To estimate the association of human papillomavirus (HPV) infection with oral lichen planus (OLP) and oral leukoplakia (OLK), and determine risk cofactors.
Seven databases were searched for ...case-control or cross-sectional studies of OLP and OLK with healthy controls, published between 1976 and 2020. The Meta package of R software was applied to calculate the pooled odds ratios (OR) and 95% confidence interval (CI).
Thirty-six articles were finally included. OLP and OLK cases had a higher association with HPV infection than controls (OLP: OR: 4.91, 95% CI: 2.76-8.72; OLK: OR: 2.51, 95% CI: 1.55-4.07). In subgroup analyses, the OR of HPV infection was higher with erosive lesions than with nonerosive lesions (OLP: OR: 5.36 and 3.47, respectively; OLK: OR: 3.34 and 3.21, respectively). Oral lesions were more strongly associated with HPV16/18 than with HPV6/11 (OLP: OR: 7.84 and 1.42, respectively; OLK: OR: 6.05 and 1.87, respectively) and varied by geographic region (OLP: OR: 4.01-7.02; OLK: OR: 1.46-27.13).
Oral HPV infection, particularly infection with HPV 16/18, was strongly associated with OLP and OLK. Risk cofactors included erosive lesions and geographic region.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The clinical value and molecular characteristics of tumor differentiation in oral squamous cell carcinoma (OSCC) remain unclear. There is a lack of a related molecular classification prediction ...system based on pathological images for precision medicine.
Integration of epidemiology, genomics, experiments, and deep learning to clarify the clinical value and molecular characteristics, and develop a novel OSCC molecular classification prediction system.
Large-scale epidemiology data (n = 118,817) demonstrated OSCC differentiation was a significant prognosis indicator (p < 0.001), and well-differentiated OSCC was more chemo-resistant than poorly differentiated OSCC. These results were confirmed in the TCGA database and in vitro. Furthermore, we found chemo-resistant related pathways and cell cycle-related pathways were up-regulated in well- and poorly differentiated OSCC, respectively. Based on the characteristics of OSCC differentiation, a molecular grade of OSCC was obtained and combined with pathological images to establish a novel prediction system through deep learning, named ShuffleNetV2-based Molecular Grade of OSCC (SMGO). Importantly, our independent multi-center cohort of OSCC (n = 340) confirmed the high accuracy of SMGO.
OSCC differentiation was a significant indicator of prognosis and chemotherapy selection. Importantly, SMGO could be an indispensable reference for OSCC differentiation and assist the decision-making of chemotherapy.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
13.
Anxiety and oral lichen planus Liao, Honglin; Luo, Yuxue; Long, Li ...
Oral diseases,
April 2021, 2021-Apr, 2021-04-00, 20210401, Volume:
27, Issue:
3
Journal Article
Peer reviewed
Objectives
To investigate the association between oral lichen planu(OLP) and anxiety.
Subjects and Methods
This study included 174 OLP patients and 174 healthy controls. We assessed anxiety by ...Self‐rating Anxiety Scale (SAS) and recorded OLP lesion type and severity. t test and analysis of variance were applied for continuous variants and chi‐square test was performed for categorical variants. Multiple linear regression and logistic regression analysis were used for multi‐variable analysis.
Results
he SAS score of OLP patients was higher than that of healthy individuals. There was no significant difference in SAS score between the OLP subgroups, obtained according to age, type, and severity, respectively. Multiple linear regression analysis showed gender was the only factor that affected the SAS score of OLP patients. Compared with weakly anxiety‐related groups, the SAS score and female ratio of highly anxiety‐related group were obviously higher. Logistic regression analysis demonstrated that males were less exposed to highly anxiety‐related types than females.
Conclusions
OLP patients tend to be more anxious compared with healthy individuals, and female patients are more anxious than male patients. There might be two types of OLP patients: weakly anxiety‐related or highly anxiety‐related. These results highlight the significance of psychological counseling in OLP disease management.
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CMK, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Objective
We attempted to investigate the role of interleukin‐6 (IL‐6) family expression in local tissues as it relates to presentations and outcomes in oral lichen planus (OLP), which is a common ...chronic inflammatory oral disease.
Materials and Methods
A clinical follow‐up cohort of OLP patients was established, and a biological sample library was constructed with categorization into erosive type (EOLP) and nonerosive type (NEOLP). Transcriptome sequencing of the lesions was then performed. A multiple regression model was used to explore the differences in IL‐6 family expression among patients with different clinical types and clinical outcomes.
Results
OLP tissue transcriptome sequencing showed that IL‐6 family expression in EOLP increased significantly. It was also found that IL‐6 family factors in the OLP recurrent erosion group were significantly increased compared to the persistent nonerosion group. Based on the multiple regression analysis of the OLP clinical cohort, it was found that the increased expression of the IL‐6 family was closely related to the clinical types and clinical outcomes of OLP.
Conclusion
The high expression of the IL‐6 family is closely related to the erosion of local mucosa and poor prognosis of OLP patients. IL‐6‐related factors may be used as therapeutic targets for OLP patients.
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CMK, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Magnetorheological polishing (MRF) has emerged as a critical non-contact sub-aperture polishing technology due to its notable attributes of high precision and minimal damage. However, MRF's inherent ...D-shaped removal function leads to reduced convergence efficiency of surface form error and introduces mid-spatial-frequency (MSF) waviness. To address these challenges, we propose magnetorheological precession finishing (MRPF) technology, which ingeniously combines MRF with bonnet precession polishing to generate a Gaussian-like removal function. A pivotal component of what we believe to be a novel approach is the design and fabrication of a specialized hemispherical magnetorheological precession polishing head. The design process incorporates magnetostatic simulations and magnetic force analysis to determine the optimal generating conditions for magnetorheological ribbons. Spot polishing experiments confirm the suitability of a 30° precession angle. Experimental results demonstrate that 8-step polishing achieves a Gaussian-like removal function. Additionally, uniform polishing of fused quartz surfaces significantly reduces Ra from 0.7 µm to 2.14 nm. This research showcases the feasibility of MRPF as a new technical route to achieve Gaussian-like removal functions and nanometer-scaled surface roughness.
Lithium ion batteries have been undergoing rapid development in the global market due to their superior performance. However, the soaring number of lithium ion batteries in the market presents ...serious disposal challenges at the end of life. Moreover, continuous mining processes are harmful to the environment. From the viewpoint of cleaner production and green chemistry, the efficient recovery and reutilization of spent lithium ion batteries are necessary. In this perspective, the overall process of lithium ion battery recycling, especially the recent advances of hydrometallurgical methods, are summarized, focusing on the leaching, separation, and purification processes. The proper disposal of the waste discharged during the recycling process is proposed, highlighting the mitigation of secondary pollution. In addition, the environmental impact of recycling processes is summarized and thoroughly evaluated by recent life cycle assessment studies, revealing the key role of recycling strategic metal elements toward sustainability in an anthropogenic cycle. Finally, the current challenges in this area are pointed out and perspectives on sustainable approaches, cleaner production, and life cycle assessment are proposed.
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IJS, KILJ, NUK, PNG, UL, UM
Using CdSe/ZnSe core–shell quantum dots (QDs) as a model, we systematically investigate the photochemical properties of QDs with the ZnSe shells under an ambient environment, which show almost ...opposite responses to either oxygen or water in comparison with CdSe/CdS core/shell QDs. While the ZnSe shells provide an efficient potential barrier for photoinduced electron transfer from the core to the surface-adsorbed oxygen, they also act as a stepping stone for hot-electron transfer directly from the ZnSe shells to oxygen. The latter process is so effective and competes favorably with ultrafast relaxation of hot electrons from the ZnSe shells to the core QDs, which can completely quench the photoluminescence (PL) with saturated adsorption of oxygen (1 bar) and initiate oxidation of the surface anion sites. Water can slowly eliminate the excess hole to neutralize the positively charged QDs, partially canceling the photochemical effects of oxygen. Alkylphosphinesthrough two distinctive reaction pathways with oxygenstop the photochemical effects of oxygen and completely recover PL. With limited thickness (around two monolayers), the ZnS outer shells substantially slow down photochemical effects on CdSe/ZnSe/ZnS core/shell/shell QDs but cannot fully stop PL quenching by oxygen.
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Red mud was evaluated as an alternative skeleton builder combined with Fenton's reagent in sewage sludge conditioning. The results show that red mud combined with Fenton's reagent showed good ...conditioning capability with the pH of the filtrate close to neutrality, indicating that red mud acted as a neutralizer as well as a skeleton builder when jointly used with Fenton's reagent. Through response surface methodology (RSM), the optimal dosages of Fe2+, H2O2 and red mud were proposed as 31.9, 33.7 and 275.1 mg/g DS (dry solids), respectively. The mechanism of the composite conditioner could be illuminated as follows: (1) extracellular polymeric substances (EPS), including loosely bound EPS and tightly bound EPS, were degraded into dissolved organics, e.g., proteins and polysaccharides; (2) bound water was released and converted into free water due to the degradation of EPS; and (3) morphology of the conditioned sludge exhibited a porous structure in contrast with the compact structure of raw sludge, and the addition of red mud formed new mineral phases and a rigid lattice structure in sludge, allowing the outflow of free water. Thus, sludge dewatering performance was effectively improved. The economic assessment for a wastewater treatment plant of 370,000 equivalent inhabitants confirms that using red mud conditioning, combined with Fenton's reagent, leads to a saving of approximately 411,000 USD/y or 50.8 USD/t DS comparing with using lime and ordinary Portland cement combined with Fenton's reagent, and approximately 612,000 USD/y or 75.5 USD/t DS comparing with the traditional treatment.
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•The feasibility of using red mud as a novel skeleton builder was demonstrated.•The degradations of LB-EPS and TB-EPS into dissolved organics were determined.•The conversion of bound water into free water was illustrated by DSC.•New mineral phases and a rigid porous structure were identified by XRD and SEM.•The economic benefits were confirmed for a WWTP of 370,000 IE.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Size- and shape-controlled CdSe/ZnSe core/shell and CdSe/ZnSe/ZnS core/shell/shell nanocrystals in a zinc-blende structure with (zinc) alkanoates as the ligands are synthesized by managing two types ...of strains. The surface-ligand strain, strain between the inorganic crystal surface and organic ligandsplays a key role for the ZnSe epitaxy and can be relieved via a two-step epitaxy. Small (acetate) ligands are necessary for both steps and branched (2-hexyl decanoate) ligands are needed for growing thick (2–16 monolayers) ZnSe shells in step 2. The CdSe–ZnSe interface results in strong/asymmetric tensile strain on the inner portion (within ∼7 monolayers) of the ZnSe shells and weak/hydrodynamic compression strain on the CdSe core QDs. The CdSe–ZnSe lattice strain does not noticeably affect the ZnSe epitaxy but significantly alters photoluminescence (PL) of CdSe/ZnSe/ZnS core/shell/shell QDs. With a proper thickness of both ZnSe and ZnS shells, CdSe/ZnSe/ZnS core/shell/shell QDs in a green-emitting window are synthesized with near-unity PL quantum yield, mono-exponential PL decay dynamics, and improved photophysical/photochemical stability.
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