Spatial inclusion is defined as the availability of space and mobility for underprivileged people, as well as the physical closeness of different social groups. This study seeks to uncover the key ...components of spatial inclusion that increase social inclusion by investigating the links between spatial and social inclusion characteristics in South Korean cities and regions. A micro-dataset on personal health and social life, as well as other publicly available data, such as Census data are examined. The results suggest that increased spatial inclusion improves social inclusion of socially underprivileged people. However, the effects of each component of spatial inclusion are distinct. While housing affordability has mixed effects on different dimensions of social inclusion, an open settlement environment generally has a positive effect on social inclusion. The findings provide important implications for promoting social inclusion in cities and regions.
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BFBNIB, NUK, PILJ, SAZU, UL, UM, UPUK
The growing interest in the self-similarity effect of avatars in virtual reality (VR) has spurred the creation of realistic avatars that closely mirror their users. However, despite extensive ...research on the self-similarity effect in single-user VR environments, our understanding of its impact in social VR settings remains underdeveloped. This shortfall exists despite the unique socio-psychological phenomena arising from the illusion of embodiment that could potentially alter these effects. To fill this gap, this paper provides an in-depth empirical investigation of how avatars' self-similarity influences social VR experiences. Our research uncovers several notable findings: 1) A high level of avatar self-similarity boosts users' sense of embodiment and social presence but has minimal effects on the overall presence and even slightly hinders immersion. These results are driven by increased self-awareness. 2) Among various factors that contribute to the self-similarity of avatars, voice stands out as a significant influencer of social VR experiences, surpassing other representational factors. 3) The impact of avatar self-similarity shows negligible differences between male and female users. Based on these findings, we discuss the pros and cons of incorporating self-similarity into social VR avatars. Our study serves as a foundation for further research in this field.
Much scholarly attention is paid to understanding subjective well-being (SWB) from a spatial perspective. Various features of a city including social capital may have significant impacts on SWB in ...addition to individual attributes and national characteristics. However, the extant empirical studies of SWB tend to focus on the national- or regional-scale analysis rather than the city-scale analysis. Particularly, few studies inquire into the impacts of social capital and urban amenities on SWB along with the spatial dependence at the city level. This paper aims to examine the spatial effects of social capital and urban characteristics on the SWB of cities. For this purpose, we construct a series of spatial panel models for SWB using data for 219 cities in South Korea, from the Korean Community Health Survey (KCHS) conducted in 2011, 2013, 2015, and 2017. The results show that income, Gini-coefficient, social trust, social networks with friends, participation in charity activities, open space, and cultural opportunities all affect the SWB. Particularly, social capital and open space have spatial spillover effects on the SWB, even after controlling for socio-demographic variables. These findings will not only draw some important policy implications for urban planning and public management to improve the level of urban SWB, but also provide a piece of significant evidence for follow-up studies of its kind.
Cannabidiol (CBD) is a chemical obtained from
; it has therapeutic effects on anxiety and cognition and anti-inflammatory properties. Although pharmacological applications of CBD in many types of ...tumors have recently been reported, the mechanism of action of CBD is not yet fully understood. In this study, we perform an mRNA-seq analysis to identify the target genes of CBD after determining the cytotoxic concentrations of CBD using an MTT assay. CBD treatment regulated the expression of genes related to DNA repair and cell division, with metallothionein (MT) family genes being identified as having highly increased expression levels induced by CBD. It was also found that the expression levels of MT family genes were decreased in colorectal cancer tissues compared to those in normal tissues, indicating that the downregulation of MT family genes might be highly associated with colorectal tumor progression. A qPCR experiment revealed that the expression levels of MT family genes were increased by CBD. Moreover, MT family genes were regulated by CBD or crude extract but not by other cannabinoids, suggesting that the expression of MT family genes was specifically induced by CBD. A synergistic effect between CBD and MT gene transfection or zinc ion treatment was found. In conclusion, MT family genes as novel target genes could synergistically increase the anticancer activity of CBD by regulating the zinc ions in human colorectal cancer cells.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
This study introduces a novel system for detecting humans inside a building by utilizing RF signals from the building's exterior. Existing RF communication devices encounter signal attenuation issues ...when passing through walls, limiting their effectiveness. In contrast, our system employs a low-power, long-distance communication signal operating at 433 MHz to enhance signal permeability, enabling the accurate detection of individuals within the building. The system analyzes received signal strength indicator (RSSI) data using variance and mean analysis algorithms to determine the presence or absence of people. The evaluation results indicate promising average accuracies of 88% for the variance analysis algorithm and 97.7% for the mean analysis algorithm. The proposed system holds potential for real-world deployment, particularly in challenging scenarios such as fire incidents, where pre-installation is challenging. Continued research and development efforts aim to enhance the system's performance and address any limitations, making it more effective and robust in various practical applications.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Poly(ADP-ribose)ylation (PARylation) by PAR polymerase 1 (PARP1) and PARylation removal by poly(ADP-ribose) glycohydrolase (PARG) critically regulate DNA damage responses; yet, conflicting reports ...obscure PARG biology and its impact on cancer cell resistance to PARP1 inhibitors. Here, we found that PARG expression is upregulated in many cancers. We employed chemical library screening to identify and optimize methylxanthine derivatives as selective bioavailable PARG inhibitors. Multiple crystal structures reveal how substituent positions on the methylxanthine core dictate binding modes and inducible-complementarity with a PARG-specific tyrosine clasp and arginine switch, supporting inhibitor specificity and a competitive inhibition mechanism. Cell-based assays show selective PARG inhibition and PARP1 hyperPARylation. Moreover, our PARG inhibitor sensitizes cells to radiation-induced DNA damage, suppresses replication fork progression and impedes cancer cell survival. In PARP inhibitor-resistant A172 glioblastoma cells, our PARG inhibitor shows comparable killing to Nedaplatin, providing further proof-of-concept that selectively inhibiting PARG can impair cancer cell survival.
In order to serve better VR experiences to users, existing predictive methods of Redirected Walking (RDW) exploit future information to reduce the number of reset occurrences. However, such methods ...often impose a precondition during deployment, either in the virtual environment's layout or the user's walking direction, which constrains its universal applications. To tackle this challenge, we propose a mechanism F-RDW that is twofold: (1) forecasts the future information of a user in the virtual space without any assumptions by using the conventional method, and (2) fuse this information while maneuvering existing RDW methods. The backbone of the first step is an LSTM-based model that ingests the user's spatial and eye-tracking data to predict the user's future position in the virtual space, and the following step feeds those predicted values into existing RDW methods (such as MPCRed, S2C, TAPF, and ARC) while respecting their internal mechanism in applicable ways. The results of our simulation test and user study demonstrate the significance of future information when using RDW in small physical spaces or complex environments. We prove that the proposed mechanism significantly reduces the number of resets and increases the traveled distance between resets, hence augmenting the redirection performance of all RDW methods explored in this work. Our project and dataset are available at https://github.com/YonseiCGnA-VR/F-RDW.
Extracts of phytocannabinoids from Cannabis sativa have been studied for therapeutic purposes. Although nonpsychoactive CBD has been studied as a promising anticancer drug because it induces ...apoptosis in many cancer cells, it is also known to induce several physiological changes. In this study, we clarify the functional role it plays in the morphological characteristics of intracellular vesicle formation as well as apoptosis in A549 human lung cancer cells. CBD treatment shows growth inhibition at concentrations above 20 μM, but FACS analysis shows low efficacy in terms of cell death. Microscopic observations suggest that multiple vesicles were detected in the cytoplasmic region of CBD-treated A549 cells. CBD treatment upregulates apoptosis-related proteins, such as p53, PARP, RIP1, RIP3, Atg12, and Beclin, indicating that CBD regulates several types of cell death. CBD treatment also induced E-cadherin, PPARγ, clathrin, β-adaptin, and Tsg101, also known to be cellular-differentiation inducers or vesicle-formation components. Treatment combining CBD with GW9662, a PPARγ inhibitor, reduced CBD-induced cytoplasmic vesicle formation. This indicates that PPARγ regulates the vesicle-formation mechanism. However, CBD-treated E-cad KO clones did not show this regulatory mechanism. These results elucidate the pharmacological and molecular networks associated with CBD in PPARγ-dependent vesicle formation and the induction of apoptosis.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The Korea Institute of Atmospheric Prediction Systems (KIAPS) began a national project to develop a new global atmospheric model system in 2011. The ultimate goal of this 9-year project is to replace ...the current operational model at the Korea Meteorological Administration (KMA), which was adopted from the United Kingdom’s Meteorological Office’s unified model (UM) in 2010. The 12-km Korean Integrated Model (KIM) system, consisting of a spectral-element non-hydrostatic dynamical core on a cubed sphere grid and a state-of-the-art physics parameterization package, has been launched in a real-time forecast framework, with initial conditions obtained via the advanced hybrid four-dimensional ensemble variational data assimilation (4DEnVar) over its native grid. A development strategy for KIM and the evolution of its performance in medium-range forecasts toward a world-class global forecast system are described. Outstanding issues in KIM 3.1 as of February 2018 are discussed, along with a future plan for operational deployment in 2020.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
We investigated the lateral distribution of the equilibrium carrier concentration (n
) along the channel and the effects of channel length (L) on the source-drain series resistance (R
) in the ...top-gate self-aligned (TG-SA) coplanar structure amorphous indium-gallium-zinc oxide (a-IGZO) thin-film transistors (TFTs). The lateral distribution of n
across the channel was extracted using the paired gate-to-source voltage (V
)-based transmission line method and the temperature-dependent transfer characteristics obtained from the TFTs with different Ls. n
abruptly decreased with an increase in the distance from the channel edge near the source/drain junctions; however, much smaller gradient of n
was observed in the region near the middle of the channel. The effect of L on the R
in the TG-SA coplanar a-IGZO TFT was investigated by applying the drain current-conductance method to the TFTs with various Ls. The increase of R
was clearly observed with an increase in L especially at low V
s, which was possibly attributed to the enhanced carrier diffusion near the source/drain junctions due to the larger gradient of the carrier concentration in the longer channel devices. Because the lateral carrier diffusion and the relatively high R
are the critical issues in the TG-SA coplanar structure-based oxide TFTs, the results in this work are expected to be useful in further improving the electrical performance and uniformity of the TG-SA coplanar structure oxide TFTs.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
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