dense plastics) and/or in large bone segments, the hard plastic embedding of the intact undecalcified tissue envelope with the implant in situ is needed. The aim of this work is to describe the advances and the possibilities of high-temperature methyl methacrylate (MMA) embedding for the histological, histomorphometrical, and biomechanical assessment of bone-implanted medical devices. Unlike routine techniques, undecalcified bone processing histology, using high-temperature MMA, requires a complex and precise sample processing methodology and the availability of sophisticated equipment and software for both sample preparation and analyses. MMA embedding permits the evaluation of biological responses to the presence of implanted medical devices without implant removal, allowing simultaneous qualitative and quantitative histological evaluation, both static and dynamic histomorphometry, and biomechanical analyses not possible with tissue decalcification. MMA embedding, despite being a demanding procedure, is still preferred to other kinds of resin-based embedding because of its peculiar characteristics, which allow the study of samples of big dimensions also implanted with hard materials without reducing the sample or removing the material. Dynamic measurements are allowed together with biomechanical investigations at the bone-biomaterial interface, obtaining a comprehensive and precise evaluation of the safety and effectiveness of medical devices for orthopedic regenerative, reconstructive, and reparative surgery.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
Osteochondral lesions (OCs) are typically of traumatic origins but are also caused by degenerative conditions, in primis osteoarthritis (OA). On the other side, OC lesions themselves, getting worse ...over time, can lead to OA, indicating that chondral and OC defects represent a risk factor for the onset of the pathology. Many animal models have been set up for years for the study of OC regeneration, being successfully employed to test different treatment strategies, from biomaterials and cells to physical and biological adjuvant therapies. These studies rely on a plethora of post-explant investigations ranging from histological and histomorphometric analyses to biomechanical ones. The present review aims to analyze the methods employed for the evaluation of OC treatments in each animal model by screening literature data within the last 10 years. According to the selected research criteria performed in two databases, 60 works were included. Data revealed that lapine (50% of studies) and ovine (23% of studies) models are predominant, and knee joints are the most used anatomical locations for creating OC defects. Analyses are mostly conducted on paraffin-embedded samples in order to perform histological/histomorphometric analyses by applying semiquantitative scoring systems and on fresh samples in order to perform biomechanical investigations by indentation tests on articular cartilage. Instead, a great heterogeneity is pointed out in terms of OC defect dimensions and animal’s age. The choice of experimental times is generally adequate for the animal models adopted, although few studies adopt very long experimental times. Improvements in data reporting and in standardization of protocols would be desirable for a better comparison of results and for ethical reasons related to appropriate and successful animal experimentation.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
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