The effects of specific inhibitors of cholinesterases on chick development were studied. Inhibitors were injected into the eggs, at final concentration ranging between 1 mM and 10 nM. Their effects ...were depending on inhibitor concentration, and detectable at stages as more advanced as more diluted were the inhibitors. The strongest teratogenic effects on gastrulation, neurulation and morphogenesis were caused by BW 284c51, specific inhibitor of acetylcholinesterase. Its effects were compared to those of ion channels blockers. The inhibitors action seems to be correlated to an altered cholinergic system and to consequently altered intercellular communications.
The general properties of the static and dynamic hysteretic behaviours of a PWL ladder circuit are described and discussed. These properties are obtained on the basis of some results reported in a ...previous paper (M.Parodi et al., Int. j. circ. theor. appl., 22, 513 (1994), concerning the static hysteretic behaviour of the same circuit.
Despite the non‐linearity of the circuit, the main features of its hysteretic behaviour are shown to depend on the parameters of the circuit components in a simple way. Moreover this behaviour is similar to those observed in a large number of experiments. For these reasons, the PWL ladder circuit is taken as the central element of a general circuit model for hysteresis. The structure of this general circuit is described at the end of the paper.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
The neuroendocrinological effects of acute oral administration of 20 mg zetidoline, a new antipsychotic drug with antidopaminergic properties, were evaluated in 8 healthy volunteers, by a ...double-blind, crossover comparison with placebo. Zetidoline significantly increased serum prolactin (p less than 0.01 at 1-3 h; p less than 0.05 at 4-6 h). No significant change was observed in blood levels of aldosterone, renin, cortisol, growth hormone and electrolyte, or in blood pressure and heart rate. The data suggest that the drug increases prolactin through blockade of dopaminergic receptors. The lack of change in the aldosterone levels may be evidence against the hypothesis of dopaminergic control of aldosterone secretion.
We report our experience with one patient with recurrent coarctation and aneurysm degeneration treated endoluminally. A novel technique was used combining balloon-expandable with self-expandable ...endografts. The balloon-expandable component expanded the area of stenosis and also created a neck to allow the implantation of the self-expandable endograft to exclude the aneurysm. Mismatch of diameters was solved with the creation of a new proximal neck, in which the distal end was progressively expanded to reach the appropriate diameter to implant the self-expandable endograft inside. Expansion of the narrow stenosis and complete exclusion of the aneurysm was achieved without a residual pressure gradient.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
PDF
