Root resorption is the loss of dental hard tissue because of odontoclastic action. In permanent teeth, it is undesirable and pathological in nature. Root resorption may occur on the inner aspect of ...the root canal (internal root resorption) or on the outer aspect of the root (external root resorption). Regardless of its location, root resorption is irreversible, and may result in discomfort for the patient, requires management and/or, in some cases, results in the premature loss of the affected tooth. Root resorption is often challenging to accurately diagnose and manage. The aim of this narrative review is to present the relevant literature on the aetiology, pathogenesis, diagnosis and management, as well as discuss the future directions of diagnosis and management of root resorption.
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A recurrence of hepatocellular carcinoma (HCC) after living donor liver transplantation (LDLT) is one of the major concerns reflecting the higher mortality of HCC. This study aimed to explore the ...impact of circulating exosomes on HCC development and recurrence. One‐shot transfusion of hepatoma serum to naïve rats induced liver cancer development with gradual elevation of alpha‐fetoprotein (AFP), but exosome‐free hepatoma serum failed to induce AFP elevation. The microarray analysis revealed miR‐92b as one of the highly expressing microribonucleic acids in hepatoma serum exosomes. Overexpression of miR‐92b enhanced the migration ability of liver cancer cell lines with active release of exosomal miR‐92b. The hepatoma‐derived exosomal miR‐92b transferred to natural killer (NK) cells, resulting in the downregulation of CD69 and NK cell‐mediated cytotoxicity. Furthermore, higher expression of miR‐92b in serum exosomes was confirmed in HCC patients before LDLT, and its value at 1 month after LDLT was maintained at a higher level in the patients with posttransplant HCC recurrence. In summary, we demonstrated the impact of circulating exosomes on liver cancer development, partly through the suppression of CD69 on NK cells by hepatoma‐derived exosomal miR‐92b. The value of circulating exosomal miR‐92b may predict the risk of posttransplant HCC recurrence.
This study demonstrates the impact of circulating exosomes on liver cancer development in rats, explores functional roles of exosomal miR‐92b in the tumor microenvironment, and verifies its clinical value for early prediction of posttransplant hepatocellular carcinoma recurrence.
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Exploring of new catalyst activation principle holds a key to unlock catalytic powers of cheap and earth‐abundant materials for large‐scale applications. In this regard, the vacancy defects have been ...proven to be effective to initiate catalytic active sites and endow high electrocatalytic activities. However, such electrocatalytically active defects reported to date have been mostly formed by anion vacancies. Herein, it is demonstrated for the first time that iron cation vacancies induce superb water splitting bifunctionality in alkaline media. A simple wet‐chemistry method is developed to grow ultrathin feroxyhyte (δ‐FeOOH) nanosheets with rich Fe vacancies on Ni foam substrate. The theoretical and experimental results confirm that, in contrast to anion vacancies, the formation of rich second neighboring Fe to Fe vacancies in δ‐FeOOH nanosheets can create catalytic active centers for both hydrogen and oxygen evolution reactions. The atomic level insight into the new catalyst activation principle based on metal vacancies is adaptable for developing other transition metal electrocatalysts, including Fe‐based ones.
Ultrathin feroxyhyte (δ‐FeOOH) nanosheets with rich Fe‐vacancies on Ni foam are synthesized, based on which an iron‐vacancy‐based catalyst activation principle to induce water‐splitting bifunctionality is proposed. Theoretical studies confirm that the formation of the second neighboring Fe to Fe vacancies in δ‐FeOOH nanosheets can create active centers for both hydrogen and oxygen evolution reactions.
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Development of stimuli‐responsive materials with complex practical functions is significant for achieving bioinspired artificial intelligence. It is challenging to fabricate stimuli‐responsive ...hydrogels showing simultaneous changes in fluorescence color, brightness, and shape in response to a single stimulus. Herein, a bilayer hydrogel strategy is designed by utilizing an aggregation‐induced emission luminogen, tetra‐(4‐pyridylphenyl)ethylene (TPE‐4Py), to fabricate hydrogels with the above capabilities. Bilayer hydrogel actuators with the ionomer of poly(acrylamide‐r‐sodium 4‐styrenesulfonate) (PAS) as a matrix of both active and passive layers and TPE‐4Py as the core function element in the active layer are prepared. At acidic pH, the protonation of TPE‐4Py leads to fluorescence color and brightness changes of the actuators and the electrostatic interactions between the protonated TPE‐4Py and benzenesulfonate groups of the PAS chains in the active layer cause the actuators to deform. The proposed TPE‐4Py/PAS‐based bilayer hydrogel actuators with such responsiveness to stimulus provide insights in the design of intelligent systems and are highly attractive material candidates in the fields of 3D/4D printing, soft robots, and smart wearable devices.
Bioinspired hydrogels with abilities of simultaneous fluorescence color and brightness changes, as well as complex shape deformation under pH stimulus by utilizing aggregation‐induced emission luminogens (AIEgens) and the bilayer hydrogel technique are designed and fabricated.
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The accurate survey is of great significance to water resources in terms of efficient utilization,ecological environment protection and resource management.However, most of the current water resource ...investigation researches were based on high-resolution satellite data,which cannot meet the accuracy requirement for survey of water resources in underlying surface of complex plain urban region.Here,an investigation method is proposed for water resources quantity,which is based on UAV( unmanned aerial vehicle) remote sensing, SWAT model and geographic information technology.in this method,the accurate distribution of surface water can be obtained by field investigation , and the total quantity of water resource including groundwater and duplicated amount between surface water and groundwater are estimated by the hydrological model with underlying surface data from the third National Land Survey.Then this method is applied to a plain city of Pizhou,where the river network is complex,to verify its feasibility and
Nonlinear optical microscopy has become a powerful tool in bioimaging research due to its unique capabilities of deep optical sectioning, high‐spatial‐resolution imaging, and 3D reconstruction of ...biological specimens. Developing organic fluorescent probes with strong nonlinear optical effects, in particular third‐harmonic generation (THG), is promising for exploiting nonlinear microscopic imaging for biomedical applications. Herein, a simple method for preparing organic nanocrystals based on an aggregation‐induced emission (AIE) luminogen (DCCN) with bright near‐infrared emission is successfully demonstrated. Aggregation‐induced nonlinear optical effects, including two‐photon fluorescence (2PF), three‐photon fluorescence (3PF), and THG, of DCCN are observed in nanoparticles, especially for crystalline nanoparticles. The nanocrystals of DCCN are successfully applied for 2PF microscopy at 1040 nm NIR‐II excitation and THG microscopy at 1560 nm NIR‐II excitation, respectively, to reconstruct the 3D vasculature of the mouse cerebral vasculature. Impressively, the THG microscopy provides much higher spatial resolution and brightness than the 2PF microscopy and can visualize small vessels with diameters of ≈2.7 µm at the deepest depth of 800 µm in a mouse brain. Thus, this is expected to inspire new insights into the development of advanced AIE materials with multiple nonlinearity, in particular THG, for multimodal nonlinear optical microscopy.
Aggregation‐induced nonlinear optical effects, in particular third‐harmonic generation, of an aggregation‐induced emission luminogen (AIEgen) are observed in nanoparticles, especially for crystalline nanoparticles. AIEgen nanocrystals enable ultradeep intravital third‐harmonic generation imaging (up to 800 µm) of mouse cerebral vasculature with high spatial resolution (≈2.7 µm) at the deepest depth of 800 µm, much superior to two‐ and three‐photon fluorescence imaging.
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Summary
Tea is the world's widely consumed nonalcohol beverage with essential economic and health benefits. Confronted with the increasing large‐scale omics‐data set particularly the genome sequence ...released in tea plant, the construction of a comprehensive knowledgebase is urgently needed to facilitate the utilization of these data sets towards molecular breeding. We hereby present the first integrative and specially designed web‐accessible database, Tea Plant Information Archive (TPIA; http://tpia.teaplant.org). The current release of TPIA employs the comprehensively annotated tea plant genome as framework and incorporates with abundant well‐organized transcriptomes, gene expressions (across species, tissues and stresses), orthologs and characteristic metabolites determining tea quality. It also hosts massive transcription factors, polymorphic simple sequence repeats, single nucleotide polymorphisms, correlations, manually curated functional genes and globally collected germplasm information. A variety of versatile analytic tools (e.g. JBrowse, blast, enrichment analysis, etc.) are established helping users to perform further comparative, evolutionary and functional analysis. We show a case application of TPIA that provides novel and interesting insights into the phytochemical content variation of section Thea of genus Camellia under a well‐resolved phylogenetic framework. The constructed knowledgebase of tea plant will serve as a central gateway for global tea community to better understand the tea plant biology that largely benefits the whole tea industry.
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Fuzzing is a simple yet effective approach to discover software bugs utilizing randomly generated inputs. However, it is limited by coverage and cannot find bugs hidden in deep execution paths of the ...program because the randomly generated inputs fail complex sanity checks, e.g., checks on magic values, checksums, or hashes. To improve coverage, existing approaches rely on imprecise heuristics or complex input mutation techniques (e.g., symbolic execution or taint analysis) to bypass sanity checks. Our novel method tackles coverage from a different angle: by removing sanity checks in the target program. T-Fuzz leverages a coverage-guided fuzzer to generate inputs. Whenever the fuzzer can no longer trigger new code paths, a light-weight, dynamic tracing based technique detects the input checks that the fuzzer-generated inputs fail. These checks are then removed from the target program. Fuzzing then continues on the transformed program, allowing the code protected by the removed checks to be triggered and potential bugs discovered. Fuzzing transformed programs to find bugs poses two challenges: (1) removal of checks leads to over-approximation and false positives, and (2) even for true bugs, the crashing input on the transformed program may not trigger the bug in the original program. As an auxiliary post-processing step, T-Fuzz leverages a symbolic execution-based approach to filter out false positives and reproduce true bugs in the original program. By transforming the program as well as mutating the input, T-Fuzz covers more code and finds more true bugs than any existing technique. We have evaluated T-Fuzz on the DARPA Cyber Grand Challenge dataset, LAVA-M dataset and 4 real-world programs (pngfix, tiffinfo, magick and pdftohtml). For the CGC dataset, T-Fuzz finds bugs in 166 binaries, Driller in 121, and AFL in 105. In addition, found 3 new bugs in previously-fuzzed programs and libraries.
Novel 3D Ni1−xCoxSe2 mesoporous nanosheet networks with tunable stoichiometry are successfully synthesized on Ni foam (Ni1−xCoxSe2 MNSN/NF with x ranging from 0 to 0.35). The collective effects of ...special morphological design and electronic structure engineering enable the integrated electrocatalyst to have very high activity for hydrogen evolution reaction (HER) and excellent stability in a wide pH range. Ni0.89Co0.11Se2 MNSN/NF is revealed to exhibit an overpotential (η10) of 85 mV at −10 mA cm−2 in alkaline medium (pH 14) and η10 of 52 mV in acidic solution (pH 0), which are the best among all selenide‐based electrocatalysts reported thus far. In particular, it is shown for the first time that the catalyst can work efficiently in neutral solution (pH 7) with a record η10 of 82 mV for all noble metal‐free electrocatalysts ever reported. Based on theoretical calculations, it is further verified that the advanced all‐pH HER activity of Ni0.89Co0.11Se2 is originated from the enhanced adsorption of both H+ and H2O induced by the substitutional doping of cobalt at an optimal level. It is believed that the present work provides a valuable route for the design and synthesis of inexpensive and efficient all‐pH HER electrocatalysts.
An integrated electrocatalyst comprising 3D mesoporous Ni0.89Co0.11Se2 nanosheet networks on Ni foam is synthesized, and it demonstrates very high activities and excellent stabilities for hydrogen evolution reaction (HER) in all‐pH conditions. Theoretical calculations verify that electronic structure engineering by optimal Co doping enhances the adsorption of H+ and H2O, leading to the advanced all‐pH HER activity of the catalyst.
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In this paper, we investigate the action growth in various backgrounds in Einstein-Maxwell-dilaton theory. We calculate the full time evolution of action growth in the anti–de Sitter dilaton black ...hole and find it approaches the late time bound from above. We investigate the black hole which is asymptotically Lifshitz and obtain its late time and full time behavior. We find the violation of Lloyd bound in the late time limit and show the full time behavior approaching the late time bound from above and exhibiting some new features for z sufficiently large.
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