The low perioperative morbidity and shorter hospital stay associated with laparoscopic hepatectomy have made it an often-used option at many liver centers, despite the fact that many patients with ...hepatocellular carcinoma have cirrhosis, which makes the procedure more difficult and dangerous. Type of surgical procedure proves not to be a primary risk factor for poor outcomes after hepatic resection for hepatocellular carcinoma, the available evidence clearly shows that laparoscopic hepatectomy is an effective alternative to the open procedure for patients with early-stage hepatocellular carcinoma, even in the presence of cirrhosis. Whether the same is true for patients with intermediate or advanced disease is less clear, since laparoscopic major hepatectomy remains a technically demanding procedure.
This study aimed to assess the efficacy and safety of bevacizumab plus preoperative chemotherapy as first-line treatment for liver-only metastatic colorectal cancer in Chinese patients compared with ...those of preoperative chemotherapy alone.Patients with histologically confirmed liver-only metastatic colorectal cancer were sequentially reviewed, and received either preoperative chemotherapy plus bevacizumab (bevacizumab group, n = 32) or preoperative chemotherapy alone (chemotherapy group, n = 57). Progression-free survival, response rate, liver resection rate, conversion rate, and safety were analyzed.With median follow-up of 28.7 months, progression-free survival was 10.9 months (95% confidence interval: 8.7-13.1 months) in bevacizumab group and 9.9 months (95% confidence interval: 6.8-13.1 months) in chemotherapy group (P = 0.472). Response rates were 59.4% in bevacizumab group and 38.6% in chemotherapy group (P = 0.059). Overall liver resection (R0, R1, and R2) rate was 68.8% in bevacizumab group and 54.4% in chemotherapy group (P = 0.185). Conversion rate was 51.9% in bevacizumab group and 40.4% in chemotherapy group (P = 0.341). No postoperative complication was observed in all patients.Bevacizumab plus preoperative chemotherapy as first-line treatment for liver-only metastatic colorectal cancer tends to achieve better clinical benefit with controllable safety in Chinese patients.
To compare the therapeutic effects of acupuncture and western medicine on minimal brain dysfunction (MBD) and to search for a clinically effective therapy for MBD.
Sixty-eight cases were randomly ...divided into an acupuncture group and a western medicine group, 34 cases in each group. The acupuncture group were treated by acupuncture at Dazhui (GV 14) and Shenque (CV 8), and the western medicine group by taking Haloperidol orally. One month constituted one course. After treatment, the total effective rate and scores of Connell's scale for diagnosis and behavior of MBD were compared between the two groups.
The total effective rate and the score after treatment were 97.1% and 10 +/- 0.37 in the acupuncture group and 82.4% and 15 +/- 0.93 in the western medicine group, with a very significant difference between the two groups (P < 0.01, P < 0.000 5), the acupuncture group being better than the western medicine group. Follow-up survey for 2-10 months showed the effects of the acupuncture group still were kept.
Acup
(Mg0.95Zn0.05)2(Ti0.8Sn0.2)O4 powder was synthesized by a solid state reaction. Then, Ni0.4Zn0.6Fe2O4 was grown on the (Mg0.95Zn0.05)(Ti0.8Sn0.2)O4 particles in a hydrothermal environment to form a ...core-shell structure. (1-x)(Mg0.95Zn0.05)2(Ti0.8Sn0.2)O4@xNi0.4Zn0.6Fe2O4 composite ceramics were sintered at 1200°C with these powders. XRD, SEM, TEM analyses indicated that high dense core-shell ceramics without any foreign phase were obtained. Different types of sharp interfaces were self-assembled owing to the minimization of direct elastic energy in the hydrothermal environment. The composites enjoy good magnetic and dielectric properties, especially, good microwave dielectric properties with high saturation magnetization when the ferrite content is 0.3–0.5. The results provided a powerful experimental basis for the sensor and transducer.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
(–)‐Methadone acts as an agonist at opioid receptors. Both (+)‐ and (–)‐enantiomers of methadone have been suggested to be potent non‐competitive antagonists of α3β4 neuronal nicotinic acetylcholine ...receptors (nAChRs). In the present study, we have examined interactions of methadone with nAChRs by using receptor binding assays, patch‐clamp recording and calcium fluorometry imaging with SH‐SY5Y cells naturally expressing α7 and α3* nAChR subtypes and SH‐EP1‐hα7 cells heterologously expressing human α7 nAChRs. Methadone potently inhibited binding of 3Hmethyllycaconitine to α7 nAChRs and that of 3Hepibatidine to α3* nAChRs. Methadone pretreatment induced up‐regulation of epibatidine binding sites in SH‐SY5Y cells. Using whole‐cell patch‐clamp recording, both isomers of methadone activated cation currents via mecamylamine‐sensitive nAChRs in SH‐SY5Y cells. Nicotine and both (+)‐ and (–)‐methadone evoked increases in Ca2+i in both fluo‐3AM loaded cell lines, and these effects were blocked by mecamylamine and by the α7 selective antagonist methyllycaconitine, suggesting effects of methadone as α7‐nAChR agonist. Sensitivity of sustained nicotine and methadone effects to blockade by CdCl2, ryanodine and xestospongin‐c implicates voltage‐operated Ca2+ channels and intracellular Ca2+ stores as downstream modulators of elevated Ca2+i. Collectively, our results suggest that methadone engages in complex and potentially pharmacologically significant interactions with nAChRs.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
According to the basic information of sequences of Ti and Al characteristic atoms in hcp Ti-Al system, the compositional variations of the electronic structure, atomic potential energies, atomic ...volumes, lattice constants and cohesive energies of the ordered hcp Ti3Al type alloys were calculated by the framework of systematic science of alloys (SSA). The electronic structure of the hcp Ti3Al compound consisted of psi(4h)Ti and psi(0h)Al atoms is 0.75Ar (3dn)0.573(3dc)2.1685(4sc)0.972(4sf)0.3093+ 025Ne(3sc)1.32 (3pc)1.19(3sf)0.49. The factors of controlling lattice stability are electronic structure, atomic energies and atomic concentration. The psi(4h)Ti atoms play a determinative role in forming D0(19) structure with a=0.2872 nm, c=0.4564 nm, atomic cohesive energy epsilon=4.810 8 eV/atom and heat of formation DeltaH=-0.3328 eV/atom. These calculated values are in good agreement with experimental values (a=0.2875 nm, c=0.460 nm, DeltaH=-0.27, -0.29 eV/atom). The calculated cohesive energy of the hcp Ti3Al compound is slightly bigger than that of the fcc Ti3Al.This is a good sign that makes it feasible to stabilized L12 structure of the hcp Ti3Al compound by ternary element. The new element should have more dc-electrons than Ti-metal and occupy at the Ti-lattice points.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Low-lying locally advanced rectal cancer (LARC) after preoperative chemoradiotherapy (CRT) can be surgically removed by either abdominperineal resection (APR) or sphincter preserving resection (SPR). ...This retrospective cohort study of 251 consecutive patients with low lying LARC who underwent CRT followed by radical surgery in a single institute, between March 2003 and November 2012, aimed to compare the oncological benefits between the two groups. 3-year disease free survival (DFS), overall survival (OS), cumulative incidence of recurrence and postoperative complications were compared between the two approaches. With median follow-up of 48.6 months, SPR group had higher 3-year DFS rate (86.4% vs 73.6%, P=0.023) and lower incidence of distant recurrence (12.0% vs 23.7%, P=0.026). The postoperative complications, incidence of local recurrence and the 3-year OS were comparable between the two groups. Pathologic T and N stage were the independent predictors for 3-year DFS (P=0.020 and P<0.001). In conclusion, our study suggest that low-lying LARC patients with a significant response to preoperative CRT can benefit from the advantage of SPR in preserving the anal sphincter function without compromising their oncologic outcome.
The systematic science of alloys （SSA） is a framework of the total energy and total volume able to be separated. The volume sequences of characteristic atoms at the central sites of the basic ...clusters in the fcc-based Au-Cu system are separated out from the experimental volumes of L10-AuCu and L12-AuCu3 compounds at room temperature only, by nine volume V-functions. From these volume sequences, the volumes, volumes of formation, ordering （excess） volumes and volume mismatch degrees of the L10-AuCu, L12-AuCu3 and L12-AuaCu compounds, Au3Cu-, AuCu- and AuCu3-type ordered alloys with maximal ordering degree, and disordered Au1-xCux alloys are calculated. Among these functions, only ordering volumes of the compounds and ordered alloys obtained by the 6th V-function are negative, i.e., the destruction of the superlattice is accompanied by an increase in volume, which is identical with the experimental results. Accompanying conclusions, the different descriptions of volumetric properties between traditional alloy theories and SSA framework are discussed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Isometric heat capacity cv and isobaric heat capacity cp of Pt with stable and metastable phases were calculated by using pure element systematic theory. These results are in excellent agreement with ...of SGTE （Scientific Group Thermodata Europe） database and JANAF （Joint Army-Navy-Air Force） experimental values. The calculation results of cv and cp of Pt metal in natural state are in good agreement with those calculated by FP（first-principles） method. It is found that the electron devotion to heat capacity is important to adjust in OA（one-atom） method while calculating heat capacity. The full information about thermodynamic properties of Pt metal with stable and metastable phases, such as entropy（S）, enthalpy（H） and Gibbs energy（G） were calculated from 0 K to random temperature. The results are in good agreement with JANAF experimental value. In contrast to SGTE database, the thermodynamic properties from 0 K to 298.15 K are implemented.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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